Nfkbia cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfkbia
Entrez Gene ID	18035
Full Name	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Synonyms	AI462015,Nfkbi
General protein information	Preferred Names nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Names NF-kappa-B inhibitor alpha I(Kappa)B(alpha) I-kappa-B-alpha I-kappaBalpha ikB-alpha ikappaBalpha nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha nuclear factor of kappa light polyp gene enhancer in B-cell 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 C1

mRNA and Protein(s)

mRNA	Protein	Name
NM_010907.2	NP_035037.2	NF-kappa-B inhibitor alpha

Pathways from BioSystems

Homologies

	NFKBIA	XP_001087842.1
Canis lupus familiaris (dog)	NFKBIA	XP_537413.3
Bos taurus (cattle)	NFKBIA	NP_001039333.1
Danio rerio (zebrafish)	nfkbiaa	NP_998349.1
Pan troglodytes (chimpanzee)	NFKBIA	XP_522823.2
Rattus norvegicus (Norway rat)	Nfkbia	NP_001099190.2
Gallus gallus (chicken)	NFKBIA	NP_001001472.2
Danio rerio (zebrafish)	nfkbiab	NP_955923.1
Anopheles gambiae (African malaria mosquito)	CACT	XP_317542.4
Homo sapiens (human)	NFKBIA	NP_065390.1
Mus musculus (house mouse)	Nfkbia	NP_035037.2
Xenopus tropicalis (tropical clawed frog)	nfkbia	NP_001004851.1
Drosophila melanogaster (fruit fly)	cact	NP_001260496.1

Gene Ontology
Bibliography

Related articles in PubMed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J
Nature communications8(1)1819(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
Title: Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of I?B?.

An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer.
Title: A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance.

Combined computational and biochemical studies indicated that the extent of NF-kappaB-responsive expression of Nfkbia, which encodes IkappaBalpha, inversely correlated with cross-talk. The Nfkbia promoter showed enhanced responsiveness to NF-kappaB activation in macrophages compared to that in fibroblasts
Title: Late-phase synthesis of I?B? insulates the TLR4-activated canonical NF-?B pathway from noncanonical NF-?B signaling in macrophages.

SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades.
Title: SM22? inhibits vascular inflammation via stabilization of I?B? in vascular smooth muscle cells.

GRK6 directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha-induced NF-kappaappaB signaling.
Title: GRK6 phosphorylates I?B? at Ser(32)/Ser(36) and enhances TNF-?-induced inflammation.

The following Nfkbia gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfkbia cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15603	NM_010907.2 Latest version!	Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (Nfkbia), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfkbia ( NM_010907.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035037.2 Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (Nfkbia), mRNA.

Price & Availability↑

CloneID	OMu15603
Clone ID Related Accession (Same CDS sequence)	NM_010907.2
Accession Version	NM_010907.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	NF-kappa-B inhibitor alpha
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158398.2, BC046754.1, AI462015.1 and CF379853.1. On Apr 1, 2009 this sequence version replaced NM_010907.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK161622.1, AK089215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCAGC CAGCTGGGCA CGGCCAGGAC TGGGCCATGG AGGGCCCGCG GGATGGCCTC 
AAGAAGGAGC GCTTGGTGGA CGATCGCCAC GACAGCGGCC TGGACTCCAT GAAGGACGAG 
GAGTACGAGC AAATGGTGAA GGAGCTGCGG GAGATCCGCC TGCAGCCGCA GGAGGCGCCG 
CTGGCCGCCG AGCCCTGGAA GCAGCAGCTC ACGGAGGACG GAGACTCGTT CCTGCACTTG 
GCAATCATCC ACGAAGAGAA GCCGCTGACC ATGGAAGTCA TTGGTCAGGT GAAGGGAGAC 
CTGGCCTTCC TCAACTTCCA GAACAACCTG CAGCAGACTC CACTCCACTT GGCTGTGATC 
ACCAACCAGC CAGGAATTGC TGAGGCACTT CTGAAAGCTG GCTGTGATCC TGAGCTCCGA 
GACTTTCGAG GAAATACCCC TCTACATCTT GCCTGTGAGC AGGGCTGCCT GGCCAGTGTA 
GCAGTCTTGA CGCAGACCTG CACACCCCAG CATCTCCACT CCGTCCTGCA GGCCACCAAC 
TACAATGGCC ACACGTGTCT GCACCTAGCC TCTATCCACG GCTACCTGGC CATCGTGGAG 
CACTTGGTGA CTTTGGGTGC TGATGTCAAC GCTCAGGAGC CCTGCAATGG CCGGACAGCC 
CTCCACCTTG CGGTGGACCT GCAGAATCCT GACCTGGTTT CGCTCTTGTT GAAATGTGGG 
GCTGATGTCA ACAGGGTAAC CTACCAAGGC TACTCCCCCT ACCAGCTTAC CTGGGGCCGC 
CCAAGTACCC GGATACAGCA GCAGCTGGGC CAGCTGACCC TGGAAAATCT CCAGATGCTA 
CCCGAGAGCG AGGATGAGGA GAGCTATGAC ACGGAGTCAG AATTCACAGA GGATGAGCTG 
CCCTATGATG ACTGTGTGTT TGGAGGCCAG CGTCTGACAT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035037.2
CDS	122..1066
Translation	MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEEYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL

Target ORF information:

RefSeq Version	NM_010907.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (Nfkbia), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010907.2

ORF Insert Sequence:

ATGTTTCAGC CAGCTGGGCA CGGCCAGGAC TGGGCCATGG AGGGCCCGCG GGATGGCCTC 
AAGAAGGAGC GCTTGGTGGA CGATCGCCAC GACAGCGGCC TGGACTCCAT GAAGGACGAG 
GAGTACGAGC AAATGGTGAA GGAGCTGCGG GAGATCCGCC TGCAGCCGCA GGAGGCGCCG 
CTGGCCGCCG AGCCCTGGAA GCAGCAGCTC ACGGAGGACG GAGACTCGTT CCTGCACTTG 
GCAATCATCC ACGAAGAGAA GCCGCTGACC ATGGAAGTCA TTGGTCAGGT GAAGGGAGAC 
CTGGCCTTCC TCAACTTCCA GAACAACCTG CAGCAGACTC CACTCCACTT GGCTGTGATC 
ACCAACCAGC CAGGAATTGC TGAGGCACTT CTGAAAGCTG GCTGTGATCC TGAGCTCCGA 
GACTTTCGAG GAAATACCCC TCTACATCTT GCCTGTGAGC AGGGCTGCCT GGCCAGTGTA 
GCAGTCTTGA CGCAGACCTG CACACCCCAG CATCTCCACT CCGTCCTGCA GGCCACCAAC 
TACAATGGCC ACACGTGTCT GCACCTAGCC TCTATCCACG GCTACCTGGC CATCGTGGAG 
CACTTGGTGA CTTTGGGTGC TGATGTCAAC GCTCAGGAGC CCTGCAATGG CCGGACAGCC 
CTCCACCTTG CGGTGGACCT GCAGAATCCT GACCTGGTTT CGCTCTTGTT GAAATGTGGG 
GCTGATGTCA ACAGGGTAAC CTACCAAGGC TACTCCCCCT ACCAGCTTAC CTGGGGCCGC 
CCAAGTACCC GGATACAGCA GCAGCTGGGC CAGCTGACCC TGGAAAATCT CCAGATGCTA 
CCCGAGAGCG AGGATGAGGA GAGCTATGAC ACGGAGTCAG AATTCACAGA GGATGAGCTG 
CCCTATGATG ACTGTGTGTT TGGAGGCCAG CGTCTGACAT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Nature communications8(1)1819(2017 Nov)
Mario Gonzalez-Meljem J,Haston S,Carreno G,Apps JR,Pozzi S,Stache C,Kaushal G,Virasami A,Panousopoulos L,Neda Mousavy-Gharavy S,Guerrero A,Rashid M,Jani N,Goding CR,Jacques TS,Adams DJ,Gil J,Andoniadou CL,Pedro Martinez-Barbera J

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Nfkbia cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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