Scin cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scin
Entrez Gene ID	20259
Full Name	scinderin
Synonyms	AW545522,adseverin
General protein information	Preferred Names scinderin Names adseverin gelsolin-like protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 B1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009132.2	NP_033158.2	adseverin isoform 2
NM_001146196.1	NP_001139668.1	adseverin isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Scin	NP_942043.1
Xenopus tropicalis (tropical clawed frog)	LOC100495760	XP_002939059.1
Homo sapiens (human)	SCIN	NP_001106177.1
Bos taurus (cattle)	SCIN	NP_776602.1
Pan troglodytes (chimpanzee)	SCIN	XP_527671.1
Canis lupus familiaris (dog)	SCIN	XP_005628852.1
Mus musculus (house mouse)	Scin	NP_001139668.1
	SCIN	XP_001082780.1
Gallus gallus (chicken)	SCIN	NP_001231522.1
Danio rerio (zebrafish)	scin	NP_001038583.1

Gene Ontology
Bibliography

Related articles in PubMed

Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism.
Cao Y, Wang Y, Sprangers S, Picavet DI, Glogauer M, McCulloch CA, Everts V
Calcified tissue international101(2)207-216(2017 Aug)

Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
Song MK, Lee ZH, Kim HH
Experimental & molecular medicine47e199(2015 Dec)

Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss.
Jiang H, Wang Y, Viniegra A, Sima C, McCulloch CA, Glogauer M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(6)2281-91(2015 Jun)

The actin binding protein adseverin regulates osteoclastogenesis.
Hassanpour S, Jiang H, Wang Y, Kuiper JW, Glogauer M
PloS one9(9)e109078(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis.
Title: Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.

Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts.
Title: Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss.

Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion.
Title: The actin binding protein adseverin regulates osteoclastogenesis.

Overexpression of Scin is associated with asthma.
Title: New asthma biomarkers: lessons from murine models of acute and chronic asthma.

adseverin induction is a specific gene regulatory effect by TCDD on thymocytes.
Title: Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor.

The following Scin gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scin cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03575	NM_009132.2 Latest version!	Mus musculus scinderin (Scin), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OMu07259	NM_001146196.1 Latest version!	Mus musculus scinderin (Scin), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scin ( NM_009132.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033158.2 Mus musculus scinderin (Scin), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu03575
Clone ID Related Accession (Same CDS sequence)	NM_009132.2
Accession Version	NM_009132.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1848bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	adseverin isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY201136.1, Y13971.1 and AK136080.1. On Apr 2, 2009 this sequence version replaced NM_009132.1. Transcript Variant: This variant (2) lacks two exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y13971.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGG AGCTGCAGCA CCCCGAGTTC GCGCGCGCAG GCCAGCAGGC TGGGCTGCAG 
GTGTGGAGGG TCGAGAAGCT GGAACTGGTA CCGGTGCCCC AGGGTGCCTA TGGTGACTTT 
TACGTCGGAG ACGCCTACCT GGTGCTGCAC ACCACCAAGT CCAGCAGGGG CTTCTCCTAC 
CGCCTGCATT TCTGGCTGGG AAAGGAGTGT TCCCAGGATG AGAGCACAGC GGCTGCCATC 
TTTACGGTCC AGATGGACGA CTATTTGGGT GGCAAGCCAG TCCAGAGCAG AGAGCTTCAA 
GGCTATGAGT CGACTGATTT TGTGGGCTAT TTCAAAGGCG GTCTGAAGTA CAAGGCTGGA 
GGTGTGGCTT CTGGACTAAA CCATGTCCTC ACCAATGATC TGACTGCGAA AAGACTTCTG 
CACGTGAAGG GTCGGAGAGT GGTCAGAGCC ACTGAAGTTC CCCTCAGCTG GGAGAGCTTC 
AACAAGGGCG ACTGCTTCAT CATTGACCTT GGCACCGAAA TTTACCAGTG GTGTGGTTCC 
TCCTGCAACA AATATGAGCG TCTGAAAGCA AGCCAGGTGG CCATTGGCAT CCGGGACAAT 
GAGAGGAAAG GAAGATCTCA ACTCATTGTG GTGGAAGAAG GAAGTGAACC ATCAGAGCTC 
ATGAAGGTTT TAGGGAGAAA GCCTGAGCTT CCAGATGGGG ACAATGATGA CGATGTCGTA 
GCAGACATAA GTAACAGGAA GATGGCGAAG CTCTACATGG TTTCAGATGC AAGTGGGTCC 
ATGAAAGTAA CACTGGTGGC TGAAGAAAAC CCGTTCTCCA TGGGAATGTT GCTTTCTGAA 
GAATGCTTCA TTTTGGACCA TGGTGCTGCA AAACAAATTT TTGTATGGAA AGGTAAAAAT 
GCTAACCCAC AGGAGAGGAA GACTGCCATG AAGACAGCTG AGGAGTTTTT ACAGAAAATG 
AAGTATTCTA CTAATACTCA AATTCAGGTT CTTCCGGAAG GCGGTGAAAC ACCAATTTTC 
AAACAGTTCT TTAAGGACTG GAAGGATAAA GACCAGAGTG ATGGCTTTGG GAAGGTGTAC 
ATCACGGAGA AAGTGGCTCA GATAAAGCAG ATTCCGTTTG ATGCCTCAAA ACTGCACAGT 
TCTCCGCAGA TGGCAGCCCA GCACAACATG GTGGACGATG GCTCTGGCGG GGTGGAGATC 
TGGCGTGTAG AGAACAGTGG TAGAGTCCAG ATTGACCCAA GCTCCTATGG CGAGTTCTAT 
GGCGGTGACT GCTACATTAT CCTCTACACT TATCCCAGAG GACAGATCAT CTACACATGG 
CAAGGAGCAA ATGCTACCAG AGATGAACTG ACCATGTCCG CGTTTCTGAC TGTCCAGTTG 
GACCGGTCCC TTGGAGGGCA GGCTGTGCAG GTCCGTGTCT CTCAAGGCAA AGAGCCTGCT 
CACCTGCTGA GTTTGTTCAA AGACAAACCA CTCATTATTT ATAAGAATGG GACATCCAAG 
AAAGAAGGGC AGGCACCGGC TCCCCCTACA CGCCTTTTTC AAGTCCGGAG GAACCTGGCA 
TCTATCACCA GAATTGTGGA GATTGAAGAA GTTCCGGGAG AGTTCACCCA GGATGACCTG 
GCAGAAGATG ATGTCATGCT ACTTGATGCG TGGGAACAGA TCTTTATTTG GATTGGCAAA 
GATGCCAATG AAGTTGAGAA AAAGGAATCA GTGAAGTCTG CCAAAATGTA CCTGGAGACA 
GACCCTTCTG GAAGAGACAA GAGGACACCG ATTGTCATCA TCAAGCAAGG GCACGAGCCC 
CCCACATTCA CAGGCTGGTT TCTGGGCTGG GACTCCAGCA GGTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033158.2
CDS	121..1968
Translation	MAQELQHPEFARAGQQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRSQLIVVEEGSEPSELMKVLGRKPELPDGDNDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPAPPTRLFQVRRNLASITRIVEIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW

Target ORF information:

RefSeq Version	NM_009132.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus scinderin (Scin), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009132.2

ORF Insert Sequence:

ATGGCGCAGG AGCTGCAGCA CCCCGAGTTC GCGCGCGCAG GCCAGCAGGC TGGGCTGCAG 
GTGTGGAGGG TCGAGAAGCT GGAACTGGTA CCGGTGCCCC AGGGTGCCTA TGGTGACTTT 
TACGTCGGAG ACGCCTACCT GGTGCTGCAC ACCACCAAGT CCAGCAGGGG CTTCTCCTAC 
CGCCTGCATT TCTGGCTGGG AAAGGAGTGT TCCCAGGATG AGAGCACAGC GGCTGCCATC 
TTTACGGTCC AGATGGACGA CTATTTGGGT GGCAAGCCAG TCCAGAGCAG AGAGCTTCAA 
GGCTATGAGT CGACTGATTT TGTGGGCTAT TTCAAAGGCG GTCTGAAGTA CAAGGCTGGA 
GGTGTGGCTT CTGGACTAAA CCATGTCCTC ACCAATGATC TGACTGCGAA AAGACTTCTG 
CACGTGAAGG GTCGGAGAGT GGTCAGAGCC ACTGAAGTTC CCCTCAGCTG GGAGAGCTTC 
AACAAGGGCG ACTGCTTCAT CATTGACCTT GGCACCGAAA TTTACCAGTG GTGTGGTTCC 
TCCTGCAACA AATATGAGCG TCTGAAAGCA AGCCAGGTGG CCATTGGCAT CCGGGACAAT 
GAGAGGAAAG GAAGATCTCA ACTCATTGTG GTGGAAGAAG GAAGTGAACC ATCAGAGCTC 
ATGAAGGTTT TAGGGAGAAA GCCTGAGCTT CCAGATGGGG ACAATGATGA CGATGTCGTA 
GCAGACATAA GTAACAGGAA GATGGCGAAG CTCTACATGG TTTCAGATGC AAGTGGGTCC 
ATGAAAGTAA CACTGGTGGC TGAAGAAAAC CCGTTCTCCA TGGGAATGTT GCTTTCTGAA 
GAATGCTTCA TTTTGGACCA TGGTGCTGCA AAACAAATTT TTGTATGGAA AGGTAAAAAT 
GCTAACCCAC AGGAGAGGAA GACTGCCATG AAGACAGCTG AGGAGTTTTT ACAGAAAATG 
AAGTATTCTA CTAATACTCA AATTCAGGTT CTTCCGGAAG GCGGTGAAAC ACCAATTTTC 
AAACAGTTCT TTAAGGACTG GAAGGATAAA GACCAGAGTG ATGGCTTTGG GAAGGTGTAC 
ATCACGGAGA AAGTGGCTCA GATAAAGCAG ATTCCGTTTG ATGCCTCAAA ACTGCACAGT 
TCTCCGCAGA TGGCAGCCCA GCACAACATG GTGGACGATG GCTCTGGCGG GGTGGAGATC 
TGGCGTGTAG AGAACAGTGG TAGAGTCCAG ATTGACCCAA GCTCCTATGG CGAGTTCTAT 
GGCGGTGACT GCTACATTAT CCTCTACACT TATCCCAGAG GACAGATCAT CTACACATGG 
CAAGGAGCAA ATGCTACCAG AGATGAACTG ACCATGTCCG CGTTTCTGAC TGTCCAGTTG 
GACCGGTCCC TTGGAGGGCA GGCTGTGCAG GTCCGTGTCT CTCAAGGCAA AGAGCCTGCT 
CACCTGCTGA GTTTGTTCAA AGACAAACCA CTCATTATTT ATAAGAATGG GACATCCAAG 
AAAGAAGGGC AGGCACCGGC TCCCCCTACA CGCCTTTTTC AAGTCCGGAG GAACCTGGCA 
TCTATCACCA GAATTGTGGA GATTGAAGAA GTTCCGGGAG AGTTCACCCA GGATGACCTG 
GCAGAAGATG ATGTCATGCT ACTTGATGCG TGGGAACAGA TCTTTATTTG GATTGGCAAA 
GATGCCAATG AAGTTGAGAA AAAGGAATCA GTGAAGTCTG CCAAAATGTA CCTGGAGACA 
GACCCTTCTG GAAGAGACAA GAGGACACCG ATTGTCATCA TCAAGCAAGG GCACGAGCCC 
CCCACATTCA CAGGCTGGTT TCTGGGCTGG GACTCCAGCA GGTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scin ( NM_001146196.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001139668.1 Mus musculus scinderin (Scin), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07259
Clone ID Related Accession (Same CDS sequence)	NM_001146196.1
Accession Version	NM_001146196.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2148bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	adseverin isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY201136.1, BC063328.1 and Y13971.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063328.1, AK173295.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGG AGCTGCAGCA CCCCGAGTTC GCGCGCGCAG GCCAGCAGGC TGGGCTGCAG 
GTGTGGAGGG TCGAGAAGCT GGAACTGGTA CCGGTGCCCC AGGGTGCCTA TGGTGACTTT 
TACGTCGGAG ACGCCTACCT GGTGCTGCAC ACCACCAAGT CCAGCAGGGG CTTCTCCTAC 
CGCCTGCATT TCTGGCTGGG AAAGGAGTGT TCCCAGGATG AGAGCACAGC GGCTGCCATC 
TTTACGGTCC AGATGGACGA CTATTTGGGT GGCAAGCCAG TCCAGAGCAG AGAGCTTCAA 
GGCTATGAGT CGACTGATTT TGTGGGCTAT TTCAAAGGCG GTCTGAAGTA CAAGGCTGGA 
GGTGTGGCTT CTGGACTAAA CCATGTCCTC ACCAATGATC TGACTGCGAA AAGACTTCTG 
CACGTGAAGG GTCGGAGAGT GGTCAGAGCC ACTGAAGTTC CCCTCAGCTG GGAGAGCTTC 
AACAAGGGCG ACTGCTTCAT CATTGACCTT GGCACCGAAA TTTACCAGTG GTGTGGTTCC 
TCCTGCAACA AATATGAGCG TCTGAAAGCA AGCCAGGTGG CCATTGGCAT CCGGGACAAT 
GAGAGGAAAG GAAGATCTCA ACTCATTGTG GTGGAAGAAG GAAGTGAACC ATCAGAGCTC 
ATGAAGGTTT TAGGGAGAAA GCCTGAGCTT CCAGATGGGG ACAATGATGA CGATGTCGTA 
GCAGACATAA GTAACAGGAA GATGGCGAAG CTCTACATGG TTTCAGATGC AAGTGGGTCC 
ATGAAAGTAA CACTGGTGGC TGAAGAAAAC CCGTTCTCCA TGGGAATGTT GCTTTCTGAA 
GAATGCTTCA TTTTGGACCA TGGTGCTGCA AAACAAATTT TTGTATGGAA AGGTAAAAAT 
GCTAACCCAC AGGAGAGGAA GACTGCCATG AAGACAGCTG AGGAGTTTTT ACAGAAAATG 
AAGTATTCTA CTAATACTCA AATTCAGGTT CTTCCGGAAG GCGGTGAAAC ACCAATTTTC 
AAACAGTTCT TTAAGGACTG GAAGGATAAA GACCAGAGTG ATGGCTTTGG GAAGGTGTAC 
ATCACGGAGA AAGTGGCTCA GATAAAGCAG ATTCCGTTTG ATGCCTCAAA ACTGCACAGT 
TCTCCGCAGA TGGCAGCCCA GCACAACATG GTGGACGATG GCTCTGGCGG GGTGGAGATC 
TGGCGTGTAG AGAACAGTGG TAGAGTCCAG ATTGACCCAA GCTCCTATGG CGAGTTCTAT 
GGCGGTGACT GCTACATTAT CCTCTACACT TATCCCAGAG GACAGATCAT CTACACATGG 
CAAGGAGCAA ATGCTACCAG AGATGAACTG ACCATGTCCG CGTTTCTGAC TGTCCAGTTG 
GACCGGTCCC TTGGAGGGCA GGCTGTGCAG GTCCGTGTCT CTCAAGGCAA AGAGCCTGCT 
CACCTGCTGA GTTTGTTCAA AGACAAACCA CTCATTATTT ATAAGAATGG GACATCCAAG 
AAAGAAGGGC AGGCACCGGC TCCCCCTACA CGCCTTTTTC AAGTCCGGAG GAACCTGGCA 
TCTATCACCA GAATTGTGGA GGTTGACGTT GATGCAAATT CATTAAATTC TAATGACACT 
TTTGTCCTAA AACTGCCACG AAACAATGGC TTCATCTGGA TAGGAAAAGG TGCTAGCCAG 
GAGGAGGAGA AAGGAGCAGA GTATGTGGCT GATGTCCTCA AGTGCAAAGC TTCAAGAATT 
CAAGAAGGCA AGGAACCAGA GGAATTCTGG AACTCTCTTG GAGGGAGGGG AGACTACCAG 
ACTTCACCAT TGCTAGAAAC TCGGGCTGAA GACCATCCAC CTCGGCTTTA TGGTTGCTCC 
AACAAAACTG GAAGATTCAT TATTGAAGAA GTTCCGGGAG AGTTCACCCA GGATGACCTG 
GCAGAAGATG ATGTCATGCT ACTTGATGCG TGGGAACAGA TCTTTATTTG GATTGGCAAA 
GATGCCAATG AAGTTGAGAA AAAGGAATCA GTGAAGTCTG CCAAAATGTA CCTGGAGACA 
GACCCTTCTG GAAGAGACAA GAGGACACCG ATTGTCATCA TCAAGCAAGG GCACGAGCCC 
CCCACATTCA CAGGCTGGTT TCTGGGCTGG GACTCCAGCA GGTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139668.1
CDS	121..2268
Translation	MAQELQHPEFARAGQQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRSQLIVVEEGSEPSELMKVLGRKPELPDGDNDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCKASRIQEGKEPEEFWNSLGGRGDYQTSPLLETRAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW

Target ORF information:

RefSeq Version	NM_001146196.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus scinderin (Scin), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001146196.1

ORF Insert Sequence:

ATGGCGCAGG AGCTGCAGCA CCCCGAGTTC GCGCGCGCAG GCCAGCAGGC TGGGCTGCAG 
GTGTGGAGGG TCGAGAAGCT GGAACTGGTA CCGGTGCCCC AGGGTGCCTA TGGTGACTTT 
TACGTCGGAG ACGCCTACCT GGTGCTGCAC ACCACCAAGT CCAGCAGGGG CTTCTCCTAC 
CGCCTGCATT TCTGGCTGGG AAAGGAGTGT TCCCAGGATG AGAGCACAGC GGCTGCCATC 
TTTACGGTCC AGATGGACGA CTATTTGGGT GGCAAGCCAG TCCAGAGCAG AGAGCTTCAA 
GGCTATGAGT CGACTGATTT TGTGGGCTAT TTCAAAGGCG GTCTGAAGTA CAAGGCTGGA 
GGTGTGGCTT CTGGACTAAA CCATGTCCTC ACCAATGATC TGACTGCGAA AAGACTTCTG 
CACGTGAAGG GTCGGAGAGT GGTCAGAGCC ACTGAAGTTC CCCTCAGCTG GGAGAGCTTC 
AACAAGGGCG ACTGCTTCAT CATTGACCTT GGCACCGAAA TTTACCAGTG GTGTGGTTCC 
TCCTGCAACA AATATGAGCG TCTGAAAGCA AGCCAGGTGG CCATTGGCAT CCGGGACAAT 
GAGAGGAAAG GAAGATCTCA ACTCATTGTG GTGGAAGAAG GAAGTGAACC ATCAGAGCTC 
ATGAAGGTTT TAGGGAGAAA GCCTGAGCTT CCAGATGGGG ACAATGATGA CGATGTCGTA 
GCAGACATAA GTAACAGGAA GATGGCGAAG CTCTACATGG TTTCAGATGC AAGTGGGTCC 
ATGAAAGTAA CACTGGTGGC TGAAGAAAAC CCGTTCTCCA TGGGAATGTT GCTTTCTGAA 
GAATGCTTCA TTTTGGACCA TGGTGCTGCA AAACAAATTT TTGTATGGAA AGGTAAAAAT 
GCTAACCCAC AGGAGAGGAA GACTGCCATG AAGACAGCTG AGGAGTTTTT ACAGAAAATG 
AAGTATTCTA CTAATACTCA AATTCAGGTT CTTCCGGAAG GCGGTGAAAC ACCAATTTTC 
AAACAGTTCT TTAAGGACTG GAAGGATAAA GACCAGAGTG ATGGCTTTGG GAAGGTGTAC 
ATCACGGAGA AAGTGGCTCA GATAAAGCAG ATTCCGTTTG ATGCCTCAAA ACTGCACAGT 
TCTCCGCAGA TGGCAGCCCA GCACAACATG GTGGACGATG GCTCTGGCGG GGTGGAGATC 
TGGCGTGTAG AGAACAGTGG TAGAGTCCAG ATTGACCCAA GCTCCTATGG CGAGTTCTAT 
GGCGGTGACT GCTACATTAT CCTCTACACT TATCCCAGAG GACAGATCAT CTACACATGG 
CAAGGAGCAA ATGCTACCAG AGATGAACTG ACCATGTCCG CGTTTCTGAC TGTCCAGTTG 
GACCGGTCCC TTGGAGGGCA GGCTGTGCAG GTCCGTGTCT CTCAAGGCAA AGAGCCTGCT 
CACCTGCTGA GTTTGTTCAA AGACAAACCA CTCATTATTT ATAAGAATGG GACATCCAAG 
AAAGAAGGGC AGGCACCGGC TCCCCCTACA CGCCTTTTTC AAGTCCGGAG GAACCTGGCA 
TCTATCACCA GAATTGTGGA GGTTGACGTT GATGCAAATT CATTAAATTC TAATGACACT 
TTTGTCCTAA AACTGCCACG AAACAATGGC TTCATCTGGA TAGGAAAAGG TGCTAGCCAG 
GAGGAGGAGA AAGGAGCAGA GTATGTGGCT GATGTCCTCA AGTGCAAAGC TTCAAGAATT 
CAAGAAGGCA AGGAACCAGA GGAATTCTGG AACTCTCTTG GAGGGAGGGG AGACTACCAG 
ACTTCACCAT TGCTAGAAAC TCGGGCTGAA GACCATCCAC CTCGGCTTTA TGGTTGCTCC 
AACAAAACTG GAAGATTCAT TATTGAAGAA GTTCCGGGAG AGTTCACCCA GGATGACCTG 
GCAGAAGATG ATGTCATGCT ACTTGATGCG TGGGAACAGA TCTTTATTTG GATTGGCAAA 
GATGCCAATG AAGTTGAGAA AAAGGAATCA GTGAAGTCTG CCAAAATGTA CCTGGAGACA 
GACCCTTCTG GAAGAGACAA GAGGACACCG ATTGTCATCA TCAAGCAAGG GCACGAGCCC 
CCCACATTCA CAGGCTGGTT TCTGGGCTGG GACTCCAGCA GGTGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism.
Calcified tissue international101(2)207-216(2017 Aug)
Cao Y,Wang Y,Sprangers S,Picavet DI,Glogauer M,McCulloch CA,Everts V

Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
Experimental & molecular medicine47e199(2015 Dec)
Song MK,Lee ZH,Kim HH

Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(6)2281-91(2015 Jun)
Jiang H,Wang Y,Viniegra A,Sima C,McCulloch CA,Glogauer M

The actin binding protein adseverin regulates osteoclastogenesis.
PloS one9(9)e109078(2014)
Hassanpour S,Jiang H,Wang Y,Kuiper JW,Glogauer M

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Scin cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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