Ppp1r17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r17
Entrez Gene ID	19051
Full Name	protein phosphatase 1, regulatory subunit 17
Synonyms	G-substrate,Gsbs,Ppp1r2
General protein information	Preferred Names protein phosphatase 1, regulatory subunit 17 Names protein phosphatase 1 regulatory subunit 17 G substrate protein phosphatase 1, regulatory (inhibitor) 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 B3\|6 27.65 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_011153.3	NP_035283.1	protein phosphatase 1 regulatory subunit 17
NM_011153.4	NP_035283.1	protein phosphatase 1 regulatory subunit 17

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPP1R17	XP_003431978.2
Mus musculus (house mouse)	Ppp1r17	NP_035283.1
Gallus gallus (chicken)	PPP1R17	XP_004939604.1
Pan troglodytes (chimpanzee)	PPP1R17	XP_001166815.1
Rattus norvegicus (Norway rat)	Ppp1r17	NP_703197.1
Homo sapiens (human)	PPP1R17	NP_006649.2
Bos taurus (cattle)	PPP1R17	XP_002686874.1
	C7orf16	XP_001083835.1
Xenopus tropicalis (tropical clawed frog)	ppp1r17	XP_002940295.1

Gene Ontology
Bibliography

Related articles in PubMed

Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.
Rousso DL, Qiao M, Kagan RD, Yamagata M, Palmiter RD, Sanes JR
Cell reports15(9)1930-44(2016 05)

Dual involvement of G-substrate in motor learning revealed by gene deletion.
Endo S, Shutoh F, Dinh TL, Okamoto T, Ikeda T, Suzuki M, Kawahara S, Yanagihara D, Sato Y, Yamada K, Sakamoto T, Kirino Y, Hartell NA, Yamaguchi K, Itohara S, Nairn AC, Greengard P, Nagao S, Ito M
Proceedings of the National Academy of Sciences of the United States of America106(9)3525-30(2009 Mar)

An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.
Chung CY, Koprich JB, Endo S, Isacson O
The Journal of neuroscience : the official journal of the Society for Neuroscience27(31)8314-23(2007 Aug)

Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases.
Nakazawa T, Endo S, Shimura M, Kondo M, Ueno S, Tamai M
Brain research. Molecular brain research135(1-2)58-68(2005 Apr)

Developmental gene expression profiling of mammalian, fetal orofacial tissue.
Mukhopadhyay P, Greene RM, Zacharias W, Weinrich MC, Singh S, Young WW Jr, Pisano MM
Birth defects research. Part A, Clinical and molecular teratology70(12)912-26(2004 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The mice with targeted G-substrate gene knockout results in the impairment of cerebellum-dependent long-term memory (optokinetic response adaptation) without influence on short-term one.
Title: Dual involvement of G-substrate in motor learning revealed by gene deletion.

G-substrate reduces vulnerability of dopaminergic cells in models of Parkinson's disease.
Title: An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.

retinal G-substrate plays a role as a downstream component of the NO-cGMP-PKG pathway. The co-localization of retinal G-substrate with protein Ser/Thr phosphatases suggests that it acts as an endogenous protein phosphatase inhibitor.
Title: Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases.

The following Ppp1r17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu07566	NM_011153.4 Latest version!	Mus musculus protein phosphatase 1, regulatory subunit 17 (Ppp1r17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu07566	NM_011153.3	Mus musculus protein phosphatase 1, regulatory subunit 17 (Ppp1r17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r17 ( NM_011153.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035283.1 Mus musculus protein phosphatase 1, regulatory subunit 17 (Ppp1r17), mRNA.

Price & Availability↑

CloneID	OMu07566
Clone ID Related Accession (Same CDS sequence)	NM_011153.3 , NM_011153.4
Accession Version	NM_011153.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-27
Organism	Mus musculus(house mouse)
Product	protein phosphatase 1 regulatory subunit 17
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC079365.5. On Nov 17, 2006 this sequence version replaced NM_011153.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC026822.1, AK078335.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGTCCACTG AGATGATGAC CACCGAGCCA GTGCCGCCTC TGGAGCTTTC AGACGACATA 
CTAGGCAAGC TGGATCCTCA GTGCAGCCCC TCAGATGACC TTTCAGACCA GTTCATTAAG 
GACTGTGACC TCAAAAAGAA GCCAAGGAAG GGGAAGAATG TACAGGCCAC TCTGAATGTT 
GAGTCAGATC AAAAGAAACC CAGGAGGAAA GACACACCAG CAGTGCACAT CCCACCTTTC 
ATCCCAGGTG TGATTTCGGA ACACTTAATC AAAAGATATG ATGTTCAAGA GAGAATTCCA 
AAGGCCAAAT CAGGCCCAGC TCTTCATAAC TCTGATATGG AACAAAAAAG GCCAAGGAGA 
AAAGACACGC CTGCCTTGCA CATGCCTCCC TTTGTTGCAG GTCTGACTCT GCTCCGGGAT 
GAGAGTGCAG GAGTGATTCT AGAGGATGAA GAAATGGATG GTGACAAGCT AGCTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035283.1
CDS	127..606
Translation	MSTEMMTTEPVPPLELSDDILGKLDPQCSPSDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPAVHIPPFIPGVISEHLIKRYDVQERIPKAKSGPALHNSDMEQKRPRRKDTPALHMPPFVAGLTLLRDESAGVILEDEEMDGDKLAI

Target ORF information:

RefSeq Version	NM_011153.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 1, regulatory subunit 17 (Ppp1r17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011153.3

ORF Insert Sequence:

ATGTCCACTG AGATGATGAC CACCGAGCCA GTGCCGCCTC TGGAGCTTTC AGACGACATA 
CTAGGCAAGC TGGATCCTCA GTGCAGCCCC TCAGATGACC TTTCAGACCA GTTCATTAAG 
GACTGTGACC TCAAAAAGAA GCCAAGGAAG GGGAAGAATG TACAGGCCAC TCTGAATGTT 
GAGTCAGATC AAAAGAAACC CAGGAGGAAA GACACACCAG CAGTGCACAT CCCACCTTTC 
ATCCCAGGTG TGATTTCGGA ACACTTAATC AAAAGATATG ATGTTCAAGA GAGAATTCCA 
AAGGCCAAAT CAGGCCCAGC TCTTCATAAC TCTGATATGG AACAAAAAAG GCCAAGGAGA 
AAAGACACGC CTGCCTTGCA CATGCCTCCC TTTGTTGCAG GTCTGACTCT GCTCCGGGAT 
GAGAGTGCAG GAGTGATTCT AGAGGATGAA GAAATGGATG GTGACAAGCT AGCTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp1r17 ( NM_011153.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035283.1 Mus musculus protein phosphatase 1, regulatory subunit 17 (Ppp1r17), mRNA.

Price & Availability↑

CloneID	OMu07566
Clone ID Related Accession (Same CDS sequence)	NM_011153.3 , NM_011153.4
Accession Version	NM_011153.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 480bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Mus musculus(house mouse)
Product	protein phosphatase 1 regulatory subunit 17
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC079365.5. On May 30, 2018 this sequence version replaced NM_011153.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF500906.1, AK078335.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCACTG AGATGATGAC CACCGAGCCA GTGCCGCCTC TGGAGCTTTC AGACGACATA 
CTAGGCAAGC TGGATCCTCA GTGCAGCCCC TCAGATGACC TTTCAGACCA GTTCATTAAG 
GACTGTGACC TCAAAAAGAA GCCAAGGAAG GGGAAGAATG TACAGGCCAC TCTGAATGTT 
GAGTCAGATC AAAAGAAACC CAGGAGGAAA GACACACCAG CAGTGCACAT CCCACCTTTC 
ATCCCAGGTG TGATTTCGGA ACACTTAATC AAAAGATATG ATGTTCAAGA GAGAATTCCA 
AAGGCCAAAT CAGGCCCAGC TCTTCATAAC TCTGATATGG AACAAAAAAG GCCAAGGAGA 
AAAGACACGC CTGCCTTGCA CATGCCTCCC TTTGTTGCAG GTCTGACTCT GCTCCGGGAT 
GAGAGTGCAG GAGTGATTCT AGAGGATGAA GAAATGGATG GTGACAAGCT AGCTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035283.1
CDS	145..624
Translation	MSTEMMTTEPVPPLELSDDILGKLDPQCSPSDDLSDQFIKDCDLKKKPRKGKNVQATLNVESDQKKPRRKDTPAVHIPPFIPGVISEHLIKRYDVQERIPKAKSGPALHNSDMEQKRPRRKDTPALHMPPFVAGLTLLRDESAGVILEDEEMDGDKLAI

Target ORF information:

RefSeq Version	NM_011153.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 1, regulatory subunit 17 (Ppp1r17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011153.4

ORF Insert Sequence:

ATGTCCACTG AGATGATGAC CACCGAGCCA GTGCCGCCTC TGGAGCTTTC AGACGACATA 
CTAGGCAAGC TGGATCCTCA GTGCAGCCCC TCAGATGACC TTTCAGACCA GTTCATTAAG 
GACTGTGACC TCAAAAAGAA GCCAAGGAAG GGGAAGAATG TACAGGCCAC TCTGAATGTT 
GAGTCAGATC AAAAGAAACC CAGGAGGAAA GACACACCAG CAGTGCACAT CCCACCTTTC 
ATCCCAGGTG TGATTTCGGA ACACTTAATC AAAAGATATG ATGTTCAAGA GAGAATTCCA 
AAGGCCAAAT CAGGCCCAGC TCTTCATAAC TCTGATATGG AACAAAAAAG GCCAAGGAGA 
AAAGACACGC CTGCCTTGCA CATGCCTCCC TTTGTTGCAG GTCTGACTCT GCTCCGGGAT 
GAGAGTGCAG GAGTGATTCT AGAGGATGAA GAAATGGATG GTGACAAGCT AGCTATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.
Cell reports15(9)1930-44(2016 05)
Rousso DL,Qiao M,Kagan RD,Yamagata M,Palmiter RD,Sanes JR

Dual involvement of G-substrate in motor learning revealed by gene deletion.
Proceedings of the National Academy of Sciences of the United States of America106(9)3525-30(2009 Mar)
Endo S,Shutoh F,Dinh TL,Okamoto T,Ikeda T,Suzuki M,Kawahara S,Yanagihara D,Sato Y,Yamada K,Sakamoto T,Kirino Y,Hartell NA,Yamaguchi K,Itohara S,Nairn AC,Greengard P,Nagao S,Ito M

An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience27(31)8314-23(2007 Aug)
Chung CY,Koprich JB,Endo S,Isacson O

Retinal G-substrate, potential downstream component of NO/cGMP/PKG pathway, is located in subtype of retinal ganglion cells and amacrine cells with protein phosphatases.
Brain research. Molecular brain research135(1-2)58-68(2005 Apr)
Nakazawa T,Endo S,Shimura M,Kondo M,Ueno S,Tamai M

Developmental gene expression profiling of mammalian, fetal orofacial tissue.
Birth defects research. Part A, Clinical and molecular teratology70(12)912-26(2004 Dec)
Mukhopadhyay P,Greene RM,Zacharias W,Weinrich MC,Singh S,Young WW Jr,Pisano MM

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Ppp1r17 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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