Pfn2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pfn2
Entrez Gene ID	18645
Full Name	profilin 2
Synonyms	Pfn
General protein information	Preferred Names profilin 2 Names profilin-2 profilin II
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 D\|3 28.15 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019410.3	NP_062283.1	profilin-2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PFN2	NP_001073228.1
Pan troglodytes (chimpanzee)	PFN2	XP_516998.3
	LOC713460	XP_001102817.2
Rattus norvegicus (Norway rat)	LOC100909840	XP_003749330.1
Rattus norvegicus (Norway rat)	Pfn2	NP_110500.1
Homo sapiens (human)	PFN2	NP_444252.1
Bos taurus (cattle)	PFN2	NP_001121669.1
Xenopus tropicalis (tropical clawed frog)	pfn2	NP_001016098.1
Mus musculus (house mouse)	Pfn2	NP_062283.1
Danio rerio (zebrafish)	pfn2l	NP_958874.2

Gene Ontology
Bibliography

Related articles in PubMed

PFN2a, a new partner of RAR? in the cytoplasm.
Andriamoratsiresy D, Piskunov A, Lutzing R, Rochette-Egly C
Biochemical and biophysical research communications495(1)846-853(2018 01)

The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.
Luscieti S, Galy B, Gutierrez L, Reinke M, Couso J, Shvartsman M, Di Pascale A, Witke W, Hentze MW, Pilo Boyl P, Sanchez M
Blood130(17)1934-1945(2017 10)

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.
Lin Q, Ponnusamy R, Widagdo J, Choi JA, Ge W, Probst C, Buckley T, Lou M, Bredy TW, Fanselow MS, Ye K, Sun YE
Proceedings of the National Academy of Sciences of the United States of America114(34)9188-9193(2017 Aug)

Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome.
Michaelsen-Preusse K, Zessin S, Grigoryan G, Scharkowski F, Feuge J, Remus A, Korte M
Proceedings of the National Academy of Sciences of the United States of America113(12)3365-70(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RARalpha competes with other PFN2a-binding proteins bearing PRMs and involved in actin filaments elongation. Consequently, the actin filament network is altered and MEFs adhesion is decreased. This novel role opens novel avenues for the understanding of pathologies characterized by increased levels of cytoplasmic RARalpha.
Title: PFN2a, a new partner of RAR? in the cytoplasm.

Pfn2 expression is controlled by the iron regulatory proteins in vivo and that Pfn2 contributes to maintaining iron homeostasis in cell lines and mice.
Title: The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.

knockdown of profilin 1 or profilin 2a led to significant decrease in cell spreading of astrocytes. the knockdown of profilin 2a resulted in a significantly reduced morphological complexity of astrocytes in both dissociated and slice culture astrocytes.
Title: Profilin isoforms modulate astrocytic morphology and the motility of astrocytic processes.

Hyper-phosphorylation of profilin2a is the molecular link between SMN and the ROCK pathway repressing neurite outgrowth in neuronal cells.
Title: The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.

Profilin II regulates the exocytosis of kainate glutamate receptors.
Title: Profilin II regulates the exocytosis of kainate glutamate receptors.

The following Pfn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pfn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15754	NM_019410.3 Latest version!	Mus musculus profilin 2 (Pfn2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pfn2 ( NM_019410.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062283.1 Mus musculus profilin 2 (Pfn2), mRNA.

Price & Availability↑

CloneID	OMu15754
Clone ID Related Accession (Same CDS sequence)	NM_019410.3
Accession Version	NM_019410.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Mus musculus(house mouse)
Product	profilin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC165888.18 and AK132651.1. On Jun 16, 2009 this sequence version replaced NM_019410.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024363.1, AK132651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGTT GGCAGAGCTA CGTGGATAAC CTGATGTGCG ATGGCTGCTG CCAGGAGGCC 
GCCATTGTCG GCTACTGCGA CGCCAAATAC GTCTGGGCAG CCACGGCCGG GGGCGTCTTC 
CAGAGCATCA CGCCAGTAGA AATAGATATG ATTGTAGGAA AAGACCGGGA AGGTTTCTTT 
ACCAACGGTT TGACTCTTGG AGCAAAGAAG TGTTCTGTGA TCAGAGATAG CCTATACGTT 
GATGGTGACT GCACAATGGA CATCCGGACA AAGAGTCAAG GTGGGGAGCC AACATACAAC 
GTTGCTGTTG GCAGGGCCGG GAGAGTCTTG GTCTTTGTAA TGGGAAAAGA AGGGGTCCAT 
GGAGGCGGAT TGAATAAGAA GGCATACTCA ATGGCAAAAT ACTTGAGAGA CTCTGGGTTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062283.1
CDS	276..698
Translation	MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPVEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF

Target ORF information:

RefSeq Version	NM_019410.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus profilin 2 (Pfn2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019410.3

ORF Insert Sequence:

ATGGCCGGTT GGCAGAGCTA CGTGGATAAC CTGATGTGCG ATGGCTGCTG CCAGGAGGCC 
GCCATTGTCG GCTACTGCGA CGCCAAATAC GTCTGGGCAG CCACGGCCGG GGGCGTCTTC 
CAGAGCATCA CGCCAGTAGA AATAGATATG ATTGTAGGAA AAGACCGGGA AGGTTTCTTT 
ACCAACGGTT TGACTCTTGG AGCAAAGAAG TGTTCTGTGA TCAGAGATAG CCTATACGTT 
GATGGTGACT GCACAATGGA CATCCGGACA AAGAGTCAAG GTGGGGAGCC AACATACAAC 
GTTGCTGTTG GCAGGGCCGG GAGAGTCTTG GTCTTTGTAA TGGGAAAAGA AGGGGTCCAT 
GGAGGCGGAT TGAATAAGAA GGCATACTCA ATGGCAAAAT ACTTGAGAGA CTCTGGGTTC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PFN2a, a new partner of RAR? in the cytoplasm.
Biochemical and biophysical research communications495(1)846-853(2018 01)
Andriamoratsiresy D,Piskunov A,Lutzing R,Rochette-Egly C

The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.
Blood130(17)1934-1945(2017 10)
Luscieti S,Galy B,Gutierrez L,Reinke M,Couso J,Shvartsman M,Di Pascale A,Witke W,Hentze MW,Pilo Boyl P,Sanchez M

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life.
Proceedings of the National Academy of Sciences of the United States of America114(34)9188-9193(2017 Aug)
Lin Q,Ponnusamy R,Widagdo J,Choi JA,Ge W,Probst C,Buckley T,Lou M,Bredy TW,Fanselow MS,Ye K,Sun YE

Neuronal profilins in health and disease: Relevance for spine plasticity and Fragile X syndrome.
Proceedings of the National Academy of Sciences of the United States of America113(12)3365-70(2016 Mar)
Michaelsen-Preusse K,Zessin S,Grigoryan G,Scharkowski F,Feuge J,Remus A,Korte M

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Pfn2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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