Myl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Myl2
Entrez Gene ID	17906
Full Name	myosin, light polypeptide 2, regulatory, cardiac, slow
Synonyms	MLC-2,MLC-2s/v,MLC-2v,Mlc2v,Mylpc
General protein information	Preferred Names myosin, light polypeptide 2, regulatory, cardiac, slow Names myosin regulatory light chain 2, ventricular/cardiac muscle isoform myosin light chain 2, slow skeletal/ventricular muscle isoform myosin light chain 2v myosin light chain, phosphorylatable, cardiac ventricles
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
NM_010861.4	NP_034991.3	myosin regulatory light chain 2, ventricular/cardiac muscle isoform
XM_006530186.3	XP_006530249.1	myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1
XM_006530186.4	XP_006530249.2	myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Myl2	NP_001030329.2
Gallus gallus (chicken)	MYL2	NP_001258858.1
Canis lupus familiaris (dog)	MYL2	NP_001003069.1
Danio rerio (zebrafish)	myl2b	NP_001035134.1
Danio rerio (zebrafish)	LOC100537244	XP_003198611.2
Xenopus tropicalis (tropical clawed frog)	myl2	NP_001107717.1
Pan troglodytes (chimpanzee)	MYL2	XP_001144828.2
Mus musculus (house mouse)	Myl2	NP_034991.3
Bos taurus (cattle)	MYL2	NP_001030197.1
Homo sapiens (human)	MYL2	NP_000423.2
	MYL2	XP_001100796.1

Gene Ontology
Bibliography

Related articles in PubMed

Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.
Sheikh F, Lyon RC, Chen J
Gene569(1)14-20(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

transgenic mouse models of hypertrophic cardiomyopathy may be caused by mutations in myosin regulatory light chain
Title: Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.

MLC2 phosphorylation regulates actin-based cytokinesis in mouse oocytes, and this regulation may be mediated via a RhoA-MLC2-actin pathway.
Title: RhoA-mediated MLC2 regulates actin dynamics for cytokinesis in meiosis.

Treatment of mice with an AT1R biased ligand, acting via beta-arrestin signalling, is able to induce an increase in cardiac contractility associated with an increase in ventricular myosin light chain-2 phosphorylation
Title: Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
Title: Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.

Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.
Title: Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

The following Myl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu19730	NM_010861.4 Latest version!	Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu35810	XM_006530186.3 Latest version!	Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu19730	XM_006530186.4 Latest version!	Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Myl2 ( NM_010861.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034991.3 Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), mRNA.

Price & Availability↑

CloneID	OMu19730
Clone ID Related Accession (Same CDS sequence)	NM_010861.4 , XM_006530186.4
Accession Version	NM_010861.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140353.2, AK002367.1 and BX529018.1. On Jan 11, 2017 this sequence version replaced NM_010861.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061144.1, CA786999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCACCAA AGAAAGCCAA GAAGCGGATA GAAGGCGGGA GCTCCAACGT GTTCTCCATG 
TTTGAGCAGA CCCAGATCCA GGAGTTCAAG GAAGCCTTCA CAATCATGGA CCAGAACAGA 
GACGGCTTCA TCGACAAGAA TGACCTAAGG GACACATTTG CTGCCCTAGG ACGAGTGAAC 
GTGAAAAATG AAGAGATCGA TGAAATGATC AAAGAGGCTC CAGGTCCAAT TAACTTCACC 
GTGTTCCTCA CGATGTTTGG GGAGAAACTT AAAGGGGCTG ATCCTGAAGA GACCATTCTC 
AACGCATTCA AGGTGTTTGA TCCCGAGGGC AAAGGGTCAC TGAAGGCTGA CTATGTCCGG 
GAGATGCTGA CCACACAAGC AGAGAGGTTC TCCAAAGAGG AGATCGACCA GATGTTCGCA 
GCCTTTCCCC CTGACGTCAC CGGCAATCTT GATTATAAGA ATTTGGTCCA CATCATTACC 
CACGGAGAAG AGAAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034991.3
CDS	77..577
Translation	MAPKKAKKRIEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD

Target ORF information:

RefSeq Version	NM_010861.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010861.4

ORF Insert Sequence:

ATGGCACCAA AGAAAGCCAA GAAGCGGATA GAAGGCGGGA GCTCCAACGT GTTCTCCATG 
TTTGAGCAGA CCCAGATCCA GGAGTTCAAG GAAGCCTTCA CAATCATGGA CCAGAACAGA 
GACGGCTTCA TCGACAAGAA TGACCTAAGG GACACATTTG CTGCCCTAGG ACGAGTGAAC 
GTGAAAAATG AAGAGATCGA TGAAATGATC AAAGAGGCTC CAGGTCCAAT TAACTTCACC 
GTGTTCCTCA CGATGTTTGG GGAGAAACTT AAAGGGGCTG ATCCTGAAGA GACCATTCTC 
AACGCATTCA AGGTGTTTGA TCCCGAGGGC AAAGGGTCAC TGAAGGCTGA CTATGTCCGG 
GAGATGCTGA CCACACAAGC AGAGAGGTTC TCCAAAGAGG AGATCGACCA GATGTTCGCA 
GCCTTTCCCC CTGACGTCAC CGGCAATCTT GATTATAAGA ATTTGGTCCA CATCATTACC 
CACGGAGAAG AGAAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Myl2 ( XM_006530186.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530249.1 Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu35810
Clone ID Related Accession (Same CDS sequence)	XM_006530186.3
Accession Version	XM_006530186.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530186.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGTTAT TTTTAACCCC AGGGGAGAGG TATTTATTGT TCCACAGCAG GGGCAGAGGC 
CAGCAGGCTC CTCGAACTCT CCAGAGGTGG CAACTGGCCT CAGACACCAT GGCACCAAAG 
AAAGCCAAGA AGCGGATAGA AGGCGGGAGC TCCAACGTGT TCTCCATGTT TGAGCAGACC 
CAGATCCAGG AGTTCAAGGA AGCCTTCACA ATCATGGACC AGAACAGAGA CGGCTTCATC 
GACAAGAATG ACCTAAGGGA CACATTTGCT GCCCTAGGAC GAGTGAACGT GAAAAATGAA 
GAGATCGATG AAATGATCAA AGAGGCTCCA GGTCCAATTA ACTTCACCGT GTTCCTCACG 
ATGTTTGGGG AGAAACTTAA AGGGGCTGAT CCTGAAGAGA CCATTCTCAA CGCATTCAAG 
GTGTTTGATC CCGAGGGCAA AGGGTCACTG AAGGCTGACT ATGTCCGGGA GATGCTGACC 
ACACAAGCAG AGAGGTTCTC CAAAGAGGAG ATCGACCAGA TGTTCGCAGC CTTTCCCCCT 
GACGTCACCG GCAATCTTGA TTATAAGAAT TTGGTCCACA TCATTACCCA CGGAGAAGAG 
AAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530249.1
CDS	16..624
Translation	MGLFLTPGERYLLFHSRGRGQQAPRTLQRWQLASDTMAPKKAKKRIEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD

Target ORF information:

RefSeq Version	XM_006530186.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530186.3

ORF Insert Sequence:

ATGGGGTTAT TTTTAACCCC AGGGGAGAGG TATTTATTGT TCCACAGCAG GGGCAGAGGC 
CAGCAGGCTC CTCGAACTCT CCAGAGGTGG CAACTGGCCT CAGACACCAT GGCACCAAAG 
AAAGCCAAGA AGCGGATAGA AGGCGGGAGC TCCAACGTGT TCTCCATGTT TGAGCAGACC 
CAGATCCAGG AGTTCAAGGA AGCCTTCACA ATCATGGACC AGAACAGAGA CGGCTTCATC 
GACAAGAATG ACCTAAGGGA CACATTTGCT GCCCTAGGAC GAGTGAACGT GAAAAATGAA 
GAGATCGATG AAATGATCAA AGAGGCTCCA GGTCCAATTA ACTTCACCGT GTTCCTCACG 
ATGTTTGGGG AGAAACTTAA AGGGGCTGAT CCTGAAGAGA CCATTCTCAA CGCATTCAAG 
GTGTTTGATC CCGAGGGCAA AGGGTCACTG AAGGCTGACT ATGTCCGGGA GATGCTGACC 
ACACAAGCAG AGAGGTTCTC CAAAGAGGAG ATCGACCAGA TGTTCGCAGC CTTTCCCCCT 
GACGTCACCG GCAATCTTGA TTATAAGAAT TTGGTCCACA TCATTACCCA CGGAGAAGAG 
AAGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Myl2 ( XM_006530186.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530249.2 Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu19730
Clone ID Related Accession (Same CDS sequence)	NM_010861.4 , XM_006530186.4
Accession Version	XM_006530186.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530186.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCACCAA AGAAAGCCAA GAAGCGGATA GAAGGCGGGA GCTCCAACGT GTTCTCCATG 
TTTGAGCAGA CCCAGATCCA GGAGTTCAAG GAAGCCTTCA CAATCATGGA CCAGAACAGA 
GACGGCTTCA TCGACAAGAA TGACCTAAGG GACACATTTG CTGCCCTAGG ACGAGTGAAC 
GTGAAAAATG AAGAGATCGA TGAAATGATC AAAGAGGCTC CAGGTCCAAT TAACTTCACC 
GTGTTCCTCA CGATGTTTGG GGAGAAACTT AAAGGGGCTG ATCCTGAAGA GACCATTCTC 
AACGCATTCA AGGTGTTTGA TCCCGAGGGC AAAGGGTCAC TGAAGGCTGA CTATGTCCGG 
GAGATGCTGA CCACACAAGC AGAGAGGTTC TCCAAAGAGG AGATCGACCA GATGTTCGCA 
GCCTTTCCCC CTGACGTCAC CGGCAATCTT GATTATAAGA ATTTGGTCCA CATCATTACC 
CACGGAGAAG AGAAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530249.2
CDS	103..603
Translation	MAPKKAKKRIEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD

Target ORF information:

RefSeq Version	XM_006530186.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus myosin, light polypeptide 2, regulatory, cardiac, slow (Myl2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530186.4

ORF Insert Sequence:

ATGGCACCAA AGAAAGCCAA GAAGCGGATA GAAGGCGGGA GCTCCAACGT GTTCTCCATG 
TTTGAGCAGA CCCAGATCCA GGAGTTCAAG GAAGCCTTCA CAATCATGGA CCAGAACAGA 
GACGGCTTCA TCGACAAGAA TGACCTAAGG GACACATTTG CTGCCCTAGG ACGAGTGAAC 
GTGAAAAATG AAGAGATCGA TGAAATGATC AAAGAGGCTC CAGGTCCAAT TAACTTCACC 
GTGTTCCTCA CGATGTTTGG GGAGAAACTT AAAGGGGCTG ATCCTGAAGA GACCATTCTC 
AACGCATTCA AGGTGTTTGA TCCCGAGGGC AAAGGGTCAC TGAAGGCTGA CTATGTCCGG 
GAGATGCTGA CCACACAAGC AGAGAGGTTC TCCAAAGAGG AGATCGACCA GATGTTCGCA 
GCCTTTCCCC CTGACGTCAC CGGCAATCTT GATTATAAGA ATTTGGTCCA CATCATTACC 
CACGGAGAAG AGAAGGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.
Gene569(1)14-20(2015 Sep)
Sheikh F,Lyon RC,Chen J

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Myl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報