Fxyd3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fxyd3
Entrez Gene ID	17178
Full Name	FXYD domain-containing ion transport regulator 3
Synonyms	Mat8
General protein information	Preferred Names FXYD domain-containing ion transport regulator 3 Names FXYD domain-containing ion transport regulator 3 chloride conductance inducer protein Mat-8 mammary tumor 8 kDa protein sodium/potassium-transporting ATPase subunit FXYD3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1
Summary	This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The encoded protein is a transmembrane protein that functions as a specific regulator of Na,K-ATPase. [provided by RefSeq, Aug 2009].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008557.2	NP_032583.1	FXYD domain-containing ion transport regulator 3 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	fxyd3	NP_001039081.1
	FXYD3	XP_002801227.1
Homo sapiens (human)	FXYD3	NP_001129479.1
Canis lupus familiaris (dog)	FXYD3	XP_005616779.1
Mus musculus (house mouse)	Fxyd3	NP_032583.1
Rattus norvegicus (Norway rat)	Fxyd3	NP_758528.1

Gene Ontology
Bibliography

Related articles in PubMed

Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression.
Vallois D, Niederh?user G, Ibberson M, Nagaraj V, Nagaray V, Marselli L, Marchetti P, Chatton JY, Thorens B
PloS one9(7)e103277(2014)

Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-R?nne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD
Diabetologia55(1)154-65(2012 Jan)

PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH, Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U, Fabritz L, Brown NA
Circulation. Cardiovascular genetics4(2)123-33(2011 Apr)

Identification of transcripts with enriched expression in the developing and adult pancreas.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD
Genome biology9(6)R99(2008)

Structural and functional properties of two human FXYD3 (Mat-8) isoforms.
Bibert S, Roy S, Schaer D, Felley-Bosco E, Geering K
The Journal of biological chemistry281(51)39142-51(2006 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Because gluco-incretin secretion depends on feeding the epigenetic regulation of Fxyd3 expression may link nutrition in early life to establishment of adult beta-cell glucose competence.
Title: Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression.

regulator of Na,K-ATPase
Title: FXYD3 (Mat-8), a new regulator of Na,K-ATPase.

Fxyd3 and Lgi4 transcripts potentially form double-stranded RNA molecules in many cell types in vivo, which may impact on their respective expression
Title: Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous antisense expression.

The following Fxyd3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fxyd3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02219	NM_008557.2 Latest version!	Mus musculus FXYD domain-containing ion transport regulator 3 (Fxyd3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fxyd3 ( NM_008557.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032583.1 Mus musculus FXYD domain-containing ion transport regulator 3 (Fxyd3), mRNA.

Price & Availability↑

CloneID	OMu02219
Clone ID Related Accession (Same CDS sequence)	NM_008557.2
Accession Version	NM_008557.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	FXYD domain-containing ion transport regulator 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC158993.2, AA959274.1, EH101686.1 and BG067532.2. On Aug 11, 2009 this sequence version replaced NM_008557.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI081078.1, BE689648.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAAGAGG TTGTTCTGAG CCTGTTGGTC CTTCTAGCAG GCCTGCCTAC TTTGGATGCC 
AATGACCCTG AAAATAAAAA TGATCCTTTC TACTATGATT GGTACAGCCT CCGAGTCGGC 
GGGCTCATTT GTGCAGGGAT TCTCTGTGCC CTGGGCATTA TAGTCCTTAT GAGTGGCAAA 
TGCAAATGCA AGTTCAGACA GAAACCCAGT CACCGCCCAG GAGAAGGGCC ACCTCTCATC 
ACACCAGGCT CAGCTCACAA CTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032583.1
CDS	92..358
Translation	MQEVVLSLLVLLAGLPTLDANDPENKNDPFYYDWYSLRVGGLICAGILCALGIIVLMSGKCKCKFRQKPSHRPGEGPPLITPGSAHNC

Target ORF information:

RefSeq Version	NM_008557.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus FXYD domain-containing ion transport regulator 3 (Fxyd3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008557.2

ORF Insert Sequence:

ATGCAAGAGG TTGTTCTGAG CCTGTTGGTC CTTCTAGCAG GCCTGCCTAC TTTGGATGCC 
AATGACCCTG AAAATAAAAA TGATCCTTTC TACTATGATT GGTACAGCCT CCGAGTCGGC 
GGGCTCATTT GTGCAGGGAT TCTCTGTGCC CTGGGCATTA TAGTCCTTAT GAGTGGCAAA 
TGCAAATGCA AGTTCAGACA GAAACCCAGT CACCGCCCAG GAGAAGGGCC ACCTCTCATC 
ACACCAGGCT CAGCTCACAA CTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression.
PloS one9(7)e103277(2014)
Vallois D,Niederh?user G,Ibberson M,Nagaraj V,Nagaray V,Marselli L,Marchetti P,Chatton JY,Thorens B

Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Diabetologia55(1)154-65(2012 Jan)
Hald J,Galbo T,Rescan C,Radzikowski L,Sprinkel AE,Heimberg H,Ahnfelt-R?nne J,Jensen J,Scharfmann R,Gradwohl G,Kaestner KH,Stoeckert C Jr,Jensen JN,Madsen OD

PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Circulation. Cardiovascular genetics4(2)123-33(2011 Apr)
Kirchhof P,Kahr PC,Kaese S,Piccini I,Vokshi I,Scheld HH,Rotering H,Fortmueller L,Laakmann S,Verheule S,Schotten U,Fabritz L,Brown NA

Identification of transcripts with enriched expression in the developing and adult pancreas.
Genome biology9(6)R99(2008)
Hoffman BG,Zavaglia B,Witzsche J,Ruiz de Algara T,Beach M,Hoodless PA,Jones SJ,Marra MA,Helgason CD

Structural and functional properties of two human FXYD3 (Mat-8) isoforms.
The Journal of biological chemistry281(51)39142-51(2006 Dec)
Bibert S,Roy S,Schaer D,Felley-Bosco E,Geering K

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Fxyd3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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