Mvk cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mvk
Entrez Gene ID	17855
Full Name	mevalonate kinase
Synonyms	2310010A05Rik,AI256848,AI414037,MK
General protein information	Preferred Names mevalonate kinase Names mevalonate kinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 F\|5 55.99 cM
Summary	This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006530183.3	XP_006530246.1	mevalonate kinase isoform X1
NM_001306205.1	NP_001293134.1	mevalonate kinase isoform 1
XM_006530185.3	XP_006530248.1	mevalonate kinase isoform X2
XM_006530185.4	XP_006530248.1	mevalonate kinase isoform X2
NM_023556.3	NP_076045.1	mevalonate kinase isoform 2
XM_006530185.2	XP_006530248.1	mevalonate kinase isoform X1
XM_006530183.2	XP_006530246.1	mevalonate kinase isoform X1

Pathways from BioSystems

Homologies

	MVK	XP_001105815.1
Canis lupus familiaris (dog)	MVK	XP_005636378.1
Schizosaccharomyces pombe (fission yeast)	erg12	NP_592837.1
Homo sapiens (human)	MVK	NP_001107657.1
Pan troglodytes (chimpanzee)	MVK	XP_003313983.1
Magnaporthe oryzae (rice blast fungus)	MGG_16219	XP_003709688.1
Xenopus tropicalis (tropical clawed frog)	mvk	XP_002932110.2
Gallus gallus (chicken)	MVK	XP_001231562.3
Danio rerio (zebrafish)	mvk	NP_001007350.1
Neurospora crassa	NCU03633	XP_961360.1
Bos taurus (cattle)	MVK	NP_001015528.1
Mus musculus (house mouse)	Mvk	NP_076045.1
Rattus norvegicus (Norway rat)	Mvk	NP_112325.1
Kluyveromyces lactis	KLLA0C07469g	XP_452532.1
Eremothecium gossypii	AGOS_AER335W	NP_985191.1
Gallus gallus (chicken)	LOC100857437	XP_003643684.2
Caenorhabditis elegans (roundworm)	mvk-1	NP_001022869.1
Saccharomyces cerevisiae (baker's yeast)	ERG12	NP_013935.1
Arabidopsis thaliana (thale cress)	MK	NP_198097.1
Oryza sativa (rice)	Os10g0329300	NP_001064360.1

Gene Ontology
Bibliography

Related articles in PubMed

Normalization of Hepatic Homeostasis in the
Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, Sturley SL
The Journal of biological chemistry292(11)4395-4410(2017 03)

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
Lowther KM, Favero F, Yang CR, Taylor HS, Seli E
Biology of reproduction96(2)341-351(2017 02)

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K
Journal of lipid research57(3)410-21(2016 Mar)

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
?i?ecio?lu M, Budak H, Geffers L, ?ankaya M, ?iftci M, Thaller C, Eichele G, K?frevio?lu ??, ?zdemir H
Journal of lipid research56(8)1551-9(2015 Aug)

Knockdown of MVK does not lead to changes in NALP3 expression or activation.
Celsi F, Piscianz E, Romano M, Crovella S
Journal of inflammation (London, England)127(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analyis of the aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome
Title: Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS).

PTH stimulated BMP-2 mRNA expression via the mevalonate pathway and ROK in osteoblastic MC3T3-E1 cells
Title: Parathyroid hormone upregulates BMP-2 mRNA expression through mevalonate kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells.

a mevalonate kinase (Mvk) allele deletion yields a murine model of hyper-IgD syndrome
Title: Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome.

The following Mvk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mvk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu35809	NM_001306205.1 Latest version!	Mus musculus mevalonate kinase (Mvk), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OMu04038	NM_023556.3 Latest version!	Mus musculus mevalonate kinase (Mvk), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu04038	XM_006530185.4 Latest version!	Mus musculus mevalonate kinase (Mvk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu35809	XM_006530183.3 Latest version!	Mus musculus mevalonate kinase (Mvk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OMu04038	XM_006530185.3	Mus musculus mevalonate kinase (Mvk), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu04038	XM_006530185.2	Mus musculus mevalonate kinase (Mvk), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu35809	XM_006530183.2	Mus musculus mevalonate kinase (Mvk), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mvk ( NM_001306205.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001293134.1 Mus musculus mevalonate kinase (Mvk), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu35809
Clone ID Related Accession (Same CDS sequence)	XM_006530183.3 , NM_001306205.1 , XM_006530183.2
Accession Version	NM_001306205.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1224bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	mevalonate kinase isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132102.3, AK149630.1 and AI849730.1. On Apr 19, 2015 this sequence version replaced XM_006530184.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGGCCT CTCACCCACC 
TGTTTGTTTG CCCGTGTGAC AGAGCAAGGT GATGTCTCGG TACCCACCTT GGAGCAACTG 
GAGAAGCTAA AGAAGATGGG GGACCTCCCC AGAGACCGTG CAGGCAATGA AGGCATGGCT 
CTGCTTGCCT TTCTCTACCT GTACCTGGCA ATCTGCCGGA AGCAGAGGAC ACTCCCGAGC 
CTGGACATGG TGGTGTGGTC GGAACTTCCC CCCGGGGCAG GCTTGGGCTC CAGCGCCGCC 
TACTCTGTGT GTCTGGCAGC CGCCCTCCTG ACTGCCTGTG AGGAGGTCTC CAACCCGCTC 
AAGGACGGGG TCTCCGTCAG CAGGTGGCCC GAGGAAGATC TGAAGTCAAT CAACAAGTGG 
GCCTTCGAAG GGGAGAGAGT GATCCATGGG AACCCTTCTG GTGTGGACAA TGCCGTCAGC 
ACCTGGGGCG GAGCCCTGCG CTTCCAGCAA GGGACGATGT CTTCCTTGAA GAGCCTCCCG 
TCTCTGCAGA TCCTGCTCAC CAACACCAAG GTCCCGCGGA GTACCAAGGC CCTTGTGGCT 
GCTGTCAGAA GCAGGCTGAC CAAGTTCCCT GAGATTGTGG CCCCGCTGCT GACCTCCATT 
GACGCAATAT CCCTGGAGTG TGAGCGCGTG CTAGGGGAGA TGGTGGCAGC TCCAGTTCCG 
GAACAGTACC TCGTACTAGA AGAGCTGATA GACATGAACC AGCACCATCT GAATGCTCTC 
GGGGTGGGCC ACAACTCCCT GGACCAGCTC TGCCAAGTAA CGGCAGCACA CGGACTGCAC 
AGCAAGCTGA CGGGCGCTGG CGGTGGCGGC TGTGGCATCA CCCTCCTGAA GCCAGGTCTA 
GAGCAAGCCA CAGTGGAGGC AGCCAAGCAG GCCCTGACCA GCTGCGGGTT TGACTGCTGG 
GAGACCAGCA TCGGCGCACC CGGAGTTTCC ACACACTCAG CTGCAGCTGT AGGGGACCCT 
GTCCGACAAG CCCTGGGCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001293134.1
CDS	110..1333
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	NM_001306205.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001306205.1

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGGCCT CTCACCCACC 
TGTTTGTTTG CCCGTGTGAC AGAGCAAGGT GATGTCTCGG TACCCACCTT GGAGCAACTG 
GAGAAGCTAA AGAAGATGGG GGACCTCCCC AGAGACCGTG CAGGCAATGA AGGCATGGCT 
CTGCTTGCCT TTCTCTACCT GTACCTGGCA ATCTGCCGGA AGCAGAGGAC ACTCCCGAGC 
CTGGACATGG TGGTGTGGTC GGAACTTCCC CCCGGGGCAG GCTTGGGCTC CAGCGCCGCC 
TACTCTGTGT GTCTGGCAGC CGCCCTCCTG ACTGCCTGTG AGGAGGTCTC CAACCCGCTC 
AAGGACGGGG TCTCCGTCAG CAGGTGGCCC GAGGAAGATC TGAAGTCAAT CAACAAGTGG 
GCCTTCGAAG GGGAGAGAGT GATCCATGGG AACCCTTCTG GTGTGGACAA TGCCGTCAGC 
ACCTGGGGCG GAGCCCTGCG CTTCCAGCAA GGGACGATGT CTTCCTTGAA GAGCCTCCCG 
TCTCTGCAGA TCCTGCTCAC CAACACCAAG GTCCCGCGGA GTACCAAGGC CCTTGTGGCT 
GCTGTCAGAA GCAGGCTGAC CAAGTTCCCT GAGATTGTGG CCCCGCTGCT GACCTCCATT 
GACGCAATAT CCCTGGAGTG TGAGCGCGTG CTAGGGGAGA TGGTGGCAGC TCCAGTTCCG 
GAACAGTACC TCGTACTAGA AGAGCTGATA GACATGAACC AGCACCATCT GAATGCTCTC 
GGGGTGGGCC ACAACTCCCT GGACCAGCTC TGCCAAGTAA CGGCAGCACA CGGACTGCAC 
AGCAAGCTGA CGGGCGCTGG CGGTGGCGGC TGTGGCATCA CCCTCCTGAA GCCAGGTCTA 
GAGCAAGCCA CAGTGGAGGC AGCCAAGCAG GCCCTGACCA GCTGCGGGTT TGACTGCTGG 
GAGACCAGCA TCGGCGCACC CGGAGTTTCC ACACACTCAG CTGCAGCTGT AGGGGACCCT 
GTCCGACAAG CCCTGGGCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mvk ( XM_006530183.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530246.1 Mus musculus mevalonate kinase (Mvk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu35809
Clone ID Related Accession (Same CDS sequence)	XM_006530183.3 , NM_001306205.1 , XM_006530183.2
Accession Version	XM_006530183.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1224bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	mevalonate kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530183.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGGCCT CTCACCCACC 
TGTTTGTTTG CCCGTGTGAC AGAGCAAGGT GATGTCTCGG TACCCACCTT GGAGCAACTG 
GAGAAGCTAA AGAAGATGGG GGACCTCCCC AGAGACCGTG CAGGCAATGA AGGCATGGCT 
CTGCTTGCCT TTCTCTACCT GTACCTGGCA ATCTGCCGGA AGCAGAGGAC ACTCCCGAGC 
CTGGACATGG TGGTGTGGTC GGAACTTCCC CCCGGGGCAG GCTTGGGCTC CAGCGCCGCC 
TACTCTGTGT GTCTGGCAGC CGCCCTCCTG ACTGCCTGTG AGGAGGTCTC CAACCCGCTC 
AAGGACGGGG TCTCCGTCAG CAGGTGGCCC GAGGAAGATC TGAAGTCAAT CAACAAGTGG 
GCCTTCGAAG GGGAGAGAGT GATCCATGGG AACCCTTCTG GTGTGGACAA TGCCGTCAGC 
ACCTGGGGCG GAGCCCTGCG CTTCCAGCAA GGGACGATGT CTTCCTTGAA GAGCCTCCCG 
TCTCTGCAGA TCCTGCTCAC CAACACCAAG GTCCCGCGGA GTACCAAGGC CCTTGTGGCT 
GCTGTCAGAA GCAGGCTGAC CAAGTTCCCT GAGATTGTGG CCCCGCTGCT GACCTCCATT 
GACGCAATAT CCCTGGAGTG TGAGCGCGTG CTAGGGGAGA TGGTGGCAGC TCCAGTTCCG 
GAACAGTACC TCGTACTAGA AGAGCTGATA GACATGAACC AGCACCATCT GAATGCTCTC 
GGGGTGGGCC ACAACTCCCT GGACCAGCTC TGCCAAGTAA CGGCAGCACA CGGACTGCAC 
AGCAAGCTGA CGGGCGCTGG CGGTGGCGGC TGTGGCATCA CCCTCCTGAA GCCAGGTCTA 
GAGCAAGCCA CAGTGGAGGC AGCCAAGCAG GCCCTGACCA GCTGCGGGTT TGACTGCTGG 
GAGACCAGCA TCGGCGCACC CGGAGTTTCC ACACACTCAG CTGCAGCTGT AGGGGACCCT 
GTCCGACAAG CCCTGGGCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530246.1
CDS	154..1377
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	XM_006530183.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530183.2

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGGCCT CTCACCCACC 
TGTTTGTTTG CCCGTGTGAC AGAGCAAGGT GATGTCTCGG TACCCACCTT GGAGCAACTG 
GAGAAGCTAA AGAAGATGGG GGACCTCCCC AGAGACCGTG CAGGCAATGA AGGCATGGCT 
CTGCTTGCCT TTCTCTACCT GTACCTGGCA ATCTGCCGGA AGCAGAGGAC ACTCCCGAGC 
CTGGACATGG TGGTGTGGTC GGAACTTCCC CCCGGGGCAG GCTTGGGCTC CAGCGCCGCC 
TACTCTGTGT GTCTGGCAGC CGCCCTCCTG ACTGCCTGTG AGGAGGTCTC CAACCCGCTC 
AAGGACGGGG TCTCCGTCAG CAGGTGGCCC GAGGAAGATC TGAAGTCAAT CAACAAGTGG 
GCCTTCGAAG GGGAGAGAGT GATCCATGGG AACCCTTCTG GTGTGGACAA TGCCGTCAGC 
ACCTGGGGCG GAGCCCTGCG CTTCCAGCAA GGGACGATGT CTTCCTTGAA GAGCCTCCCG 
TCTCTGCAGA TCCTGCTCAC CAACACCAAG GTCCCGCGGA GTACCAAGGC CCTTGTGGCT 
GCTGTCAGAA GCAGGCTGAC CAAGTTCCCT GAGATTGTGG CCCCGCTGCT GACCTCCATT 
GACGCAATAT CCCTGGAGTG TGAGCGCGTG CTAGGGGAGA TGGTGGCAGC TCCAGTTCCG 
GAACAGTACC TCGTACTAGA AGAGCTGATA GACATGAACC AGCACCATCT GAATGCTCTC 
GGGGTGGGCC ACAACTCCCT GGACCAGCTC TGCCAAGTAA CGGCAGCACA CGGACTGCAC 
AGCAAGCTGA CGGGCGCTGG CGGTGGCGGC TGTGGCATCA CCCTCCTGAA GCCAGGTCTA 
GAGCAAGCCA CAGTGGAGGC AGCCAAGCAG GCCCTGACCA GCTGCGGGTT TGACTGCTGG 
GAGACCAGCA TCGGCGCACC CGGAGTTTCC ACACACTCAG CTGCAGCTGT AGGGGACCCT 
GTCCGACAAG CCCTGGGCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mvk ( NM_023556.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_076045.1 Mus musculus mevalonate kinase (Mvk), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu04038
Clone ID Related Accession (Same CDS sequence)	XM_006530185.3 , XM_006530185.4 , NM_023556.3 , XM_006530185.2
Accession Version	NM_023556.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	mevalonate kinase isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC132102.3, AK149630.1 and AI849730.1. On Apr 19, 2015 this sequence version replaced NM_023556.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005606.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076045.1
CDS	110..1297
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	NM_023556.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023556.3

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mvk ( XM_006530185.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530248.1 Mus musculus mevalonate kinase (Mvk), transcript variant X2, mRNA.

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CloneID	OMu04038
Clone ID Related Accession (Same CDS sequence)	XM_006530185.3 , XM_006530185.4 , NM_023556.3 , XM_006530185.2
Accession Version	XM_006530185.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	mevalonate kinase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530185.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530248.1
CDS	153..1340
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	XM_006530185.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530185.3

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mvk ( XM_006530185.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530248.1 Mus musculus mevalonate kinase (Mvk), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu04038
Clone ID Related Accession (Same CDS sequence)	XM_006530185.3 , XM_006530185.4 , NM_023556.3 , XM_006530185.2
Accession Version	XM_006530185.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	mevalonate kinase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530185.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530248.1
CDS	142..1329
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	XM_006530185.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530185.4

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mvk ( XM_006530185.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530248.1 Mus musculus mevalonate kinase (Mvk), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OMu04038
Clone ID Related Accession (Same CDS sequence)	XM_006530185.3 , XM_006530185.4 , NM_023556.3 , XM_006530185.2
Accession Version	XM_006530185.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	mevalonate kinase isoform X1
Comment

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530248.1
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	XM_006530185.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530185.2

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGAGCA AGGTGATGTC 
TCGGTACCCA CCTTGGAGCA ACTGGAGAAG CTAAAGAAGA TGGGGGACCT CCCCAGAGAC 
CGTGCAGGCA ATGAAGGCAT GGCTCTGCTT GCCTTTCTCT ACCTGTACCT GGCAATCTGC 
CGGAAGCAGA GGACACTCCC GAGCCTGGAC ATGGTGGTGT GGTCGGAACT TCCCCCCGGG 
GCAGGCTTGG GCTCCAGCGC CGCCTACTCT GTGTGTCTGG CAGCCGCCCT CCTGACTGCC 
TGTGAGGAGG TCTCCAACCC GCTCAAGGAC GGGGTCTCCG TCAGCAGGTG GCCCGAGGAA 
GATCTGAAGT CAATCAACAA GTGGGCCTTC GAAGGGGAGA GAGTGATCCA TGGGAACCCT 
TCTGGTGTGG ACAATGCCGT CAGCACCTGG GGCGGAGCCC TGCGCTTCCA GCAAGGGACG 
ATGTCTTCCT TGAAGAGCCT CCCGTCTCTG CAGATCCTGC TCACCAACAC CAAGGTCCCG 
CGGAGTACCA AGGCCCTTGT GGCTGCTGTC AGAAGCAGGC TGACCAAGTT CCCTGAGATT 
GTGGCCCCGC TGCTGACCTC CATTGACGCA ATATCCCTGG AGTGTGAGCG CGTGCTAGGG 
GAGATGGTGG CAGCTCCAGT TCCGGAACAG TACCTCGTAC TAGAAGAGCT GATAGACATG 
AACCAGCACC ATCTGAATGC TCTCGGGGTG GGCCACAACT CCCTGGACCA GCTCTGCCAA 
GTAACGGCAG CACACGGACT GCACAGCAAG CTGACGGGCG CTGGCGGTGG CGGCTGTGGC 
ATCACCCTCC TGAAGCCAGG TCTAGAGCAA GCCACAGTGG AGGCAGCCAA GCAGGCCCTG 
ACCAGCTGCG GGTTTGACTG CTGGGAGACC AGCATCGGCG CACCCGGAGT TTCCACACAC 
TCAGCTGCAG CTGTAGGGGA CCCTGTCCGA CAAGCCCTGG GCCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mvk ( XM_006530183.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530246.1 Mus musculus mevalonate kinase (Mvk), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu35809
Clone ID Related Accession (Same CDS sequence)	XM_006530183.3 , NM_001306205.1 , XM_006530183.2
Accession Version	XM_006530183.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1224bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	mevalonate kinase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530183.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGGCCT CTCACCCACC 
TGTTTGTTTG CCCGTGTGAC AGAGCAAGGT GATGTCTCGG TACCCACCTT GGAGCAACTG 
GAGAAGCTAA AGAAGATGGG GGACCTCCCC AGAGACCGTG CAGGCAATGA AGGCATGGCT 
CTGCTTGCCT TTCTCTACCT GTACCTGGCA ATCTGCCGGA AGCAGAGGAC ACTCCCGAGC 
CTGGACATGG TGGTGTGGTC GGAACTTCCC CCCGGGGCAG GCTTGGGCTC CAGCGCCGCC 
TACTCTGTGT GTCTGGCAGC CGCCCTCCTG ACTGCCTGTG AGGAGGTCTC CAACCCGCTC 
AAGGACGGGG TCTCCGTCAG CAGGTGGCCC GAGGAAGATC TGAAGTCAAT CAACAAGTGG 
GCCTTCGAAG GGGAGAGAGT GATCCATGGG AACCCTTCTG GTGTGGACAA TGCCGTCAGC 
ACCTGGGGCG GAGCCCTGCG CTTCCAGCAA GGGACGATGT CTTCCTTGAA GAGCCTCCCG 
TCTCTGCAGA TCCTGCTCAC CAACACCAAG GTCCCGCGGA GTACCAAGGC CCTTGTGGCT 
GCTGTCAGAA GCAGGCTGAC CAAGTTCCCT GAGATTGTGG CCCCGCTGCT GACCTCCATT 
GACGCAATAT CCCTGGAGTG TGAGCGCGTG CTAGGGGAGA TGGTGGCAGC TCCAGTTCCG 
GAACAGTACC TCGTACTAGA AGAGCTGATA GACATGAACC AGCACCATCT GAATGCTCTC 
GGGGTGGGCC ACAACTCCCT GGACCAGCTC TGCCAAGTAA CGGCAGCACA CGGACTGCAC 
AGCAAGCTGA CGGGCGCTGG CGGTGGCGGC TGTGGCATCA CCCTCCTGAA GCCAGGTCTA 
GAGCAAGCCA CAGTGGAGGC AGCCAAGCAG GCCCTGACCA GCTGCGGGTT TGACTGCTGG 
GAGACCAGCA TCGGCGCACC CGGAGTTTCC ACACACTCAG CTGCAGCTGT AGGGGACCCT 
GTCCGACAAG CCCTGGGCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530246.1
CDS	153..1376
Translation	MLSEALLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVGMLQRLDTSFLGLSPTCLFARVTEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRTLPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSINKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKALVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHLNALGVGHNSLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLEQATVEAAKQALTSCGFDCWETSIGAPGVSTHSAAAVGDPVRQALGL

Target ORF information:

RefSeq Version	XM_006530183.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus mevalonate kinase (Mvk), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530183.3

ORF Insert Sequence:

ATGTTGTCAG AAGCCCTGCT GGTGTCCGCC CCGGGGAAGG TCATCCTCCA TGGAGAACAC 
GCTGTGGTCC ATGGCAAGGT CGCTCTGGCA GCGGCCTTGA ACTTGAGAAC TTTCCTCCTG 
CTGCGACCGC AGAGCAATGG GAAAGTGAGC GTCAATTTAC CCAACATCGG TATTAAGCAG 
GTGTGGGATG TGGGCATGCT TCAGCGACTG GACACGAGCT TTCTTGGCCT CTCACCCACC 
TGTTTGTTTG CCCGTGTGAC AGAGCAAGGT GATGTCTCGG TACCCACCTT GGAGCAACTG 
GAGAAGCTAA AGAAGATGGG GGACCTCCCC AGAGACCGTG CAGGCAATGA AGGCATGGCT 
CTGCTTGCCT TTCTCTACCT GTACCTGGCA ATCTGCCGGA AGCAGAGGAC ACTCCCGAGC 
CTGGACATGG TGGTGTGGTC GGAACTTCCC CCCGGGGCAG GCTTGGGCTC CAGCGCCGCC 
TACTCTGTGT GTCTGGCAGC CGCCCTCCTG ACTGCCTGTG AGGAGGTCTC CAACCCGCTC 
AAGGACGGGG TCTCCGTCAG CAGGTGGCCC GAGGAAGATC TGAAGTCAAT CAACAAGTGG 
GCCTTCGAAG GGGAGAGAGT GATCCATGGG AACCCTTCTG GTGTGGACAA TGCCGTCAGC 
ACCTGGGGCG GAGCCCTGCG CTTCCAGCAA GGGACGATGT CTTCCTTGAA GAGCCTCCCG 
TCTCTGCAGA TCCTGCTCAC CAACACCAAG GTCCCGCGGA GTACCAAGGC CCTTGTGGCT 
GCTGTCAGAA GCAGGCTGAC CAAGTTCCCT GAGATTGTGG CCCCGCTGCT GACCTCCATT 
GACGCAATAT CCCTGGAGTG TGAGCGCGTG CTAGGGGAGA TGGTGGCAGC TCCAGTTCCG 
GAACAGTACC TCGTACTAGA AGAGCTGATA GACATGAACC AGCACCATCT GAATGCTCTC 
GGGGTGGGCC ACAACTCCCT GGACCAGCTC TGCCAAGTAA CGGCAGCACA CGGACTGCAC 
AGCAAGCTGA CGGGCGCTGG CGGTGGCGGC TGTGGCATCA CCCTCCTGAA GCCAGGTCTA 
GAGCAAGCCA CAGTGGAGGC AGCCAAGCAG GCCCTGACCA GCTGCGGGTT TGACTGCTGG 
GAGACCAGCA TCGGCGCACC CGGAGTTTCC ACACACTCAG CTGCAGCTGT AGGGGACCCT 
GTCCGACAAG CCCTGGGCCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Normalization of Hepatic Homeostasis in the
The Journal of biological chemistry292(11)4395-4410(2017 03)
Munkacsi AB,Hammond N,Schneider RT,Senanayake DS,Higaki K,Lagutin K,Bloor SJ,Ory DS,Maue RA,Chen FW,Hernandez-Ono A,Dahlson N,Repa JJ,Ginsberg HN,Ioannou YA,Sturley SL

Embryonic poly(A)-binding protein is required at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
Biology of reproduction96(2)341-351(2017 02)
Lowther KM,Favero F,Yang CR,Taylor HS,Seli E

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.
Journal of lipid research57(3)410-21(2016 Mar)
Vergnes L,Chin RG,de Aguiar Vallim T,Fong LG,Osborne TF,Young SG,Reue K

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
Journal of lipid research56(8)1551-9(2015 Aug)
?i?ecio?lu M,Budak H,Geffers L,?ankaya M,?iftci M,Thaller C,Eichele G,K?frevio?lu ??,?zdemir H

Knockdown of MVK does not lead to changes in NALP3 expression or activation.
Journal of inflammation (London, England)127(2015)
Celsi F,Piscianz E,Romano M,Crovella S

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Mvk cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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