Scd2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scd2
Entrez Gene ID	20250
Full Name	stearoyl-Coenzyme A desaturase 2
Synonyms	Mir5114,Scd-2,mir-5114,swty
General protein information	Preferred Names stearoyl-Coenzyme A desaturase 2 Names acyl-CoA desaturase 2 Acyl-CoA desaturase 2 (Stearoyl-CoA desaturase 2) (Fatty acid desaturase 2) (Delta(9)-desaturase 2) delta(9)-desaturase 2 fatty acid desaturase 2 stearoyl-CoA desaturase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C3\|19 37.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009128.2	NP_033154.2	acyl-CoA desaturase 2

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	OLE1	NP_011460.3
Kluyveromyces lactis	KLLA0C05566g	XP_452447.1
Schizosaccharomyces pombe (fission yeast)	SPCC1281.06c	NP_588170.1
Neurospora crassa	NCU05259	XP_961824.1
Rattus norvegicus (Norway rat)	Scd	NP_114029.1
Eremothecium gossypii	AGOS_AAR153C	NP_982696.1
Drosophila melanogaster (fruit fly)	CG8630	NP_731781.1
Caenorhabditis elegans (roundworm)	fat-6	NP_001255595.1
Caenorhabditis elegans (roundworm)	fat-5	NP_507482.1
Mus musculus (house mouse)	Scd2	NP_033154.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003418	XP_311704.5
Caenorhabditis elegans (roundworm)	fat-7	NP_504814.1
Magnaporthe oryzae (rice blast fungus)	MGG_01790	XP_003714796.1

Gene Ontology
Bibliography

Related articles in PubMed

Mfsd2a Is a Transporter for the Essential ?-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL
The Journal of biological chemistry291(20)10501-14(2016 May)

Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.
Masuda M, Miyazaki-Anzai S, Keenan AL, Okamura K, Kendrick J, Chonchol M, Offermanns S, Ntambi JM, Kuro-O M, Miyazaki M
The Journal of clinical investigation125(12)4544-58(2015 Oct)

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
Patra D, DeLassus E, Liang G, Sandell LJ
PloS one9(8)e105674(2014)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Inhibition of adipogenesis caused by SCD2 depletion was associated with a decrease in PPAR-gamma mRNA and protein, whereas in mature adipocytes loss of SCD2 diminished PPARgamma protein levels, with little change in mRNA levels.
Title: Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells.

Results show that mouse stearoyl-coenzyme A desaturase (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse SCD3 uses C16:0 but not C18:0.
Title: Identification of mouse palmitoyl-coenzyme A Delta9-desaturase.

SCD2 is crucial in the synthesis of monounsaturated fatty acids that are required for maintaining normal epidermal permeability barrier function and biosynthesis of lipids during early skin and liver development.
Title: Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development.

Exercise-induced nerve center fatigue is correlated with gene expressions of B-FABP and SCD2.
Title: [Study of the genes expression of SCD-2 and B-FABP in the mice brain of exercise-induced fatigue by genechip cDNA microarray].

The following Scd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21476	NM_009128.2 Latest version!	Mus musculus stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scd2 ( NM_009128.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033154.2 Mus musculus stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA.

Price & Availability↑

CloneID	OMu21476
Clone ID Related Accession (Same CDS sequence)	NM_009128.2
Accession Version	NM_009128.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	acyl-CoA desaturase 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ110442.1, AK083922.1, CF168778.1, AK159413.1 and CJ242760.1. On May 15, 2008 this sequence version replaced NM_009128.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040384.1, AK147406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCGGCCC ACATACTGCA AGAGATCTCT GGCGCTTACT CAGCCACCAC CACAATCACA 
GCGCCACCTT CTGGGGGACA GCAGAATGGA GGCGAGAAGT TTGAAAAGAG TTCTCACCAC 
TGGGGAGCAG ATGTTCGCCC TGAACTAAAA GATGATCTAT ATGACCCCAC CTATCAGGAT 
GATGAGGGGC CCCCGCCCAA GCTGGAGTAC GTCTGGAGGA ACATCATTCT CATGGCCCTG 
CTGCATTTGG GAGCCTTGTA CGGGATCACA CTGGTTCCCT CCTGCAAGCT CTACACCTGT 
CTCTTCGCGT ATTTGTACTA TGTAATCAGC GCCCTGGGCA TCACAGCCGG GGCTCATCGC 
CTGTGGAGCC ACAGAACATA CAAGGCACGG CTGCCCCTGA GGCTCTTCCT CATCATTGCC 
AACACCATGG CGTTCCAGAA TGACGTGTAT GAATGGGCCC GAGATCACCG CGCCCACCAC 
AAGTTCTCAG AAACACACGC CGACCCTCAC AATTCCCGCC GTGGCTTCTT TTTCTCTCAC 
GTGGGTTGGC TGCTTGTGCG CAAACACCCG GCTGTCAAAG AGAAGGGCGG AAAACTGGAC 
ATGTCTGACC TGAAAGCCGA GAAGCTGGTG ATGTTCCAGA GGAGGTACTA CAAGCCCGGC 
CTCCTGCTGA TGTGCTTCGT CCTGCCCACG CTGGTGCCCT GGTACTGCTG GGGCGAGACT 
TTTGTAAACA GCCTGTGCGT TAGCACCTTC TTGCGATACG CCGTGGTGCT CAACGCCACC 
TGGCTGGTGA ACAGTGCCGC CCACCTCTAC GGATATCGCC CCTACGACAA GAACATTAGC 
TCTCGGGAGA ACATCTTGGT TTCCATGGGA GCTGTGGGCG AGGGCTTCCA CAACTACCAC 
CACGCCTTCC CCTACGACTA CTCTGCCAGT GAGTACCGCT GGCACATCAA CTTCACCACG 
TTCTTCATCG ATTGCATGGC TCTCCTGGGC CTGGCTTACG ACCGGAAGAG AGTGTCCAGG 
GCTGCTGTCT TGGCCAGGAT TAAGAGAACT GGAGACGGAA GCTGCAAGAG CGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033154.2
CDS	713..1789
Translation	MPAHILQEISGAYSATTTITAPPSGGQQNGGEKFEKSSHHWGADVRPELKDDLYDPTYQDDEGPPPKLEYVWRNIILMALLHLGALYGITLVPSCKLYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFVLPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSRAAVLARIKRTGDGSCKSG

Target ORF information:

RefSeq Version	NM_009128.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009128.2

ORF Insert Sequence:

ATGCCGGCCC ACATACTGCA AGAGATCTCT GGCGCTTACT CAGCCACCAC CACAATCACA 
GCGCCACCTT CTGGGGGACA GCAGAATGGA GGCGAGAAGT TTGAAAAGAG TTCTCACCAC 
TGGGGAGCAG ATGTTCGCCC TGAACTAAAA GATGATCTAT ATGACCCCAC CTATCAGGAT 
GATGAGGGGC CCCCGCCCAA GCTGGAGTAC GTCTGGAGGA ACATCATTCT CATGGCCCTG 
CTGCATTTGG GAGCCTTGTA CGGGATCACA CTGGTTCCCT CCTGCAAGCT CTACACCTGT 
CTCTTCGCGT ATTTGTACTA TGTAATCAGC GCCCTGGGCA TCACAGCCGG GGCTCATCGC 
CTGTGGAGCC ACAGAACATA CAAGGCACGG CTGCCCCTGA GGCTCTTCCT CATCATTGCC 
AACACCATGG CGTTCCAGAA TGACGTGTAT GAATGGGCCC GAGATCACCG CGCCCACCAC 
AAGTTCTCAG AAACACACGC CGACCCTCAC AATTCCCGCC GTGGCTTCTT TTTCTCTCAC 
GTGGGTTGGC TGCTTGTGCG CAAACACCCG GCTGTCAAAG AGAAGGGCGG AAAACTGGAC 
ATGTCTGACC TGAAAGCCGA GAAGCTGGTG ATGTTCCAGA GGAGGTACTA CAAGCCCGGC 
CTCCTGCTGA TGTGCTTCGT CCTGCCCACG CTGGTGCCCT GGTACTGCTG GGGCGAGACT 
TTTGTAAACA GCCTGTGCGT TAGCACCTTC TTGCGATACG CCGTGGTGCT CAACGCCACC 
TGGCTGGTGA ACAGTGCCGC CCACCTCTAC GGATATCGCC CCTACGACAA GAACATTAGC 
TCTCGGGAGA ACATCTTGGT TTCCATGGGA GCTGTGGGCG AGGGCTTCCA CAACTACCAC 
CACGCCTTCC CCTACGACTA CTCTGCCAGT GAGTACCGCT GGCACATCAA CTTCACCACG 
TTCTTCATCG ATTGCATGGC TCTCCTGGGC CTGGCTTACG ACCGGAAGAG AGTGTCCAGG 
GCTGCTGTCT TGGCCAGGAT TAAGAGAACT GGAGACGGAA GCTGCAAGAG CGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mfsd2a Is a Transporter for the Essential ?-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
The Journal of biological chemistry291(20)10501-14(2016 May)
Wong BH,Chan JP,Cazenave-Gassiot A,Poh RW,Foo JC,Galam DL,Ghosh S,Nguyen LN,Barathi VA,Yeo SW,Luu CD,Wenk MR,Silver DL

Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.
The Journal of clinical investigation125(12)4544-58(2015 Oct)
Masuda M,Miyazaki-Anzai S,Keenan AL,Okamura K,Kendrick J,Chonchol M,Offermanns S,Ntambi JM,Kuro-O M,Miyazaki M

Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis.
PloS one9(8)e105674(2014)
Patra D,DeLassus E,Liang G,Sandell LJ

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

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Scd2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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