Psme2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psme2
Entrez Gene ID	19188
Full Name	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Synonyms	AA589371,AI788882,PA28b
General protein information	Preferred Names proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Names proteasome activator complex subunit 2 11S regulator complex subunit beta PA28beta REG-beta activator of multicatalytic protease subunit 2 protease (prosome, macropain) 28 subunit, beta proteasome (prosome, macropain) 28 subunit, beta proteasome activator 28 subunit beta
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14 C3\|14 28.19 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011190.3	NP_035320.1	proteasome activator complex subunit 2 isoform 1
NM_001029855.1	NP_001025026.1	proteasome activator complex subunit 2 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PSME2	XP_001167654.1
	PSME2	XP_001112445.1
Bos taurus (cattle)	PSME2	NP_001014889.1
Canis lupus familiaris (dog)	PSME2	XP_537382.2
Rattus norvegicus (Norway rat)	Psme2	NP_058953.1
Xenopus tropicalis (tropical clawed frog)	psme2	NP_001011494.1
Homo sapiens (human)	PSME2	NP_002809.2
Mus musculus (house mouse)	Psme2	NP_035320.1
Rattus norvegicus (Norway rat)	LOC100362709	XP_002728490.2
Danio rerio (zebrafish)	psme2	NP_571449.1

Gene Ontology
Bibliography

Related articles in PubMed

The Mammalian Proteasome Activator PA28 Forms an Asymmetric ?
Huber EM, Groll M
Structure (London, England : 1993)25(10)1473-1480.e3(2017 Oct)

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T?cell repertoire.
Basler M, Mundt S, Groettrup M
European journal of immunology(2017 Oct)

PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
Respondek D, Voss M, K?hlewindt I, Klingel K, Kr?ger E, Beling A
PloS one12(3)e0173259(2017)

Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.
Otoda T, Takamura T, Misu H, Ota T, Murata S, Hayashi H, Takayama H, Kikuchi A, Kanamori T, Shima KR, Lan F, Takeda T, Kurita S, Ishikura K, Kita Y, Iwayama K, Kato K, Uno M, Takeshita Y, Yamamoto M, Tokuyama K, Iseki S, Tanaka K, Kaneko S
Diabetes62(3)811-24(2013 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased PA28B expression is associated with viral myocarditis.
Title: PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.

Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress.
Title: Nrf2-dependent induction of proteasome and Pa28?? regulator are required for adaptation to oxidative stress.

demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides
Title: PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.

PA28-associated proteasome preferentially digested within epitopic sequences of K(d), although correct C-terminal flankings were removed
Title: Allele-selective effect of PA28 in MHC class I antigen processing.

the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90
Title: Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.

The following Psme2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psme2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12290	NM_001029855.1 Latest version!	Mus musculus proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu07637	NM_011190.3 Latest version!	Mus musculus proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psme2 ( NM_001029855.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001025026.1 Mus musculus proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu12290
Clone ID Related Accession (Same CDS sequence)	NM_001029855.1
Accession Version	NM_001029855.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	proteasome activator complex subunit 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB869062.1, AA267668.1, AK012344.1 and AA216967.1. Transcript Variant: This variant (2) uses an alternate transcription initiation site and uses a distinct start codon, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGG GGGTACTACT CACGGTGGAT GTCTTCAGAC AAAATCTTTT CCAGGAGGCT 
GATGACTTCC TCTGCACTTT CTTGCCACGG AAAATCATAT CCCTGAGTCA GCTCTTGCAG 
GAGGATTCCC TCAATGTGGC CGACCTCTCC TCCCTCCGGG CTCCTCTGGA CATCCCTATC 
CCAGATCCTC CACCCAAGGA TGACGAGATG GAAACAGACA AGCAGGAGAA GAAGGAAGTC 
CCTAAGTGTG GCTACCTCCC GGGGAACGAG AAGCTTCTGG CCTTGCTCGC TTTGGTTAAG 
CCAGAAGTCT GGACTCTCAA AGAGAAGTGC ATTCTGGTAA TCACATGGAT CCAGCACCTG 
ATCCCCAAGA TTGAGGATGG AAATGATTTT GGGGTGGCAA TTCAGGAGAA GGTGCTGGAG 
AGAGTGAATG CTGTCAAGAC CAAAGTAGAA GCTTTCCAGA CAACCATTTC CAAGTACTTC 
TCAGAACGAG GGGACGCTGT AGCCAAGGCT TCCAAGGACA CCCATGTAAT GGATTACCGG 
GCCTTGGTGC ATGAGCGAGA TGAAGCAGCC TATGGGGCGC TTAGGGCCAT GGTGCTGGAC 
CTGAGGGCCT TCTATGCTGA GCTTTATCAT ATCATCAGCA GCAACCTAGA GAAAATCGTC 
AACCCGAAGG GTGAAGAAAA GCCATCGATG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025026.1
CDS	57..752
Translation	MAEGVLLTVDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Target ORF information:

RefSeq Version	NM_001029855.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029855.1

ORF Insert Sequence:

ATGGCTGAGG GGGTACTACT CACGGTGGAT GTCTTCAGAC AAAATCTTTT CCAGGAGGCT 
GATGACTTCC TCTGCACTTT CTTGCCACGG AAAATCATAT CCCTGAGTCA GCTCTTGCAG 
GAGGATTCCC TCAATGTGGC CGACCTCTCC TCCCTCCGGG CTCCTCTGGA CATCCCTATC 
CCAGATCCTC CACCCAAGGA TGACGAGATG GAAACAGACA AGCAGGAGAA GAAGGAAGTC 
CCTAAGTGTG GCTACCTCCC GGGGAACGAG AAGCTTCTGG CCTTGCTCGC TTTGGTTAAG 
CCAGAAGTCT GGACTCTCAA AGAGAAGTGC ATTCTGGTAA TCACATGGAT CCAGCACCTG 
ATCCCCAAGA TTGAGGATGG AAATGATTTT GGGGTGGCAA TTCAGGAGAA GGTGCTGGAG 
AGAGTGAATG CTGTCAAGAC CAAAGTAGAA GCTTTCCAGA CAACCATTTC CAAGTACTTC 
TCAGAACGAG GGGACGCTGT AGCCAAGGCT TCCAAGGACA CCCATGTAAT GGATTACCGG 
GCCTTGGTGC ATGAGCGAGA TGAAGCAGCC TATGGGGCGC TTAGGGCCAT GGTGCTGGAC 
CTGAGGGCCT TCTATGCTGA GCTTTATCAT ATCATCAGCA GCAACCTAGA GAAAATCGTC 
AACCCGAAGG GTGAAGAAAA GCCATCGATG TACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psme2 ( NM_011190.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035320.1 Mus musculus proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07637
Clone ID Related Accession (Same CDS sequence)	NM_011190.3
Accession Version	NM_011190.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	proteasome activator complex subunit 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU563130.1, BY134400.1, CA536627.1, AK012344.1, BY498670.1 and AA216967.1. On Aug 3, 2005 this sequence version replaced NM_011190.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057859.1, DV056863.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAAGC CTTGTGGGGT CCGCTTGAGT GGAGAAGCCC GAAAACAGGT GGATGTCTTC 
AGACAAAATC TTTTCCAGGA GGCTGATGAC TTCCTCTGCA CTTTCTTGCC ACGGAAAATC 
ATATCCCTGA GTCAGCTCTT GCAGGAGGAT TCCCTCAATG TGGCCGACCT CTCCTCCCTC 
CGGGCTCCTC TGGACATCCC TATCCCAGAT CCTCCACCCA AGGATGACGA GATGGAAACA 
GACAAGCAGG AGAAGAAGGA AGTCCCTAAG TGTGGCTACC TCCCGGGGAA CGAGAAGCTT 
CTGGCCTTGC TCGCTTTGGT TAAGCCAGAA GTCTGGACTC TCAAAGAGAA GTGCATTCTG 
GTAATCACAT GGATCCAGCA CCTGATCCCC AAGATTGAGG ATGGAAATGA TTTTGGGGTG 
GCAATTCAGG AGAAGGTGCT GGAGAGAGTG AATGCTGTCA AGACCAAAGT AGAAGCTTTC 
CAGACAACCA TTTCCAAGTA CTTCTCAGAA CGAGGGGACG CTGTAGCCAA GGCTTCCAAG 
GACACCCATG TAATGGATTA CCGGGCCTTG GTGCATGAGC GAGATGAAGC AGCCTATGGG 
GCGCTTAGGG CCATGGTGCT GGACCTGAGG GCCTTCTATG CTGAGCTTTA TCATATCATC 
AGCAGCAACC TAGAGAAAAT CGTCAACCCG AAGGGTGAAG AAAAGCCATC GATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035320.1
CDS	133..852
Translation	MAKPCGVRLSGEARKQVDVFRQNLFQEADDFLCTFLPRKIISLSQLLQEDSLNVADLSSLRAPLDIPIPDPPPKDDEMETDKQEKKEVPKCGYLPGNEKLLALLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKDTHVMDYRALVHERDEAAYGALRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

Target ORF information:

RefSeq Version	NM_011190.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (Psme2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011190.3

ORF Insert Sequence:

ATGGCCAAGC CTTGTGGGGT CCGCTTGAGT GGAGAAGCCC GAAAACAGGT GGATGTCTTC 
AGACAAAATC TTTTCCAGGA GGCTGATGAC TTCCTCTGCA CTTTCTTGCC ACGGAAAATC 
ATATCCCTGA GTCAGCTCTT GCAGGAGGAT TCCCTCAATG TGGCCGACCT CTCCTCCCTC 
CGGGCTCCTC TGGACATCCC TATCCCAGAT CCTCCACCCA AGGATGACGA GATGGAAACA 
GACAAGCAGG AGAAGAAGGA AGTCCCTAAG TGTGGCTACC TCCCGGGGAA CGAGAAGCTT 
CTGGCCTTGC TCGCTTTGGT TAAGCCAGAA GTCTGGACTC TCAAAGAGAA GTGCATTCTG 
GTAATCACAT GGATCCAGCA CCTGATCCCC AAGATTGAGG ATGGAAATGA TTTTGGGGTG 
GCAATTCAGG AGAAGGTGCT GGAGAGAGTG AATGCTGTCA AGACCAAAGT AGAAGCTTTC 
CAGACAACCA TTTCCAAGTA CTTCTCAGAA CGAGGGGACG CTGTAGCCAA GGCTTCCAAG 
GACACCCATG TAATGGATTA CCGGGCCTTG GTGCATGAGC GAGATGAAGC AGCCTATGGG 
GCGCTTAGGG CCATGGTGCT GGACCTGAGG GCCTTCTATG CTGAGCTTTA TCATATCATC 
AGCAGCAACC TAGAGAAAAT CGTCAACCCG AAGGGTGAAG AAAAGCCATC GATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Mammalian Proteasome Activator PA28 Forms an Asymmetric ?
Structure (London, England : 1993)25(10)1473-1480.e3(2017 Oct)
Huber EM,Groll M

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T?cell repertoire.
European journal of immunology(2017 Oct)
Basler M,Mundt S,Groettrup M

PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
PloS one12(3)e0173259(2017)
Respondek D,Voss M,K?hlewindt I,Klingel K,Kr?ger E,Beling A

Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.
Diabetes62(3)811-24(2013 Mar)
Otoda T,Takamura T,Misu H,Ota T,Murata S,Hayashi H,Takayama H,Kikuchi A,Kanamori T,Shima KR,Lan F,Takeda T,Kurita S,Ishikura K,Kita Y,Iwayama K,Kato K,Uno M,Takeshita Y,Yamamoto M,Tokuyama K,Iseki S,Tanaka K,Kaneko S

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Psme2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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