Rac2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rac2
Entrez Gene ID	19354
Full Name	RAS-related C3 botulinum substrate 2
Synonyms	AI323801,AI452260
General protein information	Preferred Names RAS-related C3 botulinum substrate 2 Names ras-related C3 botulinum toxin substrate 2 EN-7 protein p21-Rac2 protein EN-7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_009008.3	NP_033034.1	ras-related C3 botulinum toxin substrate 2 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	RAC2	NP_001188381.1
Oryza sativa (rice)	Os06g0234200	NP_001057236.1
Canis lupus familiaris (dog)	RAC2	XP_538392.4
Xenopus tropicalis (tropical clawed frog)	rac2	NP_001011285.1
Danio rerio (zebrafish)	rac2	NP_001002061.1
Magnaporthe oryzae (rice blast fungus)	MGG_02731	XP_003721025.1
Oryza sativa (rice)	Os02g0742200	NP_001048088.1
Homo sapiens (human)	RAC2	NP_002863.1
Bos taurus (cattle)	RAC2	NP_786986.1
Rattus norvegicus (Norway rat)	Rac2	NP_001008385.1
Arabidopsis thaliana (thale cress)	RAC10	NP_201093.1
	RAC2	XP_001086228.1
Mus musculus (house mouse)	Rac2	NP_033034.1
Neurospora crassa	NCU02160	XP_964519.2
Arabidopsis thaliana (thale cress)	ROP10	NP_566897.1

Gene Ontology
Bibliography

Related articles in PubMed

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X
eLife7(2018 Jan)

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1? Production.
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR
Arteriosclerosis, thrombosis, and vascular biology37(2)328-340(2017 Feb)

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.
Joshi S, Singh AR, Wong SS, Zulcic M, Jiang M, Pardo A, Selman M, Hagood JS, Durden DL
PloS one12(8)e0182851(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rac2 to modulates the level of Rac1-dependent macrophage IL-1beta expression, which consequently determines extent of atherosclerotic calcification.
Title: Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1? Production.

Rac2 signaling axis is critical in the regulation of macrophage differentiation and lung fibrosis in vivo.
Title: Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.

Rac1 and Rac2 have critical roles in skeletal metabolism.
Title: Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo.

Data indicate that cytosol-to-membrane translocation of the Nox regulatory subunit p47(phox) and the small GTPase Rac1/2 was increased in vessels from db/db mice compared with db/+ mice, an effect blunted by atorvastatin.
Title: Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways.

Rac2-deficient animals have higher rates of mortality in pulmonary fibrosis.
Title: Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis.

The following Rac2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rac2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13332	NM_009008.3 Latest version!	Mus musculus Rac family small GTPase 2 (Rac2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rac2 ( NM_009008.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033034.1 Mus musculus Rac family small GTPase 2 (Rac2), mRNA.

Price & Availability↑

CloneID	OMu13332
Clone ID Related Accession (Same CDS sequence)	NM_009008.3
Accession Version	NM_009008.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Mus musculus(house mouse)
Product	ras-related C3 botulinum toxin substrate 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK171321.1 and AL590144.10. On or before May 4, 2006 this sequence version replaced XM_001000836.1, NM_009008.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144136.1, AK171321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849383 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGCCA TCAAGTGTGT GGTGGTGGGT GATGGAGCCG TGGGCAAGAC GTGTCTTCTC 
ATCAGCTACA CCACCAACGC CTTCCCTGGA GAATACATCC CCACTGTATT TGACAACTAC 
TCAGCCAATG TGATGGTGGA CAGTAAGCCG GTGAACCTGG GGCTGTGGGA TACCGCAGGT 
CAGGAGGACT ATGACCGCCT CCGGCCACTC TCCTACCCAC AGACAGATGT ATTTCTCATC 
TGCTTCTCGC TAGTCAGCCC AGCCTCCTAT GAGAATGTCC GTGCCAAGTG GTTCCCTGAG 
GTACGGCACC ACTGCCCCAG CACCCCCATC ATCCTGGTGG GTACCAAGCT GGACCTTCGC 
GATGACAAGG ACACCATCGA GAAGCTGAAG GAGAAGAAGC TGGCTCCCAT CACCTACCCG 
CAGGGCCTGG CACTGGCCAA GGATATTGAT TCAGTCAAGT ACTTGGAATG TTCTGCACTC 
ACCCAGCGAG GCCTGAAGAC CGTCTTCGAT GAGGCAATCC GCGCAGTCCT CTGCCCACAG 
CCCACACGAC AGCAGAAGCG CCCCTGCAGC CTGCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033034.1
CDS	139..717
Translation	MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKDIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL

Target ORF information:

RefSeq Version	NM_009008.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Rac family small GTPase 2 (Rac2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009008.3

ORF Insert Sequence:

ATGCAGGCCA TCAAGTGTGT GGTGGTGGGT GATGGAGCCG TGGGCAAGAC GTGTCTTCTC 
ATCAGCTACA CCACCAACGC CTTCCCTGGA GAATACATCC CCACTGTATT TGACAACTAC 
TCAGCCAATG TGATGGTGGA CAGTAAGCCG GTGAACCTGG GGCTGTGGGA TACCGCAGGT 
CAGGAGGACT ATGACCGCCT CCGGCCACTC TCCTACCCAC AGACAGATGT ATTTCTCATC 
TGCTTCTCGC TAGTCAGCCC AGCCTCCTAT GAGAATGTCC GTGCCAAGTG GTTCCCTGAG 
GTACGGCACC ACTGCCCCAG CACCCCCATC ATCCTGGTGG GTACCAAGCT GGACCTTCGC 
GATGACAAGG ACACCATCGA GAAGCTGAAG GAGAAGAAGC TGGCTCCCAT CACCTACCCG 
CAGGGCCTGG CACTGGCCAA GGATATTGAT TCAGTCAAGT ACTTGGAATG TTCTGCACTC 
ACCCAGCGAG GCCTGAAGAC CGTCTTCGAT GAGGCAATCC GCGCAGTCCT CTGCCCACAG 
CCCACACGAC AGCAGAAGCG CCCCTGCAGC CTGCTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crk proteins transduce FGF signaling to promote lens fiber cell elongation.
eLife7(2018 Jan)
Collins TN,Mao Y,Li H,Bouaziz M,Hong A,Feng GS,Wang F,Quilliam LA,Chen L,Park T,Curran T,Zhang X

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1? Production.
Arteriosclerosis, thrombosis, and vascular biology37(2)328-340(2017 Feb)
Ceneri N,Zhao L,Young BD,Healy A,Coskun S,Vasavada H,Yarovinsky TO,Ike K,Pardi R,Qin L,Qin L,Tellides G,Hirschi K,Meadows J,Soufer R,Chun HJ,Sadeghi MM,Bender JR,Morrison AR

Rac2 is required for alternative macrophage activation and bleomycin induced pulmonary fibrosis; a macrophage autonomous phenotype.
PloS one12(8)e0182851(2017)
Joshi S,Singh AR,Wong SS,Zulcic M,Jiang M,Pardo A,Selman M,Hagood JS,Durden DL

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Rac2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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