Marcksl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Marcksl1
Entrez Gene ID	17357
Full Name	MARCKS-like 1
Synonyms	AL022768,AW215397,AW536807,D4Bc1,F52,MacMARCKS,Macs2,Macs3,Mlp,Mrp
General protein information	Preferred Names MARCKS-like 1 Names MARCKS-related protein MARCKS-like protein 1 brain protein F52 mac-MARCKS macrophage myristoylated alanine-rich C kinase substrate
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.2\|4 63.26 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010807.4	NP_034937.1	MARCKS-related protein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Marcksl1	NP_034937.1
Canis lupus familiaris (dog)	MARCKSL1	XP_854637.1
Rattus norvegicus (Norway rat)	Marcksl1	NP_110489.1
Homo sapiens (human)	MARCKSL1	NP_075385.1
Rattus norvegicus (Norway rat)	LOC100911158	XP_003750086.1
Rattus norvegicus (Norway rat)	LOC100911122	XP_003750085.1
Pan troglodytes (chimpanzee)	MARCKSL1	XP_001151702.3
	MARCKSL1	XP_002802334.1
Bos taurus (cattle)	MARCKSL1	NP_001069640.1

Gene Ontology
Bibliography

Related articles in PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, ?estan N, Gage FH, Lein ES
Development (Cambridge, England)140(22)4633-44(2013 Nov)

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.
Bj?rkblom B, Padzik A, Mohammad H, Westerlund N, Komulainen E, Hollos P, Parviainen L, Papageorgiou AC, Iljin K, Kallioniemi O, Kallajoki M, Courtney MJ, M?g?rd M, James P, Coffey ET
Molecular and cellular biology32(17)3513-26(2012 Sep)

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H
Nature immunology13(8)729-36(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutation analysis of MLP demonstrated that myristoylation was necessary to promote proliferation and that phosphorylation inhibited proliferation, indicating the functional importance of membrane localization
Title: MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation.

We suggest that the downregulation of MRP by beta3 is not required for increased cell spreading but instead that MRP downregulation is a secondary effect of increased cell spreading.
Title: The regulation of MacMARCKS expression by integrin beta3.

The following Marcksl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Marcksl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06936	NM_010807.4 Latest version!	Mus musculus MARCKS-like 1 (Marcksl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Marcksl1 ( NM_010807.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034937.1 Mus musculus MARCKS-like 1 (Marcksl1), mRNA.

Price & Availability↑

CloneID	OMu06936
Clone ID Related Accession (Same CDS sequence)	NM_010807.4
Accession Version	NM_010807.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 603bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	MARCKS-related protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CX243729.1, AK083913.1 and CD802500.1. On Sep 9, 2009 this sequence version replaced NM_010807.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CX243729.1, X61399.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCC AGAGCTCTAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCGGGC 
GCTTCCCCCG CGAAGGCCAA CGGACAGGAG AATGGCCACG TGAGAAGCAA TGGAGACTTA 
ACCCCCAAGG GTGAAGGGGA GTCACCACCC GTGAACGGAA CAGATGAGGC AGCTGGGGCT 
ACTGGTGATG CCATCGAGCC AGCGCCCCCT AGCCAGGAAG CTGAGGCCAA GGGGGAGGTC 
GCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGTGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCCTC AGCCTCCTCG 
CCAACAGAGG AAGAGCAGGA GCAGGGCGAG ATGAGCGCCT GCAGCGACGA GGGCACTGCC 
CAAGAAGGGA AGGCCGCTGC CACCCCTGAG AGCCAAGAGC CCCAGGCCAA GGGGGCAGAG 
GCTAGTGCTG CCTCCAAGGA AGGAGACACA GAAGAGGAGG CAGGGCCCCA GGCTGCAGAG 
CCATCCACTC CCTCGGGCCC AGAGAGTGGC CCCACACCTG CCAGTGCTGA GCAGAATGAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034937.1
CDS	250..852
Translation	MGSQSSKAPRGDVTAEEAAGASPAKANGQENGHVRSNGDLTPKGEGESPPVNGTDEAAGATGDAIEPAPPSQEAEAKGEVAPKETPKKKKKFSFKKPFKLSGLSFKRNRKEGGGDSSASSPTEEEQEQGEMSACSDEGTAQEGKAAATPESQEPQAKGAEASAASKEGDTEEEAGPQAAEPSTPSGPESGPTPASAEQNE

Target ORF information:

RefSeq Version	NM_010807.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus MARCKS-like 1 (Marcksl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010807.4

ORF Insert Sequence:

ATGGGCAGCC AGAGCTCTAA GGCTCCCCGG GGCGACGTGA CCGCCGAGGA GGCAGCGGGC 
GCTTCCCCCG CGAAGGCCAA CGGACAGGAG AATGGCCACG TGAGAAGCAA TGGAGACTTA 
ACCCCCAAGG GTGAAGGGGA GTCACCACCC GTGAACGGAA CAGATGAGGC AGCTGGGGCT 
ACTGGTGATG CCATCGAGCC AGCGCCCCCT AGCCAGGAAG CTGAGGCCAA GGGGGAGGTC 
GCCCCCAAGG AGACCCCCAA GAAGAAGAAG AAATTCTCTT TCAAGAAGCC TTTCAAATTG 
AGTGGCCTGT CCTTCAAGAG AAATCGGAAG GAGGGTGGGG GTGATTCCTC AGCCTCCTCG 
CCAACAGAGG AAGAGCAGGA GCAGGGCGAG ATGAGCGCCT GCAGCGACGA GGGCACTGCC 
CAAGAAGGGA AGGCCGCTGC CACCCCTGAG AGCCAAGAGC CCCAGGCCAA GGGGGCAGAG 
GCTAGTGCTG CCTCCAAGGA AGGAGACACA GAAGAGGAGG CAGGGCCCCA GGCTGCAGAG 
CCATCCACTC CCTCGGGCCC AGAGAGTGGC CCCACACCTG CCAGTGCTGA GCAGAATGAG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Development (Cambridge, England)140(22)4633-44(2013 Nov)
Miller JA,Nathanson J,Franjic D,Shim S,Dalley RA,Shapouri S,Smith KA,Sunkin SM,Bernard A,Bennett JL,Lee CK,Hawrylycz MJ,Jones AR,Amaral DG,?estan N,Gage FH,Lein ES

c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells.
Molecular and cellular biology32(17)3513-26(2012 Sep)
Bj?rkblom B,Padzik A,Mohammad H,Westerlund N,Komulainen E,Hollos P,Parviainen L,Papageorgiou AC,Iljin K,Kallioniemi O,Kallajoki M,Courtney MJ,M?g?rd M,James P,Coffey ET

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.
Nature immunology13(8)729-36(2012 Jun)
Kanaya T,Hase K,Takahashi D,Fukuda S,Hoshino K,Sasaki I,Hemmi H,Knoop KA,Kumar N,Sato M,Katsuno T,Yokosuka O,Toyooka K,Nakai K,Sakamoto A,Kitahara Y,Jinnohara T,McSorley SJ,Kaisho T,Williams IR,Ohno H

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Marcksl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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