Pcp4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pcp4
Entrez Gene ID	18546
Full Name	Purkinje cell protein 4
Synonyms	P16Rimb19,Pcp-4,Pep19
General protein information	Preferred Names Purkinje cell protein 4 Names calmodulin regulator protein PCP4 brain-specific antigen PCP-4 brain-specific polypeptide PEP-19
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 C4\|16 56.97 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008791.2	NP_032817.1	Purkinje cell protein 4
NM_008791.3	NP_032817.1	calmodulin regulator protein PCP4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PCP4	XP_853359.1
Bos taurus (cattle)	PCP4	NP_001071604.1
Mus musculus (house mouse)	Pcp4	NP_032817.1
Pan troglodytes (chimpanzee)	PCP4	XP_531603.2
Rattus norvegicus (Norway rat)	Pcp4	NP_037134.1
Gallus gallus (chicken)	PCP4	NP_001265077.1
Homo sapiens (human)	PCP4	NP_006189.2

Gene Ontology
Bibliography

Related articles in PubMed

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.
Magella B, Adam M, Potter AS, Venkatasubramanian M, Chetal K, Hay SB, Salomonis N, Potter SS
Developmental biology(2017 Nov)

MS imaging and mass spectrometric synaptosome profiling identify PEP-19/pcp4 as a synaptic molecule involved in spatial learning in mice.
Aerts J, Laeremans A, Minerva L, Boonen K, Harshavardhan B, D'hooge R, Valkenborg D, Baggerman G, Arckens L
Biochimica et biophysica acta1865(7)936-945(2017 07)

Brain ventriculomegaly in Down syndrome mice is caused by Pcp4 dose-dependent cilia dysfunction.
Raveau M, Nakahari T, Asada S, Ishihara K, Amano K, Shimohata A, Sago H, Yamakawa K
Human molecular genetics26(5)923-931(2017 03)

Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.
Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD
Cell reports15(5)999-1012(2016 05)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PEP-19/pcp4 has previously been identified as a critical determinant of synaptic plasticity.
Title: MS imaging and mass spectrometric synaptosome profiling identify PEP-19/pcp4 as a synaptic molecule involved in spatial learning in mice.

We further found that Pcp4 gene on the Ts1Rhr trisomic segment is expressed in ependymal cells, and its resumption to two copies rescued both ventricular enlargement and cilia dysfunction in Ts1Rhr mice.
Title: Brain ventriculomegaly in Down syndrome mice is caused by Pcp4 dose-dependent cilia dysfunction.

PCP4 regulates cardiac excitability through both Purkinje cell-autonomous and central mechanisms.
Title: PCP4 regulates Purkinje cell excitability and cardiac rhythmicity.

The PCP4 immunostaining-delineated CA2 neurons have distinguishable differences in cell morphology, physiology, and synaptic circuit connections compared with distal CA3 and proximal CA1 regions.
Title: Distinct physiological and developmental properties of hippocampal CA2 subfield revealed by using anti-Purkinje cell protein 4 (PCP4) immunostaining.

Data show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch.
Title: Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.

The following Pcp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pcp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02780	NM_008791.3 Latest version!	Mus musculus Purkinje cell protein 4 (Pcp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu02780	NM_008791.2	Mus musculus Purkinje cell protein 4 (Pcp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pcp4 ( NM_008791.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032817.1 Mus musculus Purkinje cell protein 4 (Pcp4), mRNA.

Price & Availability↑

CloneID	OMu02780
Clone ID Related Accession (Same CDS sequence)	NM_008791.2 , NM_008791.3
Accession Version	NM_008791.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	Purkinje cell protein 4
Comment

ATGAGTGAGA GACAAAGTGC CGGAGCGACC AACGGAAAAG ACAAGACGTC AGGAGATAAT 
GATGGGCAGA AGAAAGTCCA AGAAGAATTT GATATCGACA TGGATGCACC AGAGACAGAG 
CGTGCAGCTG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAAAA GGCAGGATCA 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032817.1
Translation	MSERQSAGATNGKDKTSGDNDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS

Target ORF information:

RefSeq Version	NM_008791.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus Purkinje cell protein 4 (Pcp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008791.2

ORF Insert Sequence:

ATGAGTGAGA GACAAAGTGC CGGAGCGACC AACGGAAAAG ACAAGACGTC AGGAGATAAT 
GATGGGCAGA AGAAAGTCCA AGAAGAATTT GATATCGACA TGGATGCACC AGAGACAGAG 
CGTGCAGCTG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAAAA GGCAGGATCA 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Pcp4 ( NM_008791.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032817.1 Mus musculus Purkinje cell protein 4 (Pcp4), mRNA.

Price & Availability↑

CloneID	OMu02780
Clone ID Related Accession (Same CDS sequence)	NM_008791.2 , NM_008791.3
Accession Version	NM_008791.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 189bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	calmodulin regulator protein PCP4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061164.1 and CB523728.1. On Jan 19, 2017 this sequence version replaced NM_008791.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061164.1, BU847673.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGA GACAAAGTGC CGGAGCGACC AACGGAAAAG ACAAGACGTC AGGAGATAAT 
GATGGGCAGA AGAAAGTCCA AGAAGAATTT GATATCGACA TGGATGCACC AGAGACAGAG 
CGTGCAGCTG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAAAA GGCAGGATCA 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032817.1
CDS	177..365
Translation	MSERQSAGATNGKDKTSGDNDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS

Target ORF information:

RefSeq Version	NM_008791.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus Purkinje cell protein 4 (Pcp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008791.3

ORF Insert Sequence:

ATGAGTGAGA GACAAAGTGC CGGAGCGACC AACGGAAAAG ACAAGACGTC AGGAGATAAT 
GATGGGCAGA AGAAAGTCCA AGAAGAATTT GATATCGACA TGGATGCACC AGAGACAGAG 
CGTGCAGCTG TGGCCATTCA GTCTCAGTTC AGAAAATTCC AGAAGAAAAA GGCAGGATCA 
CAGTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf.
Developmental biology(2017 Nov)
Magella B,Adam M,Potter AS,Venkatasubramanian M,Chetal K,Hay SB,Salomonis N,Potter SS

MS imaging and mass spectrometric synaptosome profiling identify PEP-19/pcp4 as a synaptic molecule involved in spatial learning in mice.
Biochimica et biophysica acta1865(7)936-945(2017 07)
Aerts J,Laeremans A,Minerva L,Boonen K,Harshavardhan B,D'hooge R,Valkenborg D,Baggerman G,Arckens L

Brain ventriculomegaly in Down syndrome mice is caused by Pcp4 dose-dependent cilia dysfunction.
Human molecular genetics26(5)923-931(2017 03)
Raveau M,Nakahari T,Asada S,Ishihara K,Amano K,Shimohata A,Sago H,Yamakawa K

Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.
Cell reports15(5)999-1012(2016 05)
Woodworth MB,Greig LC,Liu KX,Ippolito GC,Tucker HO,Macklis JD

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Pcp4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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