Xpr1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xpr1
Entrez Gene ID	19775
Full Name	xenotropic and polytropic retrovirus receptor 1
Synonyms	Rmc-1,Rmc1,Sxv,Syg1,XR
General protein information	Preferred Names xenotropic and polytropic retrovirus receptor 1 Names xenotropic and polytropic retrovirus receptor 1 receptor for MCF virus 1 suppressor of yeast G deletion susceptibility to xenotropic virus xenotropic and polytropic murine leukemia virus receptor xenotropic and polytropic retrovirus receptor 1 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 G3\|1 66.49 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011273.2	NP_035403.1	xenotropic and polytropic retrovirus receptor 1

Pathways from BioSystems

Homologies

Arabidopsis thaliana (thale cress)	PHO1;H1	NP_564940.1
Oryza sativa (rice)	Os06g0493600	NP_001057682.1
Xenopus tropicalis (tropical clawed frog)	xpr1	NP_001016753.1
Homo sapiens (human)	XPR1	NP_004727.2
	XPR1	XP_001115004.2
Canis lupus familiaris (dog)	XPR1	NP_001184089.1
Gallus gallus (chicken)	XPR1	XP_003641709.1
Kluyveromyces lactis	KLLA0F27467g	XP_456302.1
Schizosaccharomyces pombe (fission yeast)	SPCC1827.07c	NP_588554.2
Mus musculus (house mouse)	Xpr1	NP_035403.1
Danio rerio (zebrafish)	si:dkey-6n6.7	NP_001232029.1
Drosophila melanogaster (fruit fly)	CG10483	NP_648000.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005557	XP_315560.2
Magnaporthe oryzae (rice blast fungus)	MGG_13413	XP_003711457.1
Neurospora crassa	NCU04201	XP_961161.1
Pan troglodytes (chimpanzee)	XPR1	XP_524986.2
Bos taurus (cattle)	XPR1	NP_001179812.1
Rattus norvegicus (Norway rat)	Xpr1	NP_001099462.1
Saccharomyces cerevisiae (baker's yeast)	SYG1	NP_012217.3
Eremothecium gossypii	AGOS_ADL080W	NP_984016.2

Gene Ontology
Bibliography

Related articles in PubMed

Expression of Phosphate Transporters during Dental Mineralization.
Merametdjian L, Beck-Cormier S, Bon N, Couasnay G, Sourice S, Guicheux J, Gaucher C, Beck L
Journal of dental research97(2)209-217(2018 Feb)

Analysis of gene expression and functional characterization of XPR1: a pathogenic gene for primary familial brain calcification.
Yao XP, Zhao M, Wang C, Guo XX, Su HZ, Dong EL, Chen HT, Lai JH, Liu YB, Wang N, Chen WJ
Cell and tissue research370(2)267-273(2017 11)

Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse.
Hartmann S, Hasenkamp N, Mayer J, Michaux J, Morand S, Mazzoni CJ, Roca AL, Greenwood AD
BMC genomics16613(2015 Aug)

Escape variants of the XPR1 gammaretrovirus receptor are rare due to reliance on a splice donor site and a short hypervariable loop.
Lu X, Martin C, Bouchard C, Kozak CA
Virology468-47063-71(2014 Nov)

Expression of the mammalian Xenotropic Polytropic Virus Receptor 1 (XPR1) in tobacco leaves leads to phosphate export.
Wege S, Poirier Y
FEBS letters588(3)482-9(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study evaluated the effects of XPR1 variants on XPR1 gammaretrovirus entry.
Title: Escape variants of the XPR1 gammaretrovirus receptor are rare due to reliance on a splice donor site and a short hypervariable loop.

These results show that tobacco leaves are a good heterologous system to study the transport activity of members of the PHO1/XPR1 family.
Title: Expression of the mammalian Xenotropic Polytropic Virus Receptor 1 (XPR1) in tobacco leaves leads to phosphate export.

subspecies origins of xenotropic and polytropic mouse leukemia virus endogenous retroviruses and their coevolutionary trajectory with their XPR1 receptor
Title: Endogenous gammaretrovirus acquisition in Mus musculus subspecies carrying functional variants of the XPR1 virus receptor.

results indicate that Xpr1 is a novel, atypical G-protein-coupled receptor (GPCR) and that xenotropic or polytropic retrovirus binding can disrupt the cAMP-mediated signaling function of Xpr1, leading to the apoptosis of infected cells
Title: Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.

This study is the first to demonstrate that the expression of retro-viral receptor, XPR1, is regulated by RANKL-RANK signaling.
Title: RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.

The following Xpr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xpr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16361	NM_011273.2 Latest version!	Mus musculus xenotropic and polytropic retrovirus receptor 1 (Xpr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$412.30 $589.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xpr1 ( NM_011273.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035403.1 Mus musculus xenotropic and polytropic retrovirus receptor 1 (Xpr1), mRNA.

Price & Availability↑

CloneID	OMu16361
Clone ID Related Accession (Same CDS sequence)	NM_011273.2
Accession Version	NM_011273.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2088bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	xenotropic and polytropic retrovirus receptor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY122762.1, AF114753.1, AF198104.1 and AC110268.17. On Jul 23, 2005 this sequence version replaced NM_011273.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147403.1, BC153872.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGTTCG CCGAGCACCT CTCCGCGCAC ATCACTCCCG AGTGGAGGAA GCAGTACATC 
CAGTATGAGG CATTCAAGGA TATGCTGTAT TCAGCTCAGG ACCAGGCACC TTCAGTTGAA 
GTTACAGATG AGGATACAGT TAAGAGATAT TTTGCCAAGT TTGAAGAAAA GTTTTTCCAA 
ACCTGTGAAA AGGAACTTGC CAAAATCAAC ACATTTTATT CAGAGAAGCT GGCAGAGGCT 
CAGCGCAGGT TTGCTACACT TCAGAATGAG CTTCAGTCAT CGCTGGATGT GCAGAAAGAA 
AGCAGTGGTG TCACGACATT GCGACAGCGC AGAAAGCCAG TGTTCCACCT GTCCCACGAG 
GAGCGTGTCC AACATAGGAA CATTAAAGAC CTTAAGCTGG CCTTCAGCGA GTTCTACCTC 
AGTCTCATCC TGCTGCAGAA CTATCAGAAT CTGAATTTTA CAGGGTTTCG GAAAATCCTC 
AAAAAGCATG ACAAGATCCT GGAAACATCT CGTGGAGCAG ATTGGCGAGT GATTCATGTA 
GAGGTGGCCC CATTTTATAC ATGCAAGAAA ATTAACCAGC TCATTTCTGA GACTGAGGCT 
GTGGTCACCA ATGAACTTGA AGATGGTGAC AGACAAAAGG CTATGAAGCG GTTACGGGTC 
CCTCCATTGG GAGCTGCTCA GCCTGCACCA GCATGGACTA CTTTTAGAGT TGGCCTATTT 
TGTGGAATAT TCATTGTGCT GAATATTACC CTTGTGTTTG CAGCTGTATT TAAACTTGAA 
ACAGATAGAA CTGTATGGCC CTTGATAAGA ATCTATCGGG GTGGCTTTCT TCTGATTGAA 
TTCCTTTTTC TACTGGGCAT CAACACATAT GGTTGGAGAC AAGCTGGAGT AAATCATGTC 
CTCATCTTTG AACTTAATCC AAGAAACAAT TTGTCTCATC AGCATCTCTT TGAGATTGCT 
GGATTCCTGG GGATCTTGTG GTGCCTGAGC CTTCTGGCAT GCTTCTTCGC TCCAATTAGT 
ATCATCCCTA TATATGTGTA TCCACTAGCC CTTTATGGGT TTATGGTCTT CTTTCTTATC 
AACCCCACCA AAACTTTCTA CTATAAATCC AGATTTTGGC TGCTCAAACT TCTGTTTCGA 
GTATTTACTG CTCCCTTCCA TAAGGTAGGC TTTGCTGATT TCTGGCTGGC CGATCAGCTG 
AACAGCCTGT CAGTGATTCT CATGGACCTG GAATATATGA TCTGCTTCTA CAGTTTTGAG 
CTTAAATGGG ATGAGAGTAA GGGCCTGTTG CCAAATGATC CACAAGAACC AGAATTTTGC 
CACAAATATT CATATGGTGT GCGAGCCATT GTTCAATGTA TTCCAGCTTG GCTTCGCTTC 
ATCCAGTGCC TGCGCCGGTA CCGTGACACG AGGAGGGCTT TTCCTCATCT AGTAAATGCT 
GGCAAATACT CCACAACTTT CTTCACCGTG ACATTTGCAG CCCTTTACAG CACTCACGAA 
GAACAAAATC ACTCTGACAC CGTGGTGTTC TTTTACCTGT GGGTCTTCTT TTGTATCATC 
AGTTCCTGCT ATACCCTCAT CTGGGATCTC AAGATGGACT GGGGTCTCTT TGATAAGAAT 
GCAGGAGAAA ACACTTTCCT CCGGGAAGAA ATTGTATACC CTCAAAAAGC CTATTACTAC 
TGTGCCATCA TAGAAGATGT GATACTGCGC TTCGCTTGGA CTATCCAAAT CTCTATTACT 
GCTACGTTTA AGCCTCATGT TGGGAACATC ATTGCTACTG TCTTTGCCCC CCTTGAGGTT 
TTCCGGCGAT TTGTGTGGAA CTTCTTCCGT CTGGAGAACG AGCATCTAAA TAACTGTGGT 
GAATTCCGAG CCGTGCGGGA CATCTCTGTG GCCCCCCTCA ACGCGGATGA CCAGACACTA 
CTTGAGCAGA TGATGGACCA GGAGGATGGG GTTCGAAACC GCCAGAAGAA CCGGTCGTGG 
AAGTACAATC AGAGCATATC CCTGCGTAGG CCCCGCCTGG CTTCCCAATC CAAGGCTCGC 
GACACTAAGG TATTGATAGA AGACACAGAT GACGAAGCTA ACACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035403.1
CDS	211..2298
Translation	MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDVQKESSGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVIHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVFAAVFKLETDRTVWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRNNLSHQHLFEIAGFLGILWCLSLLACFFAPISIIPIYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSFELKWDESKGLLPNDPQEPEFCHKYSYGVRAIVQCIPAWLRFIQCLRRYRDTRRAFPHLVNAGKYSTTFFTVTFAALYSTHEEQNHSDTVVFFYLWVFFCIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITATFKPHVGNIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQEDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT

Target ORF information:

RefSeq Version	NM_011273.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus xenotropic and polytropic retrovirus receptor 1 (Xpr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011273.2

ORF Insert Sequence:

ATGAAGTTCG CCGAGCACCT CTCCGCGCAC ATCACTCCCG AGTGGAGGAA GCAGTACATC 
CAGTATGAGG CATTCAAGGA TATGCTGTAT TCAGCTCAGG ACCAGGCACC TTCAGTTGAA 
GTTACAGATG AGGATACAGT TAAGAGATAT TTTGCCAAGT TTGAAGAAAA GTTTTTCCAA 
ACCTGTGAAA AGGAACTTGC CAAAATCAAC ACATTTTATT CAGAGAAGCT GGCAGAGGCT 
CAGCGCAGGT TTGCTACACT TCAGAATGAG CTTCAGTCAT CGCTGGATGT GCAGAAAGAA 
AGCAGTGGTG TCACGACATT GCGACAGCGC AGAAAGCCAG TGTTCCACCT GTCCCACGAG 
GAGCGTGTCC AACATAGGAA CATTAAAGAC CTTAAGCTGG CCTTCAGCGA GTTCTACCTC 
AGTCTCATCC TGCTGCAGAA CTATCAGAAT CTGAATTTTA CAGGGTTTCG GAAAATCCTC 
AAAAAGCATG ACAAGATCCT GGAAACATCT CGTGGAGCAG ATTGGCGAGT GATTCATGTA 
GAGGTGGCCC CATTTTATAC ATGCAAGAAA ATTAACCAGC TCATTTCTGA GACTGAGGCT 
GTGGTCACCA ATGAACTTGA AGATGGTGAC AGACAAAAGG CTATGAAGCG GTTACGGGTC 
CCTCCATTGG GAGCTGCTCA GCCTGCACCA GCATGGACTA CTTTTAGAGT TGGCCTATTT 
TGTGGAATAT TCATTGTGCT GAATATTACC CTTGTGTTTG CAGCTGTATT TAAACTTGAA 
ACAGATAGAA CTGTATGGCC CTTGATAAGA ATCTATCGGG GTGGCTTTCT TCTGATTGAA 
TTCCTTTTTC TACTGGGCAT CAACACATAT GGTTGGAGAC AAGCTGGAGT AAATCATGTC 
CTCATCTTTG AACTTAATCC AAGAAACAAT TTGTCTCATC AGCATCTCTT TGAGATTGCT 
GGATTCCTGG GGATCTTGTG GTGCCTGAGC CTTCTGGCAT GCTTCTTCGC TCCAATTAGT 
ATCATCCCTA TATATGTGTA TCCACTAGCC CTTTATGGGT TTATGGTCTT CTTTCTTATC 
AACCCCACCA AAACTTTCTA CTATAAATCC AGATTTTGGC TGCTCAAACT TCTGTTTCGA 
GTATTTACTG CTCCCTTCCA TAAGGTAGGC TTTGCTGATT TCTGGCTGGC CGATCAGCTG 
AACAGCCTGT CAGTGATTCT CATGGACCTG GAATATATGA TCTGCTTCTA CAGTTTTGAG 
CTTAAATGGG ATGAGAGTAA GGGCCTGTTG CCAAATGATC CACAAGAACC AGAATTTTGC 
CACAAATATT CATATGGTGT GCGAGCCATT GTTCAATGTA TTCCAGCTTG GCTTCGCTTC 
ATCCAGTGCC TGCGCCGGTA CCGTGACACG AGGAGGGCTT TTCCTCATCT AGTAAATGCT 
GGCAAATACT CCACAACTTT CTTCACCGTG ACATTTGCAG CCCTTTACAG CACTCACGAA 
GAACAAAATC ACTCTGACAC CGTGGTGTTC TTTTACCTGT GGGTCTTCTT TTGTATCATC 
AGTTCCTGCT ATACCCTCAT CTGGGATCTC AAGATGGACT GGGGTCTCTT TGATAAGAAT 
GCAGGAGAAA ACACTTTCCT CCGGGAAGAA ATTGTATACC CTCAAAAAGC CTATTACTAC 
TGTGCCATCA TAGAAGATGT GATACTGCGC TTCGCTTGGA CTATCCAAAT CTCTATTACT 
GCTACGTTTA AGCCTCATGT TGGGAACATC ATTGCTACTG TCTTTGCCCC CCTTGAGGTT 
TTCCGGCGAT TTGTGTGGAA CTTCTTCCGT CTGGAGAACG AGCATCTAAA TAACTGTGGT 
GAATTCCGAG CCGTGCGGGA CATCTCTGTG GCCCCCCTCA ACGCGGATGA CCAGACACTA 
CTTGAGCAGA TGATGGACCA GGAGGATGGG GTTCGAAACC GCCAGAAGAA CCGGTCGTGG 
AAGTACAATC AGAGCATATC CCTGCGTAGG CCCCGCCTGG CTTCCCAATC CAAGGCTCGC 
GACACTAAGG TATTGATAGA AGACACAGAT GACGAAGCTA ACACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of Phosphate Transporters during Dental Mineralization.
Journal of dental research97(2)209-217(2018 Feb)
Merametdjian L,Beck-Cormier S,Bon N,Couasnay G,Sourice S,Guicheux J,Gaucher C,Beck L

Analysis of gene expression and functional characterization of XPR1: a pathogenic gene for primary familial brain calcification.
Cell and tissue research370(2)267-273(2017 11)
Yao XP,Zhao M,Wang C,Guo XX,Su HZ,Dong EL,Chen HT,Lai JH,Liu YB,Wang N,Chen WJ

Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse.
BMC genomics16613(2015 Aug)
Hartmann S,Hasenkamp N,Mayer J,Michaux J,Morand S,Mazzoni CJ,Roca AL,Greenwood AD

Escape variants of the XPR1 gammaretrovirus receptor are rare due to reliance on a splice donor site and a short hypervariable loop.
Virology468-47063-71(2014 Nov)
Lu X,Martin C,Bouchard C,Kozak CA

Expression of the mammalian Xenotropic Polytropic Virus Receptor 1 (XPR1) in tobacco leaves leads to phosphate export.
FEBS letters588(3)482-9(2014 Jan)
Wege S,Poirier Y

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Xpr1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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