Pim2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pim2
Entrez Gene ID	18715
Full Name	proviral integration site 2
Synonyms	DXCch3,Pim-2
General protein information	Preferred Names proviral integration site 2 Names serine/threonine-protein kinase pim-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X A1.1\|X 3.55 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_138606.2	NP_613072.1	serine/threonine-protein kinase pim-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	PIM2	NP_006866.2
Rattus norvegicus (Norway rat)	Pim2	NP_001165574.1
	PIM2	XP_001104389.1
Bos taurus (cattle)	PIM2	NP_001193307.1
Pan troglodytes (chimpanzee)	PIM2	XP_528972.3
Canis lupus familiaris (dog)	PIM2	XP_548990.3
Danio rerio (zebrafish)	pim1	NP_571614.1
Mus musculus (house mouse)	Pim2	NP_613072.1

Gene Ontology
Bibliography

Related articles in PubMed

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.
Deng G, Nagai Y, Xiao Y, Li Z, Dai S, Ohtani T, Banham A, Li B, Wu SL, Hancock W, Samanta A, Zhang H, Greene MI
The Journal of biological chemistry290(33)20211-20(2015 Aug)

Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.
Din S, Konstandin MH, Johnson B, Emathinger J, V?lkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA
Circulation research115(3)376-87(2014 Jul)

Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.
An N, Lin YW, Mahajan S, Kellner JN, Wang Y, Li Z, Kraft AS, Kang Y
Stem cells (Dayton, Ohio)31(6)1202-12(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

studies define a pathway for limiting the regulation of Foxp3 function because the Pim-2 kinase represents a potential therapeutic target for modulating the Treg cell suppressive activities in controlling immune responses
Title: Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.

Loss of PIM2 is associated with abnormal hematopoietic phenotypes.
Title: Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.

Pim2 facilitated allograft rejection primarily by modulating the apoptosis of effector T cells and the function of regulatory T cells.
Title: Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway.

signals from IL-7 and RAG DSBs activate distinct Pim kinase family members that have context-dependent activities in regulating pre-B cell proliferation and survival.
Title: RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation.

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM 1, 2 kinases in lymphoma
Title: Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.

The following Pim2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pim2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18639	NM_138606.2 Latest version!	Mus musculus proviral integration site 2 (Pim2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pim2 ( NM_138606.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_613072.1 Mus musculus proviral integration site 2 (Pim2), mRNA.

Price & Availability↑

CloneID	OMu18639
Clone ID Related Accession (Same CDS sequence)	NM_138606.2
Accession Version	NM_138606.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase pim-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from L41495.1 and BC022727.1. On or before Mar 21, 2007 this sequence version replaced NM_145736.1, NM_145737.2, NM_138606.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L41495.1, SRR1660817.176182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 7781606 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGCGCGCG CGACGAATCT TAACGCTGCG CCGTCTGCAG GCGCTTCCGG GCCGCCAGAT 
TCCCTGCCTT CCACCCTGGC GCCCCCCAGC CCTGGCTCTC CGGCCGCTCT GCCCCGGGCA 
TCCACGCCCT GCGGGCTCAG CGGATTCAGC GGGCTCAATA TACGCAGCAC CTCCTCCATG 
TTGACCAAGC CTCTGCAGGG GCATCCTTCG CCCCCTGTGA CCCCCACGCA GCCTCCAGGA 
GGCAAGGATC GGGCAGCTTT CGAGGCCGAA TACCGACTTG GCCCCCTCCT GGGTAAGGGA 
GGCTTTGGCA CCGTCTTCGC GGGACACCGC GTCACGGATA GACGTCAGGT GGCCATCAAA 
GTAATCTCCC GGAACCGTGT GCTAGGCTGG TCCACCGTGT CAGACTCAGT CACCTGCCCA 
CTTGAGGTTG CGCTGCTGTG GAAGGTGGGT GAAGGCAATG GCCATCCGGG TGTGATACGC 
CTTCTTGACT GGTTCGAAAC ACCCGAAGGC TTCATGCTGG TCCTTGAGCG GCCTATGCCT 
GCTCAGGATC TCTTCGACTA TATCACAGAG AAGGGGCCGC TGGGTGAAAG CTGTAGCCGC 
AGCTTCTTTA CCCAAGTCGT GGCAGCTGTC CAGCACTGCC ACGCCCGTGG AGTTGTCCAT 
CGGGATATCA AGGATGAGAA CATCCTGATC GACCTATGCC GGGGTTCCAT TAAACTCATT 
GATTTTGGTT CCGGCGCCCT GCTTCACGAT GAGCCGTACA CTGACTTTGA TGGGACAAGA 
GTGTATAGCC CTCCAGAGTG GATCTCGCGA CACCAGTACC ATGCCCTGCC AGCGACCGTC 
TGGTCACTAG GTGTCCTACT CTATGACATG GTCTGTGGGG ACATTCCCTT CGAGAGAGAC 
CAGGAGATTC TGGAGGCTGA GCTGCACTTC CCTGCTCATG TCTCCCCAGA TTGCTGTGCC 
CTAATCCGCC GGTGCCTGGC CCCTAAACCC TGCTCCCGAC CCTCACTGGA GGAGATTCTG 
CTGGACCCCT GGATGCAATC ACCAGCTGAA GAAAAGCCCA TCAACTCCTC CAAAGGAAGC 
CCCACCCCCT TGCCCTGGTC CCTGCTTCCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_613072.1
CDS	14..1126
Translation	LARATNLNAAPSAGASGPPDSLPSTLAPPSPGSPAALPRASTPCGLSGFSGLNIRSTSSMLTKPLQGHPSPPVTPTQPPGGKDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEKPINSSKGSPTPLPWSLLP

Target ORF information:

RefSeq Version	NM_138606.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proviral integration site 2 (Pim2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138606.2

ORF Insert Sequence:

CTGGCGCGCG CGACGAATCT TAACGCTGCG CCGTCTGCAG GCGCTTCCGG GCCGCCAGAT 
TCCCTGCCTT CCACCCTGGC GCCCCCCAGC CCTGGCTCTC CGGCCGCTCT GCCCCGGGCA 
TCCACGCCCT GCGGGCTCAG CGGATTCAGC GGGCTCAATA TACGCAGCAC CTCCTCCATG 
TTGACCAAGC CTCTGCAGGG GCATCCTTCG CCCCCTGTGA CCCCCACGCA GCCTCCAGGA 
GGCAAGGATC GGGCAGCTTT CGAGGCCGAA TACCGACTTG GCCCCCTCCT GGGTAAGGGA 
GGCTTTGGCA CCGTCTTCGC GGGACACCGC GTCACGGATA GACGTCAGGT GGCCATCAAA 
GTAATCTCCC GGAACCGTGT GCTAGGCTGG TCCACCGTGT CAGACTCAGT CACCTGCCCA 
CTTGAGGTTG CGCTGCTGTG GAAGGTGGGT GAAGGCAATG GCCATCCGGG TGTGATACGC 
CTTCTTGACT GGTTCGAAAC ACCCGAAGGC TTCATGCTGG TCCTTGAGCG GCCTATGCCT 
GCTCAGGATC TCTTCGACTA TATCACAGAG AAGGGGCCGC TGGGTGAAAG CTGTAGCCGC 
AGCTTCTTTA CCCAAGTCGT GGCAGCTGTC CAGCACTGCC ACGCCCGTGG AGTTGTCCAT 
CGGGATATCA AGGATGAGAA CATCCTGATC GACCTATGCC GGGGTTCCAT TAAACTCATT 
GATTTTGGTT CCGGCGCCCT GCTTCACGAT GAGCCGTACA CTGACTTTGA TGGGACAAGA 
GTGTATAGCC CTCCAGAGTG GATCTCGCGA CACCAGTACC ATGCCCTGCC AGCGACCGTC 
TGGTCACTAG GTGTCCTACT CTATGACATG GTCTGTGGGG ACATTCCCTT CGAGAGAGAC 
CAGGAGATTC TGGAGGCTGA GCTGCACTTC CCTGCTCATG TCTCCCCAGA TTGCTGTGCC 
CTAATCCGCC GGTGCCTGGC CCCTAAACCC TGCTCCCGAC CCTCACTGGA GGAGATTCTG 
CTGGACCCCT GGATGCAATC ACCAGCTGAA GAAAAGCCCA TCAACTCCTC CAAAGGAAGC 
CCCACCCCCT TGCCCTGGTC CCTGCTTCCC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation.
The Journal of biological chemistry290(33)20211-20(2015 Aug)
Deng G,Nagai Y,Xiao Y,Li Z,Dai S,Ohtani T,Banham A,Li B,Wu SL,Hancock W,Samanta A,Zhang H,Greene MI

Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.
Circulation research115(3)376-87(2014 Jul)
Din S,Konstandin MH,Johnson B,Emathinger J,V?lkers M,Toko H,Collins B,Ormachea L,Samse K,Kubli DA,De La Torre A,Kraft AS,Gustafsson AB,Kelly DP,Sussman MA

Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.
Stem cells (Dayton, Ohio)31(6)1202-12(2013 Jun)
An N,Lin YW,Mahajan S,Kellner JN,Wang Y,Li Z,Kraft AS,Kang Y

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Pim2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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