Ptgdr cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptgdr
Entrez Gene ID	19214
Full Name	prostaglandin D receptor
Synonyms	DP,PGD
General protein information	Preferred Names prostaglandin D receptor Names prostaglandin D2 receptor PGD receptor PGD2 receptor prostanoid DP receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 C1\|14 22.59 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008962.4	NP_032988.3	prostaglandin D2 receptor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ptgdr	NP_001128636.1
Xenopus tropicalis (tropical clawed frog)	ptgdr	XP_002936956.2
Homo sapiens (human)	PTGDR	NP_000944.1
Pan troglodytes (chimpanzee)	PTGDR	XP_509948.3
Mus musculus (house mouse)	Ptgdr	NP_032988.3
Canis lupus familiaris (dog)	PTGDR	XP_853494.1
	PTGDR	XP_001103541.1
Bos taurus (cattle)	PTGDR	NP_001091503.1
Rattus norvegicus (Norway rat)	Ptgdrl	NP_071577.1

Gene Ontology
Bibliography

Related articles in PubMed

Decidualisation and placentation defects are a major cause of age-related reproductive decline.
Woods L, Perez-Garcia V, Kieckbusch J, Wang X, DeMayo F, Colucci F, Hemberger M
Nature communications8(1)352(2017 09)

Virus-induced inflammasome activation is suppressed by prostaglandin D
Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S
Proceedings of the National Academy of Sciences of the United States of America114(27)E5444-E5453(2017 Jul)

Interleukin-1? induces sleep independent of prostaglandin D
Zhang BJ, Shao SR, Aritake K, Takeuchi A, Urade Y, Huang ZL, Lazarus M, Qu WM
Neuroscience340258-267(2017 Jan)

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.
Ma X, Aoki T, Tsuruyama T, Narumiya S
Cancer research75(14)2822-32(2015 Jul)

PGD2 DP1 receptor stimulation following stroke ameliorates cerebral blood flow and outcomes.
Ahmad AS
Neuroscience279260-8(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A role for PGD2 signals acting through PTGDR in suppression of intestinal tumors.
Title: Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR.

Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation.
Title: Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.

PGD(2)-DP signaling reduces vascular permeability both in vivo.
Title: Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway.

platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis.
Title: Niacin and biosynthesis of PGD?by platelet COX-1 in mice and humans.

The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation
Title: Distinct roles of prostaglandin D2 receptors in chronic skin inflammation.

The following Ptgdr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptgdr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18074	NM_008962.4 Latest version!	Mus musculus prostaglandin D receptor (Ptgdr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptgdr ( NM_008962.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032988.3 Mus musculus prostaglandin D receptor (Ptgdr), mRNA.

Price & Availability↑

CloneID	OMu18074
Clone ID Related Accession (Same CDS sequence)	NM_008962.4
Accession Version	NM_008962.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Mus musculus(house mouse)
Product	prostaglandin D2 receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK032488.1 and BC132297.1. On Mar 21, 2009 this sequence version replaced NM_008962.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032488.1, BC132297.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGAACGAGT CCTATCGCTG TCAGACATCC ACCTGGGTGG AAAGGGGCTC CTCGGCGACG 
ATGGGCGCTG TGCTCTTCGG TGCGGGGCTT CTGGGCAATC TTCTGGCGCT GGTGCTGCTG 
GCGCGCTCGG GACTGGGGTC TTGCCGGCCA GGGCCACTAC ACCCGCCGCC CTCGGTCTTT 
TATGTGCTCG TGTGTGGCTT GACGGTCACC GACTTGCTGG GCAAGTGTCT GATCAGCCCG 
ATGGTCCTGG CTGCCTACGC GCAAAACCAG AGCCTAAAGG AACTGCTGCC TGCCTCAGGC 
AATCAGTTAT GCGAAACGTT CGCCTTCCTG ATGTCCTTCT TTGGGCTAGC CTCGACCTTA 
CAGCTGTTGG CTATGGCGGT GGAGTGCTGG CTGTCTCTGG GACACCCCTT CTTCTACCAA 
AGGCACGTCA CCTTGCGCCG GGGAGTGCTG GTGGCACCGG TCGTGGCCGC CTTCTGCTTG 
GCTTTCTGTG CGCTCCCCTT TGCTGGTTTT GGGAAGTTCG TGCAGTACTG TCCAGGCACC 
TGGTGTTTCA TCCAGATGAT CCACAAGGAG CGTTCATTTT CGGTAATAGG CTTCTCTGTG 
CTCTACTCCA GCCTCATGGC GCTGCTGGTC CTCGCAACCG TGGTGTGCAA CCTGGGTGCC 
ATGTACAACC TCTATGACAT GCACAGGCGC CAGAGGCACT ATCCTCACCG CTGCTCCAGG 
GACCGCGCCC AGTCAGGCTC AGACTACAGG CACGGGTCCC TGCATCCTTT GGAGGAGCTG 
GACCACTTTG TGCTGCTGGC TCTCATGACA GTGCTCTTCA CCATGTGTTC CCTGCCTTTA 
ATTTATCGTG CGTACTATGG AGCCTTTAAA CTTGAGAACA AAGCTGAAGG AGACTCAGAA 
GACCTCCAAG CCTTGCGTTT CCTGTCTGTG ATTTCCATAG TGGACCCCTG GATCTTCATC 
ATCTTCAGGA CTTCAGTATT CCGGATGTTA TTTCACAAGG TTTTCACAAG ACCTCTGATC 
TACAGAAACT GGAGCAGCCA TTCCCAGCAA AGTAACGTGG AATCCACTTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032988.3
CDS	123..1196
Translation	MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQSLKELLPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQMIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMHRRQRHYPHRCSRDRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKLENKAEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQQSNVESTL

Target ORF information:

RefSeq Version	NM_008962.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus prostaglandin D receptor (Ptgdr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008962.4

ORF Insert Sequence:

ATGAACGAGT CCTATCGCTG TCAGACATCC ACCTGGGTGG AAAGGGGCTC CTCGGCGACG 
ATGGGCGCTG TGCTCTTCGG TGCGGGGCTT CTGGGCAATC TTCTGGCGCT GGTGCTGCTG 
GCGCGCTCGG GACTGGGGTC TTGCCGGCCA GGGCCACTAC ACCCGCCGCC CTCGGTCTTT 
TATGTGCTCG TGTGTGGCTT GACGGTCACC GACTTGCTGG GCAAGTGTCT GATCAGCCCG 
ATGGTCCTGG CTGCCTACGC GCAAAACCAG AGCCTAAAGG AACTGCTGCC TGCCTCAGGC 
AATCAGTTAT GCGAAACGTT CGCCTTCCTG ATGTCCTTCT TTGGGCTAGC CTCGACCTTA 
CAGCTGTTGG CTATGGCGGT GGAGTGCTGG CTGTCTCTGG GACACCCCTT CTTCTACCAA 
AGGCACGTCA CCTTGCGCCG GGGAGTGCTG GTGGCACCGG TCGTGGCCGC CTTCTGCTTG 
GCTTTCTGTG CGCTCCCCTT TGCTGGTTTT GGGAAGTTCG TGCAGTACTG TCCAGGCACC 
TGGTGTTTCA TCCAGATGAT CCACAAGGAG CGTTCATTTT CGGTAATAGG CTTCTCTGTG 
CTCTACTCCA GCCTCATGGC GCTGCTGGTC CTCGCAACCG TGGTGTGCAA CCTGGGTGCC 
ATGTACAACC TCTATGACAT GCACAGGCGC CAGAGGCACT ATCCTCACCG CTGCTCCAGG 
GACCGCGCCC AGTCAGGCTC AGACTACAGG CACGGGTCCC TGCATCCTTT GGAGGAGCTG 
GACCACTTTG TGCTGCTGGC TCTCATGACA GTGCTCTTCA CCATGTGTTC CCTGCCTTTA 
ATTTATCGTG CGTACTATGG AGCCTTTAAA CTTGAGAACA AAGCTGAAGG AGACTCAGAA 
GACCTCCAAG CCTTGCGTTT CCTGTCTGTG ATTTCCATAG TGGACCCCTG GATCTTCATC 
ATCTTCAGGA CTTCAGTATT CCGGATGTTA TTTCACAAGG TTTTCACAAG ACCTCTGATC 
TACAGAAACT GGAGCAGCCA TTCCCAGCAA AGTAACGTGG AATCCACTTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Decidualisation and placentation defects are a major cause of age-related reproductive decline.
Nature communications8(1)352(2017 09)
Woods L,Perez-Garcia V,Kieckbusch J,Wang X,DeMayo F,Colucci F,Hemberger M

Virus-induced inflammasome activation is suppressed by prostaglandin D
Proceedings of the National Academy of Sciences of the United States of America114(27)E5444-E5453(2017 Jul)
Vijay R,Fehr AR,Janowski AM,Athmer J,Wheeler DL,Grunewald M,Sompallae R,Kurup SP,Meyerholz DK,Sutterwala FS,Narumiya S,Perlman S

Interleukin-1? induces sleep independent of prostaglandin D
Neuroscience340258-267(2017 Jan)
Zhang BJ,Shao SR,Aritake K,Takeuchi A,Urade Y,Huang ZL,Lazarus M,Qu WM

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.
Cancer research75(14)2822-32(2015 Jul)
Ma X,Aoki T,Tsuruyama T,Narumiya S

PGD2 DP1 receptor stimulation following stroke ameliorates cerebral blood flow and outcomes.
Neuroscience279260-8(2014 Oct)
Ahmad AS

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Ptgdr cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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