Matn3 cDNA ORF clone, Mus musculus(house mouse)

Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development.
Metwalli KA, Do MA, Nguyen K, Mallick S, Kin K, Farokhnia N, Jun G, Fakhouri WD
Journal of dental research97(2)226-236(2018 Feb)

Absence of collagen IX accelerates hypertrophic differentiation in the embryonic mouse spine through a disturbance of the Ihh-PTHrP feedback loop.
Kamper M, Paulsson M, Zaucke F
Cell and tissue research367(2)359-367(2017 Feb)

Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress.
Wang YC, Liu JS, Chen JY, Wu SQ, Wang GR, Nie J, Zhang SK, Guo QL, Luo JM
International journal of molecular medicine36(6)1648-56(2015 Dec)

Data show that hand osteoarthritis (HOA)-related matrilin-3 mutation (T298M) leads to a high expression level of growth arrest DNA damage-inducible gene 153 (GADD153)
Title: Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress.

MATN3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing BMP-2/Smad1 activity
Title: Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist.

study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients
Title: Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases.

MATN3 plays a regulatory role in cartilage homeostasis due to its capacity to induce IL-1Ra, upregulate gene expression of major cartilage matrix components, and downregulate the expression of OA-associated matrix-degrading proteinases in chondrocytes.
Title: Matrilin-3 induction of IL-1 receptor antagonist is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression.

Lack of COMP and matrilin 3 leads to increased deposition of TIMP-3, which causes partial inactivation of matrix metalloproteinases in bone, including MMP-13.
Title: Abnormal bone quality in cartilage oligomeric matrix protein and matrilin 3 double-deficient mice caused by increased tissue inhibitor of metalloproteinases 3 deposition and delayed aggrecan degradation.