Gadd45b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gadd45b
Entrez Gene ID	17873
Full Name	growth arrest and DNA-damage-inducible 45 beta
Synonyms	AI323528,Myd118
General protein information	Preferred Names growth arrest and DNA-damage-inducible 45 beta Names growth arrest and DNA damage-inducible protein GADD45 beta myeloid differentiation primary response gene 118 myeloid differentiation primary response protein MyD118 negative growth regulatory protein MyD118
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10 C1\|10 39.72 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008655.1	NP_032681.1	growth arrest and DNA damage-inducible protein GADD45 beta

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GADD45B	XP_001151983.1
Canis lupus familiaris (dog)	GADD45B	XP_542187.1
Gallus gallus (chicken)	LOC100859853	XP_003643868.2
Xenopus tropicalis (tropical clawed frog)	gadd45b	XP_002941163.2
	GADD45B	XP_001098598.1
Bos taurus (cattle)	GADD45B	NP_001035694.1
Mus musculus (house mouse)	Gadd45b	NP_032681.1
Danio rerio (zebrafish)	gadd45ba	NP_998196.1
Danio rerio (zebrafish)	gadd45bb	NP_001012386.1
Rattus norvegicus (Norway rat)	Gadd45b	NP_001008322.1
Homo sapiens (human)	GADD45B	NP_056490.2

Gene Ontology
Bibliography

Related articles in PubMed

GADD45? loss ablates innate immunosuppression in cancer.
Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes S, Sica A, Alesse E, Zazzeroni F, Franzoso G
Cancer research(2017 Dec)

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons.
Frangeul L, Kehayas V, Sanchez-Mut JV, Fi?vre S, Krishna-K K, Pouchelon G, Telley L, Bellone C, Holtmaat A, Gr?ff J, Macklis JD, Jabaudon D
Nature communications8(1)2015(2017 Dec)

Epigenetic Modulation of Intestinal Na
Kumar A, Malhotra P, Coffing HP, Priyamvada S, Natarajan Anbazhagan A, Krishnan HR, Gill RK, Alrefai WA, Gavin DP, Pandey SC, Dudeja PK, Saksena S
American journal of physiology. Gastrointestinal and liver physiologyajpgi002932017(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study indicates that PPAR alpha activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver and that epigenetic change at the Gadd45b promoter is critical for Gadd45b induction.
Title: PPAR? activation drives demethylation of the CpG islands of the Gadd45b promoter in the mouse liver.

Using whole-body knockout mice as well as liver/hepatocyte-specific gain- and loss-of-function strategies, the authors revealed a role for liver GADD45beta in the coordination of liver fatty acid uptake, through cytoplasmic retention of FABP1, ultimately impacting obesity-driven hyperglycaemia.
Title: Fasting-induced liver GADD45? restrains hepatic fatty acid uptake and improves metabolic health.

Data suggest that the increased expression of Gadd45beta induced by repeated administration of L-DOPA may be beneficial in patients with Parkinson's disease.
Title: Gadd45? ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model.

Results indicate a role for Gadd45b in stress-induced senescence and in tissue aging.
Title: Gadd45b deficiency promotes premature senescence and skin aging.

lower nucleus accumbens levels may affect Bdnf expression possibly leading to altered alcohol-drinking behavior
Title: Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors.

The following Gadd45b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gadd45b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14584	NM_008655.1 Latest version!	Mus musculus growth arrest and DNA-damage-inducible 45 beta (Gadd45b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gadd45b ( NM_008655.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032681.1 Mus musculus growth arrest and DNA-damage-inducible 45 beta (Gadd45b), mRNA.

Price & Availability↑

CloneID	OMu14584
Clone ID Related Accession (Same CDS sequence)	NM_008655.1
Accession Version	NM_008655.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	growth arrest and DNA damage-inducible protein GADD45 beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X54149.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X54149.1, AK149895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGACCCTGG AAGAGCTGGT GGCGAGCGAC AACGCGGTTC AGAAGATGCA GGCGGTGACT 
GCCGCGGTGG AGCAGCTGCT GGTGGCCGCG CAGCGTCAGG ATCGCCTCAC CGTGGGGGTG 
TACGAGGCGG CCAAACTGAT GAATGTGGAC CCCGACAGCG TGGTCTTGTG CCTCCTGGCC 
ATAGACGAAG AAGAGGAGGA TGATATCGCT CTGCAGATTC ACTTCACCCT GATCCAGTCG 
TTCTGCTGCG ACAATGACAT TGACATCGTC CGGGTATCAG GCATGCAGAG GCTGGCGCAG 
CTCCTGGGGG AGCCGGCGGA GACATTGGGC ACAACCGAAG CCCGAGACCT GCACTGCCTC 
CTGGTCACGA ACTGTCATAC AGATTCCTGG AAAAGCCAAG GCTTGGTGGA GGTGGCCAGT 
TACTGTGAAG AGAGCAGAGG CAATAACCAA TGGGTCCCCT ATATCTCTCT AGAGGAACGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032681.1
CDS	226..708
Translation	MTLEELVASDNAVQKMQAVTAAVEQLLVAAQRQDRLTVGVYEAAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDIDIVRVSGMQRLAQLLGEPAETLGTTEARDLHCLLVTNCHTDSWKSQGLVEVASYCEESRGNNQWVPYISLEER

Target ORF information:

RefSeq Version	NM_008655.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus growth arrest and DNA-damage-inducible 45 beta (Gadd45b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008655.1

ORF Insert Sequence:

ATGACCCTGG AAGAGCTGGT GGCGAGCGAC AACGCGGTTC AGAAGATGCA GGCGGTGACT 
GCCGCGGTGG AGCAGCTGCT GGTGGCCGCG CAGCGTCAGG ATCGCCTCAC CGTGGGGGTG 
TACGAGGCGG CCAAACTGAT GAATGTGGAC CCCGACAGCG TGGTCTTGTG CCTCCTGGCC 
ATAGACGAAG AAGAGGAGGA TGATATCGCT CTGCAGATTC ACTTCACCCT GATCCAGTCG 
TTCTGCTGCG ACAATGACAT TGACATCGTC CGGGTATCAG GCATGCAGAG GCTGGCGCAG 
CTCCTGGGGG AGCCGGCGGA GACATTGGGC ACAACCGAAG CCCGAGACCT GCACTGCCTC 
CTGGTCACGA ACTGTCATAC AGATTCCTGG AAAAGCCAAG GCTTGGTGGA GGTGGCCAGT 
TACTGTGAAG AGAGCAGAGG CAATAACCAA TGGGTCCCCT ATATCTCTCT AGAGGAACGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GADD45? loss ablates innate immunosuppression in cancer.
Cancer research(2017 Dec)
Verzella D,Bennett J,Fischietti M,Thotakura AK,Recordati C,Pasqualini F,Capece D,Vecchiotti D,D'Andrea D,Di Francesco B,De Maglie M,Begalli F,Tornatore L,Papa S,Lawrence T,Forbes S,Sica A,Alesse E,Zazzeroni F,Franzoso G

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons.
Nature communications8(1)2015(2017 Dec)
Frangeul L,Kehayas V,Sanchez-Mut JV,Fi?vre S,Krishna-K K,Pouchelon G,Telley L,Bellone C,Holtmaat A,Gr?ff J,Macklis JD,Jabaudon D

Epigenetic Modulation of Intestinal Na
American journal of physiology. Gastrointestinal and liver physiologyajpgi002932017(2017 Nov)
Kumar A,Malhotra P,Coffing HP,Priyamvada S,Natarajan Anbazhagan A,Krishnan HR,Gill RK,Alrefai WA,Gavin DP,Pandey SC,Dudeja PK,Saksena S

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Gadd45b cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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