Ppp1ca cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1ca
Entrez Gene ID	19045
Full Name	protein phosphatase 1, catalytic subunit, alpha isoform
Synonyms	Ppp1c,dism2
General protein information	Preferred Names protein phosphatase 1, catalytic subunit, alpha isoform Names serine/threonine-protein phosphatase PP1-alpha catalytic subunit PP-1A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 A

mRNA and Protein(s)

mRNA	Protein	Name
NM_031868.2	NP_114074.1	serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ppp1cab	NP_997875.1
Danio rerio (zebrafish)	ppp1caa	NP_999976.1
Schizosaccharomyces pombe (fission yeast)	dis2	NP_596317.1
Neurospora crassa	NCU00043	XP_956154.2
	PPP1CA	XP_002799514.1
Mus musculus (house mouse)	Ppp1ca	NP_114074.1
Eremothecium gossypii	AGOS_AFR166C	NP_985713.2
Homo sapiens (human)	PPP1CA	NP_002699.1
Magnaporthe oryzae (rice blast fungus)	MGG_10195	XP_003713825.1
Arabidopsis thaliana (thale cress)	TOPP2	NP_851218.1
Oryza sativa (rice)	Os02g0820000	NP_001048539.1
Canis lupus familiaris (dog)	PPP1CA	NP_001003064.1
Bos taurus (cattle)	PPP1CA	NP_001030393.1
Caenorhabditis elegans (roundworm)	gsp-2	NP_001022616.1
Saccharomyces cerevisiae (baker's yeast)	GLC7	NP_011059.3
Kluyveromyces lactis	KLLA0F12496g	XP_455645.1
Arabidopsis thaliana (thale cress)	TOPP5	NP_190266.1
Pan troglodytes (chimpanzee)	PPP1CA	XP_001151893.2
Rattus norvegicus (Norway rat)	Ppp1ca	NP_113715.1

Gene Ontology
Bibliography

Related articles in PubMed

The heterotrimeric G protein G?
Pradhan S, Khatlani T, Nairn AC, Vijayan KV
The Journal of biological chemistry292(32)13133-13142(2017 08)

Protein Phosphatase 1? enhances renal aldosterone signaling via mineralocorticoid receptor stabilization.
Nagarajan S, Vohra T, Loffing J, Faresse N
Molecular and cellular endocrinology45074-82(2017 Jul)

Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.
Bose SK, Hutson I, Harris CA
Endocrinology157(12)4943-4960(2016 Dec)

Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.
Zhou T, Li J, Zhao P, Liu H, Jia D, Jia H, He L, Cang Y, Boast S, Chen YH, Thibault H, Scherrer-Crosbie M, Goff SP, Li B
Proceedings of the National Academy of Sciences of the United States of America112(51)15666-71(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in quiescent platelets; then, Ppp1ca and Plcb3 interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G protein-coupled receptor signaling. (Ppp1ca = protein phosphatase 1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3)
Title: The heterotrimeric G protein G?

Ang IV functions via regulating the activity of PP1
Title: Angiotensin IV upregulates the activity of protein phosphatase 1? in Neura-2A cells.

Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.
Title: Cell surface expression of the major amyloid-? peptide (A?)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a.

analysis of selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection
Title: Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection.

Our findings clearly confirm that contextual memory formation involves CREB and PP1 as positive and negative regulators, respectively, and show for the first time that temporal memory formation shares this mechanism.
Title: RNA interference in hippocampus demonstrates opposing roles for CREB and PP1alpha in contextual and temporal long-term memory.

The following Ppp1ca gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1ca cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22616	NM_031868.2 Latest version!	Mus musculus protein phosphatase 1 catalytic subunit alpha (Ppp1ca), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1ca ( NM_031868.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_114074.1 Mus musculus protein phosphatase 1 catalytic subunit alpha (Ppp1ca), mRNA.

Price & Availability↑

CloneID	OMu22616
Clone ID Related Accession (Same CDS sequence)	NM_031868.2
Accession Version	NM_031868.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC109138.10. On Mar 21, 2007 this sequence version replaced NM_031868.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK151582.1, AK167244.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCCGACA GCGAGAAGCT CAACCTGGAC TCCATCATCG GGCGCCTGCT GGAAGTGCAG 
GGCTCACGGC CTGGGAAGAA CGTGCAGCTG ACAGAGAACG AGATCCGTGG TCTGTGCCTC 
AAATCCCGGG AGATTTTCCT GAGCCAGCCC ATTCTTCTGG AGCTTGAGGC GCCCCTCAAG 
ATCTGTGGTG ACATCCATGG CCAGTACTAT GACCTTCTAC GGCTGTTTGA GTATGGTGGC 
TTCCCTCCAG AGAGCAACTA CCTCTTCTTG GGGGATTATG TAGATCGGGG CAAGCAGTCT 
TTGGAGACCA TCTGCCTGTT GCTGGCCTAT AAGATCAGAT ACCCGGAGAA TTTCTTTCTA 
CTTCGTGGGA ACCATGAGTG TGCCAGCATC AACCGCATTT ATGGCTTCTA TGATGAATGC 
AAGAGAAGAT ACAACATCAA ACTGTGGAAG ACGTTCACTG ACTGCTTCAA CTGCCTGCCC 
ATTGCAGCCA TTGTGGATGA GAAGATCTTC TGCTGCCACG GGGGCCTGTC TCCAGACTTG 
CAATCCATGG AGCAGATTAG GCGTATTATG CGGCCCACAG ACGTGCCTGA CCAGGGCCTA 
CTGTGTGATC TCCTGTGGTC TGACCCTGAC AAGGATGTTC AAGGCTGGGG CGAGAATGAC 
CGTGGTGTCT CCTTTACCTT TGGGGCTGAG GTGGTAGCCA AGTTCCTGCA CAAGCATGAT 
TTGGACCTCA TCTGCAGAGC ACATCAGGTT GTAGAAGATG GCTATGAGTT CTTTGCCAAG 
AGACAGTTGG TGACACTCTT CTCAGCTCCC AACTACTGTG GAGAGTTTGA CAATGCTGGT 
GCCATGATGA GTGTGGATGA GACCCTCATG TGTTCCTTCC AGATCCTCAA GCCCGCTGAT 
AAGAATAAGG GCAAGTATGG GCAGTTCAGC GGCCTGAACC CCGGAGGCCG GCCCATCACT 
CCACCCCGCA ATTCTGCCAA AGCCAAGAAA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114074.1
CDS	44..1036
Translation	MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIRYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK

Target ORF information:

RefSeq Version	NM_031868.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 1 catalytic subunit alpha (Ppp1ca), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031868.2

ORF Insert Sequence:

ATGTCCGACA GCGAGAAGCT CAACCTGGAC TCCATCATCG GGCGCCTGCT GGAAGTGCAG 
GGCTCACGGC CTGGGAAGAA CGTGCAGCTG ACAGAGAACG AGATCCGTGG TCTGTGCCTC 
AAATCCCGGG AGATTTTCCT GAGCCAGCCC ATTCTTCTGG AGCTTGAGGC GCCCCTCAAG 
ATCTGTGGTG ACATCCATGG CCAGTACTAT GACCTTCTAC GGCTGTTTGA GTATGGTGGC 
TTCCCTCCAG AGAGCAACTA CCTCTTCTTG GGGGATTATG TAGATCGGGG CAAGCAGTCT 
TTGGAGACCA TCTGCCTGTT GCTGGCCTAT AAGATCAGAT ACCCGGAGAA TTTCTTTCTA 
CTTCGTGGGA ACCATGAGTG TGCCAGCATC AACCGCATTT ATGGCTTCTA TGATGAATGC 
AAGAGAAGAT ACAACATCAA ACTGTGGAAG ACGTTCACTG ACTGCTTCAA CTGCCTGCCC 
ATTGCAGCCA TTGTGGATGA GAAGATCTTC TGCTGCCACG GGGGCCTGTC TCCAGACTTG 
CAATCCATGG AGCAGATTAG GCGTATTATG CGGCCCACAG ACGTGCCTGA CCAGGGCCTA 
CTGTGTGATC TCCTGTGGTC TGACCCTGAC AAGGATGTTC AAGGCTGGGG CGAGAATGAC 
CGTGGTGTCT CCTTTACCTT TGGGGCTGAG GTGGTAGCCA AGTTCCTGCA CAAGCATGAT 
TTGGACCTCA TCTGCAGAGC ACATCAGGTT GTAGAAGATG GCTATGAGTT CTTTGCCAAG 
AGACAGTTGG TGACACTCTT CTCAGCTCCC AACTACTGTG GAGAGTTTGA CAATGCTGGT 
GCCATGATGA GTGTGGATGA GACCCTCATG TGTTCCTTCC AGATCCTCAA GCCCGCTGAT 
AAGAATAAGG GCAAGTATGG GCAGTTCAGC GGCCTGAACC CCGGAGGCCG GCCCATCACT 
CCACCCCGCA ATTCTGCCAA AGCCAAGAAA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The heterotrimeric G protein G?
The Journal of biological chemistry292(32)13133-13142(2017 08)
Pradhan S,Khatlani T,Nairn AC,Vijayan KV

Protein Phosphatase 1? enhances renal aldosterone signaling via mineralocorticoid receptor stabilization.
Molecular and cellular endocrinology45074-82(2017 Jul)
Nagarajan S,Vohra T,Loffing J,Faresse N

Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.
Endocrinology157(12)4943-4960(2016 Dec)
Bose SK,Hutson I,Harris CA

Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America112(51)15666-71(2015 Dec)
Zhou T,Li J,Zhao P,Liu H,Jia D,Jia H,He L,Cang Y,Boast S,Chen YH,Thibault H,Scherrer-Crosbie M,Goff SP,Li B

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Ppp1ca cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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