Gene Symbol | Nfkbib |
Entrez Gene ID | 18036 |
Full Name | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta |
Synonyms | I(Kappa)B(beta),I-kappa-B-beta,IKB-beta,IKappaBbeta,IkB,IkBb,NF-kappa-BIB,ikB-B |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome | |
Summary | This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. |