Utp14b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Utp14b
Entrez Gene ID	195434
Full Name	UTP14B small subunit processome component
Synonyms	4932411L21Rik,jsd
General protein information	Preferred Names UTP14B small subunit processome component Names U3 small nucleolar RNA-associated protein 14 homolog B UTP14, U3 small nucleolar ribonucleoprotein, homolog B juvenile spermatogonial depletion protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C4\|1 40.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001981.3	NP_001001981.2	U3 small nucleolar RNA-associated protein 14 homolog B
NM_001136226.1	NP_001129698.1	U3 small nucleolar RNA-associated protein 14 homolog B

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	UTP14C	XP_509792.2
	UTP14C	XP_001106440.1
Mus musculus (house mouse)	Utp14b	NP_001001981.2
Gallus gallus (chicken)	UTP14A	XP_420142.4
Danio rerio (zebrafish)	si:dkey-251i10.3	NP_001243557.1
Xenopus tropicalis (tropical clawed frog)	utp14a	NP_001008205.1
Homo sapiens (human)	UTP14C	NP_067677.4
Rattus norvegicus (Norway rat)	LOC102551819	XP_006245370.1

Gene Ontology
Bibliography

Related articles in PubMed

shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.
Song HW, Bettegowda A, Oliver D, Yan W, Phan MH, de Rooij DG, Corbett MA, Wilkinson MF
PloS one10(3)e0118549(2015)

Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.
Shetty G, Porter KL, Zhou W, Shao SH, Weng CC, Meistrich ML
Endocrinology152(9)3504-14(2011 Sep)

Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.
Zhou W, Wang G, Small CL, Liu Z, Weng CC, Yang L, Griswold MD, Meistrich ML
Biology of reproduction83(5)759-66(2010 Nov)

Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice.
Wang G, Weng CC, Shao SH, Zhou W, de Gendt K, Braun RE, Verhoeven G, Meistrich ML
Journal of andrology30(3)338-48(2009 May-Jun)

p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.
Shetty G, Shao SH, Weng CC
Endocrinology149(6)2773-81(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In adult male mice homozygous for the juvenile spermatogonial depletion (Utp14b jsd) mutation in the Utp14b gene, type A spermatogonia proliferate but undergo apoptosis before differentiation.
Title: p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.

The novel cell-type-specific promoter for Utp14b likely evolved later, as the protein may have acquired a germ cell-specific function in spermatid development.
Title: Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.

inhibition of spermatogonial differentiation in jsd mice is a result of testosterone acting through the AR only at scrotal temperatures
Title: Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations.

The following Utp14b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Utp14b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21546	NM_001136226.1 Latest version!	Mus musculus UTP14B small subunit processome component (Utp14b), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
OMu21546	NM_001001981.3 Latest version!	Mus musculus UTP14B small subunit processome component (Utp14b), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Utp14b ( NM_001001981.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001001981.2 Mus musculus UTP14B small subunit processome component (Utp14b), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu21546
Clone ID Related Accession (Same CDS sequence)	NM_001001981.3 , NM_001136226.1
Accession Version	NM_001001981.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Mus musculus(house mouse)
Product	U3 small nucleolar RNA-associated protein 14 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ048800.1, AY316161.1, AK029972.1 and BM213836.2. On Oct 28, 2008 this sequence version replaced NM_001001981.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY316161.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCAA AGATGAGACC AGATCCTTCT TCAAGAGCTA ACAGGCCCTG TGAGAAGAAG 
GAGGCTGCTA CCATGAACAT GGCCAGGAAT GTGACAGACC TTCTGGCTTT GAGCCAGCAG 
GAAGAACTAG TGGATTTGCC AGAAAACTAT CCACTGAGTA CGAGTGAAGA TGAGGGGGAC 
AGTGATGGAG AAGGAAAACG TCAAAAACTT CTGGAAGCAG TCAGTTCCCT TGGTAGAAAG 
AATAAATGGA AGTTGGCAGA GAGATCTGAG GCTAGTCGGA TGGTTTCAGA GTTCAATGTC 
ACTTCTGAAG GATCAGGTGA AAAGCTGGTC CTTTCCGATT TGCTTGGGTC TGCTACAGCA 
TTATCTTCGG TGGCTGCTGT GAAAAAACAG CTGCATAGAG TCAAGTCAAA GACGCTCACC 
CCACCCCTTA ACAAAGAAGA GGCTGACCGA GCCCTCAGGG AAGCAGCATT CAGCAAAACC 
TCACAAATGC TCTCCAGGTG GGATCCGGTG GTTCTGAAGA ACCGGCAGGC AGAGCAGTTG 
ATTTTTCCCA TGGAGAAGGA GCCGCCAGCG GTTGCACCCA TTGAACATGT TTTTACTGAC 
TGGAAAGTAA GAACCCCTCT GGAACGAGAA GTTTTTAACC TTCTTCATAA GAACAAGCAG 
CCAGTAACAG ACCCTTTATT GACTCCCGTG GAAACAGCCT CCATCAGAGC CATGAGCCTG 
GAAGAAGCCA AGATACGCCG AGCAGAGCTT CAGAGGACGC GAGCTCTACA GTCCTATTAT 
GAGGCTAGAG CTCGAAGAGA GAAGAGAATC AAGAGTAAGA AGTATCACAG AGCTCTAAAG 
AAAGGAAAGG CCAAGAAAGC CTTAAAAGAG TTTGAAGAGC TGTGGAAAGA CTGCCCAAAT 
GCTGCATTGC AAGAACTGGA GAAAATGGAA AAGGCCAGAA TGACAGAACG GATGAGCCTT 
AAGCACCAGG GCAGTGGGAA ATGGGCAAAG TCAAAGGCAA TTATGGCCAA ATATGACCCT 
GAGGCTCGAA AAGCTATGCA AGAACAATTG GCTAAGAACA GAGAACTGAC ACAGAAACTC 
CAGGTAGTTT CAGAGAGTGA GGAAGAGGAC GGATGCACAG AAGAGGGAAT AGTCTCTGTC 
TCCCATGGAA TGGATGACCT ACAGATGAAT GCAGATGGTG TAAATCCCTG GATGCTTAGC 
AGTTGCAACA GCAATGCAAA GCGGGGTGAG ATCAAGACCG ATCCTGAACA GATGCCTGAG 
TTTGTGGCCC ATGTGTCTTC TGAGAGTGAG GGAGATGAAA GACCAGTGGC AGAAGAACTT 
GTGTTAAAAG AAAGATCCTT TCAAGAAAGA GTTGATCCCA ACAATGCTAA GCTAATGGAT 
GGCCAAGAAA CAGAAGACTC TGATAGCCAG GAGGTATTAC AGAAACTCAA CAAGGAAAGT 
CATCAATCTG ACAATCAAAA AGTGAGTTCA GAGGAAAATG TTCTCCATAT CCAGAGAGAG 
GACCTTGCCT CAGAGAAGTT GTTGGTGCTT CAAAGGCTAG AGAGAGCACA TGTTCTGGAA 
CAACAAGGAG AGTTGAGCAA AGAAGAACAT TATCCAAAAA AAGGGCTTTC CAGACCTTTG 
TTGAAAGGGG ATTGGAAGGA GATGAAGCCA CTCACCAACC CTGATGCCTC TGGAGGGAAG 
AAAAAGAAGG AACAAATGAT TGATCTACGG AACCTCCTAA CTGCTAACTC ATCTCCTGTG 
AGGTCTTTGG CTGTGCCCAC AATACAGCAG TTAGAAGATG AAGTGGAGAC CGATCACAAG 
CAGCTAATAA GGGAAGCTTT TGCTGGGGAT GATGTCATAA GAGAGTTCTT AAAAGAGAAG 
AGGGAAGCTA TAGAGACAAA TAAACCAAAG GACTTGGACC TGTCATTGCC TGGATGGGGT 
GAGTGGGTTG GTATGGGCCT GAAGCCCAGC GCCAAGAAAA GACGCCGTTT TCTTATTAAA 
GCTCCTGAGA GTTCTCCAAG AAAAGACAAG AATTTGCCGA ATGTGATTAT CAGTGAGAAG 
CGCAACATCC ATGCAGCTGC TCATCAGGTG CGGGCGCTTC CACACCCATT CACCCACCAG 
CAGCAGTTTG AAAGGACTAT CCAAAACCCT ATTGGGTACA TGTGGAACAC CCAGAGGACC 
TTCCAAAAGC TGACAGTTCC CAAGGTTGGC ACCAAGCTAG GCCATATCAT TAAGCCCATA 
AAAGCAGAAA ATGTAGGGTA CTGCTCTTCC ACAAGGTCTG ACCTCTCTAT CCTACAGAGC 
AGTCAGAAGT GCCTCTCCAG AAAACAGCAA AAACAACTGA AGAAGTTGAG CTCTGCAGAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001981.2
CDS	481..2823
Translation	MKPKMRPDPSSRANRPCEKKEAATMNMARNVTDLLALSQQEELVDLPENYPLSTSEDEGDSDGEGKRQKLLEAVSSLGRKNKWKLAERSEASRMVSEFNVTSEGSGEKLVLSDLLGSATALSSVAAVKKQLHRVKSKTLTPPLNKEEADRALREAAFSKTSQMLSRWDPVVLKNRQAEQLIFPMEKEPPAVAPIEHVFTDWKVRTPLEREVFNLLHKNKQPVTDPLLTPVETASIRAMSLEEAKIRRAELQRTRALQSYYEARARREKRIKSKKYHRALKKGKAKKALKEFEELWKDCPNAALQELEKMEKARMTERMSLKHQGSGKWAKSKAIMAKYDPEARKAMQEQLAKNRELTQKLQVVSESEEEDGCTEEGIVSVSHGMDDLQMNADGVNPWMLSSCNSNAKRGEIKTDPEQMPEFVAHVSSESEGDERPVAEELVLKERSFQERVDPNNAKLMDGQETEDSDSQEVLQKLNKESHQSDNQKVSSEENVLHIQREDLASEKLLVLQRLERAHVLEQQGELSKEEHYPKKGLSRPLLKGDWKEMKPLTNPDASGGKKKKEQMIDLRNLLTANSSPVRSLAVPTIQQLEDEVETDHKQLIREAFAGDDVIREFLKEKREAIETNKPKDLDLSLPGWGEWVGMGLKPSAKKRRRFLIKAPESSPRKDKNLPNVIISEKRNIHAAAHQVRALPHPFTHQQQFERTIQNPIGYMWNTQRTFQKLTVPKVGTKLGHIIKPIKAENVGYCSSTRSDLSILQSSQKCLSRKQQKQLKKLSSAD

Target ORF information:

RefSeq Version	NM_001001981.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus UTP14B small subunit processome component (Utp14b), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001981.3

ORF Insert Sequence:

ATGAAGCCAA AGATGAGACC AGATCCTTCT TCAAGAGCTA ACAGGCCCTG TGAGAAGAAG 
GAGGCTGCTA CCATGAACAT GGCCAGGAAT GTGACAGACC TTCTGGCTTT GAGCCAGCAG 
GAAGAACTAG TGGATTTGCC AGAAAACTAT CCACTGAGTA CGAGTGAAGA TGAGGGGGAC 
AGTGATGGAG AAGGAAAACG TCAAAAACTT CTGGAAGCAG TCAGTTCCCT TGGTAGAAAG 
AATAAATGGA AGTTGGCAGA GAGATCTGAG GCTAGTCGGA TGGTTTCAGA GTTCAATGTC 
ACTTCTGAAG GATCAGGTGA AAAGCTGGTC CTTTCCGATT TGCTTGGGTC TGCTACAGCA 
TTATCTTCGG TGGCTGCTGT GAAAAAACAG CTGCATAGAG TCAAGTCAAA GACGCTCACC 
CCACCCCTTA ACAAAGAAGA GGCTGACCGA GCCCTCAGGG AAGCAGCATT CAGCAAAACC 
TCACAAATGC TCTCCAGGTG GGATCCGGTG GTTCTGAAGA ACCGGCAGGC AGAGCAGTTG 
ATTTTTCCCA TGGAGAAGGA GCCGCCAGCG GTTGCACCCA TTGAACATGT TTTTACTGAC 
TGGAAAGTAA GAACCCCTCT GGAACGAGAA GTTTTTAACC TTCTTCATAA GAACAAGCAG 
CCAGTAACAG ACCCTTTATT GACTCCCGTG GAAACAGCCT CCATCAGAGC CATGAGCCTG 
GAAGAAGCCA AGATACGCCG AGCAGAGCTT CAGAGGACGC GAGCTCTACA GTCCTATTAT 
GAGGCTAGAG CTCGAAGAGA GAAGAGAATC AAGAGTAAGA AGTATCACAG AGCTCTAAAG 
AAAGGAAAGG CCAAGAAAGC CTTAAAAGAG TTTGAAGAGC TGTGGAAAGA CTGCCCAAAT 
GCTGCATTGC AAGAACTGGA GAAAATGGAA AAGGCCAGAA TGACAGAACG GATGAGCCTT 
AAGCACCAGG GCAGTGGGAA ATGGGCAAAG TCAAAGGCAA TTATGGCCAA ATATGACCCT 
GAGGCTCGAA AAGCTATGCA AGAACAATTG GCTAAGAACA GAGAACTGAC ACAGAAACTC 
CAGGTAGTTT CAGAGAGTGA GGAAGAGGAC GGATGCACAG AAGAGGGAAT AGTCTCTGTC 
TCCCATGGAA TGGATGACCT ACAGATGAAT GCAGATGGTG TAAATCCCTG GATGCTTAGC 
AGTTGCAACA GCAATGCAAA GCGGGGTGAG ATCAAGACCG ATCCTGAACA GATGCCTGAG 
TTTGTGGCCC ATGTGTCTTC TGAGAGTGAG GGAGATGAAA GACCAGTGGC AGAAGAACTT 
GTGTTAAAAG AAAGATCCTT TCAAGAAAGA GTTGATCCCA ACAATGCTAA GCTAATGGAT 
GGCCAAGAAA CAGAAGACTC TGATAGCCAG GAGGTATTAC AGAAACTCAA CAAGGAAAGT 
CATCAATCTG ACAATCAAAA AGTGAGTTCA GAGGAAAATG TTCTCCATAT CCAGAGAGAG 
GACCTTGCCT CAGAGAAGTT GTTGGTGCTT CAAAGGCTAG AGAGAGCACA TGTTCTGGAA 
CAACAAGGAG AGTTGAGCAA AGAAGAACAT TATCCAAAAA AAGGGCTTTC CAGACCTTTG 
TTGAAAGGGG ATTGGAAGGA GATGAAGCCA CTCACCAACC CTGATGCCTC TGGAGGGAAG 
AAAAAGAAGG AACAAATGAT TGATCTACGG AACCTCCTAA CTGCTAACTC ATCTCCTGTG 
AGGTCTTTGG CTGTGCCCAC AATACAGCAG TTAGAAGATG AAGTGGAGAC CGATCACAAG 
CAGCTAATAA GGGAAGCTTT TGCTGGGGAT GATGTCATAA GAGAGTTCTT AAAAGAGAAG 
AGGGAAGCTA TAGAGACAAA TAAACCAAAG GACTTGGACC TGTCATTGCC TGGATGGGGT 
GAGTGGGTTG GTATGGGCCT GAAGCCCAGC GCCAAGAAAA GACGCCGTTT TCTTATTAAA 
GCTCCTGAGA GTTCTCCAAG AAAAGACAAG AATTTGCCGA ATGTGATTAT CAGTGAGAAG 
CGCAACATCC ATGCAGCTGC TCATCAGGTG CGGGCGCTTC CACACCCATT CACCCACCAG 
CAGCAGTTTG AAAGGACTAT CCAAAACCCT ATTGGGTACA TGTGGAACAC CCAGAGGACC 
TTCCAAAAGC TGACAGTTCC CAAGGTTGGC ACCAAGCTAG GCCATATCAT TAAGCCCATA 
AAAGCAGAAA ATGTAGGGTA CTGCTCTTCC ACAAGGTCTG ACCTCTCTAT CCTACAGAGC 
AGTCAGAAGT GCCTCTCCAG AAAACAGCAA AAACAACTGA AGAAGTTGAG CTCTGCAGAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Utp14b ( NM_001136226.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001129698.1 Mus musculus UTP14B small subunit processome component (Utp14b), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu21546
Clone ID Related Accession (Same CDS sequence)	NM_001001981.3 , NM_001136226.1
Accession Version	NM_001136226.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2343bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Mus musculus(house mouse)
Product	U3 small nucleolar RNA-associated protein 14 homolog B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK029972.1, AC156613.9 and BM213836.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK029972.1, BB616382.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCAA AGATGAGACC AGATCCTTCT TCAAGAGCTA ACAGGCCCTG TGAGAAGAAG 
GAGGCTGCTA CCATGAACAT GGCCAGGAAT GTGACAGACC TTCTGGCTTT GAGCCAGCAG 
GAAGAACTAG TGGATTTGCC AGAAAACTAT CCACTGAGTA CGAGTGAAGA TGAGGGGGAC 
AGTGATGGAG AAGGAAAACG TCAAAAACTT CTGGAAGCAG TCAGTTCCCT TGGTAGAAAG 
AATAAATGGA AGTTGGCAGA GAGATCTGAG GCTAGTCGGA TGGTTTCAGA GTTCAATGTC 
ACTTCTGAAG GATCAGGTGA AAAGCTGGTC CTTTCCGATT TGCTTGGGTC TGCTACAGCA 
TTATCTTCGG TGGCTGCTGT GAAAAAACAG CTGCATAGAG TCAAGTCAAA GACGCTCACC 
CCACCCCTTA ACAAAGAAGA GGCTGACCGA GCCCTCAGGG AAGCAGCATT CAGCAAAACC 
TCACAAATGC TCTCCAGGTG GGATCCGGTG GTTCTGAAGA ACCGGCAGGC AGAGCAGTTG 
ATTTTTCCCA TGGAGAAGGA GCCGCCAGCG GTTGCACCCA TTGAACATGT TTTTACTGAC 
TGGAAAGTAA GAACCCCTCT GGAACGAGAA GTTTTTAACC TTCTTCATAA GAACAAGCAG 
CCAGTAACAG ACCCTTTATT GACTCCCGTG GAAACAGCCT CCATCAGAGC CATGAGCCTG 
GAAGAAGCCA AGATACGCCG AGCAGAGCTT CAGAGGACGC GAGCTCTACA GTCCTATTAT 
GAGGCTAGAG CTCGAAGAGA GAAGAGAATC AAGAGTAAGA AGTATCACAG AGCTCTAAAG 
AAAGGAAAGG CCAAGAAAGC CTTAAAAGAG TTTGAAGAGC TGTGGAAAGA CTGCCCAAAT 
GCTGCATTGC AAGAACTGGA GAAAATGGAA AAGGCCAGAA TGACAGAACG GATGAGCCTT 
AAGCACCAGG GCAGTGGGAA ATGGGCAAAG TCAAAGGCAA TTATGGCCAA ATATGACCCT 
GAGGCTCGAA AAGCTATGCA AGAACAATTG GCTAAGAACA GAGAACTGAC ACAGAAACTC 
CAGGTAGTTT CAGAGAGTGA GGAAGAGGAC GGATGCACAG AAGAGGGAAT AGTCTCTGTC 
TCCCATGGAA TGGATGACCT ACAGATGAAT GCAGATGGTG TAAATCCCTG GATGCTTAGC 
AGTTGCAACA GCAATGCAAA GCGGGGTGAG ATCAAGACCG ATCCTGAACA GATGCCTGAG 
TTTGTGGCCC ATGTGTCTTC TGAGAGTGAG GGAGATGAAA GACCAGTGGC AGAAGAACTT 
GTGTTAAAAG AAAGATCCTT TCAAGAAAGA GTTGATCCCA ACAATGCTAA GCTAATGGAT 
GGCCAAGAAA CAGAAGACTC TGATAGCCAG GAGGTATTAC AGAAACTCAA CAAGGAAAGT 
CATCAATCTG ACAATCAAAA AGTGAGTTCA GAGGAAAATG TTCTCCATAT CCAGAGAGAG 
GACCTTGCCT CAGAGAAGTT GTTGGTGCTT CAAAGGCTAG AGAGAGCACA TGTTCTGGAA 
CAACAAGGAG AGTTGAGCAA AGAAGAACAT TATCCAAAAA AAGGGCTTTC CAGACCTTTG 
TTGAAAGGGG ATTGGAAGGA GATGAAGCCA CTCACCAACC CTGATGCCTC TGGAGGGAAG 
AAAAAGAAGG AACAAATGAT TGATCTACGG AACCTCCTAA CTGCTAACTC ATCTCCTGTG 
AGGTCTTTGG CTGTGCCCAC AATACAGCAG TTAGAAGATG AAGTGGAGAC CGATCACAAG 
CAGCTAATAA GGGAAGCTTT TGCTGGGGAT GATGTCATAA GAGAGTTCTT AAAAGAGAAG 
AGGGAAGCTA TAGAGACAAA TAAACCAAAG GACTTGGACC TGTCATTGCC TGGATGGGGT 
GAGTGGGTTG GTATGGGCCT GAAGCCCAGC GCCAAGAAAA GACGCCGTTT TCTTATTAAA 
GCTCCTGAGA GTTCTCCAAG AAAAGACAAG AATTTGCCGA ATGTGATTAT CAGTGAGAAG 
CGCAACATCC ATGCAGCTGC TCATCAGGTG CGGGCGCTTC CACACCCATT CACCCACCAG 
CAGCAGTTTG AAAGGACTAT CCAAAACCCT ATTGGGTACA TGTGGAACAC CCAGAGGACC 
TTCCAAAAGC TGACAGTTCC CAAGGTTGGC ACCAAGCTAG GCCATATCAT TAAGCCCATA 
AAAGCAGAAA ATGTAGGGTA CTGCTCTTCC ACAAGGTCTG ACCTCTCTAT CCTACAGAGC 
AGTCAGAAGT GCCTCTCCAG AAAACAGCAA AAACAACTGA AGAAGTTGAG CTCTGCAGAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129698.1
CDS	488..2830
Translation	MKPKMRPDPSSRANRPCEKKEAATMNMARNVTDLLALSQQEELVDLPENYPLSTSEDEGDSDGEGKRQKLLEAVSSLGRKNKWKLAERSEASRMVSEFNVTSEGSGEKLVLSDLLGSATALSSVAAVKKQLHRVKSKTLTPPLNKEEADRALREAAFSKTSQMLSRWDPVVLKNRQAEQLIFPMEKEPPAVAPIEHVFTDWKVRTPLEREVFNLLHKNKQPVTDPLLTPVETASIRAMSLEEAKIRRAELQRTRALQSYYEARARREKRIKSKKYHRALKKGKAKKALKEFEELWKDCPNAALQELEKMEKARMTERMSLKHQGSGKWAKSKAIMAKYDPEARKAMQEQLAKNRELTQKLQVVSESEEEDGCTEEGIVSVSHGMDDLQMNADGVNPWMLSSCNSNAKRGEIKTDPEQMPEFVAHVSSESEGDERPVAEELVLKERSFQERVDPNNAKLMDGQETEDSDSQEVLQKLNKESHQSDNQKVSSEENVLHIQREDLASEKLLVLQRLERAHVLEQQGELSKEEHYPKKGLSRPLLKGDWKEMKPLTNPDASGGKKKKEQMIDLRNLLTANSSPVRSLAVPTIQQLEDEVETDHKQLIREAFAGDDVIREFLKEKREAIETNKPKDLDLSLPGWGEWVGMGLKPSAKKRRRFLIKAPESSPRKDKNLPNVIISEKRNIHAAAHQVRALPHPFTHQQQFERTIQNPIGYMWNTQRTFQKLTVPKVGTKLGHIIKPIKAENVGYCSSTRSDLSILQSSQKCLSRKQQKQLKKLSSAD

Target ORF information:

RefSeq Version	NM_001136226.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus UTP14B small subunit processome component (Utp14b), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001136226.1

ORF Insert Sequence:

ATGAAGCCAA AGATGAGACC AGATCCTTCT TCAAGAGCTA ACAGGCCCTG TGAGAAGAAG 
GAGGCTGCTA CCATGAACAT GGCCAGGAAT GTGACAGACC TTCTGGCTTT GAGCCAGCAG 
GAAGAACTAG TGGATTTGCC AGAAAACTAT CCACTGAGTA CGAGTGAAGA TGAGGGGGAC 
AGTGATGGAG AAGGAAAACG TCAAAAACTT CTGGAAGCAG TCAGTTCCCT TGGTAGAAAG 
AATAAATGGA AGTTGGCAGA GAGATCTGAG GCTAGTCGGA TGGTTTCAGA GTTCAATGTC 
ACTTCTGAAG GATCAGGTGA AAAGCTGGTC CTTTCCGATT TGCTTGGGTC TGCTACAGCA 
TTATCTTCGG TGGCTGCTGT GAAAAAACAG CTGCATAGAG TCAAGTCAAA GACGCTCACC 
CCACCCCTTA ACAAAGAAGA GGCTGACCGA GCCCTCAGGG AAGCAGCATT CAGCAAAACC 
TCACAAATGC TCTCCAGGTG GGATCCGGTG GTTCTGAAGA ACCGGCAGGC AGAGCAGTTG 
ATTTTTCCCA TGGAGAAGGA GCCGCCAGCG GTTGCACCCA TTGAACATGT TTTTACTGAC 
TGGAAAGTAA GAACCCCTCT GGAACGAGAA GTTTTTAACC TTCTTCATAA GAACAAGCAG 
CCAGTAACAG ACCCTTTATT GACTCCCGTG GAAACAGCCT CCATCAGAGC CATGAGCCTG 
GAAGAAGCCA AGATACGCCG AGCAGAGCTT CAGAGGACGC GAGCTCTACA GTCCTATTAT 
GAGGCTAGAG CTCGAAGAGA GAAGAGAATC AAGAGTAAGA AGTATCACAG AGCTCTAAAG 
AAAGGAAAGG CCAAGAAAGC CTTAAAAGAG TTTGAAGAGC TGTGGAAAGA CTGCCCAAAT 
GCTGCATTGC AAGAACTGGA GAAAATGGAA AAGGCCAGAA TGACAGAACG GATGAGCCTT 
AAGCACCAGG GCAGTGGGAA ATGGGCAAAG TCAAAGGCAA TTATGGCCAA ATATGACCCT 
GAGGCTCGAA AAGCTATGCA AGAACAATTG GCTAAGAACA GAGAACTGAC ACAGAAACTC 
CAGGTAGTTT CAGAGAGTGA GGAAGAGGAC GGATGCACAG AAGAGGGAAT AGTCTCTGTC 
TCCCATGGAA TGGATGACCT ACAGATGAAT GCAGATGGTG TAAATCCCTG GATGCTTAGC 
AGTTGCAACA GCAATGCAAA GCGGGGTGAG ATCAAGACCG ATCCTGAACA GATGCCTGAG 
TTTGTGGCCC ATGTGTCTTC TGAGAGTGAG GGAGATGAAA GACCAGTGGC AGAAGAACTT 
GTGTTAAAAG AAAGATCCTT TCAAGAAAGA GTTGATCCCA ACAATGCTAA GCTAATGGAT 
GGCCAAGAAA CAGAAGACTC TGATAGCCAG GAGGTATTAC AGAAACTCAA CAAGGAAAGT 
CATCAATCTG ACAATCAAAA AGTGAGTTCA GAGGAAAATG TTCTCCATAT CCAGAGAGAG 
GACCTTGCCT CAGAGAAGTT GTTGGTGCTT CAAAGGCTAG AGAGAGCACA TGTTCTGGAA 
CAACAAGGAG AGTTGAGCAA AGAAGAACAT TATCCAAAAA AAGGGCTTTC CAGACCTTTG 
TTGAAAGGGG ATTGGAAGGA GATGAAGCCA CTCACCAACC CTGATGCCTC TGGAGGGAAG 
AAAAAGAAGG AACAAATGAT TGATCTACGG AACCTCCTAA CTGCTAACTC ATCTCCTGTG 
AGGTCTTTGG CTGTGCCCAC AATACAGCAG TTAGAAGATG AAGTGGAGAC CGATCACAAG 
CAGCTAATAA GGGAAGCTTT TGCTGGGGAT GATGTCATAA GAGAGTTCTT AAAAGAGAAG 
AGGGAAGCTA TAGAGACAAA TAAACCAAAG GACTTGGACC TGTCATTGCC TGGATGGGGT 
GAGTGGGTTG GTATGGGCCT GAAGCCCAGC GCCAAGAAAA GACGCCGTTT TCTTATTAAA 
GCTCCTGAGA GTTCTCCAAG AAAAGACAAG AATTTGCCGA ATGTGATTAT CAGTGAGAAG 
CGCAACATCC ATGCAGCTGC TCATCAGGTG CGGGCGCTTC CACACCCATT CACCCACCAG 
CAGCAGTTTG AAAGGACTAT CCAAAACCCT ATTGGGTACA TGTGGAACAC CCAGAGGACC 
TTCCAAAAGC TGACAGTTCC CAAGGTTGGC ACCAAGCTAG GCCATATCAT TAAGCCCATA 
AAAGCAGAAA ATGTAGGGTA CTGCTCTTCC ACAAGGTCTG ACCTCTCTAT CCTACAGAGC 
AGTCAGAAGT GCCTCTCCAG AAAACAGCAA AAACAACTGA AGAAGTTGAG CTCTGCAGAT 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.
PloS one10(3)e0118549(2015)
Song HW,Bettegowda A,Oliver D,Yan W,Phan MH,de Rooij DG,Corbett MA,Wilkinson MF

Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature.
Endocrinology152(9)3504-14(2011 Sep)
Shetty G,Porter KL,Zhou W,Shao SH,Weng CC,Meistrich ML

Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice.
Biology of reproduction83(5)759-66(2010 Nov)
Zhou W,Wang G,Small CL,Liu Z,Weng CC,Yang L,Griswold MD,Meistrich ML

Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice.
Journal of andrology30(3)338-48(2009 May-Jun)
Wang G,Weng CC,Shao SH,Zhou W,de Gendt K,Braun RE,Verhoeven G,Meistrich ML

p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.
Endocrinology149(6)2773-81(2008 Jun)
Shetty G,Shao SH,Weng CC

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Utp14b cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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