Pdcd6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdcd6
Entrez Gene ID	18570
Full Name	programmed cell death 6
Synonyms	AV299538,Alg2,MA-3,PS2,alg-2
General protein information	Preferred Names programmed cell death 6 Names programmed cell death protein 6 ALG-257 PMP41 apoptosis-linked gene 2 protein probable calcium-binding protein ALG-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 C1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006517156.1	XP_006517219.1	programmed cell death protein 6 isoform X1
NM_011051.3	NP_035181.1	programmed cell death protein 6 isoform 1
NM_001359996.1	NP_001346925.1	programmed cell death protein 6 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Pdcd6	NP_001100922.1
Gallus gallus (chicken)	PDCD6	XP_004935237.1
Danio rerio (zebrafish)	pdcd6	NP_957244.1
Drosophila melanogaster (fruit fly)	Alg-2	NP_001104459.2
Neurospora crassa	NCU02738	XP_965123.1
Xenopus tropicalis (tropical clawed frog)	pdcd6	NP_001008004.1
Homo sapiens (human)	PDCD6	NP_037364.1
	LOC723043	XP_001119112.2
Bos taurus (cattle)	PDCD6	NP_001098967.1
Eremothecium gossypii	AGOS_AFR570W	NP_986117.1
Canis lupus familiaris (dog)	PDCD6	XP_851917.1
Pan troglodytes (chimpanzee)	PDCD6	XP_003950538.1
Mus musculus (house mouse)	Pdcd6	NP_035181.1
Caenorhabditis elegans (roundworm)	CELE_M04F3.4	NP_001249716.1
Magnaporthe oryzae (rice blast fungus)	MGG_04818	XP_003713748.1

Gene Ontology
Bibliography

Related articles in PubMed

ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Zhang D, Wang F, Pang Y, Zhao E, Zhu S, Chen F, Cui H
Biochemical and biophysical research communications486(2)300-306(2017 04)

EF5 Is the High-Affinity Mg(2+) Site in ALG-2.
Tanner JJ, Frey BB, Pemberton T, Henzl MT
Biochemistry55(36)5128-41(2016 09)

Prediction of a new ligand-binding site for type 2 motif based on the crystal structure of ALG-2 by dry and wet approaches.
Takahashi T, Suzuki H, Inuzuka T, Shibata H, Maki M
International journal of molecular sciences13(6)7532-49(2012)

The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.
Draeby I, Woods YL, la Cour JM, Mollerup J, Bourdon JC, Berchtold MW
Archives of biochemistry and biophysics467(1)87-94(2007 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Title: ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.

Substitution of either L52 with Ala or F148 with Ser of ALG-2 caused loss of binding abilities to PLSCR3 lacking type 1 motif but retained those to PLSCR3 lacking type 2 motif
Title: Prediction of a new ligand-binding site for type 2 motif based on the crystal structure of ALG-2 by dry and wet approaches.

ALG-2 is physiologically dispensable for apoptotic responses (ALG-2 protein)
Title: Apoptosis-linked gene 2-deficient mice exhibit normal T-cell development and function.

The following Pdcd6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdcd6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu07369	NM_011051.3 Latest version!	Mus musculus programmed cell death 6 (Pdcd6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu48691	NM_001359996.1 Latest version!	Mus musculus programmed cell death 6 (Pdcd6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu48691	XM_006517156.1 Latest version!	Mus musculus programmed cell death 6 (Pdcd6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdcd6 ( NM_011051.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035181.1 Mus musculus programmed cell death 6 (Pdcd6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07369
Clone ID Related Accession (Same CDS sequence)	NM_011051.3
Accession Version	NM_011051.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	programmed cell death protein 6 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU604816.1, AK028223.1, AK008610.1 and AV299538.1. On Dec 18, 2007 this sequence version replaced NM_011051.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK008610.1, AK028223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCT ACTCCTACCG CCCAGGCCCG GGTGGTGGCC CCGGCCCTGC TGCTGGAGCT 
GCACTGCCAG ACCAGAGCTT CCTGTGGAAC GTCTTCCAGC GGGTTGATAA AGACAGGAGT 
GGAGTGATTT CAGACAATGA GCTTCAGCAA GCATTATCCA ATGGTACATG GACTCCATTT 
AACCCAGTGA CTGTGAGGTC AATCATTTCT ATGTTTGACC GAGAAAACAA GGCTGGTGTG 
AACTTCAGTG AATTCACGGG TGTGTGGAAG TATATCACAG ACTGGCAGAA TGTCTTCCGG 
ACCTACGACA GGGACAACTC TGGGATGATT GACAAGAACG AGCTCAAACA AGCACTCTCA 
GGTTTTGGCT ACCGGCTCTC TGATCAGTTC CATGACATCC TCATCCGAAA ATTTGACAGG 
CAAGGACGGG GCCAGATCGC ATTTGATGAC TTCATCCAGG GCTGCATCGT CTTGCAGAGG 
TTGACAGACA TATTCAGACG CTATGACACG GATCAGGATG GCTGGATTCA GGTGTCTTAT 
GAGCAATATC TCTCCATGGT CTTCAGCATT GTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035181.1
CDS	120..695
Translation	MAAYSYRPGPGGGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDNELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV

Target ORF information:

RefSeq Version	NM_011051.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus programmed cell death 6 (Pdcd6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011051.3

ORF Insert Sequence:

ATGGCTGCCT ACTCCTACCG CCCAGGCCCG GGTGGTGGCC CCGGCCCTGC TGCTGGAGCT 
GCACTGCCAG ACCAGAGCTT CCTGTGGAAC GTCTTCCAGC GGGTTGATAA AGACAGGAGT 
GGAGTGATTT CAGACAATGA GCTTCAGCAA GCATTATCCA ATGGTACATG GACTCCATTT 
AACCCAGTGA CTGTGAGGTC AATCATTTCT ATGTTTGACC GAGAAAACAA GGCTGGTGTG 
AACTTCAGTG AATTCACGGG TGTGTGGAAG TATATCACAG ACTGGCAGAA TGTCTTCCGG 
ACCTACGACA GGGACAACTC TGGGATGATT GACAAGAACG AGCTCAAACA AGCACTCTCA 
GGTTTTGGCT ACCGGCTCTC TGATCAGTTC CATGACATCC TCATCCGAAA ATTTGACAGG 
CAAGGACGGG GCCAGATCGC ATTTGATGAC TTCATCCAGG GCTGCATCGT CTTGCAGAGG 
TTGACAGACA TATTCAGACG CTATGACACG GATCAGGATG GCTGGATTCA GGTGTCTTAT 
GAGCAATATC TCTCCATGGT CTTCAGCATT GTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pdcd6 ( NM_001359996.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001346925.1 Mus musculus programmed cell death 6 (Pdcd6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu48691
Clone ID Related Accession (Same CDS sequence)	XM_006517156.1 , NM_001359996.1
Accession Version	NM_001359996.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	programmed cell death protein 6 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT009486.7. On Jan 24, 2018 this sequence version replaced XM_006517156.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ958520.1, BG865619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCT ACTCCTACCG CCCAGGCCCG GGTGGTGGCC CCGGCCCTGC TGCTGGAGCT 
GCACTGCCAG ACCAGAGCTT CCTGTGGAAC GTCTTCCAGC GGGTTGATAA AGACAGGAGT 
GGAGTGATTT CAGACAATGA GCTTCAGCAA GCATTATCCA ATGGTACATG GACTCCATTT 
AACCCAGTGA CTGTGAGGTC AATCATTTCT ATGTTTGACC GAGAAAACAA GGCTGGTGTG 
AACTTCAGTG AATTCACGGG TGTGTGGAAG TATATCACAG ACTGGCAGAA TGTCTTCCGG 
ACCTACGACA GGGACAACTC TGGGATGATT GACAAGAACG AGCTCAAACA AGCACTCTCA 
GGCTACCGGC TCTCTGATCA GTTCCATGAC ATCCTCATCC GAAAATTTGA CAGGCAAGGA 
CGGGGCCAGA TCGCATTTGA TGACTTCATC CAGGGCTGCA TCGTCTTGCA GAGGTTGACA 
GACATATTCA GACGCTATGA CACGGATCAG GATGGCTGGA TTCAGGTGTC TTATGAGCAA 
TATCTCTCCA TGGTCTTCAG CATTGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346925.1
CDS	120..689
Translation	MAAYSYRPGPGGGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDNELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV

Target ORF information:

RefSeq Version	NM_001359996.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus programmed cell death 6 (Pdcd6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359996.1

ORF Insert Sequence:

ATGGCTGCCT ACTCCTACCG CCCAGGCCCG GGTGGTGGCC CCGGCCCTGC TGCTGGAGCT 
GCACTGCCAG ACCAGAGCTT CCTGTGGAAC GTCTTCCAGC GGGTTGATAA AGACAGGAGT 
GGAGTGATTT CAGACAATGA GCTTCAGCAA GCATTATCCA ATGGTACATG GACTCCATTT 
AACCCAGTGA CTGTGAGGTC AATCATTTCT ATGTTTGACC GAGAAAACAA GGCTGGTGTG 
AACTTCAGTG AATTCACGGG TGTGTGGAAG TATATCACAG ACTGGCAGAA TGTCTTCCGG 
ACCTACGACA GGGACAACTC TGGGATGATT GACAAGAACG AGCTCAAACA AGCACTCTCA 
GGCTACCGGC TCTCTGATCA GTTCCATGAC ATCCTCATCC GAAAATTTGA CAGGCAAGGA 
CGGGGCCAGA TCGCATTTGA TGACTTCATC CAGGGCTGCA TCGTCTTGCA GAGGTTGACA 
GACATATTCA GACGCTATGA CACGGATCAG GATGGCTGGA TTCAGGTGTC TTATGAGCAA 
TATCTCTCCA TGGTCTTCAG CATTGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pdcd6 ( XM_006517156.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006517219.1 Mus musculus programmed cell death 6 (Pdcd6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu48691
Clone ID Related Accession (Same CDS sequence)	XM_006517156.1 , NM_001359996.1
Accession Version	XM_006517156.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	programmed cell death protein 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCCT ACTCCTACCG CCCAGGCCCG GGTGGTGGCC CCGGCCCTGC TGCTGGAGCT 
GCACTGCCAG ACCAGAGCTT CCTGTGGAAC GTCTTCCAGC GGGTTGATAA AGACAGGAGT 
GGAGTGATTT CAGACAATGA GCTTCAGCAA GCATTATCCA ATGGTACATG GACTCCATTT 
AACCCAGTGA CTGTGAGGTC AATCATTTCT ATGTTTGACC GAGAAAACAA GGCTGGTGTG 
AACTTCAGTG AATTCACGGG TGTGTGGAAG TATATCACAG ACTGGCAGAA TGTCTTCCGG 
ACCTACGACA GGGACAACTC TGGGATGATT GACAAGAACG AGCTCAAACA AGCACTCTCA 
GGCTACCGGC TCTCTGATCA GTTCCATGAC ATCCTCATCC GAAAATTTGA CAGGCAAGGA 
CGGGGCCAGA TCGCATTTGA TGACTTCATC CAGGGCTGCA TCGTCTTGCA GAGGTTGACA 
GACATATTCA GACGCTATGA CACGGATCAG GATGGCTGGA TTCAGGTGTC TTATGAGCAA 
TATCTCTCCA TGGTCTTCAG CATTGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006517219.1
CDS	369..938
Translation	MAAYSYRPGPGGGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDNELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV

Target ORF information:

RefSeq Version	XM_006517156.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus programmed cell death 6 (Pdcd6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006517156.1

ORF Insert Sequence:

ATGGCTGCCT ACTCCTACCG CCCAGGCCCG GGTGGTGGCC CCGGCCCTGC TGCTGGAGCT 
GCACTGCCAG ACCAGAGCTT CCTGTGGAAC GTCTTCCAGC GGGTTGATAA AGACAGGAGT 
GGAGTGATTT CAGACAATGA GCTTCAGCAA GCATTATCCA ATGGTACATG GACTCCATTT 
AACCCAGTGA CTGTGAGGTC AATCATTTCT ATGTTTGACC GAGAAAACAA GGCTGGTGTG 
AACTTCAGTG AATTCACGGG TGTGTGGAAG TATATCACAG ACTGGCAGAA TGTCTTCCGG 
ACCTACGACA GGGACAACTC TGGGATGATT GACAAGAACG AGCTCAAACA AGCACTCTCA 
GGCTACCGGC TCTCTGATCA GTTCCATGAC ATCCTCATCC GAAAATTTGA CAGGCAAGGA 
CGGGGCCAGA TCGCATTTGA TGACTTCATC CAGGGCTGCA TCGTCTTGCA GAGGTTGACA 
GACATATTCA GACGCTATGA CACGGATCAG GATGGCTGGA TTCAGGTGTC TTATGAGCAA 
TATCTCTCCA TGGTCTTCAG CATTGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ALG2 regulates glioblastoma cell proliferation, migration and tumorigenicity.
Biochemical and biophysical research communications486(2)300-306(2017 04)
Zhang D,Wang F,Pang Y,Zhao E,Zhu S,Chen F,Cui H

EF5 Is the High-Affinity Mg(2+) Site in ALG-2.
Biochemistry55(36)5128-41(2016 09)
Tanner JJ,Frey BB,Pemberton T,Henzl MT

Prediction of a new ligand-binding site for type 2 motif based on the crystal structure of ALG-2 by dry and wet approaches.
International journal of molecular sciences13(6)7532-49(2012)
Takahashi T,Suzuki H,Inuzuka T,Shibata H,Maki M

The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.
Archives of biochemistry and biophysics467(1)87-94(2007 Nov)
Draeby I,Woods YL,la Cour JM,Mollerup J,Bourdon JC,Berchtold MW

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Pdcd6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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