Magoh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Magoh
Entrez Gene ID	17149
Full Name	mago homolog, exon junction complex core component
Synonyms	Mago-m,Mos2
General protein information	Preferred Names mago homolog, exon junction complex core component Names protein mago nashi homolog mago-nashi homolog, proliferation-associated
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 C7\|4 50.18 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001282737.1	NP_001269666.1	protein mago nashi homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	MAGOH	NP_002361.1
Pan troglodytes (chimpanzee)	LOC100613301	XP_003308156.1
Canis lupus familiaris (dog)	MAGOH	XP_536702.1
Mus musculus (house mouse)	Magoh	NP_001269666.1
	MAGOH	XP_001112786.1
Bos taurus (cattle)	MAGOH	NP_001029417.1
Rattus norvegicus (Norway rat)	Magoh	NP_001094006.1
Gallus gallus (chicken)	MAGOH2	NP_989656.1

Gene Ontology
Bibliography

Related articles in PubMed

Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
Mao H, Brown HE, Silver DL
RNA (New York, N.Y.)23(1)23-31(2017 01)

Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.
Mao H, McMahon JJ, Tsai YH, Wang Z, Silver DL
PLoS genetics12(9)e1006282(2016 Sep)

Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.
Pilaz LJ, McMahon JJ, Miller EE, Lennox AL, Suzuki A, Salmon E, Silver DL
Neuron89(1)83-99(2016 Jan)

Generation of a Magoh conditional allele in mice.
McMahon JJ, Shi L, Silver DL
Genesis (New York, N.Y. : 2000)52(8)752-8(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we first show that Eif4a3 haploinsufficiency phenocopies aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant mice.we show that genetic ablation of one downstream pathway, p53, significantly rescues microcephaly of all 3 EJC mutant
Title: Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.

findings show 2 genes MAGOH and MAGOHB are expressed in mammals; in macrophages, expression of MAGOHB but not MAGOH mRNA increases after LPS stimulation; both MAGOH proteins interact with other exon junction complex (EJC) components, incorporate into mRNA-bound EJCs and activate nonsense-mediated decay
Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

These results point to a central role for Magoh in melanocyte development.
Title: The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes.

mouse magoh is involved in cyclin-dependent kinase regulation.
Title: Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation.

Magoh haploinsufficiency causes microcephaly because of intermediate neural progenitors depletion and neuronal apoptosis.
Title: The exon junction complex component Magoh controls brain size by regulating neural stem cell division.

The following Magoh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Magoh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19892	NM_001282737.1 Latest version!	Mus musculus mago homolog, exon junction complex core component (Magoh), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Magoh ( NM_001282737.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001269666.1 Mus musculus mago homolog, exon junction complex core component (Magoh), mRNA.

Price & Availability↑

CloneID	OMu19892
Clone ID Related Accession (Same CDS sequence)	NM_001282737.1
Accession Version	NM_001282737.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-06
Organism	Mus musculus(house mouse)
Product	protein mago nashi homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY134232.1 and AK011512.1. On Apr 19, 2014 this sequence version replaced NM_010760.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU847701.1, BI154777.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAGTG ACTTTTACCT GCGTTACTAC GTGGGCCACA AAGGCAAGTT CGGTCATGAG 
TTCCTGGAGT TTGAATTCCG ACCTGACGGT AAATTGCGAT ACGCCAACAA CAGCAATTAC 
AAAAATGACG TCATGATCAG GAAAGAGGCT TATGTGCATA AAAGTGTGAT GGAAGAGTTA 
AAGAGAATTA TTGATGACAG TGAAATCACC AAAGAAGATG ATGCTCTGTG GCCCCCTCCT 
GATCGCGTGG GCCGGCAGGA GCTTGAAATT GTCATTGGAG ATGAACACAT TTCTTTCACA 
ACATCAAAAA TTGGTTCCCT TATTGATGTC AACCAGTCCA AGGATCCGGA AGGCTTGCGA 
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTAGTCT TCAGTCTGAT TGGATTACAC 
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001269666.1
CDS	104..544
Translation	MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI

Target ORF information:

RefSeq Version	NM_001282737.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus mago homolog, exon junction complex core component (Magoh), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001282737.1

ORF Insert Sequence:

ATGGAGAGTG ACTTTTACCT GCGTTACTAC GTGGGCCACA AAGGCAAGTT CGGTCATGAG 
TTCCTGGAGT TTGAATTCCG ACCTGACGGT AAATTGCGAT ACGCCAACAA CAGCAATTAC 
AAAAATGACG TCATGATCAG GAAAGAGGCT TATGTGCATA AAAGTGTGAT GGAAGAGTTA 
AAGAGAATTA TTGATGACAG TGAAATCACC AAAGAAGATG ATGCTCTGTG GCCCCCTCCT 
GATCGCGTGG GCCGGCAGGA GCTTGAAATT GTCATTGGAG ATGAACACAT TTCTTTCACA 
ACATCAAAAA TTGGTTCCCT TATTGATGTC AACCAGTCCA AGGATCCGGA AGGCTTGCGA 
GTATTTTATT ATCTTGTCCA GGACCTGAAG TGTTTAGTCT TCAGTCTGAT TGGATTACAC 
TTCAAGATTA AACCAATCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex.
RNA (New York, N.Y.)23(1)23-31(2017 01)
Mao H,Brown HE,Silver DL

Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.
PLoS genetics12(9)e1006282(2016 Sep)
Mao H,McMahon JJ,Tsai YH,Wang Z,Silver DL

Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.
Neuron89(1)83-99(2016 Jan)
Pilaz LJ,McMahon JJ,Miller EE,Lennox AL,Suzuki A,Salmon E,Silver DL

Generation of a Magoh conditional allele in mice.
Genesis (New York, N.Y. : 2000)52(8)752-8(2014 Aug)
McMahon JJ,Shi L,Silver DL

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Magoh cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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