Lrrc4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrc4
Entrez Gene ID	192198
Full Name	leucine rich repeat containing 4
Synonyms	MBAG1,NGL-2,NGL2,NLG-2,Nag14
General protein information	Preferred Names leucine rich repeat containing 4 Names leucine-rich repeat-containing protein 4 LIBG-like protein LRRC4-like protein brain tumor-associated protein MBAG1 netrin-G2 ligand
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_138682.2	NP_619623.2	leucine-rich repeat-containing protein 4 precursor

Pathways from BioSystems

Homologies

	LRRC4	XP_001090221.1
Mus musculus (house mouse)	Lrrc4	NP_619623.2
Rattus norvegicus (Norway rat)	Lrrc4	NP_001032413.1
Xenopus tropicalis (tropical clawed frog)	lrrc4	XP_002939414.1
Pan troglodytes (chimpanzee)	LRRC4	XP_001151566.1
Bos taurus (cattle)	LRRC4	NP_001014938.1
Danio rerio (zebrafish)	LOC566572	NP_001093494.1
Homo sapiens (human)	LRRC4	NP_071426.1
Canis lupus familiaris (dog)	LRRC4	XP_849461.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.
Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y
PloS one10(3)e0121550(2015)

Netrin-G/NGL complexes encode functional synaptic diversification.
Matsukawa H, Akiyoshi-Nishimura S, Zhang Q, Luj?n R, Yamaguchi K, Goto H, Yaguchi K, Hashikawa T, Sano C, Shigemoto R, Nakashiba T, Itohara S
The Journal of neuroscience : the official journal of the Society for Neuroscience34(47)15779-92(2014 Nov)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our results identify NGL-2 as a central component of pathway-specific development in the outer retina.
Title: NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina.

These results demonstrate that NGL-2 is critical for pathway-specific synapse development and functional integration of distinct inputs.
Title: NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons.

Promotes neurite extension of hippocampal neurons, and induces differentiation of glioblastoma U251 cells into astrocyte-like cells.
Title: Leucine-rich repeat C4 protein is involved in nervous tissue development and neurite outgrowth, and induction of glioma cell differentiation.

Together, these findings provide clues to the function of LRRC4 as a negative regulator of cell growth and underscore a link between the above-mentioned cyclins, cyclin-associated molecules and tumorigenicity.
Title: Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system.

LRRC4 may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system.
Title: Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily.

The following Lrrc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58221	NM_138682.2 Latest version!	Mus musculus leucine rich repeat containing 4 (Lrrc4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$384.30 $549.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrc4 ( NM_138682.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_619623.2 Mus musculus leucine rich repeat containing 4 (Lrrc4), mRNA.

Price & Availability↑

CloneID	OMu58221
Clone ID Related Accession (Same CDS sequence)	NM_138682.2
Accession Version	NM_138682.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat-containing protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068662.5 and BE945283.1. On Jan 31, 2007 this sequence version replaced NM_138682.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DQ177325.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACACCTGGA ATGCCGTCCT GCTTCCCGTC 
GTCTACCTCA CGGCGCAAGT GTGGATTCTG TGTGCAGCCA TCGCTGCTGC CGCTTCAGCC 
GGGCCCCAAA ACTGCCCCTC CGTCTGTTCC TGCAGTAACC AGTTCAGCAA GGTGGTGTGC 
ACCCGCCGGG GACTCTCTGA GGTCCCACAG GGTATTCCTT CCAACACCCG GTATCTCAAC 
CTCATGGAAA ACAACATCCA GATGATTCAG GCCGACACCT TCAGGCACCT CCATCACCTG 
GAGGTCCTGC AGCTGGGCAG GAACTCCATC AGGCAGATAG AGGTGGGGGC CTTCAATGGC 
CTCGCCAGTC TCAACACTCT GGAACTGTTC GACAACTGGC TGACAGTCAT CCCCAGTGGG 
GCCTTTGAGT ACCTGTCCAA ACTGCGGGAG CTCTGGCTGC GAAACAATCC CATTGAGAGC 
ATCCCTTCTT ATGCCTTCAA CCGGGTGCCC TCCCTCATGC GTCTGGACTT GGGGGAACTC 
AAGAAGCTGG AGTATATCTC TGAGGGGGCT TTTGAGGGGC TGTTCAACCT CAAGTACCTG 
AACTTGGGCA TGTGCAACAT TAAGGATATG CCCAATCTTA CACCCCTGGT GGGGCTCGAG 
GAGCTTGAGA TGTCAGGGAA CCACTTTCCT GAGATCAGGC CTGGGTCCTT CCATGGCCTA 
AGCTCCCTCA AAAAACTGTG GGTGATGAAC TCACAGGTCA GCCTGATTGA GCGGAATGCT 
TTTGACGGAC TGGCTTCCCT CGTGGAACTC AACTTAGCCC ACAATAACCT CTCATCTTTG 
CCCCATGACC TCTTCACACC CCTGAGATAC CTGGTGGAGT TGCACCTACA CCACAATCCT 
TGGAACTGTG ATTGTGATAT TCTGTGGCTG GCTTGGTGGC TTCGGGAGTA TATCCCAACC 
AATTCCACCT GCTGTGGCCG CTGTCATGCT CCCATGCACA TGCGAGGCCG CTACCTGGTA 
GAGGTGGACC AGGCTGCCTT TCAGTGCTCT GCCCCTTTCA TCATGGATGC ACCCCGGGAC 
CTCAATATCT CTGAGGATCG GATGGCAGAA CTGAAGTGTC GGACTCCCCC TATGTCCTCT 
GTGAAGTGGT TGCTGCCCAA TGGGACAGTG CTCAGCCACG CCTCCCGGCA TCCCCGGATC 
TCTGTTCTCA ATGATGGCAC CTTGAACTTT TCTCGTGTGC TGCTCATAGA CACTGGAGTA 
TACACATGCA TGGTGACCAA TGTGGCAGGC AACTCCAATG CCTCGGCCTA CCTCAATGTG 
AGCTCGGCCG AGCTCAACAC CCCCAACTTC AGCTTCTTCA CCACTGTAAC AGTGGAAACC 
ACAGAGATAT CACCTGAGGA CATAACACGG AAGTACAAGC CTGTTCCCAC CACATCCACT 
GGTTACCAGC CGGCATATAC CACCTCTACC ACGGTGCTCA TTCAGACCAC CCGTGTGCCC 
AAGCAGGTGC CAGTACCCTC CACAGATACC ACTGACAAGA TGCAGACCAG CCTGGATGAA 
GTCATGAAGA CCACCAAGAT CATCATTGGC TGCTTTGTGG CAGTGACTCT CCTAGCTGCT 
GCCATGTTGA TTGTCTTCTA TAAACTTCGC AAGCGGCACC AGCAGCGGAG TACAGTCACA 
GCTGCCAGGA CAGTAGAGAT TATCCAGGTG GATGAAGACA TCCCAGCAGC AGCACCTGCA 
GCAGCAACAG CAGCTCCGTC CGGTGTATCA GGTGAGGGGG CAGTAGTGTT GCCCACAATA 
CATGACCATA TTAACTACAA CACCTACAAA CCAGCACATG GGGCCCACTG GACAGAAAAC 
AGCCTGGGGA ACTCTCTGCA CCCCACAGTC ACCACTATCT CTGAACCTTA TATAATTCAG 
ACCCATACCA AGGACAAGGT ACAGGAAACT CAAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619623.2
CDS	134..2092
Translation	MKLLWQVTVHHTWNAVLLPVVYLTAQVWILCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQAAFQCSAPFIMDAPRDLNISEDRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSRVLLIDTGVYTCMVTNVAGNSNASAYLNVSSAELNTPNFSFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPSTDTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAAAPAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI

Target ORF information:

RefSeq Version	NM_138682.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat containing 4 (Lrrc4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138682.2

ORF Insert Sequence:

ATGAAGCTCT TGTGGCAGGT AACTGTGCAC CACACCTGGA ATGCCGTCCT GCTTCCCGTC 
GTCTACCTCA CGGCGCAAGT GTGGATTCTG TGTGCAGCCA TCGCTGCTGC CGCTTCAGCC 
GGGCCCCAAA ACTGCCCCTC CGTCTGTTCC TGCAGTAACC AGTTCAGCAA GGTGGTGTGC 
ACCCGCCGGG GACTCTCTGA GGTCCCACAG GGTATTCCTT CCAACACCCG GTATCTCAAC 
CTCATGGAAA ACAACATCCA GATGATTCAG GCCGACACCT TCAGGCACCT CCATCACCTG 
GAGGTCCTGC AGCTGGGCAG GAACTCCATC AGGCAGATAG AGGTGGGGGC CTTCAATGGC 
CTCGCCAGTC TCAACACTCT GGAACTGTTC GACAACTGGC TGACAGTCAT CCCCAGTGGG 
GCCTTTGAGT ACCTGTCCAA ACTGCGGGAG CTCTGGCTGC GAAACAATCC CATTGAGAGC 
ATCCCTTCTT ATGCCTTCAA CCGGGTGCCC TCCCTCATGC GTCTGGACTT GGGGGAACTC 
AAGAAGCTGG AGTATATCTC TGAGGGGGCT TTTGAGGGGC TGTTCAACCT CAAGTACCTG 
AACTTGGGCA TGTGCAACAT TAAGGATATG CCCAATCTTA CACCCCTGGT GGGGCTCGAG 
GAGCTTGAGA TGTCAGGGAA CCACTTTCCT GAGATCAGGC CTGGGTCCTT CCATGGCCTA 
AGCTCCCTCA AAAAACTGTG GGTGATGAAC TCACAGGTCA GCCTGATTGA GCGGAATGCT 
TTTGACGGAC TGGCTTCCCT CGTGGAACTC AACTTAGCCC ACAATAACCT CTCATCTTTG 
CCCCATGACC TCTTCACACC CCTGAGATAC CTGGTGGAGT TGCACCTACA CCACAATCCT 
TGGAACTGTG ATTGTGATAT TCTGTGGCTG GCTTGGTGGC TTCGGGAGTA TATCCCAACC 
AATTCCACCT GCTGTGGCCG CTGTCATGCT CCCATGCACA TGCGAGGCCG CTACCTGGTA 
GAGGTGGACC AGGCTGCCTT TCAGTGCTCT GCCCCTTTCA TCATGGATGC ACCCCGGGAC 
CTCAATATCT CTGAGGATCG GATGGCAGAA CTGAAGTGTC GGACTCCCCC TATGTCCTCT 
GTGAAGTGGT TGCTGCCCAA TGGGACAGTG CTCAGCCACG CCTCCCGGCA TCCCCGGATC 
TCTGTTCTCA ATGATGGCAC CTTGAACTTT TCTCGTGTGC TGCTCATAGA CACTGGAGTA 
TACACATGCA TGGTGACCAA TGTGGCAGGC AACTCCAATG CCTCGGCCTA CCTCAATGTG 
AGCTCGGCCG AGCTCAACAC CCCCAACTTC AGCTTCTTCA CCACTGTAAC AGTGGAAACC 
ACAGAGATAT CACCTGAGGA CATAACACGG AAGTACAAGC CTGTTCCCAC CACATCCACT 
GGTTACCAGC CGGCATATAC CACCTCTACC ACGGTGCTCA TTCAGACCAC CCGTGTGCCC 
AAGCAGGTGC CAGTACCCTC CACAGATACC ACTGACAAGA TGCAGACCAG CCTGGATGAA 
GTCATGAAGA CCACCAAGAT CATCATTGGC TGCTTTGTGG CAGTGACTCT CCTAGCTGCT 
GCCATGTTGA TTGTCTTCTA TAAACTTCGC AAGCGGCACC AGCAGCGGAG TACAGTCACA 
GCTGCCAGGA CAGTAGAGAT TATCCAGGTG GATGAAGACA TCCCAGCAGC AGCACCTGCA 
GCAGCAACAG CAGCTCCGTC CGGTGTATCA GGTGAGGGGG CAGTAGTGTT GCCCACAATA 
CATGACCATA TTAACTACAA CACCTACAAA CCAGCACATG GGGCCCACTG GACAGAAAAC 
AGCCTGGGGA ACTCTCTGCA CCCCACAGTC ACCACTATCT CTGAACCTTA TATAATTCAG 
ACCCATACCA AGGACAAGGT ACAGGAAACT CAAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.
PloS one10(3)e0121550(2015)
Gu Z,Imai F,Kim IJ,Fujita H,Katayama Ki,Mori K,Yoshihara Y,Yoshida Y

Netrin-G/NGL complexes encode functional synaptic diversification.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(47)15779-92(2014 Nov)
Matsukawa H,Akiyoshi-Nishimura S,Zhang Q,Luj?n R,Yamaguchi K,Goto H,Yaguchi K,Hashikawa T,Sano C,Shigemoto R,Nakashiba T,Itohara S

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

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Lrrc4 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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