Mmp8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp8
Entrez Gene ID	17394
Full Name	matrix metallopeptidase 8
Synonyms	BB138268
General protein information	Preferred Names matrix metallopeptidase 8 Names neutrophil collagenase collagenase-2 matrix metalloproteinase-8
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A1
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008611.4	NP_032637.3	neutrophil collagenase preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MMP8	XP_002692980.2
Homo sapiens (human)	MMP8	NP_002415.1
	MMP8	XP_001098000.2
Canis lupus familiaris (dog)	MMP8	XP_546547.3
Rattus norvegicus (Norway rat)	Mmp8	NP_071557.1
Pan troglodytes (chimpanzee)	MMP8	XP_003313323.1
Danio rerio (zebrafish)	mmp13a	XP_005169256.1
Mus musculus (house mouse)	Mmp8	NP_032637.3

Gene Ontology
Bibliography

Related articles in PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P
Bone107131-142(2018 Feb)

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.
Sim?n-Carrasco L, Gra?a O, Salm?n M, Jacob HKC, Gutierrez A, Jim?nez G, Drosten M, Barbacid M
Genes & development31(14)1456-1468(2017 Jul)

Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells.
Zhang F, Li S, Song J, Liu J, Cui Y, Chen H
Atherosclerosis26190-98(2017 Jun)

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression.
Title: MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions.

MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3
Title: Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion.

Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.
Title: Fusion Peptides CPU1 and CPU2 Inhibit Matrix Metalloproteinases and Protect Mice from Endotoxin Shock Within a Strict Time Window.

A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin and therefore increasing the bioavailability of TGF-beta.
Title: A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization.

the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.
Title: Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

The following Mmp8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22338	NM_008611.4 Latest version!	Mus musculus matrix metallopeptidase 8 (Mmp8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp8 ( NM_008611.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032637.3 Mus musculus matrix metallopeptidase 8 (Mmp8), mRNA.

Price & Availability↑

CloneID	OMu22338
Clone ID Related Accession (Same CDS sequence)	NM_008611.4
Accession Version	NM_008611.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1398bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	neutrophil collagenase preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY204369.1, AK137468.1 and BY548872.1. On Nov 15, 2007 this sequence version replaced NM_008611.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089336.1, AK155901.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849387, SAMN00849388 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTCGCC TGAAGACACT TCCATTACTG ATCTTCCTCC ACACACAGCT TGCCAATGCC 
TTCCCAGTAC CTGAACACCT GGAAGAGAAA AATATAAAAA CTGCTGAGAA TTACCTACGA 
AAATTCTACA ACTTACCAAG CAATCAATTC CGGTCTTCGA GGAATGCCAC GATGGTTGCA 
GAGAAGCTTA AAGAGATGCA GCGCTTCTTC AGCTTAGCAG AGACTGGGAA GTTAGATGCA 
GCTACAATGG GGATTATGGA AATGCCTCGA TGTGGAGTGC CTGACTCTGG TGATTTCTTG 
CTAACCCCAG GAAGTCCCAA GTGGACACAC ACTAACCTGA CCTACAGGAT TATAAACCAT 
ACGCCACAGC TGTCAAGGGC TGAAGTGAAA ACAGCAATTG AGAAAGCTTT TCACGTCTGG 
AGTGTAGCAT CGCCCCTGAC CTTCACCGAG ATCTTACAGG GAGAAGCAGA CATCAACATT 
GCTTTCGTCT CAAGAGACCA TGGTGACAAT TCTCCATTTG ATGGACCCAA TGGAATCCTT 
GCCCATGCCT TTCAACCAGG CCAAGGTATT GGAGGAGATG CTCATTTTGA TTCAGAAGAA 
ACGTGGACTC AAGATTCCAA AAATTACAAC CTATTTCTCG TGGCTGCTCA TGAATTTGGA 
CATTCTTTGG GACTCTCTCA CTCCACTGAT CCTGGTGCCT TGATGTACCC AAACTATGCT 
TACAGGGAAC CCAGCACCTA TTCACTACCT CAAGATGATA TCAATGGCAT TCAGACAATC 
TATGGACCTT CAGACAACCC CATCCAACCT ACTGGGCCCA GCACACCCAA AGCCTGTGAC 
CCCCACCTGA GATTTGATGC TACTACCACA CTCCGTGGGG AGATTTACTT CTTTAAAGAC 
AAGTACTTCT GGAGACGGCA TCCTCAGCTG AGAACAGTTG ACCTCAATTT CATATCTCTG 
TTCTGGCCCT TCCTACCCAA CGGTCTTCAG GCTGCTTATG AAGATTTTGA CAGAGACCTA 
GTTTTCCTAT TTAAAGGCAG ACAGTACTGG GCTCTAAGTG GCTATGACCT GCAGCAAGGT 
TACCCCAGAG ATATATCCAA CTATGGATTC CCAAGGAGTG TCCAAGCCAT TGATGCAGCT 
GTTTCCTATA ACGGGAAGAC ATACTTCTTC ATAAACAACC AGTGCTGGAG ATATGACAAT 
CAAAGAAGAT CCATGGACCC AGGTTACCCC AAAAGCATAC CAAGCATGTT CCCAGGAGTA 
AACTGTAGAG TCGATGCAGT TTTCCTGCAG GACTCCTTCT TCCTCTTCTT CAGTGGACCA 
CAATATTTTG CATTTAATTT TGTCAGTCAC AGAGTCACTA GAGTTGCAAG AAGCAATTTA 
TGGCTTAACT GTTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032637.3
CDS	108..1505
Translation	MFRLKTLPLLIFLHTQLANAFPVPEHLEEKNIKTAENYLRKFYNLPSNQFRSSRNATMVAEKLKEMQRFFSLAETGKLDAATMGIMEMPRCGVPDSGDFLLTPGSPKWTHTNLTYRIINHTPQLSRAEVKTAIEKAFHVWSVASPLTFTEILQGEADINIAFVSRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDSEETWTQDSKNYNLFLVAAHEFGHSLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYGPSDNPIQPTGPSTPKACDPHLRFDATTTLRGEIYFFKDKYFWRRHPQLRTVDLNFISLFWPFLPNGLQAAYEDFDRDLVFLFKGRQYWALSGYDLQQGYPRDISNYGFPRSVQAIDAAVSYNGKTYFFINNQCWRYDNQRRSMDPGYPKSIPSMFPGVNCRVDAVFLQDSFFLFFSGPQYFAFNFVSHRVTRVARSNLWLNCS

Target ORF information:

RefSeq Version	NM_008611.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 8 (Mmp8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008611.4

ORF Insert Sequence:

ATGTTTCGCC TGAAGACACT TCCATTACTG ATCTTCCTCC ACACACAGCT TGCCAATGCC 
TTCCCAGTAC CTGAACACCT GGAAGAGAAA AATATAAAAA CTGCTGAGAA TTACCTACGA 
AAATTCTACA ACTTACCAAG CAATCAATTC CGGTCTTCGA GGAATGCCAC GATGGTTGCA 
GAGAAGCTTA AAGAGATGCA GCGCTTCTTC AGCTTAGCAG AGACTGGGAA GTTAGATGCA 
GCTACAATGG GGATTATGGA AATGCCTCGA TGTGGAGTGC CTGACTCTGG TGATTTCTTG 
CTAACCCCAG GAAGTCCCAA GTGGACACAC ACTAACCTGA CCTACAGGAT TATAAACCAT 
ACGCCACAGC TGTCAAGGGC TGAAGTGAAA ACAGCAATTG AGAAAGCTTT TCACGTCTGG 
AGTGTAGCAT CGCCCCTGAC CTTCACCGAG ATCTTACAGG GAGAAGCAGA CATCAACATT 
GCTTTCGTCT CAAGAGACCA TGGTGACAAT TCTCCATTTG ATGGACCCAA TGGAATCCTT 
GCCCATGCCT TTCAACCAGG CCAAGGTATT GGAGGAGATG CTCATTTTGA TTCAGAAGAA 
ACGTGGACTC AAGATTCCAA AAATTACAAC CTATTTCTCG TGGCTGCTCA TGAATTTGGA 
CATTCTTTGG GACTCTCTCA CTCCACTGAT CCTGGTGCCT TGATGTACCC AAACTATGCT 
TACAGGGAAC CCAGCACCTA TTCACTACCT CAAGATGATA TCAATGGCAT TCAGACAATC 
TATGGACCTT CAGACAACCC CATCCAACCT ACTGGGCCCA GCACACCCAA AGCCTGTGAC 
CCCCACCTGA GATTTGATGC TACTACCACA CTCCGTGGGG AGATTTACTT CTTTAAAGAC 
AAGTACTTCT GGAGACGGCA TCCTCAGCTG AGAACAGTTG ACCTCAATTT CATATCTCTG 
TTCTGGCCCT TCCTACCCAA CGGTCTTCAG GCTGCTTATG AAGATTTTGA CAGAGACCTA 
GTTTTCCTAT TTAAAGGCAG ACAGTACTGG GCTCTAAGTG GCTATGACCT GCAGCAAGGT 
TACCCCAGAG ATATATCCAA CTATGGATTC CCAAGGAGTG TCCAAGCCAT TGATGCAGCT 
GTTTCCTATA ACGGGAAGAC ATACTTCTTC ATAAACAACC AGTGCTGGAG ATATGACAAT 
CAAAGAAGAT CCATGGACCC AGGTTACCCC AAAAGCATAC CAAGCATGTT CCCAGGAGTA 
AACTGTAGAG TCGATGCAGT TTTCCTGCAG GACTCCTTCT TCCTCTTCTT CAGTGGACCA 
CAATATTTTG CATTTAATTT TGTCAGTCAC AGAGTCACTA GAGTTGCAAG AAGCAATTTA 
TGGCTTAACT GTTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Bone107131-142(2018 Feb)
Rauch F,Geng Y,Lamplugh L,Hekmatnejad B,Gaumond MH,Penney J,Yamanaka Y,Moffatt P

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.
Genes & development31(14)1456-1468(2017 Jul)
Sim?n-Carrasco L,Gra?a O,Salm?n M,Jacob HKC,Gutierrez A,Jim?nez G,Drosten M,Barbacid M

Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells.
Atherosclerosis26190-98(2017 Jun)
Zhang F,Li S,Song J,Liu J,Cui Y,Chen H

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

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Mmp8 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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