Ndn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ndn
Entrez Gene ID	17984
Full Name	necdin
Synonyms	AI528698,Peg6
General protein information	Preferred Names necdin Names necdin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 34.36 cM\|7 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_010882.3	NP_035012.2	necdin

Pathways from BioSystems

Homologies

	NDN	NP_001165573.1
Rattus norvegicus (Norway rat)	Ndn	NP_001008558.1
Bos taurus (cattle)	NDN	NP_001014982.1
Mus musculus (house mouse)	Ndn	NP_035012.2
Canis lupus familiaris (dog)	NDN	XP_005618297.1
Homo sapiens (human)	NDN	NP_002478.1
Pan troglodytes (chimpanzee)	NDN	XP_510257.2

Gene Ontology
Bibliography

Related articles in PubMed

Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome.
Matarazzo V, Caccialupi L, Schaller F, Shvarev Y, Kourdougli N, Bertoni A, Menuet C, Voituron N, Deneris E, Gaspar P, Bezin L, Durbec P, Hilaire G, Muscatelli F
eLife6(2017 Oct)

Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
Ju H, Lee S, Lee J, Ghil S
Biochemical and biophysical research communications489(2)109-115(2017 07)

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K
Nature communications710943(2016 Mar)

Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.
Nakagaki A, Osanai H, Kishino T
Gene553(1)63-8(2014 Dec)

The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin.
Ju H, Lee S, Kang S, Kim SS, Ghil S
Cell communication and signaling : CCS1239(2014 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Necdin expression was further associated with suppression of both cell proliferation and death in osteoblasts.
Title: Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.

Data reveal that necdin promotes mitochondrial biogenesis through stabilization of endogenous PGC-1alpha to exert neuroprotection against mitochondrial insults.
Title: Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.

Necdin is a candidate downstream effector for Galphao.
Title: The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin.

Our data suggest that necdin suppresses PIAS1 both by inhibiting SUMO E3 ligase activity and by promoting ubiquitin-dependent degradation.
Title: Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.

Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex.
Title: Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex.

The following Ndn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ndn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14804	NM_010882.3 Latest version!	Mus musculus necdin (Ndn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ndn ( NM_010882.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035012.2 Mus musculus necdin (Ndn), mRNA.

Price & Availability↑

CloneID	OMu14804
Clone ID Related Accession (Same CDS sequence)	NM_010882.3
Accession Version	NM_010882.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	necdin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AU080413.1, AK135444.1 and BY669518.1. On Oct 25, 2006 this sequence version replaced NM_010882.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## imprinted gene :: PMID: 9302265 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGGAAC AAAGTAAGGA CCTGAGCGAC CCTAACTTTG CAGCCGAGGT CCCCGACTGT 
GAGATGCAGG ACAGCGATGC CGTTCCGGTG GGGATCCCTC CTCCCGCTTC TCTGGCCGCT 
AACCTCGCAG GGCCACCGTG CGCTCCCGAA GGCCCTATGG CAGCCCAACA GGCCTCGCCA 
CCGCCCGAAG AACGGATAGA AGATGTTGAC CCTAAAATCC TGCAGCAGGC CGCAGAGGAG 
GGCCGCGCCC ACCAGCCCCA GAGTCCAGCC CGGCCGATCC CAGCACCGCC AGCCCCTGCC 
CAGCTGGTGC AGAAGGCGCA CGAGCTCATG TGGTACGTGT TGGTGAAGGA CCAGAAGAGG 
ATGGTCCTCT GGTTTCCAGA CATGGTGAAA GAGGTCATGG GCAGCTACAA GAAATGGTGC 
AGAAGCATCC TCAGGCGCAC CAGCGTCATC CTCGCCAGAG TGTTCGGGCT GCACCTGAGG 
CTGACCAATC TCCACACCAT GGAGTTTGCC CTGGTCAAAG CCCTCAGCCC AGAGGAGCTA 
GACAGGGTGG CGCTCAACAA CCGTATGCCC ATGACAGGCC TCCTGCTCAT GATCCTGAGC 
CTCATCTATG TGAAGGGCCG CGGGGCCAGA GAGGGTGCGG TCTGGAATGT GCTGCGCATC 
CTGGGGCTGA GGCCCTGGAA GAAGCACTCC ACCTTCGGAG ACGTGAGGAA GATAATCACC 
GAGGAGTTCG TCCAGCAGAA TTACCTGAAG TACCAGCGTG TGCCCCACAT CGAGCCTCCC 
GAGTACGAGT TCTTCTGGGG GTCCAGAGCT AACCGTGAAA TCACCAAGAT GCAGATCATG 
GAGTTCCTGG CCAGAGTCTT CAAGAAAGAT CCCCAGGCGT GGCCTTCCCG ATACAGGGAG 
GCTCTGGAGC AGGCCAGAGC TCTGCGGGAG GCTAATCTTG CTGCCCAGGC CCCCCGCAGC 
AGTGTCTCTG AGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035012.2
CDS	132..1109
Translation	MSEQSKDLSDPNFAAEVPDCEMQDSDAVPVGIPPPASLAANLAGPPCAPEGPMAAQQASPPPEERIEDVDPKILQQAAEEGRAHQPQSPARPIPAPPAPAQLVQKAHELMWYVLVKDQKRMVLWFPDMVKEVMGSYKKWCRSILRRTSVILARVFGLHLRLTNLHTMEFALVKALSPEELDRVALNNRMPMTGLLLMILSLIYVKGRGAREGAVWNVLRILGLRPWKKHSTFGDVRKIITEEFVQQNYLKYQRVPHIEPPEYEFFWGSRANREITKMQIMEFLARVFKKDPQAWPSRYREALEQARALREANLAAQAPRSSVSED

Target ORF information:

RefSeq Version	NM_010882.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus necdin (Ndn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010882.3

ORF Insert Sequence:

ATGTCGGAAC AAAGTAAGGA CCTGAGCGAC CCTAACTTTG CAGCCGAGGT CCCCGACTGT 
GAGATGCAGG ACAGCGATGC CGTTCCGGTG GGGATCCCTC CTCCCGCTTC TCTGGCCGCT 
AACCTCGCAG GGCCACCGTG CGCTCCCGAA GGCCCTATGG CAGCCCAACA GGCCTCGCCA 
CCGCCCGAAG AACGGATAGA AGATGTTGAC CCTAAAATCC TGCAGCAGGC CGCAGAGGAG 
GGCCGCGCCC ACCAGCCCCA GAGTCCAGCC CGGCCGATCC CAGCACCGCC AGCCCCTGCC 
CAGCTGGTGC AGAAGGCGCA CGAGCTCATG TGGTACGTGT TGGTGAAGGA CCAGAAGAGG 
ATGGTCCTCT GGTTTCCAGA CATGGTGAAA GAGGTCATGG GCAGCTACAA GAAATGGTGC 
AGAAGCATCC TCAGGCGCAC CAGCGTCATC CTCGCCAGAG TGTTCGGGCT GCACCTGAGG 
CTGACCAATC TCCACACCAT GGAGTTTGCC CTGGTCAAAG CCCTCAGCCC AGAGGAGCTA 
GACAGGGTGG CGCTCAACAA CCGTATGCCC ATGACAGGCC TCCTGCTCAT GATCCTGAGC 
CTCATCTATG TGAAGGGCCG CGGGGCCAGA GAGGGTGCGG TCTGGAATGT GCTGCGCATC 
CTGGGGCTGA GGCCCTGGAA GAAGCACTCC ACCTTCGGAG ACGTGAGGAA GATAATCACC 
GAGGAGTTCG TCCAGCAGAA TTACCTGAAG TACCAGCGTG TGCCCCACAT CGAGCCTCCC 
GAGTACGAGT TCTTCTGGGG GTCCAGAGCT AACCGTGAAA TCACCAAGAT GCAGATCATG 
GAGTTCCTGG CCAGAGTCTT CAAGAAAGAT CCCCAGGCGT GGCCTTCCCG ATACAGGGAG 
GCTCTGGAGC AGGCCAGAGC TCTGCGGGAG GCTAATCTTG CTGCCCAGGC CCCCCGCAGC 
AGTGTCTCTG AGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome.
eLife6(2017 Oct)
Matarazzo V,Caccialupi L,Schaller F,Shvarev Y,Kourdougli N,Bertoni A,Menuet C,Voituron N,Deneris E,Gaspar P,Bezin L,Durbec P,Hilaire G,Muscatelli F

Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
Biochemical and biophysical research communications489(2)109-115(2017 07)
Ju H,Lee S,Lee J,Ghil S

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
Nature communications710943(2016 Mar)
Hasegawa K,Yasuda T,Shiraishi C,Fujiwara K,Przedborski S,Mochizuki H,Yoshikawa K

Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.
Gene553(1)63-8(2014 Dec)
Nakagaki A,Osanai H,Kishino T

The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin.
Cell communication and signaling : CCS1239(2014 Jul)
Ju H,Lee S,Kang S,Kim SS,Ghil S

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Ndn cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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