Gene Symbol | Pten |
Entrez Gene ID | 19211 |
Full Name | phosphatase and tensin homolog |
Synonyms | 2310035O07Rik,A130070J02Rik,AI463227,B430203M17Rik,MMAC1,PTENbeta,TEP1 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]. |