Ogn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ogn
Entrez Gene ID	18295
Full Name	osteoglycin
Synonyms	3110079A16Rik,OG,OIF,SLRR3A,mimecan,mimican
General protein information	Preferred Names osteoglycin Names mimecan
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A5

mRNA and Protein(s)

mRNA	Protein	Name
NM_008760.4	NP_032786.1	mimecan precursor
NM_008760.5	NP_032786.1	mimecan precursor

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	ogn	NP_001013588.1
Homo sapiens (human)	OGN	NP_054776.1
Pan troglodytes (chimpanzee)	OGN	XP_001145422.1
Bos taurus (cattle)	OGN	NP_776371.1
Mus musculus (house mouse)	Ogn	NP_032786.1
Gallus gallus (chicken)	OGN	NP_989540.1
Danio rerio (zebrafish)	zgc:193598	NP_001124122.1
Xenopus tropicalis (tropical clawed frog)	ogn	XP_002934273.1
Rattus norvegicus (Norway rat)	Ogn	NP_001099573.1
	OGN	XP_001103195.2
Canis lupus familiaris (dog)	OGN	XP_853340.2
Rattus norvegicus (Norway rat)	LOC100910855	XP_006253758.1

Gene Ontology
Bibliography

Related articles in PubMed

Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H
Immunity47(6)1100-1113.e6(2017 Dec)

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.
Deckx S, Heggermont W, Carai P, Rienks M, Dresselaers T, Himmelreich U, van Leeuwen R, Lommen W, van der Velden J, Gonzalez A, Diez J, Papageorgiou AP, Heymans S
Matrix biology : journal of the International Society for Matrix Biology(2017 Sep)

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell41(4)349-365.e3(2017 05)

Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.
Freire PP, Cury SS, de Oliveira G, Fernandez GJ, Moraes LN, da Silva Duran BO, Ferreira JH, Fuziwara CS, Kimura ET, Dal-Pai-Silva M, Carvalho RF
PloS one12(11)e0188464(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin.
Title: Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4.
Title: A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis.

elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1).
Title: C/EBP? LIP augments cell death by inducing osteoglycin.

These results reveal a novel pathway in which miR-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells.
Title: Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.

OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
Title: Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway.

The following Ogn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ogn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19511	NM_008760.5 Latest version!	Mus musculus osteoglycin (Ogn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OMu19511	NM_008760.4	Mus musculus osteoglycin (Ogn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ogn ( NM_008760.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032786.1 Mus musculus osteoglycin (Ogn), mRNA.

Price & Availability↑

CloneID	OMu19511
Clone ID Related Accession (Same CDS sequence)	NM_008760.4 , NM_008760.5
Accession Version	NM_008760.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-20
Organism	Mus musculus(house mouse)
Product	mimecan precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC160978.4. On Apr 27, 2007 this sequence version replaced NM_008760.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028300.1, AK053650.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACTG TGCACTCTAC ATTTCTCCTG CTACTCTTCG TGCCTCTGAC ACAGCAAGCA 
CCACAGTCGC AGCTGGACTC ACATGTTAAC TATGAGTATG CAACAGGCAA TTCTGAAGAA 
ACCAAATTTA GCCAGGATTA TGAAGATAAA TACCTGGATG GGAAAAGTAT TAAGGAAAAA 
GAAACTATGA TAATTCCTGA TGAGAAAAGT CTTCAGTTAC AAAAAGATGA AGTTATACCA 
TCATTACCAA CCAAGAAAGA AAATGATGAA ATGCCCACAT GCCTGTTGTG TGTCTGCTTA 
AGTGGCTCTG TCTACTGTGA AGAAGTTGAC ATTGATGCTG TACCACCATT GCCAAAGGAA 
TCAGCTTATC TTTATGCACG ATTCAACAAA ATTAAAAAGC TGACTGCCAA GGATTTTGCA 
GACATGCCAA ACCTAAGAAG ACTTGATTTT ACGGGAAATT TGATAGAAGA CATAGAAGAT 
GGGACTTTTT CAAAACTTTC TCTGTTAGAA GAACTTACAC TTGCTGAAAA CCAACTACTA 
AGACTTCCAG TTCTTCCTCC AAAGCTTACT TTACTTAATG CCAAACACAA CAAAATCAAG 
AGTAAAGGAA TTAAAGCAAA CACATTCAAA AAACTGAATA AACTCTCTTT TCTCTATTTG 
GACCATAACG ACCTGGAATC TGTGCCTCCT AATTTACCAG AAAGTCTACG TGTAATTCAC 
CTTCAGTTTA ACAGCATATC TTCACTTACA GATGATACAT TCTGCAAGGC TAATGACACT 
CGTTACATTC GGGAGCGAAT TGAAGAGATT CGCCTGGAGG GCAATCCAAT TGCTCTGGGA 
AAGCATCCAA ACAGTTTTAT CTGCTTAAAA AGATTACCCA TAGGGTCATA CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032786.1
CDS	127..1023
Translation	METVHSTFLLLLFVPLTQQAPQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF

Target ORF information:

RefSeq Version	NM_008760.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus osteoglycin (Ogn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008760.4

ORF Insert Sequence:

ATGGAGACTG TGCACTCTAC ATTTCTCCTG CTACTCTTCG TGCCTCTGAC ACAGCAAGCA 
CCACAGTCGC AGCTGGACTC ACATGTTAAC TATGAGTATG CAACAGGCAA TTCTGAAGAA 
ACCAAATTTA GCCAGGATTA TGAAGATAAA TACCTGGATG GGAAAAGTAT TAAGGAAAAA 
GAAACTATGA TAATTCCTGA TGAGAAAAGT CTTCAGTTAC AAAAAGATGA AGTTATACCA 
TCATTACCAA CCAAGAAAGA AAATGATGAA ATGCCCACAT GCCTGTTGTG TGTCTGCTTA 
AGTGGCTCTG TCTACTGTGA AGAAGTTGAC ATTGATGCTG TACCACCATT GCCAAAGGAA 
TCAGCTTATC TTTATGCACG ATTCAACAAA ATTAAAAAGC TGACTGCCAA GGATTTTGCA 
GACATGCCAA ACCTAAGAAG ACTTGATTTT ACGGGAAATT TGATAGAAGA CATAGAAGAT 
GGGACTTTTT CAAAACTTTC TCTGTTAGAA GAACTTACAC TTGCTGAAAA CCAACTACTA 
AGACTTCCAG TTCTTCCTCC AAAGCTTACT TTACTTAATG CCAAACACAA CAAAATCAAG 
AGTAAAGGAA TTAAAGCAAA CACATTCAAA AAACTGAATA AACTCTCTTT TCTCTATTTG 
GACCATAACG ACCTGGAATC TGTGCCTCCT AATTTACCAG AAAGTCTACG TGTAATTCAC 
CTTCAGTTTA ACAGCATATC TTCACTTACA GATGATACAT TCTGCAAGGC TAATGACACT 
CGTTACATTC GGGAGCGAAT TGAAGAGATT CGCCTGGAGG GCAATCCAAT TGCTCTGGGA 
AAGCATCCAA ACAGTTTTAT CTGCTTAAAA AGATTACCCA TAGGGTCATA CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ogn ( NM_008760.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032786.1 Mus musculus osteoglycin (Ogn), mRNA.

Price & Availability↑

CloneID	OMu19511
Clone ID Related Accession (Same CDS sequence)	NM_008760.4 , NM_008760.5
Accession Version	NM_008760.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	mimecan precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB630217.1, AK160760.1, AK163772.1 and BE629408.1. On Feb 6, 2019 this sequence version replaced NM_008760.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK053650.1, AK160760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACTG TGCACTCTAC ATTTCTCCTG CTACTCTTCG TGCCTCTGAC ACAGCAAGCA 
CCACAGTCGC AGCTGGACTC ACATGTTAAC TATGAGTATG CAACAGGCAA TTCTGAAGAA 
ACCAAATTTA GCCAGGATTA TGAAGATAAA TACCTGGATG GGAAAAGTAT TAAGGAAAAA 
GAAACTATGA TAATTCCTGA TGAGAAAAGT CTTCAGTTAC AAAAAGATGA AGTTATACCA 
TCATTACCAA CCAAGAAAGA AAATGATGAA ATGCCCACAT GCCTGTTGTG TGTCTGCTTA 
AGTGGCTCTG TCTACTGTGA AGAAGTTGAC ATTGATGCTG TACCACCATT GCCAAAGGAA 
TCAGCTTATC TTTATGCACG ATTCAACAAA ATTAAAAAGC TGACTGCCAA GGATTTTGCA 
GACATGCCAA ACCTAAGAAG ACTTGATTTT ACGGGAAATT TGATAGAAGA CATAGAAGAT 
GGGACTTTTT CAAAACTTTC TCTGTTAGAA GAACTTACAC TTGCTGAAAA CCAACTACTA 
AGACTTCCAG TTCTTCCTCC AAAGCTTACT TTACTTAATG CCAAACACAA CAAAATCAAG 
AGTAAAGGAA TTAAAGCAAA CACATTCAAA AAACTGAATA AACTCTCTTT TCTCTATTTG 
GACCATAACG ACCTGGAATC TGTGCCTCCT AATTTACCAG AAAGTCTACG TGTAATTCAC 
CTTCAGTTTA ACAGCATATC TTCACTTACA GATGATACAT TCTGCAAGGC TAATGACACT 
CGTTACATTC GGGAGCGAAT TGAAGAGATT CGCCTGGAGG GCAATCCAAT TGCTCTGGGA 
AAGCATCCAA ACAGTTTTAT CTGCTTAAAA AGATTACCCA TAGGGTCATA CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032786.1
CDS	183..1079
Translation	METVHSTFLLLLFVPLTQQAPQSQLDSHVNYEYATGNSEETKFSQDYEDKYLDGKSIKEKETMIIPDEKSLQLQKDEVIPSLPTKKENDEMPTCLLCVCLSGSVYCEEVDIDAVPPLPKESAYLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTFCKANDTRYIRERIEEIRLEGNPIALGKHPNSFICLKRLPIGSYF

Target ORF information:

RefSeq Version	NM_008760.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus osteoglycin (Ogn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008760.5

ORF Insert Sequence:

ATGGAGACTG TGCACTCTAC ATTTCTCCTG CTACTCTTCG TGCCTCTGAC ACAGCAAGCA 
CCACAGTCGC AGCTGGACTC ACATGTTAAC TATGAGTATG CAACAGGCAA TTCTGAAGAA 
ACCAAATTTA GCCAGGATTA TGAAGATAAA TACCTGGATG GGAAAAGTAT TAAGGAAAAA 
GAAACTATGA TAATTCCTGA TGAGAAAAGT CTTCAGTTAC AAAAAGATGA AGTTATACCA 
TCATTACCAA CCAAGAAAGA AAATGATGAA ATGCCCACAT GCCTGTTGTG TGTCTGCTTA 
AGTGGCTCTG TCTACTGTGA AGAAGTTGAC ATTGATGCTG TACCACCATT GCCAAAGGAA 
TCAGCTTATC TTTATGCACG ATTCAACAAA ATTAAAAAGC TGACTGCCAA GGATTTTGCA 
GACATGCCAA ACCTAAGAAG ACTTGATTTT ACGGGAAATT TGATAGAAGA CATAGAAGAT 
GGGACTTTTT CAAAACTTTC TCTGTTAGAA GAACTTACAC TTGCTGAAAA CCAACTACTA 
AGACTTCCAG TTCTTCCTCC AAAGCTTACT TTACTTAATG CCAAACACAA CAAAATCAAG 
AGTAAAGGAA TTAAAGCAAA CACATTCAAA AAACTGAATA AACTCTCTTT TCTCTATTTG 
GACCATAACG ACCTGGAATC TGTGCCTCCT AATTTACCAG AAAGTCTACG TGTAATTCAC 
CTTCAGTTTA ACAGCATATC TTCACTTACA GATGATACAT TCTGCAAGGC TAATGACACT 
CGTTACATTC GGGAGCGAAT TGAAGAGATT CGCCTGGAGG GCAATCCAAT TGCTCTGGGA 
AAGCATCCAA ACAGTTTTAT CTGCTTAAAA AGATTACCCA TAGGGTCATA CTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity47(6)1100-1113.e6(2017 Dec)
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H

Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.
Matrix biology : journal of the International Society for Matrix Biology(2017 Sep)
Deckx S,Heggermont W,Carai P,Rienks M,Dresselaers T,Himmelreich U,van Leeuwen R,Lommen W,van der Velden J,Gonzalez A,Diez J,Papageorgiou AP,Heymans S

Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Developmental cell41(4)349-365.e3(2017 05)
Naiman N,Fujioka K,Fujino M,Valerius MT,Potter SS,McMahon AP,Kobayashi A

Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.
PloS one12(11)e0188464(2017)
Freire PP,Cury SS,de Oliveira G,Fernandez GJ,Moraes LN,da Silva Duran BO,Ferreira JH,Fuziwara CS,Kimura ET,Dal-Pai-Silva M,Carvalho RF

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Ogn cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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