Pea15a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pea15a
Entrez Gene ID	18611
Full Name	phosphoprotein enriched in astrocytes 15A
Synonyms	Mat1,PEA-15,Pea15,Pkcs15
General protein information	Preferred Names phosphoprotein enriched in astrocytes 15A Names astrocytic phosphoprotein PEA-15 15 kDa phosphoprotein enriched in astrocytes mammary transforming gene 1 phosphoprotein enriched in astrocytes 15
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 79.54 cM
Summary	This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_011063.2	NP_035193.1	astrocytic phosphoprotein PEA-15 isoform 2
NM_011063.3	NP_035193.1	astrocytic phosphoprotein PEA-15 isoform 2
NM_001329869.1	NP_001316798.1	astrocytic phosphoprotein PEA-15 isoform 2
XM_006496702.1	XP_006496765.1	astrocytic phosphoprotein PEA-15 isoform X1
NM_001329871.1	NP_001316800.1	astrocytic phosphoprotein PEA-15 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	PEA15	NP_003759.1
Bos taurus (cattle)	PEA15	NP_001068924.1
Mus musculus (house mouse)	Pea15a	NP_035193.1
Rattus norvegicus (Norway rat)	Pea15	NP_001013249.1
Pan troglodytes (chimpanzee)	PEA15	XP_003308618.1
Canis lupus familiaris (dog)	PEA15	XP_005640955.1
Danio rerio (zebrafish)	LOC557745	XP_683349.2
Xenopus tropicalis (tropical clawed frog)	pea15	NP_001120300.1

Gene Ontology
Bibliography

Related articles in PubMed

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.
Perruolo G, Viggiano D, Fiory F, Cassese A, Nigro C, Liotti A, Miele C, Beguinot F, Formisano P
Scientific reports629967(2016 Jul)

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities.
Wei Y
Pharmaceuticals (Basel, Switzerland)8(3)455-73(2015 Jul)

Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.
Ramos JW, Townsend DA, Piarulli D, Kolata S, Light K, Hale G, Matzel LD
BMC neuroscience10134(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that PEA-15 contributes to the specification of the cytokine pattern of activated Th cells, thus highlighting a potential new target to interfere with T cell functional polarization and subsequent immune response.
Title: Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.

Activated astrocytes are known to clear the Abeta deposited in the extracellular milieu, which is why they play a key role in regulating the progression of Alzheimer's disease (AD).
Title: Quantitative proteomics reveals that PEA15 regulates astroglial A? phagocytosis in an Alzheimer's disease mouse model.

PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism
Title: PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1.

Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) represses transcription of the ped/pea-15 gene.
Title: Peroxisome proliferator-activated receptor-? activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1.

PEA-15 did not differentiate and showed markedly enhanced autophagy. In these same cells, the autophagy inhibitor 3-methyladenine rescued TGF-beta1 effect on both autophagy and myogenesis, indicating that PEA-15 mediates TGF-beta1 effects in muscle.
Title: PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.

The following Pea15a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pea15a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu07401	NM_001329869.1 Latest version!	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu07401	NM_011063.3 Latest version!	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu83474	NM_001329871.1 Latest version!	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu07401	XM_006496702.1 Latest version!	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu07401	NM_011063.2	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pea15a ( NM_011063.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035193.1 Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu07401
Clone ID Related Accession (Same CDS sequence)	NM_011063.2 , NM_011063.3 , NM_001329869.1 , XM_006496702.1
Accession Version	NM_011063.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	astrocytic phosphoprotein PEA-15 isoform 2
Comment

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035193.1
Translation	MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA

Target ORF information:

RefSeq Version	NM_011063.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011063.2

ORF Insert Sequence:

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pea15a ( NM_011063.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035193.1 Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu07401
Clone ID Related Accession (Same CDS sequence)	NM_011063.2 , NM_011063.3 , NM_001329869.1 , XM_006496702.1
Accession Version	NM_011063.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	astrocytic phosphoprotein PEA-15 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY278511.1, AC074310.29, AK153141.1 and BE992884.1. On Aug 7, 2016 this sequence version replaced NM_011063.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Both variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.171004.1, AK153141.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035193.1
CDS	211..603
Translation	MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA

Target ORF information:

RefSeq Version	NM_011063.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011063.3

ORF Insert Sequence:

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pea15a ( NM_001329869.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001316798.1 Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu07401
Clone ID Related Accession (Same CDS sequence)	NM_011063.2 , NM_011063.3 , NM_001329869.1 , XM_006496702.1
Accession Version	NM_001329869.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	astrocytic phosphoprotein PEA-15 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC074310.29, AK153141.1 and BE992884.1. On Aug 7, 2016 this sequence version replaced XM_017319302.1. Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2). Both variants 2 and 3 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.1660123.1, SRR7345562.3976071.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164136 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316798.1
CDS	249..641
Translation	MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA

Target ORF information:

RefSeq Version	NM_001329869.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329869.1

ORF Insert Sequence:

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pea15a ( NM_001329871.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001316800.1 Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu83474
Clone ID Related Accession (Same CDS sequence)	NM_001329871.1
Accession Version	NM_001329871.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 327bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	astrocytic phosphoprotein PEA-15 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC074310.29, CD807366.1, AK153141.1 and BE992884.1. Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 2. The resulting isoform (3) has a shorter N-terminus compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.237063.1, SRR1660815.32980.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAACAA CCTCTCCTAC 
ATTGAGCACA TCTTTGAGAT ATCTCGCCGT CCTGACCTCC TCACTATGGT GGTTGACTAC 
AGAACCCGTG TGCTGAAGAT CTCTGAGGAG GAGGAGCTGG ACACCAAGCT AACCCGTATT 
CCCAGTGCCA AGAAGTACAA AGACATTATC CGGCAGCCCT CTGAAGAAGA AATCATCAAA 
TTGGCTCCCC CACCAAAGAA GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316800.1
CDS	211..537
Translation	MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKNNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA

Target ORF information:

RefSeq Version	NM_001329871.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329871.1

ORF Insert Sequence:

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAACAA CCTCTCCTAC 
ATTGAGCACA TCTTTGAGAT ATCTCGCCGT CCTGACCTCC TCACTATGGT GGTTGACTAC 
AGAACCCGTG TGCTGAAGAT CTCTGAGGAG GAGGAGCTGG ACACCAAGCT AACCCGTATT 
CCCAGTGCCA AGAAGTACAA AGACATTATC CGGCAGCCCT CTGAAGAAGA AATCATCAAA 
TTGGCTCCCC CACCAAAGAA GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pea15a ( XM_006496702.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496765.1 Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu07401
Clone ID Related Accession (Same CDS sequence)	NM_011063.2 , NM_011063.3 , NM_001329869.1 , XM_006496702.1
Accession Version	XM_006496702.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	astrocytic phosphoprotein PEA-15 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496765.1
CDS	217..609
Translation	MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA

Target ORF information:

RefSeq Version	XM_006496702.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496702.1

ORF Insert Sequence:

ATGGCAGAGT ACGGAACTCT CCTTCAGGAC CTGACCAACA ACATCACCCT TGAAGATCTG 
GAACAGCTCA AGTCAGCCTG CAAGGAGGAC ATCCCCAGTG AGAAGAGTGA GGAGATCACC 
ACAGGCAGTG CCTGGTTTAG CTTCCTGGAG AGCCACAACA AGCTGGACAA AGACAACCTC 
TCCTACATTG AGCACATCTT TGAGATATCT CGCCGTCCTG ACCTCCTCAC TATGGTGGTT 
GACTACAGAA CCCGTGTGCT GAAGATCTCT GAGGAGGAGG AGCTGGACAC CAAGCTAACC 
CGTATTCCCA GTGCCAAGAA GTACAAAGAC ATTATCCGGC AGCCCTCTGA AGAAGAAATC 
ATCAAATTGG CTCCCCCACC AAAGAAGGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.
Scientific reports629967(2016 Jul)
Perruolo G,Viggiano D,Fiory F,Cassese A,Nigro C,Liotti A,Miele C,Beguinot F,Formisano P

On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities.
Pharmaceuticals (Basel, Switzerland)8(3)455-73(2015 Jul)
Wei Y

Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.
BMC neuroscience10134(2009 Nov)
Ramos JW,Townsend DA,Piarulli D,Kolata S,Light K,Hale G,Matzel LD

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Pea15a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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