Hps6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hps6
Entrez Gene ID	20170
Full Name	HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Synonyms	5330434M19Rik,BLOC2,ru
General protein information	Preferred Names HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Names Hermansky-Pudlak syndrome 6 protein homolog ruby eye ruby-eye protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19 C3\|19 38.75 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_176785.3	NP_789742.2	Hermansky-Pudlak syndrome 6 protein homolog

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HPS6	XP_851823.2
Pan troglodytes (chimpanzee)	HPS6	XP_001170704.1
Rattus norvegicus (Norway rat)	Hps6	NP_852097.1
	HPS6	XP_001111761.1
Mus musculus (house mouse)	Hps6	NP_789742.2
Gallus gallus (chicken)	HPS6	XP_001233664.1
Danio rerio (zebrafish)	LOC101882947	XP_005156992.1
Xenopus tropicalis (tropical clawed frog)	hps6	XP_002940614.2
Homo sapiens (human)	HPS6	NP_079023.2
Bos taurus (cattle)	HPS6	NP_001075055.1

Gene Ontology
Bibliography

Related articles in PubMed

Ferritin is secreted via 2 distinct nonclassical vesicular pathways.
Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG
Blood131(3)342-352(2018 Jan)

BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells.
Ma J, Zhang Z, Yang L, Kriston-Vizi J, Cutler DF, Li W
Journal of genetics and genomics = Yi chuan xue bao43(12)686-693(2016 Dec)

BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.
Dennis MK, Mantegazza AR, Snir OL, Tenza D, Acosta-Ruiz A, Delevoye C, Zorger R, Sitaram A, de Jesus-Rojas W, Ravichandran K, Rux J, Sviderskaya EV, Bennett DC, Raposo G, Marks MS, Setty SR
The Journal of cell biology209(4)563-77(2015 May)

Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome.
Sharda A, Kim SH, Jasuja R, Gopal S, Flaumenhaft R, Furie BC, Furie B
Blood125(10)1633-42(2015 Mar)

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.
Li K, Yang L, Zhang C, Niu Y, Li W, Liu JJ
Journal of cell science127(Pt 21)4574-88(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells
Title: BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells.

BLOC-2 functions to direct recycling endosomal tubular transport intermediates to maturing melanosomes and thereby promote cargo delivery and optimal pigmentation.
Title: BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.

The product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of BLOC-2 complex and with ocular albinism in regulating melanosome size.
Title: Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.

Data suggest functional links between OCA2 and the BLOC-1, BLOC-2, and AP-3 protein complexes involved in melanosome biogenesis.
Title: Functional interactions between OCA2 and the protein complexes BLOC-1, BLOC-2, and AP-3 inferred from epistatic analyses of mouse coat pigmentation.

The identification of the feeble mutation led to our subsequent observations that AP-3, as well as the BLOC-1 and BLOC-2 are essential for plasmacytoid dendritic cells signaling through TLR7 and TLR9.
Title: Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.

The following Hps6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hps6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58607	NM_176785.3 Latest version!	Mus musculus HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (Hps6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hps6 ( NM_176785.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_789742.2 Mus musculus HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (Hps6), mRNA.

Price & Availability↑

CloneID	OMu58607
Clone ID Related Accession (Same CDS sequence)	NM_176785.3
Accession Version	NM_176785.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	Hermansky-Pudlak syndrome 6 protein homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC150685.2, AF536239.1 and AK040849.1. On Jul 31, 2009 this sequence version replaced NM_176785.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGAAGCGTG CAGGAACTCT GCGCCTGCTT TCGGATCTGA GCAACTTCAC CGGCGCGGCC 
CGGCTCCGCG AGTTGTTGGC GGGGGACCCA GCTGTCCTAG TCCGCTGCAG CCCTGACGGC 
CGCCACTTGC TGCTATTAAG ACCCCCCGGA TCGCCCGCCC CACAGCTTCT AGTGGCTGTG 
CGTGGGCCCG GCCTGCCGCT GGAGCGTGCC TGGCCGGAGG GCGACCCCTC GCCGCTGGAC 
GTCTTTTTCG TGCCGTGGCT GGCGCGACCC GCGCTGATCT TGGTATGGGA GAGTGGCCTA 
GCAGAGGTTT GGGGCGTGGG GATGGAGCCT GGATGGAAGC TACTTCAGAG CACTGAGCTG 
TGTCCGGATG GTGGAGCCCG CGTGATGGCC GTGGCCGCAA CCCGAGGCCG CCTAGTTTGG 
TGCGAGGAGC GTCAGCCGGG TGTTAAGGAC CAACCAGAGC AGCTTTCAAC GGCCTTCAGC 
CACCGTGTGT GCTTCAAGAC CCTGGAAACC AGCGGGGAGG CTGGCACCAA ACTAGGCTGC 
ACCCACATCC TGCTACACCA TTGCCCCCTT TTTGGACTGA TAGCCTCCCG CAAGGACCTC 
TTCCTGGTGC CTACTACCAA CACTTGGTCT GGTGTGGCCC ACCTTCTGCT CATCTGGAGC 
CCAAGCAAGG GGAAGGTAAT AGTTGCTGCT CCATCTCTTG GTCTTTCACA CAGTAAAAGC 
CTGAATCCCA AACAAGGGGA CACTTGGGAC TTCCGGACCC TGCTGCGAGG CCTTCCTGGA 
TTCCTGTCCC CCAGGGAGCC ACTGGCTGTA CACACTTGGG CCCCATCTTC GCAGGGCTTG 
TTGTTGCTTG ACTTGAAAGG GAAGGTGAGC CTAGTGCAGT GCCATGGTGG TACTCGAACC 
GTGGGAATCC TGCAGGAGGC CCCTGTAAGC CTAAAAGGGT CTGCAGCCCT GGGGACATTT 
CACGGCACTT TAGCCTGTGT CCTGGGCTCC ACCTTGGAAC TACTGGACAT GAGCAGTGGG 
CGGCTGTTGG AAAAAAAGGT TCTCAGTACA GACAGAGTAC ATTTGCTGGA GCCTCCAGCC 
CCGGGCATGA AGAACGAGGA AGAGCTGGAG ACCCGAGGAG CCCTACGATT GCTTTCAGCC 
TTGGGTCTCT TTTGTGTGTG TTGGGAAACT CCCCAAGGCC TTGAGCTGCC TTCAGACAAG 
GACCTGGTGT TTGAGGAGGC CTGTGGGTAC TACCAGCGTC GGAGCCTTCG AGGTACCCAG 
CTTACCCCAG AAGAACTGAG ACACAACAGC ATGTTTCGGG CACCTCAGGC CCTGGCCTCC 
ATCCTCCAGG GCCACCTGCC CCCGTCTACA CTCCTGACAA CCCTGAGGGC TGAGCTCCGG 
GATTATCGTA GTATAGAACA GCTCAAGGCC CAGCTGGTGG CTGGGGACGA TGAGGAGGCT 
GGCTGGACTG AGTTAGCGGA GCACGAGGTG GCCCGCCTGC TGAGAACCCA GTTGACAGGA 
GACCAGCTGG CCCAATTCAA CACCATTTTC CAAGCCCTTC CTACAGCAGC TTGGGGTGCC 
ACCCTCCAGG CACTGCAGCT CCAGCCAGAT AGGAGTGGCA GGCTGAGGTC CCAAGCACCC 
CCGGATGTAT GGAAGAAGGT CCTAAGGGCT CCAACAGCTG GAAAGGAACA TCCCAATGGA 
ATACTGCCGC CCTTTGAACT CCTGTGTCAG TGCCTGGGCC AGCTCGAGCC TCAGTGGCTC 
CCCCCATTTG TGAAACTGGC ACAGCAGCAG GGTGGCCCCG GCTGGGGGGC TGAAGGCCCC 
AGTCTGCCCC TTTACCGCCG AGCCCTGGCA GTGCTAGGTG AGGAAGGGAA GAGGCCTGAG 
GCTCTGGAAC TCGAGTTGCT TTTGGGCAGT GGGCGACCCA AAGCCGTGCT ACAAGCTGTA 
AGGCAGCTGA TAAAGAAAGA AGAGTGGGAA CGGGCTCTGG AAGCCGGGCT GGCCCTGGAT 
GCCTCCAGCC CCCTGCTTCG AAGTGAGATC TTTAAGCTGC TGCTGGCAGA GTTTGCCCAG 
CACCGCCGCC TGGATGCACA CCTCCCTCTC CTCTGTCGCC TGTGCCCACC GGAAGTGGCT 
CCACATGAGC TCCTACTTCT GCTGAGGACA CATCTCCCAG ATGATGAGGG AACCACCCCT 
TTCCCTGAGC CTGGGGCAGA GCCCCCTCTC ACAGTGGGCT TGGTCAGAGC CCTGCTAGAA 
CAGACTGGGG CTCAAGGAAG GCCGTCTGGC CCAGTTCAAA GCACCTATGA GGACATCTTA 
TGGGACCCAG GCACTCCACC CCCTACACCA CCTCGTGGAC CCACTGCTTC TCTCCCGGCA 
TCAGACCATC CAGGACAAGA AGCCTGGGTA CCACCTGGAC AAGGGCTCGG TGCAGCTGAT 
GTGGGAGTTC ATTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789742.2
CDS	149..2566
Translation	MKRAGTLRLLSDLSNFTGAARLRELLAGDPAVLVRCSPDGRHLLLLRPPGSPAPQLLVAVRGPGLPLERAWPEGDPSPLDVFFVPWLARPALILVWESGLAEVWGVGMEPGWKLLQSTELCPDGGARVMAVAATRGRLVWCEERQPGVKDQPEQLSTAFSHRVCFKTLETSGEAGTKLGCTHILLHHCPLFGLIASRKDLFLVPTTNTWSGVAHLLLIWSPSKGKVIVAAPSLGLSHSKSLNPKQGDTWDFRTLLRGLPGFLSPREPLAVHTWAPSSQGLLLLDLKGKVSLVQCHGGTRTVGILQEAPVSLKGSAALGTFHGTLACVLGSTLELLDMSSGRLLEKKVLSTDRVHLLEPPAPGMKNEEELETRGALRLLSALGLFCVCWETPQGLELPSDKDLVFEEACGYYQRRSLRGTQLTPEELRHNSMFRAPQALASILQGHLPPSTLLTTLRAELRDYRSIEQLKAQLVAGDDEEAGWTELAEHEVARLLRTQLTGDQLAQFNTIFQALPTAAWGATLQALQLQPDRSGRLRSQAPPDVWKKVLRAPTAGKEHPNGILPPFELLCQCLGQLEPQWLPPFVKLAQQQGGPGWGAEGPSLPLYRRALAVLGEEGKRPEALELELLLGSGRPKAVLQAVRQLIKKEEWERALEAGLALDASSPLLRSEIFKLLLAEFAQHRRLDAHLPLLCRLCPPEVAPHELLLLLRTHLPDDEGTTPFPEPGAEPPLTVGLVRALLEQTGAQGRPSGPVQSTYEDILWDPGTPPPTPPRGPTASLPASDHPGQEAWVPPGQGLGAADVGVHL

Target ORF information:

RefSeq Version	NM_176785.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (Hps6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176785.3

ORF Insert Sequence:

ATGAAGCGTG CAGGAACTCT GCGCCTGCTT TCGGATCTGA GCAACTTCAC CGGCGCGGCC 
CGGCTCCGCG AGTTGTTGGC GGGGGACCCA GCTGTCCTAG TCCGCTGCAG CCCTGACGGC 
CGCCACTTGC TGCTATTAAG ACCCCCCGGA TCGCCCGCCC CACAGCTTCT AGTGGCTGTG 
CGTGGGCCCG GCCTGCCGCT GGAGCGTGCC TGGCCGGAGG GCGACCCCTC GCCGCTGGAC 
GTCTTTTTCG TGCCGTGGCT GGCGCGACCC GCGCTGATCT TGGTATGGGA GAGTGGCCTA 
GCAGAGGTTT GGGGCGTGGG GATGGAGCCT GGATGGAAGC TACTTCAGAG CACTGAGCTG 
TGTCCGGATG GTGGAGCCCG CGTGATGGCC GTGGCCGCAA CCCGAGGCCG CCTAGTTTGG 
TGCGAGGAGC GTCAGCCGGG TGTTAAGGAC CAACCAGAGC AGCTTTCAAC GGCCTTCAGC 
CACCGTGTGT GCTTCAAGAC CCTGGAAACC AGCGGGGAGG CTGGCACCAA ACTAGGCTGC 
ACCCACATCC TGCTACACCA TTGCCCCCTT TTTGGACTGA TAGCCTCCCG CAAGGACCTC 
TTCCTGGTGC CTACTACCAA CACTTGGTCT GGTGTGGCCC ACCTTCTGCT CATCTGGAGC 
CCAAGCAAGG GGAAGGTAAT AGTTGCTGCT CCATCTCTTG GTCTTTCACA CAGTAAAAGC 
CTGAATCCCA AACAAGGGGA CACTTGGGAC TTCCGGACCC TGCTGCGAGG CCTTCCTGGA 
TTCCTGTCCC CCAGGGAGCC ACTGGCTGTA CACACTTGGG CCCCATCTTC GCAGGGCTTG 
TTGTTGCTTG ACTTGAAAGG GAAGGTGAGC CTAGTGCAGT GCCATGGTGG TACTCGAACC 
GTGGGAATCC TGCAGGAGGC CCCTGTAAGC CTAAAAGGGT CTGCAGCCCT GGGGACATTT 
CACGGCACTT TAGCCTGTGT CCTGGGCTCC ACCTTGGAAC TACTGGACAT GAGCAGTGGG 
CGGCTGTTGG AAAAAAAGGT TCTCAGTACA GACAGAGTAC ATTTGCTGGA GCCTCCAGCC 
CCGGGCATGA AGAACGAGGA AGAGCTGGAG ACCCGAGGAG CCCTACGATT GCTTTCAGCC 
TTGGGTCTCT TTTGTGTGTG TTGGGAAACT CCCCAAGGCC TTGAGCTGCC TTCAGACAAG 
GACCTGGTGT TTGAGGAGGC CTGTGGGTAC TACCAGCGTC GGAGCCTTCG AGGTACCCAG 
CTTACCCCAG AAGAACTGAG ACACAACAGC ATGTTTCGGG CACCTCAGGC CCTGGCCTCC 
ATCCTCCAGG GCCACCTGCC CCCGTCTACA CTCCTGACAA CCCTGAGGGC TGAGCTCCGG 
GATTATCGTA GTATAGAACA GCTCAAGGCC CAGCTGGTGG CTGGGGACGA TGAGGAGGCT 
GGCTGGACTG AGTTAGCGGA GCACGAGGTG GCCCGCCTGC TGAGAACCCA GTTGACAGGA 
GACCAGCTGG CCCAATTCAA CACCATTTTC CAAGCCCTTC CTACAGCAGC TTGGGGTGCC 
ACCCTCCAGG CACTGCAGCT CCAGCCAGAT AGGAGTGGCA GGCTGAGGTC CCAAGCACCC 
CCGGATGTAT GGAAGAAGGT CCTAAGGGCT CCAACAGCTG GAAAGGAACA TCCCAATGGA 
ATACTGCCGC CCTTTGAACT CCTGTGTCAG TGCCTGGGCC AGCTCGAGCC TCAGTGGCTC 
CCCCCATTTG TGAAACTGGC ACAGCAGCAG GGTGGCCCCG GCTGGGGGGC TGAAGGCCCC 
AGTCTGCCCC TTTACCGCCG AGCCCTGGCA GTGCTAGGTG AGGAAGGGAA GAGGCCTGAG 
GCTCTGGAAC TCGAGTTGCT TTTGGGCAGT GGGCGACCCA AAGCCGTGCT ACAAGCTGTA 
AGGCAGCTGA TAAAGAAAGA AGAGTGGGAA CGGGCTCTGG AAGCCGGGCT GGCCCTGGAT 
GCCTCCAGCC CCCTGCTTCG AAGTGAGATC TTTAAGCTGC TGCTGGCAGA GTTTGCCCAG 
CACCGCCGCC TGGATGCACA CCTCCCTCTC CTCTGTCGCC TGTGCCCACC GGAAGTGGCT 
CCACATGAGC TCCTACTTCT GCTGAGGACA CATCTCCCAG ATGATGAGGG AACCACCCCT 
TTCCCTGAGC CTGGGGCAGA GCCCCCTCTC ACAGTGGGCT TGGTCAGAGC CCTGCTAGAA 
CAGACTGGGG CTCAAGGAAG GCCGTCTGGC CCAGTTCAAA GCACCTATGA GGACATCTTA 
TGGGACCCAG GCACTCCACC CCCTACACCA CCTCGTGGAC CCACTGCTTC TCTCCCGGCA 
TCAGACCATC CAGGACAAGA AGCCTGGGTA CCACCTGGAC AAGGGCTCGG TGCAGCTGAT 
GTGGGAGTTC ATTTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ferritin is secreted via 2 distinct nonclassical vesicular pathways.
Blood131(3)342-352(2018 Jan)
Truman-Rosentsvit M,Berenbaum D,Spektor L,Cohen LA,Belizowsky-Moshe S,Lifshitz L,Ma J,Li W,Kesselman E,Abutbul-Ionita I,Danino D,Gutierrez L,Li H,Li K,Lou H,Regoni M,Poli M,Glaser F,Rouault TA,Meyron-Holtz EG

BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells.
Journal of genetics and genomics = Yi chuan xue bao43(12)686-693(2016 Dec)
Ma J,Zhang Z,Yang L,Kriston-Vizi J,Cutler DF,Li W

BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.
The Journal of cell biology209(4)563-77(2015 May)
Dennis MK,Mantegazza AR,Snir OL,Tenza D,Acosta-Ruiz A,Delevoye C,Zorger R,Sitaram A,de Jesus-Rojas W,Ravichandran K,Rux J,Sviderskaya EV,Bennett DC,Raposo G,Marks MS,Setty SR

Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome.
Blood125(10)1633-42(2015 Mar)
Sharda A,Kim SH,Jasuja R,Gopal S,Flaumenhaft R,Furie BC,Furie B

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.
Journal of cell science127(Pt 21)4574-88(2014 Nov)
Li K,Yang L,Zhang C,Niu Y,Li W,Liu JJ

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Hps6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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