Gene Symbol | ABCB1A |
Entrez Gene ID | 18671 |
Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
Synonyms | Abcb4,Evi32,Mdr1a,Mdr3,P-gp,Pgp,Pgy-3,Pgy3,mdr-3 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome | |
Summary | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]. |