Hexim1 cDNA ORF clone, Mus musculus(house mouse)

Rn7SK small nuclear RNA is involved in neuronal differentiation.
Bazi Z, Bertacchi M, Abasi M, Mohammadi-Yeganeh S, Soleimani M, Wagner N, Ghanbarian H
Journal of cellular biochemistry(2017 Nov)

Rapidly progressive course of Trypanosoma cruzi infection in mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene.
Mascareno E, Gupta R, Martello LA, Dhar-Mascareno M, Salciccioli L, Beckles D, Walsh MG, Machado FS, Tanowitz HB, Haseeb MA
Microbes and infection(2017 Sep)

Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet.
Dhar-Mascareno M, Rozenberg I, Iqbal J, Hussain MM, Beckles D, Mascareno E
The international journal of biochemistry & cell biology8356-64(2017 02)

Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal.
Dhar-Mascareno M, Ramirez SN, Rozenberg I, Rouille Y, Kral JG, Mascareno EJ
Molecular endocrinology (Baltimore, Md.)30(3)314-24(2016 Mar)

Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.
Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H
Biochemical and biophysical research communications453(3)600-5(2014 Oct)

Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively.
Title: Hexim1 heterozygosity stabilizes atherosclerotic plaque and decreased steatosis in ApoE null mice fed atherogenic diet.

Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus.
Title: Hexim1, a Novel Regulator of Leptin Function, Modulates Obesity and Glucose Disposal.

conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition
Title: Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.

HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy
Title: Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse.

a crucial role for the HEXIM1/P-TEFb pathway in the regulation of satellite cell-mediated muscle regeneration and identify HEXIM1 as a potential therapeutic target for degenerative muscular diseases.
Title: HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration.