Ran cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ran
Entrez Gene ID	19384
Full Name	RAN, member RAS oncogene family
General protein information	Preferred Names RAN, member RAS oncogene family Names GTP-binding nuclear protein Ran GTPase Ran ras-like protein TC4 ras-related nuclear protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G1.3

mRNA and Protein(s)

mRNA	Protein	Name
XM_006504280.4	XP_006504343.1	GTP-binding nuclear protein Ran isoform X1
NM_009391.3	NP_033417.1	GTP-binding nuclear protein Ran
XM_006504280.2	XP_006504343.1	GTP-binding nuclear protein Ran isoform X1
XM_006504280.3	XP_006504343.1	GTP-binding nuclear protein Ran isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RAN	XP_003952405.1
Homo sapiens (human)	RAN	NP_006316.1
	RAN	XP_001104422.1
Canis lupus familiaris (dog)	RAN	NP_001181913.1
Mus musculus (house mouse)	Ran	NP_033417.1
Gallus gallus (chicken)	RAN	NP_990589.1
Drosophila melanogaster (fruit fly)	ran	NP_727499.1
Saccharomyces cerevisiae (baker's yeast)	GSP1	NP_013396.1
Kluyveromyces lactis	KLLA0C05126g	XP_452429.1
Arabidopsis thaliana (thale cress)	RAN-1	NP_197501.1
Bos taurus (cattle)	RAN	NP_001029877.1
Danio rerio (zebrafish)	ran	NP_571384.1
Caenorhabditis elegans (roundworm)	ran-1	NP_499369.1
Eremothecium gossypii	AGOS_AGR294C	NP_986960.1
Neurospora crassa	NCU09269	XP_964704.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007699	XP_564524.3
Saccharomyces cerevisiae (baker's yeast)	GSP2	NP_014828.1
Schizosaccharomyces pombe (fission yeast)	spi1	NP_596827.1
Rattus norvegicus (Norway rat)	Ran	NP_445891.1
Kluyveromyces lactis	KLLA0A04499g	XP_451197.1
Magnaporthe oryzae (rice blast fungus)	MGG_09952	XP_003710062.1
Arabidopsis thaliana (thale cress)	RAN3	NP_200330.1
Arabidopsis thaliana (thale cress)	RAN2	NP_197502.1
Oryza sativa (rice)	Os01g0611100	NP_001043550.1
Xenopus tropicalis (tropical clawed frog)	ran	NP_001004829.1

Gene Ontology
Bibliography

Related articles in PubMed

Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA
eLife6(2017 Oct)

Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.
Chen WS, Chen YJ, Huang YA, Hsieh BY, Chiu HC, Kao PY, Chao CY, Hwang E
Scientific reports742297(2017 Feb)

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.
Shibano T, Mamada H, Hakuno F, Takahashi S, Taira M
PloS one10(5)e0127271(2015)

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L
The Journal of experimental medicine211(10)1937-45(2014 Sep)

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, W?lke S, Bausch A, Griffiths G, M?ller-Taubenberger A, Itzen A, Hilbi H
PLoS pathogens9(9)e1003598(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Augmented expression of Ran in progranulin-deficient neurons restores nuclear TDP-43 levels and improves their survival.
Title: Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

Data suggest Ran activation by RanBP1 in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.
Title: Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.

Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha leading to cellular senescence in normal cells.
Title: Downregulation of the small GTPase ras-related nuclear protein accelerates cellular ageing.

a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important consequences for oncogenic transformation.
Title: Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.

A critical function of RanBP2 is to capture recycling RanGTP-importin-beta complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.
Title: Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

The following Ran gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ran cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20695	NM_009391.3 Latest version!	Mus musculus RAN, member RAS oncogene family (Ran), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu20695	XM_006504280.4 Latest version!	Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu20695	XM_006504280.2	Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu20695	XM_006504280.3	Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ran ( NM_009391.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033417.1 Mus musculus RAN, member RAS oncogene family (Ran), mRNA.

Price & Availability↑

CloneID	OMu20695
Clone ID Related Accession (Same CDS sequence)	XM_006504280.4 , NM_009391.3 , XM_006504280.2 , XM_006504280.3
Accession Version	NM_009391.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	GTP-binding nuclear protein Ran
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002436.1, AK075900.1 and AC110566.17. On Sep 15, 2006 this sequence version replaced NM_009391.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075900.1, AK151341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033417.1
CDS	135..785
Translation	MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Target ORF information:

RefSeq Version	NM_009391.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAN, member RAS oncogene family (Ran), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009391.3

ORF Insert Sequence:

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ran ( XM_006504280.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006504343.1 Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu20695
Clone ID Related Accession (Same CDS sequence)	XM_006504280.4 , NM_009391.3 , XM_006504280.2 , XM_006504280.3
Accession Version	XM_006504280.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	GTP-binding nuclear protein Ran isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006504280.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006504343.1
CDS	118..768
Translation	MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Target ORF information:

RefSeq Version	XM_006504280.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504280.4

ORF Insert Sequence:

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ran ( XM_006504280.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006504343.1 Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu20695
Clone ID Related Accession (Same CDS sequence)	XM_006504280.4 , NM_009391.3 , XM_006504280.2 , XM_006504280.3
Accession Version	XM_006504280.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	GTP-binding nuclear protein Ran isoform X1
Comment

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006504343.1
Translation	MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Target ORF information:

RefSeq Version	XM_006504280.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504280.2

ORF Insert Sequence:

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ran ( XM_006504280.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006504343.1 Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu20695
Clone ID Related Accession (Same CDS sequence)	XM_006504280.4 , NM_009391.3 , XM_006504280.2 , XM_006504280.3
Accession Version	XM_006504280.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	GTP-binding nuclear protein Ran isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006504280.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006504343.1
CDS	124..774
Translation	MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Target ORF information:

RefSeq Version	XM_006504280.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAN, member RAS oncogene family (Ran), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006504280.3

ORF Insert Sequence:

ATGGCCGCCC AGGGAGAGCC GCAGGTCCAG TTCAAGCTCG TCCTGGTGGG CGACGGCGGC 
ACCGGGAAGA CAACCTTCGT GAAGCGCCAC TTGACGGGCG AGTTTGAGAA GAAGTATGTA 
GCCACCCTGG GCGTGGAGGT GCACCCGCTC GTCTTCCATA CCAACAGAGG ACCCATCAAG 
TTCAACGTGT GGGACACGGC CGGCCAGGAG AAGTTCGGGG GCCTGCGCGA TGGCTACTAC 
ATCCAAGCCC AGTGTGCCAT TATAATGTTT GATGTAACCT CAAGAGTTAC TTACAAGAAT 
GTACCTAACT GGCATAGAGA TCTGGTACGA GTGTGTGAAA ACATCCCCAT TGTATTGTGT 
GGCAACAAAG TGGATATTAA AGACAGGAAA GTGAAGGCAA AATCTATTGT CTTCCACCGG 
AAGAAGAATC TTCAGTACTA TGACATTTCT GCCAAAAGTA ACTACAACTT TGAAAAGCCT 
TTCCTCTGGC TTGCCAGAAA GCTCATTGGA GATCCTAACT TGGAGTTTGT TGCCATGCCT 
GCTCTTGCCC CACCTGAGGT GGTCATGGAC CCAGCTTTGG CAGCACAGTA CGAGCATGAT 
TTAGAGGTTG CTCAGACGAC TGCTCTCCCA GATGAGGATG ATGACCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

eLife6(2017 Oct)
Connell M,Chen H,Jiang J,Kuan CW,Fotovati A,Chu TL,He Z,Lengyell TC,Li H,Kroll T,Li AM,Goldowitz D,Frappart L,Ploubidou A,Patel MS,Pilarski LM,Simpson EM,Lange PF,Allan DW,Maxwell CA

Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.
Scientific reports742297(2017 Feb)
Chen WS,Chen YJ,Huang YA,Hsieh BY,Chiu HC,Kao PY,Chao CY,Hwang E

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes.
PloS one10(5)e0127271(2015)
Shibano T,Mamada H,Hakuno F,Takahashi S,Taira M

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
The Journal of experimental medicine211(10)1937-45(2014 Sep)
Ward ME,Taubes A,Chen R,Miller BL,Sephton CF,Gelfand JM,Minami S,Boscardin J,Martens LH,Seeley WW,Yu G,Herz J,Filiano AJ,Arrant AE,Roberson ED,Kraft TW,Farese RV Jr,Green A,Gan L

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
PLoS pathogens9(9)e1003598(2013 Sep)
Rothmeier E,Pfaffinger G,Hoffmann C,Harrison CF,Grabmayr H,Repnik U,Hannemann M,W?lke S,Bausch A,Griffiths G,M?ller-Taubenberger A,Itzen A,Hilbi H

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Ran cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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