S100a10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	S100a10
Entrez Gene ID	20194
Full Name	S100 calcium binding protein A10 (calpactin)
Synonyms	42C,AA409961,AL024248,CAL12,CLP11,Cal1l,p10,p11
General protein information	Preferred Names S100 calcium binding protein A10 (calpactin) Names protein S100-A10 S100 calcium binding protein A10 (calgizzarin) S100 calcium-binding protein A10 calcium binding protein A11 (calgizzarin) calpactin I light chain calpactin-1 light chain cellular ligand of annexin II
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F2.1\|3 40.51 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009112.2	NP_033138.1	protein S100-A10
XM_017319508.1	XP_017174997.1	protein S100-A10 isoform X1
XM_030252479.1	XP_030108339.1	protein S100-A10 isoform X1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	s100a10a	NP_001005961.1
Homo sapiens (human)	S100A10	NP_002957.1
Canis lupus familiaris (dog)	S100A10	XP_003432305.1
Gallus gallus (chicken)	S100A10	NP_990837.1
Rattus norvegicus (Norway rat)	S100a10	NP_112376.1
Pan troglodytes (chimpanzee)	S100A10	XP_513807.3
Bos taurus (cattle)	S100A10	NP_777075.1
Mus musculus (house mouse)	S100a10	NP_033138.1
	S100A10	NP_001028124.1
Danio rerio (zebrafish)	s100a10b	NP_998168.1

Gene Ontology
Bibliography

Related articles in PubMed

Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases.
Luo M, Flood EC, Almeida D, Yan L, Berlin DA, Heerdt PM, Hajjar KA
The Journal of experimental medicine214(9)2535-2545(2017 Sep)

Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, Greengard P
Neuron95(3)564-576.e4(2017 Aug)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

p11KO male mice showed lower conditioned place preference than WT. In females there were no CPP differences between p11KO and WT.
Title: Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice.

data indicate that focal inhibition of p11 action in the dorsal striatum could be a promising PD therapeutic target to improve motor function while reducing l-dopa-induced dyskinesias
Title: Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.

p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-alpha-induced depression.
Title: Probable involvement of p11 with interferon alpha induced depression.

p11 homeostasis in the NAc, particularly in dopamine receptor-1 expressing medium spiny neurons, may underlie pathophysiological mechanisms of cocaine rewarding action.
Title: Cell-type specific expression of p11 controls cocaine reward.

p11 and AnxA2 cooperate to create a unique binding pocket, but the optimal binding condition is not achieved without conformational changes associated with target binding. Upon interaction with the SMARCA3 peptide, both Asp60 in p11 and Ser12 in AnxA2 flip inward toward the peptide-binding groove, forming additional intermolecular hydrogen bonds.
Title: SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.

The following S100a10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the S100a10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14978	NM_009112.2 Latest version!	Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu80575	XM_030252479.1 Latest version!	Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu80575	XM_017319508.1 Latest version!	Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

S100a10 ( NM_009112.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033138.1 Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), mRNA.

Price & Availability↑

CloneID	OMu14978
Clone ID Related Accession (Same CDS sequence)	NM_009112.2
Accession Version	NM_009112.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	protein S100-A10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU559648.1, AK161647.1 and D18288.1. On or before Jan 5, 2014 this sequence version replaced XM_006543794.1, XM_003689348.1, NM_009112.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB841906.2, CB595147.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCCATCCC AAATGGAGCA CGCCATGGAA ACCATGATGC TTACGTTTCA CAGGTTTGCA 
GGCGACAAAG ACCACTTGAC AAAGGAGGAC CTGAGAGTGC TCATGGAACG GGAGTTCCCT 
GGGTTTTTGG AAAATCAAAA GGACCCTCTG GCTGTGGACA AAATAATGAA GGACCTGGAC 
CAGTGCCGAG ATGGCAAAGT GGGCTTCCAG AGCTTTCTAT CACTAGTGGC AGGGCTCACC 
ATTGCATGCA ATGACTATTT TGTAGTAAAC ATGAAGCAGA AGGGGAAGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033138.1
CDS	116..409
Translation	MPSQMEHAMETMMLTFHRFAGDKDHLTKEDLRVLMEREFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFLSLVAGLTIACNDYFVVNMKQKGKK

Target ORF information:

RefSeq Version	NM_009112.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009112.2

ORF Insert Sequence:

ATGCCATCCC AAATGGAGCA CGCCATGGAA ACCATGATGC TTACGTTTCA CAGGTTTGCA 
GGCGACAAAG ACCACTTGAC AAAGGAGGAC CTGAGAGTGC TCATGGAACG GGAGTTCCCT 
GGGTTTTTGG AAAATCAAAA GGACCCTCTG GCTGTGGACA AAATAATGAA GGACCTGGAC 
CAGTGCCGAG ATGGCAAAGT GGGCTTCCAG AGCTTTCTAT CACTAGTGGC AGGGCTCACC 
ATTGCATGCA ATGACTATTT TGTAGTAAAC ATGAAGCAGA AGGGGAAGAA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100a10 ( XM_017319508.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017174997.1 Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu80575
Clone ID Related Accession (Same CDS sequence)	XM_017319508.1 , XM_030252479.1
Accession Version	XM_017319508.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	protein S100-A10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCC TCCAGGCTCC TCCCGCTCCG GGGCGCCTCC GCCCTCTGTA CCCGCCTCGC 
GTACAAAGAC GCGCGGTCTT CGGCACTAGC CTCATCGTGG TGTGCCCAGC TCTTCCAAGG 
ACTGCTGCGC TTCGGGGCCC AGGTTTCGAC AGACTCTTCA AAATGCCATC CCAAATGGAG 
CACGCCATGG AAACCATGAT GCTTACGTTT CACAGGTTTG CAGGCGACAA AGACCACTTG 
ACAAAGGAGG ACCTGAGAGT GCTCATGGAA CGGGAGTTCC CTGGGTTTTT GGAAAATCAA 
AAGGACCCTC TGGCTGTGGA CAAAATAATG AAGGACCTGG ACCAGTGCCG AGATGGCAAA 
GTGGGCTTCC AGAGCTTTCT ATCACTAGTG GCAGGGCTCA CCATTGCATG CAATGACTAT 
TTTGTAGTAA ACATGAAGCA GAAGGGGAAG AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017174997.1
CDS	3..458
Translation	MPALQAPPAPGRLRPLYPPRVQRRAVFGTSLIVVCPALPRTAALRGPGFDRLFKMPSQMEHAMETMMLTFHRFAGDKDHLTKEDLRVLMEREFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFLSLVAGLTIACNDYFVVNMKQKGKK

Target ORF information:

RefSeq Version	XM_017319508.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017319508.1

ORF Insert Sequence:

ATGCCTGCCC TCCAGGCTCC TCCCGCTCCG GGGCGCCTCC GCCCTCTGTA CCCGCCTCGC 
GTACAAAGAC GCGCGGTCTT CGGCACTAGC CTCATCGTGG TGTGCCCAGC TCTTCCAAGG 
ACTGCTGCGC TTCGGGGCCC AGGTTTCGAC AGACTCTTCA AAATGCCATC CCAAATGGAG 
CACGCCATGG AAACCATGAT GCTTACGTTT CACAGGTTTG CAGGCGACAA AGACCACTTG 
ACAAAGGAGG ACCTGAGAGT GCTCATGGAA CGGGAGTTCC CTGGGTTTTT GGAAAATCAA 
AAGGACCCTC TGGCTGTGGA CAAAATAATG AAGGACCTGG ACCAGTGCCG AGATGGCAAA 
GTGGGCTTCC AGAGCTTTCT ATCACTAGTG GCAGGGCTCA CCATTGCATG CAATGACTAT 
TTTGTAGTAA ACATGAAGCA GAAGGGGAAG AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

S100a10 ( XM_030252479.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030108339.1 Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu80575
Clone ID Related Accession (Same CDS sequence)	XM_017319508.1 , XM_030252479.1
Accession Version	XM_030252479.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	protein S100-A10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTGCCC TCCAGGCTCC TCCCGCTCCG GGGCGCCTCC GCCCTCTGTA CCCGCCTCGC 
GTACAAAGAC GCGCGGTCTT CGGCACTAGC CTCATCGTGG TGTGCCCAGC TCTTCCAAGG 
ACTGCTGCGC TTCGGGGCCC AGGTTTCGAC AGACTCTTCA AAATGCCATC CCAAATGGAG 
CACGCCATGG AAACCATGAT GCTTACGTTT CACAGGTTTG CAGGCGACAA AGACCACTTG 
ACAAAGGAGG ACCTGAGAGT GCTCATGGAA CGGGAGTTCC CTGGGTTTTT GGAAAATCAA 
AAGGACCCTC TGGCTGTGGA CAAAATAATG AAGGACCTGG ACCAGTGCCG AGATGGCAAA 
GTGGGCTTCC AGAGCTTTCT ATCACTAGTG GCAGGGCTCA CCATTGCATG CAATGACTAT 
TTTGTAGTAA ACATGAAGCA GAAGGGGAAG AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030108339.1
CDS	131..586
Translation	MPALQAPPAPGRLRPLYPPRVQRRAVFGTSLIVVCPALPRTAALRGPGFDRLFKMPSQMEHAMETMMLTFHRFAGDKDHLTKEDLRVLMEREFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFLSLVAGLTIACNDYFVVNMKQKGKK

Target ORF information:

RefSeq Version	XM_030252479.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus S100 calcium binding protein A10 (calpactin) (S100a10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030252479.1

ORF Insert Sequence:

ATGCCTGCCC TCCAGGCTCC TCCCGCTCCG GGGCGCCTCC GCCCTCTGTA CCCGCCTCGC 
GTACAAAGAC GCGCGGTCTT CGGCACTAGC CTCATCGTGG TGTGCCCAGC TCTTCCAAGG 
ACTGCTGCGC TTCGGGGCCC AGGTTTCGAC AGACTCTTCA AAATGCCATC CCAAATGGAG 
CACGCCATGG AAACCATGAT GCTTACGTTT CACAGGTTTG CAGGCGACAA AGACCACTTG 
ACAAAGGAGG ACCTGAGAGT GCTCATGGAA CGGGAGTTCC CTGGGTTTTT GGAAAATCAA 
AAGGACCCTC TGGCTGTGGA CAAAATAATG AAGGACCTGG ACCAGTGCCG AGATGGCAAA 
GTGGGCTTCC AGAGCTTTCT ATCACTAGTG GCAGGGCTCA CCATTGCATG CAATGACTAT 
TTTGTAGTAA ACATGAAGCA GAAGGGGAAG AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annexin A2 supports pulmonary microvascular integrity by linking vascular endothelial cadherin and protein tyrosine phosphatases.
The Journal of experimental medicine214(9)2535-2545(2017 Sep)
Luo M,Flood EC,Almeida D,Yan L,Berlin DA,Heerdt PM,Hajjar KA

Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Neuron95(3)564-576.e4(2017 Aug)
Medrihan L,Sagi Y,Inde Z,Krupa O,Daniels C,Peyrache A,Greengard P

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A