Ccn3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccn3
Entrez Gene ID	18133
Full Name	nephroblastoma overexpressed gene
Synonyms	C130088N23Rik,CCN3
General protein information	Preferred Names nephroblastoma overexpressed gene Names protein NOV homolog CCN family member 3 nephroblastoma-overexpressed gene protein homolog novH
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15 D1\|15 21.49 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010930.4	NP_035060.1	protein NOV homolog precursor
NM_010930.5	NP_035060.1	CCN family member 3 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NOV	XP_001142595.1
Xenopus tropicalis (tropical clawed frog)	nov	XP_002938019.1
Bos taurus (cattle)	NOV	NP_001095852.1
Mus musculus (house mouse)	Nov	NP_035060.1
Rattus norvegicus (Norway rat)	Nov	NP_110495.1
Homo sapiens (human)	NOV	NP_002505.1
	NOV	XP_001097136.1
Canis lupus familiaris (dog)	NOV	XP_532317.3
Gallus gallus (chicken)	NOV	NP_990599.1

Gene Ontology
Bibliography

Related articles in PubMed

CCN3 secretion is regulated by palmitoylation via ZDHHC22.
Kim Y, Yang H, Min JK, Park YJ, Jeong SH, Jang SW, Shim S
Biochemical and biophysical research communications495(4)2573-2578(2018 Jan)

EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice.
Cao J, Singh SP, McClung JA, Joseph G, Vanella L, Barbagallo I, Jiang H, Falck JR, Arad M, Shapiro JI, Abraham NG
American journal of physiology. Heart and circulatory physiology313(2)H368-H380(2017 Aug)

CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis.
Shi H, Zhang C, Pasupuleti V, Hu X, Prosdocimo DA, Wu W, Qing Y, Wu S, Mohammad H, Gerson SL, Perbal B, Klenotic PA, Dong N, Lin Z
The American journal of pathology187(6)1230-1237(2017 Jun)

Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.
Valenti G, Quinn HM, Heynen GJJE, Lan L, Holland JD, Vogel R, Wulf-Goldenberg A, Birchmeier W
Cancer research77(8)2134-2147(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Administration of EET alters Wnt1, NOV, and HO-1 signaling to prevent obesity-induced cardiomyopathy in obese mice.
Title: EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice.

results show that NOV is a new adipocytokine that could be involved in obesity-associated insulin-resistance.
Title: NOV/CCN3: A New Adipocytokine Involved in Obesity-Associated Insulin Resistance.

Genetic and pharmacological approaches implicated the ERK1/2 pathway as a critical regulator of CCN3-dependent AAA development.
Title: Matricellular protein CCN3 mitigates abdominal aortic aneurysm.

tight regulation of CCN3 expression is necessary for normal cortical neuronal connectivity during development, and RAB25 negatively regulates neuronal differentiation as a downstream effector of CCN3
Title: CCN3 overexpression inhibits growth of callosal projections via upregulation of RAB25.

Reduced NOV expression limits inflammation and interstitial renal fibrosis after obstructive nephropathy in mice.
Title: Reduced NOV/CCN3 Expression Limits Inflammation and Interstitial Renal Fibrosis after Obstructive Nephropathy in Mice.

The following Ccn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23228	NM_010930.5 Latest version!	Mus musculus cellular communication network factor 3 (Ccn3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
View Old Accession Versions >>
OMu23228	NM_010930.4	Mus musculus nephroblastoma overexpressed gene (Nov), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccn3 ( NM_010930.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035060.1 Mus musculus nephroblastoma overexpressed gene (Nov), mRNA.

Price & Availability↑

CloneID	OMu23228
Clone ID Related Accession (Same CDS sequence)	NM_010930.4 , NM_010930.5
Accession Version	NM_010930.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Mus musculus(house mouse)
Product	protein NOV homolog precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC129583.15. On Nov 17, 2006 this sequence version replaced NM_010930.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X96585.1, AK136407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCTCT TCCTGCGAAA GCGATGCCTC TGCCTAGGCT TCCTGCTCTT CCATCTCTTA 
AGTCAAGTCT CTGCATCTCT GCGCTGCCCT TCTCGGTGCC CACCCAAGTG CCCCAGTATA 
TCACCGACCT GCGCCCCCGG GGTGCGCTCG GTGCTGGACG GCTGCTCCTG CTGTCCGGTG 
TGCGCCCGCC AGCGCGGGGA GAGTTGTTCT GAGATGAGAC CCTGTGACCA GAGCAGTGGT 
CTCTACTGTG ACCGCAGCGC AGACCCCAAC AACCAGACTG GCATTTGCAT GGTTCCAGAG 
GGAGACAACT GTGTGTTCGA TGGGGTCATT TACCGCAACG GAGAGAAGTT TGAGCCGAAC 
TGTCAGTACT TCTGCACCTG CAGAGATGGG CAGATTGGCT GTCTGCCCCG CTGCCAGCTA 
GACGTGCTAC TGCCGGGTCC TGACTGCCCA GCTCCGAGAA AAGTCGCAGT GCCAGGGGAG 
TGCTGCGAAA AGTGGACCTG TGGCTCAGAC GAGCAGGGGA CGCAGGGGAC GCTGGGAGGC 
TTGGCCCTTC CAGCCTATAG ACCGGAAGCC ACCGTAGGAG TTGAAGTCTC TGACTCCAGC 
ATTAACTGCA TTGAGCAGAC GACGGAGTGG AGCGCATGTT CCAAGAGCTG TGGAATGGGC 
GTGTCCACCC GGGTCACCAA CAGGAATCGC CAGTGTGAGA TGGTAAAACA GACTCGTCTC 
TGCATCGTTC GGCCTTGTGA ACAAGAGCCC GAGGAAGTAA CAGACAAGAA AGGTAAAAAG 
TGTCTCCGCA CCAAGAAATC CCTGAAAGCC ATCCACCTAC AGTTCGAGAA TTGCACTAGC 
TTGTACACCT ATAAGCCCCG GTTCTGTGGG GTCTGCAGTG ATGGCCGCTG CTGTACCCCC 
CACAACACCA AAACCATCCA GGTGGAGTTT CAGTGTCTCC CGGGGGAAAT CATCAAGAAA 
CCAGTCATGG TCATTGGAAC CTGTACCTGC TACTCCAACT GCCCTCAGAA CAATGAGGCC 
TTCCTCCAAG ATCTGGAGCT GAAGACAAGC AGAGGAGAAA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035060.1
CDS	45..1109
Translation	MSLFLRKRCLCLGFLLFHLLSQVSASLRCPSRCPPKCPSISPTCAPGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNQTGICMVPEGDNCVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPRCQLDVLLPGPDCPAPRKVAVPGECCEKWTCGSDEQGTQGTLGGLALPAYRPEATVGVEVSDSSINCIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEVTDKKGKKCLRTKKSLKAIHLQFENCTSLYTYKPRFCGVCSDGRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYSNCPQNNEAFLQDLELKTSRGEI

Target ORF information:

RefSeq Version	NM_010930.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus nephroblastoma overexpressed gene (Nov), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010930.4

ORF Insert Sequence:

ATGAGCCTCT TCCTGCGAAA GCGATGCCTC TGCCTAGGCT TCCTGCTCTT CCATCTCTTA 
AGTCAAGTCT CTGCATCTCT GCGCTGCCCT TCTCGGTGCC CACCCAAGTG CCCCAGTATA 
TCACCGACCT GCGCCCCCGG GGTGCGCTCG GTGCTGGACG GCTGCTCCTG CTGTCCGGTG 
TGCGCCCGCC AGCGCGGGGA GAGTTGTTCT GAGATGAGAC CCTGTGACCA GAGCAGTGGT 
CTCTACTGTG ACCGCAGCGC AGACCCCAAC AACCAGACTG GCATTTGCAT GGTTCCAGAG 
GGAGACAACT GTGTGTTCGA TGGGGTCATT TACCGCAACG GAGAGAAGTT TGAGCCGAAC 
TGTCAGTACT TCTGCACCTG CAGAGATGGG CAGATTGGCT GTCTGCCCCG CTGCCAGCTA 
GACGTGCTAC TGCCGGGTCC TGACTGCCCA GCTCCGAGAA AAGTCGCAGT GCCAGGGGAG 
TGCTGCGAAA AGTGGACCTG TGGCTCAGAC GAGCAGGGGA CGCAGGGGAC GCTGGGAGGC 
TTGGCCCTTC CAGCCTATAG ACCGGAAGCC ACCGTAGGAG TTGAAGTCTC TGACTCCAGC 
ATTAACTGCA TTGAGCAGAC GACGGAGTGG AGCGCATGTT CCAAGAGCTG TGGAATGGGC 
GTGTCCACCC GGGTCACCAA CAGGAATCGC CAGTGTGAGA TGGTAAAACA GACTCGTCTC 
TGCATCGTTC GGCCTTGTGA ACAAGAGCCC GAGGAAGTAA CAGACAAGAA AGGTAAAAAG 
TGTCTCCGCA CCAAGAAATC CCTGAAAGCC ATCCACCTAC AGTTCGAGAA TTGCACTAGC 
TTGTACACCT ATAAGCCCCG GTTCTGTGGG GTCTGCAGTG ATGGCCGCTG CTGTACCCCC 
CACAACACCA AAACCATCCA GGTGGAGTTT CAGTGTCTCC CGGGGGAAAT CATCAAGAAA 
CCAGTCATGG TCATTGGAAC CTGTACCTGC TACTCCAACT GCCCTCAGAA CAATGAGGCC 
TTCCTCCAAG ATCTGGAGCT GAAGACAAGC AGAGGAGAAA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ccn3 ( NM_010930.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035060.1 Mus musculus cellular communication network factor 3 (Ccn3), mRNA.

Price & Availability↑

CloneID	OMu23228
Clone ID Related Accession (Same CDS sequence)	NM_010930.4 , NM_010930.5
Accession Version	NM_010930.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Mus musculus(house mouse)
Product	CCN family member 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC129583.15. On Jul 6, 2018 this sequence version replaced NM_010930.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X96585.1, AK136407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCTCT TCCTGCGAAA GCGATGCCTC TGCCTAGGCT TCCTGCTCTT CCATCTCTTA 
AGTCAAGTCT CTGCATCTCT GCGCTGCCCT TCTCGGTGCC CACCCAAGTG CCCCAGTATA 
TCACCGACCT GCGCCCCCGG GGTGCGCTCG GTGCTGGACG GCTGCTCCTG CTGTCCGGTG 
TGCGCCCGCC AGCGCGGGGA GAGTTGTTCT GAGATGAGAC CCTGTGACCA GAGCAGTGGT 
CTCTACTGTG ACCGCAGCGC AGACCCCAAC AACCAGACTG GCATTTGCAT GGTTCCAGAG 
GGAGACAACT GTGTGTTCGA TGGGGTCATT TACCGCAACG GAGAGAAGTT TGAGCCGAAC 
TGTCAGTACT TCTGCACCTG CAGAGATGGG CAGATTGGCT GTCTGCCCCG CTGCCAGCTA 
GACGTGCTAC TGCCGGGTCC TGACTGCCCA GCTCCGAGAA AAGTCGCAGT GCCAGGGGAG 
TGCTGCGAAA AGTGGACCTG TGGCTCAGAC GAGCAGGGGA CGCAGGGGAC GCTGGGAGGC 
TTGGCCCTTC CAGCCTATAG ACCGGAAGCC ACCGTAGGAG TTGAAGTCTC TGACTCCAGC 
ATTAACTGCA TTGAGCAGAC GACGGAGTGG AGCGCATGTT CCAAGAGCTG TGGAATGGGC 
GTGTCCACCC GGGTCACCAA CAGGAATCGC CAGTGTGAGA TGGTAAAACA GACTCGTCTC 
TGCATCGTTC GGCCTTGTGA ACAAGAGCCC GAGGAAGTAA CAGACAAGAA AGGTAAAAAG 
TGTCTCCGCA CCAAGAAATC CCTGAAAGCC ATCCACCTAC AGTTCGAGAA TTGCACTAGC 
TTGTACACCT ATAAGCCCCG GTTCTGTGGG GTCTGCAGTG ATGGCCGCTG CTGTACCCCC 
CACAACACCA AAACCATCCA GGTGGAGTTT CAGTGTCTCC CGGGGGAAAT CATCAAGAAA 
CCAGTCATGG TCATTGGAAC CTGTACCTGC TACTCCAACT GCCCTCAGAA CAATGAGGCC 
TTCCTCCAAG ATCTGGAGCT GAAGACAAGC AGAGGAGAAA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035060.1
CDS	63..1127
Translation	MSLFLRKRCLCLGFLLFHLLSQVSASLRCPSRCPPKCPSISPTCAPGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNQTGICMVPEGDNCVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPRCQLDVLLPGPDCPAPRKVAVPGECCEKWTCGSDEQGTQGTLGGLALPAYRPEATVGVEVSDSSINCIEQTTEWSACSKSCGMGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEVTDKKGKKCLRTKKSLKAIHLQFENCTSLYTYKPRFCGVCSDGRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYSNCPQNNEAFLQDLELKTSRGEI

Target ORF information:

RefSeq Version	NM_010930.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus cellular communication network factor 3 (Ccn3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010930.5

ORF Insert Sequence:

ATGAGCCTCT TCCTGCGAAA GCGATGCCTC TGCCTAGGCT TCCTGCTCTT CCATCTCTTA 
AGTCAAGTCT CTGCATCTCT GCGCTGCCCT TCTCGGTGCC CACCCAAGTG CCCCAGTATA 
TCACCGACCT GCGCCCCCGG GGTGCGCTCG GTGCTGGACG GCTGCTCCTG CTGTCCGGTG 
TGCGCCCGCC AGCGCGGGGA GAGTTGTTCT GAGATGAGAC CCTGTGACCA GAGCAGTGGT 
CTCTACTGTG ACCGCAGCGC AGACCCCAAC AACCAGACTG GCATTTGCAT GGTTCCAGAG 
GGAGACAACT GTGTGTTCGA TGGGGTCATT TACCGCAACG GAGAGAAGTT TGAGCCGAAC 
TGTCAGTACT TCTGCACCTG CAGAGATGGG CAGATTGGCT GTCTGCCCCG CTGCCAGCTA 
GACGTGCTAC TGCCGGGTCC TGACTGCCCA GCTCCGAGAA AAGTCGCAGT GCCAGGGGAG 
TGCTGCGAAA AGTGGACCTG TGGCTCAGAC GAGCAGGGGA CGCAGGGGAC GCTGGGAGGC 
TTGGCCCTTC CAGCCTATAG ACCGGAAGCC ACCGTAGGAG TTGAAGTCTC TGACTCCAGC 
ATTAACTGCA TTGAGCAGAC GACGGAGTGG AGCGCATGTT CCAAGAGCTG TGGAATGGGC 
GTGTCCACCC GGGTCACCAA CAGGAATCGC CAGTGTGAGA TGGTAAAACA GACTCGTCTC 
TGCATCGTTC GGCCTTGTGA ACAAGAGCCC GAGGAAGTAA CAGACAAGAA AGGTAAAAAG 
TGTCTCCGCA CCAAGAAATC CCTGAAAGCC ATCCACCTAC AGTTCGAGAA TTGCACTAGC 
TTGTACACCT ATAAGCCCCG GTTCTGTGGG GTCTGCAGTG ATGGCCGCTG CTGTACCCCC 
CACAACACCA AAACCATCCA GGTGGAGTTT CAGTGTCTCC CGGGGGAAAT CATCAAGAAA 
CCAGTCATGG TCATTGGAAC CTGTACCTGC TACTCCAACT GCCCTCAGAA CAATGAGGCC 
TTCCTCCAAG ATCTGGAGCT GAAGACAAGC AGAGGAGAAA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CCN3 secretion is regulated by palmitoylation via ZDHHC22.
Biochemical and biophysical research communications495(4)2573-2578(2018 Jan)
Kim Y,Yang H,Min JK,Park YJ,Jeong SH,Jang SW,Shim S

EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice.
American journal of physiology. Heart and circulatory physiology313(2)H368-H380(2017 Aug)
Cao J,Singh SP,McClung JA,Joseph G,Vanella L,Barbagallo I,Jiang H,Falck JR,Arad M,Shapiro JI,Abraham NG

CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis.
The American journal of pathology187(6)1230-1237(2017 Jun)
Shi H,Zhang C,Pasupuleti V,Hu X,Prosdocimo DA,Wu W,Qing Y,Wu S,Mohammad H,Gerson SL,Perbal B,Klenotic PA,Dong N,Lin Z

Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.
Cancer research77(8)2134-2147(2017 Apr)
Valenti G,Quinn HM,Heynen GJJE,Lan L,Holland JD,Vogel R,Wulf-Goldenberg A,Birchmeier W

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Ccn3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報