Mapk11 cDNA ORF clone, Mus musculus(house mouse)

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.
Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD
PLoS biology16(1)e2004111(2018 Jan)

Activin A induces skeletal muscle catabolism via p38? mitogen-activated protein kinase.
Ding H, Zhang G, Sin KW, Liu Z, Lin RK, Li M, Li YP
Journal of cachexia, sarcopenia and muscle8(2)202-212(2017 Apr)

Complex genetics architecture contributes to Salmonella resistance in AcB60 mice.
Beatty S, Rached-D'Astous L, Malo D
Mammalian genome : official journal of the International Mammalian Genome Society28(1-2)38-46(2017 Feb)

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani RV, Jim?nez-Andrade GY, Sano Y, Choo MK, Seavitt J, Venigalla RK, Otsu K, Georgopoulos K, Arthur JS, Park JM
The Journal of biological chemistry292(5)1762-1772(2017 02)

Site-specific phosphorylation of tau inhibits amyloid-? toxicity in Alzheimer's mice.
Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay J, Poljak A, Delerue F, Ke YD, Ittner LM
Science (New York, N.Y.)354(6314)904-908(2016 11)

in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11), located within the Ity8 interval, and representing a potential positional candidate gene
Title: Complex genetics architecture contributes to Salmonella resistance in AcB60 mice.

Double deficiency of p38alpha and p38beta in naive CD4(+) T cells resulted in an attenuation of MAPK-activated protein kinase (MK)-dependent mTOR signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Title: Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

propose that active p38-Mapk14/11 act as enablers, and Erk1/2 as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Title: p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.

Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
Title: p38? Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261.

Data indicate that alternatively activated p38alpha and p38beta up-regulates the transcription factors NFATc1 and IRF4.
Title: Counter-regulation of T cell effector function by differentially activated p38.