Mocs2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mocs2
Entrez Gene ID	17434
Full Name	molybdenum cofactor synthesis 2
Synonyms	AI415403
General protein information	Preferred Names molybdenum cofactor synthesis 2 Names molybdopterin synthase sulfur carrier subunit MOCS2B molybdenum cofactor synthesis protein 2 large subunit molybdenum cofactor synthesis protein 2B
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 D2.2
Summary	Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. Based on experiments with the human molybdopterin synthase ortholog, they are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013826.3	NP_038854.2	molybdopterin synthase sulfur carrier subunit isoform Mocs2A
NM_001113375.1	NP_001106846.1	molybdopterin synthase sulfur carrier subunit isoform Mocs2B2
NM_001113374.1	NP_001106845.1	molybdopterin synthase sulfur carrier subunit isoform Mocs2B
XM_030247178.1	XP_030103038.1	molybdopterin synthase sulfur carrier subunit isoform X1

Pathways from BioSystems

Homologies

	MOCS2	XP_001095584.1
Canis lupus familiaris (dog)	MOCS2	XP_005619387.1
Bos taurus (cattle)	MOCS2	NP_001014867.1
Arabidopsis thaliana (thale cress)	AT2G43760	NP_001078051.1
Magnaporthe oryzae (rice blast fungus)	MGG_17889	XP_003720671.1
Neurospora crassa	NCU03170	XP_964576.1
Oryza sativa (rice)	Os02g0140300	NP_001045852.1
Pan troglodytes (chimpanzee)	MOCS2	XP_001149868.1
Drosophila melanogaster (fruit fly)	Mocs2	NP_651340.1
Caenorhabditis elegans (roundworm)	T27A3.6	NP_491763.1
Homo sapiens (human)	MOCS2	NP_004522.1
Mus musculus (house mouse)	Mocs2	NP_001106845.1
Rattus norvegicus (Norway rat)	Mocs2	NP_001007634.1
Gallus gallus (chicken)	MOCS2	XP_003642989.1
Anopheles gambiae (African malaria mosquito)	MOC2B_ANOGA	XP_003436776.1
Danio rerio (zebrafish)	mocs2	XP_001338032.3
Xenopus tropicalis (tropical clawed frog)	mocs2	XP_002933074.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.
Jakubiczka-Smorag J, Santamaria-Araujo JA, Metz I, Kumar A, Hakroush S, Brueck W, Schwarz G, Burfeind P, Reiss J, Smorag L
Human genetics135(7)813-26(2016 Jul)

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
PLoS genetics5(6)e1000511(2009 Jun)

Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome research11(10)1758-65(2001 Oct)

Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames.
Stallmeyer B, Drugeon G, Reiss J, Haenni AL, Mendel RR
American journal of human genetics64(3)698-705(1999 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mocs2-deficient mice recapitulate the severe phenotype observed in humans and can now serve as a model for preclinical therapeutic approaches for MoCo deficiency type B.
Title: Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.

The following Mocs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mocs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu05013	NM_001113374.1 Latest version!	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu05017	NM_001113375.1 Latest version!	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu13049	NM_013826.3 Latest version!	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu05013	XM_030247178.1 Latest version!	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mocs2 ( NM_001113374.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001106845.1 Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu05013
Clone ID Related Accession (Same CDS sequence)	NM_001113374.1 , XM_030247178.1
Accession Version	NM_001113374.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Mus musculus(house mouse)
Product	molybdopterin synthase sulfur carrier subunit isoform Mocs2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT025598.9 and AK002719.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' end, compared to variant 1, and encodes the large subunit (Mocs2B). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC004631.1, AK002719.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCGAGCT TGGAGATCAG CAACTCCTGC TTCAGCCCGG AGATGAGGTT GCCATCATCC 
CGCCAATCAG TGGAGGATAA TGCATCTGAG CCATCTGGGA AAGATGTGGA CGATGTCCAG 
GAGAAACCTA AAGACATAAT ACAGTTCACT GCCGAGAAGC TCTCTGTGGG GGAAGTGTCA 
CAGTTGGTGG TGTCCCCTCT GTGTGGTGCA GTGTCTCTCT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GCAAGAAAGT CATTAGCTTA GAATATGAAG CGTATGTACC GATGGCAGAA 
AATGAAATCA GAAAAATTTG TAATGACATT AGACAGAAAT GGCCCGTGAG ACACATAGCA 
GTATTCCATC GGCTTGGTTT GGTTCCAGTG TCAGAAGCAA GCACAGTTAT TGCTGTGTCT 
TCAGCTCACA GAGCCGCGTC CCTCGAAGCC GTGAGCTACG CCATTGATTC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAT GAAGAATCAA CCTCATCTTG GAAAAGAAAC 
AAAGAGTGCT TCTGGGCAGC TGGTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106845.1
CDS	135..704
Translation	MSSLEISNSCFSPEMRLPSSRQSVEDNASEPSGKDVDDVQEKPKDIIQFTAEKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYVPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAAGD

Target ORF information:

RefSeq Version	NM_001113374.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113374.1

ORF Insert Sequence:

ATGTCGAGCT TGGAGATCAG CAACTCCTGC TTCAGCCCGG AGATGAGGTT GCCATCATCC 
CGCCAATCAG TGGAGGATAA TGCATCTGAG CCATCTGGGA AAGATGTGGA CGATGTCCAG 
GAGAAACCTA AAGACATAAT ACAGTTCACT GCCGAGAAGC TCTCTGTGGG GGAAGTGTCA 
CAGTTGGTGG TGTCCCCTCT GTGTGGTGCA GTGTCTCTCT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GCAAGAAAGT CATTAGCTTA GAATATGAAG CGTATGTACC GATGGCAGAA 
AATGAAATCA GAAAAATTTG TAATGACATT AGACAGAAAT GGCCCGTGAG ACACATAGCA 
GTATTCCATC GGCTTGGTTT GGTTCCAGTG TCAGAAGCAA GCACAGTTAT TGCTGTGTCT 
TCAGCTCACA GAGCCGCGTC CCTCGAAGCC GTGAGCTACG CCATTGATTC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAT GAAGAATCAA CCTCATCTTG GAAAAGAAAC 
AAAGAGTGCT TCTGGGCAGC TGGTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mocs2 ( NM_001113375.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001106846.1 Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OMu05017
Clone ID Related Accession (Same CDS sequence)	NM_001113375.1
Accession Version	NM_001113375.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 474bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-20
Organism	Mus musculus(house mouse)
Product	molybdopterin synthase sulfur carrier subunit isoform Mocs2B2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT025598.9 and CX220128.1. Transcript Variant: This variant (3) lacks an alternate exon in the 5' end and uses an alternate in-frame splice site in the 3' end, compared to variant 1. Variant 3 encodes a variant of the large subunit (Mocs2B2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CX220128.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGTCGAGCT TGGAGATCAG CAACTCCTGC TTCAGCCCGG AGATGAGGTT GCCATCATCC 
CGCCAATCAG TGGAGGATAA TGCATCTGAG CCATCTGGGA AAGATGTGGA CGATGTCCAG 
GAGAAACCTA AAGACATAAT ACAGTTCACT GCCGAGAAGC TCTCTGTGGG GGAAGTGTCA 
CAGTTGGTGG TGTCCCCTCT GTGTGGTGCA GTGTCTCTCT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GCAAGAAAGT CATTAGCTTA GAATATGAAG CTTTGGTTCC AGTGTCAGAA 
GCAAGCACAG TTATTGCTGT GTCTTCAGCT CACAGAGCCG CGTCCCTCGA AGCCGTGAGC 
TACGCCATTG ATTCTTTAAA AGCCAAGGTG CCCATATGGA AAAAGGAAAT ATATGAAGAA 
TCAACCTCAT CTTGGAAAAG AAACAAAGAG TGCTTCTGGG CAGCTGGTGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001106846.1
CDS	135..608
Translation	MSSLEISNSCFSPEMRLPSSRQSVEDNASEPSGKDVDDVQEKPKDIIQFTAEKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEALVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAAGD

Target ORF information:

RefSeq Version	NM_001113375.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001113375.1

ORF Insert Sequence:

ATGTCGAGCT TGGAGATCAG CAACTCCTGC TTCAGCCCGG AGATGAGGTT GCCATCATCC 
CGCCAATCAG TGGAGGATAA TGCATCTGAG CCATCTGGGA AAGATGTGGA CGATGTCCAG 
GAGAAACCTA AAGACATAAT ACAGTTCACT GCCGAGAAGC TCTCTGTGGG GGAAGTGTCA 
CAGTTGGTGG TGTCCCCTCT GTGTGGTGCA GTGTCTCTCT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GCAAGAAAGT CATTAGCTTA GAATATGAAG CTTTGGTTCC AGTGTCAGAA 
GCAAGCACAG TTATTGCTGT GTCTTCAGCT CACAGAGCCG CGTCCCTCGA AGCCGTGAGC 
TACGCCATTG ATTCTTTAAA AGCCAAGGTG CCCATATGGA AAAAGGAAAT ATATGAAGAA 
TCAACCTCAT CTTGGAAAAG AAACAAAGAG TGCTTCTGGG CAGCTGGTGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mocs2 ( NM_013826.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038854.2 Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13049
Clone ID Related Accession (Same CDS sequence)	NM_013826.3
Accession Version	NM_013826.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	molybdopterin synthase sulfur carrier subunit isoform Mocs2A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CT025598.9 and AK010112.1. On Jan 13, 2008 this sequence version replaced NM_013826.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the small subunit (Mocs2A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: CX208245.1, SRR1660817.145602.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END##

ATGGTTCCTA GGTGCCAGAT TGACGTGTTG TATTTTGCAA AAAGTGCTGA AATAGCCGGA 
GTTCGCTCGG AGACCATTTC TGTGCCACAG GAAATCAAAG CGTCAGAGCT GTGGAAGGAG 
CTAGAGAGTC TCCATCCTGG GTTGGCTGAT GTTAGAAACC AGGTGATATT TGCTGTTCGT 
CAAGAGTATG TCGAGCTTGG AGATCAGCAA CTCCTGCTTC AGCCCGGAGA TGAGGTTGCC 
ATCATCCCGC CAATCAGTGG AGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038854.2
CDS	70..336
Translation	MVPRCQIDVLYFAKSAEIAGVRSETISVPQEIKASELWKELESLHPGLADVRNQVIFAVRQEYVELGDQQLLLQPGDEVAIIPPISGG

Target ORF information:

RefSeq Version	NM_013826.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013826.3

ORF Insert Sequence:

ATGGTTCCTA GGTGCCAGAT TGACGTGTTG TATTTTGCAA AAAGTGCTGA AATAGCCGGA 
GTTCGCTCGG AGACCATTTC TGTGCCACAG GAAATCAAAG CGTCAGAGCT GTGGAAGGAG 
CTAGAGAGTC TCCATCCTGG GTTGGCTGAT GTTAGAAACC AGGTGATATT TGCTGTTCGT 
CAAGAGTATG TCGAGCTTGG AGATCAGCAA CTCCTGCTTC AGCCCGGAGA TGAGGTTGCC 
ATCATCCCGC CAATCAGTGG AGGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mocs2 ( XM_030247178.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030103038.1 Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu05013
Clone ID Related Accession (Same CDS sequence)	NM_001113374.1 , XM_030247178.1
Accession Version	XM_030247178.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	molybdopterin synthase sulfur carrier subunit isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGAGCT TGGAGATCAG CAACTCCTGC TTCAGCCCGG AGATGAGGTT GCCATCATCC 
CGCCAATCAG TGGAGGATAA TGCATCTGAG CCATCTGGGA AAGATGTGGA CGATGTCCAG 
GAGAAACCTA AAGACATAAT ACAGTTCACT GCCGAGAAGC TCTCTGTGGG GGAAGTGTCA 
CAGTTGGTGG TGTCCCCTCT GTGTGGTGCA GTGTCTCTCT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GCAAGAAAGT CATTAGCTTA GAATATGAAG CGTATGTACC GATGGCAGAA 
AATGAAATCA GAAAAATTTG TAATGACATT AGACAGAAAT GGCCCGTGAG ACACATAGCA 
GTATTCCATC GGCTTGGTTT GGTTCCAGTG TCAGAAGCAA GCACAGTTAT TGCTGTGTCT 
TCAGCTCACA GAGCCGCGTC CCTCGAAGCC GTGAGCTACG CCATTGATTC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAT GAAGAATCAA CCTCATCTTG GAAAAGAAAC 
AAAGAGTGCT TCTGGGCAGC TGGTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030103038.1
CDS	334..903
Translation	MSSLEISNSCFSPEMRLPSSRQSVEDNASEPSGKDVDDVQEKPKDIIQFTAEKLSVGEVSQLVVSPLCGAVSLFVGTTRNNFEGKKVISLEYEAYVPMAENEIRKICNDIRQKWPVRHIAVFHRLGLVPVSEASTVIAVSSAHRAASLEAVSYAIDSLKAKVPIWKKEIYEESTSSWKRNKECFWAAGD

Target ORF information:

RefSeq Version	XM_030247178.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus molybdenum cofactor synthesis 2 (Mocs2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030247178.1

ORF Insert Sequence:

ATGTCGAGCT TGGAGATCAG CAACTCCTGC TTCAGCCCGG AGATGAGGTT GCCATCATCC 
CGCCAATCAG TGGAGGATAA TGCATCTGAG CCATCTGGGA AAGATGTGGA CGATGTCCAG 
GAGAAACCTA AAGACATAAT ACAGTTCACT GCCGAGAAGC TCTCTGTGGG GGAAGTGTCA 
CAGTTGGTGG TGTCCCCTCT GTGTGGTGCA GTGTCTCTCT TTGTAGGGAC TACAAGAAAT 
AACTTTGAAG GCAAGAAAGT CATTAGCTTA GAATATGAAG CGTATGTACC GATGGCAGAA 
AATGAAATCA GAAAAATTTG TAATGACATT AGACAGAAAT GGCCCGTGAG ACACATAGCA 
GTATTCCATC GGCTTGGTTT GGTTCCAGTG TCAGAAGCAA GCACAGTTAT TGCTGTGTCT 
TCAGCTCACA GAGCCGCGTC CCTCGAAGCC GTGAGCTACG CCATTGATTC TTTAAAAGCC 
AAGGTGCCCA TATGGAAAAA GGAAATATAT GAAGAATCAA CCTCATCTTG GAAAAGAAAC 
AAAGAGTGCT TCTGGGCAGC TGGTGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.
Human genetics135(7)813-26(2016 Jul)
Jakubiczka-Smorag J,Santamaria-Araujo JA,Metz I,Kumar A,Hakroush S,Brueck W,Schwarz G,Burfeind P,Reiss J,Smorag L

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
PLoS genetics5(6)e1000511(2009 Jun)
Sansom SN,Griffiths DS,Faedo A,Kleinjan DJ,Ruan Y,Smith J,van Heyningen V,Rubenstein JL,Livesey FJ

Protein-protein interaction panel using mouse full-length cDNAs.
Genome research11(10)1758-65(2001 Oct)
Suzuki H,Fukunishi Y,Kagawa I,Saito R,Oda H,Endo T,Kondo S,Bono H,Okazaki Y,Hayashizaki Y

Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames.
American journal of human genetics64(3)698-705(1999 Mar)
Stallmeyer B,Drugeon G,Reiss J,Haenni AL,Mendel RR

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Mocs2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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