Gene Symbol | Ppargc1a |
Entrez Gene ID | 19017 |
Full Name | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
Synonyms | A830037N07Rik,Gm11133,PGC-1,PPARGC-1-alpha,Pgc-1alpha,Pgc1,Pgco1,Ppargc1 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. |