Rrm2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rrm2
Entrez Gene ID	20135
Full Name	ribonucleotide reductase M2
Synonyms	AA407299,R2
General protein information	Preferred Names ribonucleotide reductase M2 Names ribonucleoside-diphosphate reductase subunit M2 ribonucleoside-diphosphate reductase M2 chain ribonucleotide reductase small chain ribonucleotide reductase small subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 A1.3\|12 8.5 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009104.2	NP_033130.1	ribonucleoside-diphosphate reductase subunit M2

Pathways from BioSystems

Homologies

	RRM2	XP_001091447.2
Canis lupus familiaris (dog)	RRM2	XP_540076.2
Gallus gallus (chicken)	RRM2	XP_004935811.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006818	XP_308927.4
Eremothecium gossypii	AGOS_AAL136C	NP_982406.1
Danio rerio (zebrafish)	rrm2	NP_571525.1
Danio rerio (zebrafish)	LOC100330864	XP_002665783.1
Drosophila melanogaster (fruit fly)	RnrS	NP_525111.1
Schizosaccharomyces pombe (fission yeast)	suc22	NP_596546.1
Xenopus tropicalis (tropical clawed frog)	rrm2.2	NP_001007890.1
Homo sapiens (human)	RRM2	NP_001159403.1
Pan troglodytes (chimpanzee)	RRM2	XP_003949799.1
Kluyveromyces lactis	KLLA0F15103g	XP_455757.1
Neurospora crassa	NCU07887	XP_962820.1
Arabidopsis thaliana (thale cress)	TSO2	NP_189342.1
Bos taurus (cattle)	RRM2	NP_001231110.1
Mus musculus (house mouse)	Rrm2	NP_033130.1
Rattus norvegicus (Norway rat)	Rrm2	NP_001020911.1
Rattus norvegicus (Norway rat)	LOC100359539	XP_006255398.1
Caenorhabditis elegans (roundworm)	rnr-2	NP_497821.1
Saccharomyces cerevisiae (baker's yeast)	RNR2	NP_012508.1
Magnaporthe oryzae (rice blast fungus)	MGG_06408	XP_003717161.1
Oryza sativa (rice)	Os06g0127900	NP_001056668.1

Gene Ontology
Bibliography

Related articles in PubMed

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.
Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taguchi C, Tateishi S, Kawada T, Kim YI, Murai A, Horio F
BMC genetics17(1)73(2016 06)

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse.
Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang F, Fan HY
Cell research26(3)275-87(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This work reveals that binding of RRM1 to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
Title: A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

mice carrying extra alleles of the RNR regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR activity and reduced chromosomal breakage at fragile sites
Title: Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.

R2 expression may discriminate cervical cancer phenotype and radiochemotherapy outcome
Title: Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis.

analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 improves cardiac performance
Title: Transgenic overexpression of ribonucleotide reductase improves cardiac performance.

Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
Title: Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice.

The following Rrm2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rrm2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22602	NM_009104.2 Latest version!	Mus musculus ribonucleotide reductase M2 (Rrm2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rrm2 ( NM_009104.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033130.1 Mus musculus ribonucleotide reductase M2 (Rrm2), mRNA.

Price & Availability↑

CloneID	OMu22602
Clone ID Related Accession (Same CDS sequence)	NM_009104.2
Accession Version	NM_009104.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	ribonucleoside-diphosphate reductase subunit M2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085136.1 and BF468116.2. On May 14, 2009 this sequence version replaced NM_009104.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085136.1, AK147111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCTCCG TCCGCACCCC GCTCGCCACC ATCGCTGACC AGCAGCAGCT GCAGTTGTCG 
CCGCTGAAGC GACTCACCCT GGCTGACAAG GAGAACACGC CCCCGACTCT CAGCAGCACC 
CGCGTCCTGG CCAGCAAAGC TGCGAGGAGA ATCTTCCAGG ACTCCGCCGA GCTGGAAAGT 
AAAGCGCCTA CTAACCCCAG CGTTGAGGAT GAGCCGTTAC TGAGAGAAAA CCCCCGCCGC 
TTCGTTGTCT TTCCCATCGA GTACCATGAT ATCTGGCAGA TGTACAAGAA AGCCGAGGCC 
TCCTTTTGGA CTGCCGAGGA GGTGGACCTT TCCAAGGATA TTCAGCACTG GGAAGCTCTG 
AAACCCGATG AGAGACATTT TATATCTCAC GTTCTGGCTT TCTTTGCAGC GAGTGATGGC 
ATAGTCAATG AGAACTTGGT GGAGCGATTT AGCCAAGAAG TTCAAGTTAC AGAGGCCCGC 
TGTTTCTATG GCTTCCAAAT TGCCATGGAA AACATACACT CTGAAATGTA CAGTCTCCTT 
ATTGACACTT ACATTAAAGA TCCCAAGGAA AGAGAATATC TCTTCAATGC TATTGAAACA 
ATGCCTTGTG TGAAGAAGAA GGCTGACTGG GCCTTGCGCT GGATTGGGGA CAAAGAGGCT 
ACGTATGGAG AACGCGTTGT GGCCTTTGCC GCCGTAGAAG GAATCTTCTT TTCCGGTTCT 
TTTGCATCGA TATTCTGGCT CAAGAAACGG GGGCTGATGC CGGGCCTTAC ATTTTCCAAT 
GAGCTTATTA GCAGAGACGA GGGTTTACAC TGTGACTTTG CCTGCCTGAT GTTCAAGCAC 
CTGGTACACA AGCCAGCAGA GCAGAGGGTC CGAGAGATAA TCACCAACGC CGTTAGGATA 
GAGCAGGAGT TCCTCACGGA GGCCTTGCCC GTGAAGCTCA TCGGGATGAA CTGCACTTTG 
ATGAAGCAGT ACATTGAGTT TGTGGCCGAC AGGCTTATGC TGGAGCTGGG TTTTAACAAG 
ATTTTCAGAG TAGAAAATCC GTTTGACTTC ATGGAAAATA TCTCACTAGA AGGAAAGACA 
AACTTCTTTG AGAAGCGAGT AGGCGAGTAT CAGAGGATGG GAGTCATGTC GAATTCGACA 
GAGAACTCTT TTACCTTGGA TGCTGACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033130.1
CDS	94..1266
Translation	MLSVRTPLATIADQQQLQLSPLKRLTLADKENTPPTLSSTRVLASKAARRIFQDSAELESKAPTNPSVEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF

Target ORF information:

RefSeq Version	NM_009104.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribonucleotide reductase M2 (Rrm2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009104.2

ORF Insert Sequence:

ATGCTCTCCG TCCGCACCCC GCTCGCCACC ATCGCTGACC AGCAGCAGCT GCAGTTGTCG 
CCGCTGAAGC GACTCACCCT GGCTGACAAG GAGAACACGC CCCCGACTCT CAGCAGCACC 
CGCGTCCTGG CCAGCAAAGC TGCGAGGAGA ATCTTCCAGG ACTCCGCCGA GCTGGAAAGT 
AAAGCGCCTA CTAACCCCAG CGTTGAGGAT GAGCCGTTAC TGAGAGAAAA CCCCCGCCGC 
TTCGTTGTCT TTCCCATCGA GTACCATGAT ATCTGGCAGA TGTACAAGAA AGCCGAGGCC 
TCCTTTTGGA CTGCCGAGGA GGTGGACCTT TCCAAGGATA TTCAGCACTG GGAAGCTCTG 
AAACCCGATG AGAGACATTT TATATCTCAC GTTCTGGCTT TCTTTGCAGC GAGTGATGGC 
ATAGTCAATG AGAACTTGGT GGAGCGATTT AGCCAAGAAG TTCAAGTTAC AGAGGCCCGC 
TGTTTCTATG GCTTCCAAAT TGCCATGGAA AACATACACT CTGAAATGTA CAGTCTCCTT 
ATTGACACTT ACATTAAAGA TCCCAAGGAA AGAGAATATC TCTTCAATGC TATTGAAACA 
ATGCCTTGTG TGAAGAAGAA GGCTGACTGG GCCTTGCGCT GGATTGGGGA CAAAGAGGCT 
ACGTATGGAG AACGCGTTGT GGCCTTTGCC GCCGTAGAAG GAATCTTCTT TTCCGGTTCT 
TTTGCATCGA TATTCTGGCT CAAGAAACGG GGGCTGATGC CGGGCCTTAC ATTTTCCAAT 
GAGCTTATTA GCAGAGACGA GGGTTTACAC TGTGACTTTG CCTGCCTGAT GTTCAAGCAC 
CTGGTACACA AGCCAGCAGA GCAGAGGGTC CGAGAGATAA TCACCAACGC CGTTAGGATA 
GAGCAGGAGT TCCTCACGGA GGCCTTGCCC GTGAAGCTCA TCGGGATGAA CTGCACTTTG 
ATGAAGCAGT ACATTGAGTT TGTGGCCGAC AGGCTTATGC TGGAGCTGGG TTTTAACAAG 
ATTTTCAGAG TAGAAAATCC GTTTGACTTC ATGGAAAATA TCTCACTAGA AGGAAAGACA 
AACTTCTTTG AGAAGCGAGT AGGCGAGTAT CAGAGGATGG GAGTCATGTC GAATTCGACA 
GAGAACTCTT TTACCTTGGA TGCTGACTTC TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12.
BMC genetics17(1)73(2016 06)
Kobayashi M,Suzuki M,Ohno T,Tsuzuki K,Taguchi C,Tateishi S,Kawada T,Kim YI,Murai A,Horio F

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse.
Cell research26(3)275-87(2016 Mar)
Yu C,Ji SY,Dang YJ,Sha QQ,Yuan YF,Zhou JJ,Yan LY,Qiao J,Tang F,Fan HY

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Rrm2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報