Igbp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igbp1
Entrez Gene ID	18518
Full Name	immunoglobulin (CD79A) binding protein 1
Synonyms	AI115586,AI662457,AW208785,C81413,Pc52,Tap42,p52
General protein information	Preferred Names immunoglobulin (CD79A) binding protein 1 Names immunoglobulin-binding protein 1 CD79a-binding protein 1 alpha 4 alpha4 phosphoprotein lymphocyte signal transduction molecule alpha 4 phosphoprotein, component, 52 kDa protein phosphatase 2/4/6 regulatory subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_008784.3	NP_032810.4	immunoglobulin-binding protein 1

Pathways from BioSystems

Homologies

	LOC694663	XP_001083324.2
Bos taurus (cattle)	LOC534155	NP_001098458.1
Mus musculus (house mouse)	Igbp1	NP_032810.4
Rattus norvegicus (Norway rat)	Igbp1	NP_113812.1
Homo sapiens (human)	IGBP1	NP_001542.1
Xenopus tropicalis (tropical clawed frog)	igbp1	NP_001072440.1
Canis lupus familiaris (dog)	IGBP1	XP_005641500.1
Drosophila melanogaster (fruit fly)	Tap42	NP_723811.1
Bos taurus (cattle)	IGBP1	NP_001229513.1
Caenorhabditis elegans (roundworm)	ppfr-4	NP_497591.1
Danio rerio (zebrafish)	igbp1	NP_998687.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008797	XP_001237618.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy.
Eleftheriadou O, Boguslavskyi A, Longman MR, Cowan J, Francois A, Heads RJ, Wadzinski BE, Ryan A, Shattock MJ, Snabaitis AK
Basic research in cardiology112(4)37(2017 Jul)

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.
LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW
The Journal of biological chemistry286(20)17665-71(2011 May)

Alpha4 is an essential regulator of PP2A phosphatase activity.
Kong M, Ditsworth D, Lindsten T, Thompson CB
Molecular cell36(1)51-60(2009 Oct)

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.
Grech G, Bl?zquez-Domingo M, Kolbus A, Bakker WJ, M?llner EW, Beug H, von Lindern M
Blood112(7)2750-60(2008 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation.
Title: The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

Alpha4 (Igbp1) plays a required role in regulating the assembly and maintenance of adaptive PP2A phosphatase complexes.
Title: Alpha4 is an essential regulator of PP2A phosphatase activity.

alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6
Title: The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

results show that alpha4, a noncatalytic subunit of protein phosphatase 2A, is required to repress apoptosis in murine cells
Title: The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis.

The following Igbp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igbp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13365	NM_008784.3 Latest version!	Mus musculus immunoglobulin (CD79A) binding protein 1 (Igbp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igbp1 ( NM_008784.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032810.4 Mus musculus immunoglobulin (CD79A) binding protein 1 (Igbp1), mRNA.

Price & Availability↑

CloneID	OMu13365
Clone ID Related Accession (Same CDS sequence)	NM_008784.3
Accession Version	NM_008784.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1023bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	immunoglobulin-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV654442.1, AK017166.1, CX203560.1 and BC056186.1. On Aug 15, 2009 this sequence version replaced NM_008784.2. Sequence Note: An in-frame AUG is located 19 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. CCDS Note: A downstream start codon is annotated for this CCDS representation based on strong conservation in a variety of mammalian species. It should be noted that an alternative upstream start codon, which would result in a protein that is 19 aa longer at the N-terminus, also exists. However, the upstream start codon is mouse-specific and has a weak Kozak signal. It is possible that the upstream start codon is used in mouse at least some of the time, while leaky scanning by ribosomes may allow downstream start codon use more of the time. There is no experimental evidence indicating which start codon is preferentially used in vivo. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK017166.1, BC089567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGT CTGAAGACGA GTTACTGCTG CCGCGGCTTC CGGAGCTCTT TGAAACAAGC 
AAAAAACTTC TGGAGGACGT GGAAGTAGCA ACTGAACCCA CCGGCTCCCG AACAATCCAG 
GATAAGGTGT CCAAAGGACT AGAACTCCTT GAGAAGGCTG CTGGAATGTT ATCGCAGCTT 
GATTTGTTCA GCCGAAATGA AGATCTGGAA GAGATTGCTT CCACCGACCT GAAGTACCTG 
ATGGTGCCAG CGTTGCAAGG AGCCCTCACC ATGAAACAAG TCAACCCCAG CAAGCGTCTA 
GATCATTTGC AGCGGGCTCG AGAACACTTC GTACATTTCT TAACTCAGTG TCATTGCTAT 
CATGTGGCAG AGTTTCAGCT ACCCCAAACC AAGACTAACT CAGCTGAAAA TAATACTGCT 
AGCTCCTCCA TGGCCTATCC AAATCTCGTT GCTATGGCAT CTCAAAGACA GGCTAAAATA 
GAGAGATACA AGCAGAAGAA GGAGGTGGAG CATAGGTTGT CTGCACTGAA ATCTGCTGTG 
GAAAGTGGTC AAGCAGATGA TGAGCGCGTT CGGGAATATC ACCTCCTTCA CCTTCGGAGG 
TGGATTGCTG TCAGCTTAGA AGAGCTTGAG AGCATTGACC AGGAAATAAA GATCCTGAAA 
GAAAAAGACT CTCCAAGAGA GGAAACAGCT TGTCACTCAT CTCTTCCAGA GAAGCCTCCA 
ATGAAACCCT TCATCCTCAC TCGGAACAAG GCACAAGCCA AAGTATTTGG AACTGGTTAT 
CCAAGCCTGG CAACTATGAC GGTGAGTGAC TGGTATGAAC AACATCAAAA ATACGGAGTA 
TTACCCGACC GGGGAATAGC CAAGCCGGCA TCAGCTGATT TCCAAAGAGC AGCTCAGCAG 
CAGGAAGATC AAGAGCAAAA GGATGAGGAG AGTGAGGAGA AAGCCTTGCA CAGGATGCGA 
GAGTGGGACG ACTGGAAGGA CACCCATCCC AGGGGCTACG GCAACCGACA GAACATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032810.4
CDS	76..1098
Translation	MAASEDELLLPRLPELFETSKKLLEDVEVATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVNPSKRLDHLQRAREHFVHFLTQCHCYHVAEFQLPQTKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRLSALKSAVESGQADDERVREYHLLHLRRWIAVSLEELESIDQEIKILKEKDSPREETACHSSLPEKPPMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQHQKYGVLPDRGIAKPASADFQRAAQQQEDQEQKDEESEEKALHRMREWDDWKDTHPRGYGNRQNMG

Target ORF information:

RefSeq Version	NM_008784.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus immunoglobulin (CD79A) binding protein 1 (Igbp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008784.3

ORF Insert Sequence:

ATGGCAGCGT CTGAAGACGA GTTACTGCTG CCGCGGCTTC CGGAGCTCTT TGAAACAAGC 
AAAAAACTTC TGGAGGACGT GGAAGTAGCA ACTGAACCCA CCGGCTCCCG AACAATCCAG 
GATAAGGTGT CCAAAGGACT AGAACTCCTT GAGAAGGCTG CTGGAATGTT ATCGCAGCTT 
GATTTGTTCA GCCGAAATGA AGATCTGGAA GAGATTGCTT CCACCGACCT GAAGTACCTG 
ATGGTGCCAG CGTTGCAAGG AGCCCTCACC ATGAAACAAG TCAACCCCAG CAAGCGTCTA 
GATCATTTGC AGCGGGCTCG AGAACACTTC GTACATTTCT TAACTCAGTG TCATTGCTAT 
CATGTGGCAG AGTTTCAGCT ACCCCAAACC AAGACTAACT CAGCTGAAAA TAATACTGCT 
AGCTCCTCCA TGGCCTATCC AAATCTCGTT GCTATGGCAT CTCAAAGACA GGCTAAAATA 
GAGAGATACA AGCAGAAGAA GGAGGTGGAG CATAGGTTGT CTGCACTGAA ATCTGCTGTG 
GAAAGTGGTC AAGCAGATGA TGAGCGCGTT CGGGAATATC ACCTCCTTCA CCTTCGGAGG 
TGGATTGCTG TCAGCTTAGA AGAGCTTGAG AGCATTGACC AGGAAATAAA GATCCTGAAA 
GAAAAAGACT CTCCAAGAGA GGAAACAGCT TGTCACTCAT CTCTTCCAGA GAAGCCTCCA 
ATGAAACCCT TCATCCTCAC TCGGAACAAG GCACAAGCCA AAGTATTTGG AACTGGTTAT 
CCAAGCCTGG CAACTATGAC GGTGAGTGAC TGGTATGAAC AACATCAAAA ATACGGAGTA 
TTACCCGACC GGGGAATAGC CAAGCCGGCA TCAGCTGATT TCCAAAGAGC AGCTCAGCAG 
CAGGAAGATC AAGAGCAAAA GGATGAGGAG AGTGAGGAGA AAGCCTTGCA CAGGATGCGA 
GAGTGGGACG ACTGGAAGGA CACCCATCCC AGGGGCTACG GCAACCGACA GAACATGGGC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy.
Basic research in cardiology112(4)37(2017 Jul)
Eleftheriadou O,Boguslavskyi A,Longman MR,Cowan J,Francois A,Heads RJ,Wadzinski BE,Ryan A,Shattock MJ,Snabaitis AK

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.
The Journal of biological chemistry286(20)17665-71(2011 May)
LeNoue-Newton M,Watkins GR,Zou P,Germane KL,McCorvey LR,Wadzinski BE,Spiller BW

Alpha4 is an essential regulator of PP2A phosphatase activity.
Molecular cell36(1)51-60(2009 Oct)
Kong M,Ditsworth D,Lindsten T,Thompson CB

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.
Blood112(7)2750-60(2008 Oct)
Grech G,Bl?zquez-Domingo M,Kolbus A,Bakker WJ,M?llner EW,Beug H,von Lindern M

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Igbp1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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