Nptx1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nptx1
Entrez Gene ID	18164
Full Name	neuronal pentraxin 1
Synonyms	D11Bwg1004e,Np1
General protein information	Preferred Names neuronal pentraxin 1 Names neuronal pentraxin-1 NP-I neuronal pentraxin I
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 E2\|11 83.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008730.2	NP_032756.1	neuronal pentraxin-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	NPTX1	NP_002513.2
Rattus norvegicus (Norway rat)	Nptx1	NP_714957.1
Xenopus tropicalis (tropical clawed frog)	nptx1	NP_001121479.1
	NPTX1	XP_001110666.2
Pan troglodytes (chimpanzee)	NPTX1	XP_523739.2
Canis lupus familiaris (dog)	NPTX1	XP_540475.2
Mus musculus (house mouse)	Nptx1	NP_032756.1
Gallus gallus (chicken)	NPTX1	XP_420081.3
Danio rerio (zebrafish)	nptx1l	NP_998101.1
Bos taurus (cattle)	NPTX1	NP_001179283.1

Gene Ontology
Bibliography

Related articles in PubMed

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
Farhy-Tselnicker I, van Casteren ACM, Lee A, Chang VT, Aricescu AR, Allen NJ
Neuron96(2)428-445.e13(2017 Oct)

Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice.
Hooper AWM, Alamilla JF, Venier RE, Gillespie DC, Igdoura SA
Human molecular genetics26(4)661-673(2017 02)

Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period.
Gu Y, Tran T, Murase S, Borrell A, Kirkwood A, Quinlan EM
The Journal of neuroscience : the official journal of the Society for Neuroscience36(40)10285-10295(2016 Oct)

Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease.
Akerberg BN, Sarangam ML, Stankunas K
Developmental biology407(1)158-72(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neuronal pentraxin 1 accumulates on the postsynaptic terminal forming functional synapses.
Title: Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.

work highlights a potential role for synaptic proteins, such as NP1 and glutamate receptors in lysosomal storage diseases.
Title: Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice.

Results demonstrate a novel mechanism of neuronal death and predict that inhibition of NP1 expression is a promising strategy to prevent hypoxic-ischemic injury in immature brain
Title: Genetic deletion of neuronal pentraxin 1 expression prevents brain injury in a neonatal mouse model of cerebral hypoxia-ischemia.

results demonstrate that extracellular release of NP1 promote hypoxic-ischemic neuronal death possibly via surface clustering with GluR1 at synaptic sites and that NP1, not its family member NP2, is involved in the neuronal death mechanisms
Title: Critical role of extracellularly secreted neuronal pentraxin 1 in ischemic neuronal death.

Genetic deletion of NP1 prevents hypoxic-ischemic neuronal death by reducing synaptic clustering of GluR1.
Title: Genetic deletion of NP1 prevents hypoxic-ischemic neuronal death via reducing AMPA receptor synaptic localization in hippocampal neurons.

The following Nptx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nptx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02655	NM_008730.2 Latest version!	Mus musculus neuronal pentraxin 1 (Nptx1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nptx1 ( NM_008730.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032756.1 Mus musculus neuronal pentraxin 1 (Nptx1), mRNA.

Price & Availability↑

CloneID	OMu02655
Clone ID Related Accession (Same CDS sequence)	NM_008730.2
Accession Version	NM_008730.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-04
Organism	Mus musculus(house mouse)
Product	neuronal pentraxin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY261600.1, BY288383.1, BY273353.1, AK140128.1 and AL669881.19. On Dec 20, 2006 this sequence version replaced NM_008730.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093479.1, SRR1660817.231933.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGCCG GCCGCGCCGC ACGCACCTGT GCGCTGCTCG CCCTCTGCCT CCTGGGCAGT 
GGGGCCCAAG ATTTCGGGCC GACCCGCTTC ATCTGCACTT CGGTGCCGGT GGATGCAGAC 
ATGTGTGCCG CGTCCGTGGC TGCGGGCGGC GCGGAGGAGC TTCGGAGCAA CGTGCTGCAG 
CTCCGCGAGA CCGTGCTGCA GCAGAAGGAG ACCATCCTCA GCCAGAAGGA GACCATCAGG 
GAGCTGACCA CCAAGCTTGG CCGCTGCGAG AGCCAGAGCA CCCTGGACTC GGGTCCCGGC 
GAGGCCAGGT CGGGAGGCGG CCGCAAGCAG CCTGGCTCGG GCAAGAACAC GATGGGCGAC 
CTGTCCCGGA CGCCGGCCGC GGAGACGCTC AGCCAACTCG GGCAAACTTT GCAATCTCTC 
AAAACCCGAC TGGAGAACCT CGAGCAGTAC AGCCGCCTCA ATTCTTCCAG CCAAACCAAC 
AGCCTCAAGG ATCTGCTGCA GAGCAAGATC GATGACCTGG AGCGGCAGGT GCTGTCTCGG 
GTGAACACTC TGGAGGAGGG GAAAGGGGGC CCCAAGAACG ACACAGAGGA AAGGGCCAAG 
ATCGAGAGCG CCTTGACCTC CCTACACCAA CGGATCAGCG AGCTGGAGAA AGGTCAGAAA 
GACAATCGCC CCGGAGACAA GTTTCAGCTG ACATTCCCAC TGCGGACCAA CTACATGTAT 
GCCAAGGTGA AGAAGAGCCT GCCAGAGATG TATGCCTTCA CCGTGTGCAT GTGGCTCAAG 
TCCAGTGCGG CGCCTGGAGT GGGCACACCC TTCTCTTATG CTGTGCCTGG GCAGGCCAAC 
GAACTGGTCC TCATCGAGTG GGGCAACAAC CCCATGGAGA TACTCATTAA TGACAAGGTG 
GCCAAGCTGC CGTTTGTAAT CAACGATGGC AAATGGCATC ACATCTGTGT CACCTGGACC 
ACCCGGGATG GGGTCTGGGA GGCCTATCAG GATGGCACCC AGGGTGGCAA TGGAGAGAAC 
TTGGCACCCT ATCACCCCAT CAAACCACAG GGCGTGCTGG TGCTGGGTCA GGAACAGGAC 
ACTCTAGGTG GAGGGTTTGA TGCCACCCAA GCATTTGTGG GTGAGCTAGC CCATTTCAAC 
ATCTGGGACC GCAAGCTGAC CCCCGGGGAG GTGTACAACC TGGCCACCTG CAGCAGCAAG 
GCTCTCTCTG GCAATGTCAT CGCCTGGGCT GAGTCCCAGA TCGAGATCTT TGGTGGAGCC 
ACCAAGTGGA CATTCGAGGC TTGTCGCCAG ATCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032756.1
CDS	232..1530
Translation	MLAGRAARTCALLALCLLGSGAQDFGPTRFICTSVPVDADMCAASVAAGGAEELRSNVLQLRETVLQQKETILSQKETIRELTTKLGRCESQSTLDSGPGEARSGGGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTNSLKDLLQSKIDDLERQVLSRVNTLEEGKGGPKNDTEERAKIESALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKSSAAPGVGTPFSYAVPGQANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGNGENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSSKALSGNVIAWAESQIEIFGGATKWTFEACRQIN

Target ORF information:

RefSeq Version	NM_008730.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuronal pentraxin 1 (Nptx1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008730.2

ORF Insert Sequence:

ATGCTGGCCG GCCGCGCCGC ACGCACCTGT GCGCTGCTCG CCCTCTGCCT CCTGGGCAGT 
GGGGCCCAAG ATTTCGGGCC GACCCGCTTC ATCTGCACTT CGGTGCCGGT GGATGCAGAC 
ATGTGTGCCG CGTCCGTGGC TGCGGGCGGC GCGGAGGAGC TTCGGAGCAA CGTGCTGCAG 
CTCCGCGAGA CCGTGCTGCA GCAGAAGGAG ACCATCCTCA GCCAGAAGGA GACCATCAGG 
GAGCTGACCA CCAAGCTTGG CCGCTGCGAG AGCCAGAGCA CCCTGGACTC GGGTCCCGGC 
GAGGCCAGGT CGGGAGGCGG CCGCAAGCAG CCTGGCTCGG GCAAGAACAC GATGGGCGAC 
CTGTCCCGGA CGCCGGCCGC GGAGACGCTC AGCCAACTCG GGCAAACTTT GCAATCTCTC 
AAAACCCGAC TGGAGAACCT CGAGCAGTAC AGCCGCCTCA ATTCTTCCAG CCAAACCAAC 
AGCCTCAAGG ATCTGCTGCA GAGCAAGATC GATGACCTGG AGCGGCAGGT GCTGTCTCGG 
GTGAACACTC TGGAGGAGGG GAAAGGGGGC CCCAAGAACG ACACAGAGGA AAGGGCCAAG 
ATCGAGAGCG CCTTGACCTC CCTACACCAA CGGATCAGCG AGCTGGAGAA AGGTCAGAAA 
GACAATCGCC CCGGAGACAA GTTTCAGCTG ACATTCCCAC TGCGGACCAA CTACATGTAT 
GCCAAGGTGA AGAAGAGCCT GCCAGAGATG TATGCCTTCA CCGTGTGCAT GTGGCTCAAG 
TCCAGTGCGG CGCCTGGAGT GGGCACACCC TTCTCTTATG CTGTGCCTGG GCAGGCCAAC 
GAACTGGTCC TCATCGAGTG GGGCAACAAC CCCATGGAGA TACTCATTAA TGACAAGGTG 
GCCAAGCTGC CGTTTGTAAT CAACGATGGC AAATGGCATC ACATCTGTGT CACCTGGACC 
ACCCGGGATG GGGTCTGGGA GGCCTATCAG GATGGCACCC AGGGTGGCAA TGGAGAGAAC 
TTGGCACCCT ATCACCCCAT CAAACCACAG GGCGTGCTGG TGCTGGGTCA GGAACAGGAC 
ACTCTAGGTG GAGGGTTTGA TGCCACCCAA GCATTTGTGG GTGAGCTAGC CCATTTCAAC 
ATCTGGGACC GCAAGCTGAC CCCCGGGGAG GTGTACAACC TGGCCACCTG CAGCAGCAAG 
GCTCTCTCTG GCAATGTCAT CGCCTGGGCT GAGTCCCAGA TCGAGATCTT TGGTGGAGCC 
ACCAAGTGGA CATTCGAGGC TTGTCGCCAG ATCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation.
Neuron96(2)428-445.e13(2017 Oct)
Farhy-Tselnicker I,van Casteren ACM,Lee A,Chang VT,Aricescu AR,Allen NJ

Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice.
Human molecular genetics26(4)661-673(2017 02)
Hooper AWM,Alamilla JF,Venier RE,Gillespie DC,Igdoura SA

Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(40)10285-10295(2016 Oct)
Gu Y,Tran T,Murase S,Borrell A,Kirkwood A,Quinlan EM

Endocardial Brg1 disruption illustrates the developmental origins of semilunar valve disease.
Developmental biology407(1)158-72(2015 Nov)
Akerberg BN,Sarangam ML,Stankunas K

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Nptx1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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