Srsf3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srsf3
Entrez Gene ID	20383
Full Name	serine/arginine-rich splicing factor 3
Synonyms	AL024116,Sfrs3,X16
General protein information	Preferred Names serine/arginine-rich splicing factor 3 Names serine/arginine-rich splicing factor 3 pre-mRNA-splicing factor SRP20 splicing factor, arginine/serine-rich 3 (SRp20)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 A3.3\|17 15.03 cM
Summary	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013663.5	NP_038691.1	serine/arginine-rich splicing factor 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SRSF3	NP_001182483.1
Homo sapiens (human)	SRSF3	NP_003008.1
Bos taurus (cattle)	SRSF3	NP_001029872.1
Mus musculus (house mouse)	Srsf3	NP_038691.1
Xenopus tropicalis (tropical clawed frog)	srsf3	NP_001005054.1
Pan troglodytes (chimpanzee)	SRSF3	XP_003950874.1
Canis lupus familiaris (dog)	SRSF3	XP_532124.3
Rattus norvegicus (Norway rat)	Srsf3	NP_001041372.1

Gene Ontology
Bibliography

Related articles in PubMed

Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Zhou J, Wang R, Zhang J, Zhu L, Liu W, Lu S, Chen P, Li H, Yin B, Yuan J, Qiang B, Shu P, Peng X
Biochimica et biophysica acta1860(12)1159-1168(2017 Dec)

Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts.
Boutej H, Rahimian R, Thammisetty SS, B?land LC, Lalancette-H?bert M, Kriz J
Cell reports21(11)3220-3233(2017 Dec)

Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates.
Ajiro M, Jia R, Wang RH, Deng CX, Zheng ZM
International journal of biological sciences11(11)1248-56(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data liver/mammary gland expressing Srsf3 siRNA displayed a suppressed level of Srsf3 protein, but not the mRNA.
Title: Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates.

potential role in preventing hepatic carcinogenesis by regulating splicing to suppress fibrosis, mitogenic splicing, and epithelial to mesenchymal transition
Title: Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice.

Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver
Title: Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.

This study provides the first evidence for a SRSF3-driven genetic programme required for morphological and functional differentiation of hepatocytes that may have relevance for human liver disease and metabolic dysregulation.
Title: Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.

SRSF3 and SRSF4 proteins bind to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 in histone mRNA metabolism.
Title: The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.

The following Srsf3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srsf3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09758	NM_013663.5 Latest version!	Mus musculus serine and arginine-rich splicing factor 3 (Srsf3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srsf3 ( NM_013663.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038691.1 Mus musculus serine and arginine-rich splicing factor 3 (Srsf3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09758
Clone ID Related Accession (Same CDS sequence)	NM_013663.5
Accession Version	NM_013663.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-14
Organism	Mus musculus(house mouse)
Product	serine/arginine-rich splicing factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY249648.1, AK078891.1 and BB008721.1. On Sep 10, 2010 this sequence version replaced NM_013663.4. Transcript Variant: This variant (1) represents the protein-coding transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU513700.1, AK078891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCATCGTG ATTCCTGTCC CTTGGATTGT AAGGTTTATG TAGGTAATCT TGGAAATAAT 
GGAAACAAGA CTGAATTAGA ACGGGCTTTT GGCTATTATG GACCACTCAG AAGTGTGTGG 
GTTGCTCGAA ACCCTCCTGG CTTTGCTTTC GTCGAATTTG AGGATCCCCG AGATGCTGCT 
GATGCTGTCC GGGAACTAGA TGGAAGAACA CTGTGTGGCT GCCGTGTAAG AGTGGAACTG 
TCGAATGGTG AAAAGAGAAG TCGGAATCGT GGGCCGCCTC CCTCTTGGGG TCGTCGTCCT 
CGAGATGATT ACCGCAGGAG GAGTCCTCCA CCTCGGCGCA GATCCCCAAG AAGGAGAAGC 
TTTTCCCGAA GCCGGAGCAG GTCACTTTCT AGAGATAGGA GAAGAGAAAG GTCTCTGTCT 
CGTGAGAGAA ATCACAAGCC GTCTCGATCC TTCTCTAGGT CTCGTAGCCG ATCTAGGTCA 
AATGAAAGGA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038691.1
CDS	130..624
Translation	MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK

Target ORF information:

RefSeq Version	NM_013663.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine and arginine-rich splicing factor 3 (Srsf3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013663.5

ORF Insert Sequence:

ATGCATCGTG ATTCCTGTCC CTTGGATTGT AAGGTTTATG TAGGTAATCT TGGAAATAAT 
GGAAACAAGA CTGAATTAGA ACGGGCTTTT GGCTATTATG GACCACTCAG AAGTGTGTGG 
GTTGCTCGAA ACCCTCCTGG CTTTGCTTTC GTCGAATTTG AGGATCCCCG AGATGCTGCT 
GATGCTGTCC GGGAACTAGA TGGAAGAACA CTGTGTGGCT GCCGTGTAAG AGTGGAACTG 
TCGAATGGTG AAAAGAGAAG TCGGAATCGT GGGCCGCCTC CCTCTTGGGG TCGTCGTCCT 
CGAGATGATT ACCGCAGGAG GAGTCCTCCA CCTCGGCGCA GATCCCCAAG AAGGAGAAGC 
TTTTCCCGAA GCCGGAGCAG GTCACTTTCT AGAGATAGGA GAAGAGAAAG GTCTCTGTCT 
CGTGAGAGAA ATCACAAGCC GTCTCGATCC TTCTCTAGGT CTCGTAGCCG ATCTAGGTCA 
AATGAAAGGA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Biochimica et biophysica acta1860(12)1159-1168(2017 Dec)
Zhou J,Wang R,Zhang J,Zhu L,Liu W,Lu S,Chen P,Li H,Yin B,Yuan J,Qiang B,Shu P,Peng X

Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts.
Cell reports21(11)3220-3233(2017 Dec)
Boutej H,Rahimian R,Thammisetty SS,B?land LC,Lalancette-H?bert M,Kriz J

Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates.
International journal of biological sciences11(11)1248-56(2015)
Ajiro M,Jia R,Wang RH,Deng CX,Zheng ZM

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Srsf3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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