Acot4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acot4
Entrez Gene ID	171282
Full Name	acyl-CoA thioesterase 4
Synonyms	B430212I04Rik,PTE-Ib,Pte1b,Pte2b
General protein information	Preferred Names acyl-CoA thioesterase 4 Names acyl-coenzyme A thioesterase 4 PTE-2b peroxisomal acyl coenzyme A thioester hydrolase Ib peroxisomal acyl-CoA thioesterase 2B peroxisomal long-chain acyl-CoA thioesterase Ib
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_134247.3	NP_599008.3	peroxisomal succinyl-coenzyme A thioesterase
XM_017314967.1	XP_017170456.1	acyl-coenzyme A thioesterase 4 isoform X1
XM_017314967.2	XP_017170456.1	peroxisomal succinyl-coenzyme A thioesterase isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC512541	XP_002691046.1
Pan troglodytes (chimpanzee)	ACOT4	XP_510049.2
Mus musculus (house mouse)	Acot4	NP_599008.3
	ACOT4	XP_001091182.1
Homo sapiens (human)	ACOT4	NP_689544.3
Canis lupus familiaris (dog)	ACOT4	XP_547893.2
Bos taurus (cattle)	ACOT4	NP_001092411.2
Rattus norvegicus (Norway rat)	Acot4	NP_001102910.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Boj SF, van Es JH, Huch M, Li VS, Jos? A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H
Cell151(7)1595-607(2012 Dec)

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(11)1855-64(2006 Sep)

The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.
Westin MA, Hunt MC, Alexson SE
The Journal of biological chemistry280(46)38125-32(2005 Nov)

Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.
Westin MA, Alexson SE, Hunt MC
The Journal of biological chemistry279(21)21841-8(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids
Title: The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.

The following Acot4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acot4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu15989	NM_134247.3 Latest version!	Mus musculus acyl-CoA thioesterase 4 (Acot4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
OMu78152	XM_017314967.2 Latest version!	Mus musculus acyl-CoA thioesterase 4 (Acot4), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu78152	XM_017314967.1	Mus musculus acyl-CoA thioesterase 4 (Acot4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acot4 ( NM_134247.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_599008.3 Mus musculus acyl-CoA thioesterase 4 (Acot4), mRNA.

Price & Availability↑

CloneID	OMu15989
Clone ID Related Accession (Same CDS sequence)	NM_134247.3
Accession Version	NM_134247.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	peroxisomal succinyl-coenzyme A thioesterase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK046630.1, BC113185.1 and AC133183.3. On Nov 20, 2009 this sequence version replaced NM_134247.2. ##Evidence-Data-START## Transcript exon combination :: AK046630.1, AK050420.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGA CACTGAGCGT GGAGCCCACG GGCCGCAGCT GCTGGGACGA GCCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCG CGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCGTGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA CGTGCAGACG 
CCCTTCTTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CCGATGGCGG GCGGCGGCTG 
GCGCGGACGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGGAC AAGGACCCTT TCCAGGCATC 
ATCGATGTTT ATGGTGTTGG AGGAGGCCTG TTGGAATACC GAGCCGGCCT TGTGGCTGGC 
CATGGCTTTG CCACATTGGC TCTGGCTTTT TATGACTTTG AGGATCTCCC CAAAGAGCTC 
AACGTCATAG AAGTGGACTA CTTTGAAGAA GCAGTGCGGT ACATGCTTCG ACATCCAAAG 
GTAAAAGGCC CAGACATTGG GCTTCTGGGT CTTTCCCTAG GAGCTGATGT CTGTCTGATC 
ATGGCTTCCT TCTTGAATAA TGTCTCAGCC ACAGTTTCCA TCAATGGCTC TGCATTCAGT 
GGAAACAGAC ATATCAAGTA CAAGCAGACC ATGATTCCGC CGTTGGGCCA TGACCTGAGG 
AGAATGAAGG TGGCTTTCTC TGGCATTCTG GACATTGTGG ATATACGGAA TGATGCTGTA 
GGAGGCTGTG AGAACCCCAG CATGATACCA ATAGAGAAGG CCAAGGGGCC CATCCTCTTT 
GTGGCTGGCC AGGATGATCA TTGCTGGAGG AGTGAGTTAT ATACTCAGAT AGCCTCGGAC 
CGGTTACAGG CTCATGGAAA GGAAAGGCCC CAGGTACTCT CTTACCCTGG GACTGGGCAT 
TACATCGAAC CACCTTACTT TCCCATGTGC CCAGCTTCCC TGCACAAAAT AGTGAACGAA 
GCTGTGATTT GGGGAGGGGA GGTCAAGGCT CACTCCAAAG CCCAGATAGA TGCATGGAAG 
CAAATTCTAT TCTTCTTTGG CAAACACCTG GGCAGTACCC ACAGCAGAGC CTCCTGTAGA 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599008.3
CDS	133..1398
Translation	MAATLSVEPTGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGALFRAHARYRADSHGELDLARVPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFLVELEVLDGHEPDGGRRLARTVHERHFMAPGVRRVPVREGRVRATLFLPPGQGPFPGIIDVYGVGGGLLEYRAGLVAGHGFATLALAFYDFEDLPKELNVIEVDYFEEAVRYMLRHPKVKGPDIGLLGLSLGADVCLIMASFLNNVSATVSINGSAFSGNRHIKYKQTMIPPLGHDLRRMKVAFSGILDIVDIRNDAVGGCENPSMIPIEKAKGPILFVAGQDDHCWRSELYTQIASDRLQAHGKERPQVLSYPGTGHYIEPPYFPMCPASLHKIVNEAVIWGGEVKAHSKAQIDAWKQILFFFGKHLGSTHSRASCRL

Target ORF information:

RefSeq Version	NM_134247.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus acyl-CoA thioesterase 4 (Acot4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134247.3

ORF Insert Sequence:

ATGGCAGCGA CACTGAGCGT GGAGCCCACG GGCCGCAGCT GCTGGGACGA GCCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCG CGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCGTGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA CGTGCAGACG 
CCCTTCTTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CCGATGGCGG GCGGCGGCTG 
GCGCGGACGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGGAC AAGGACCCTT TCCAGGCATC 
ATCGATGTTT ATGGTGTTGG AGGAGGCCTG TTGGAATACC GAGCCGGCCT TGTGGCTGGC 
CATGGCTTTG CCACATTGGC TCTGGCTTTT TATGACTTTG AGGATCTCCC CAAAGAGCTC 
AACGTCATAG AAGTGGACTA CTTTGAAGAA GCAGTGCGGT ACATGCTTCG ACATCCAAAG 
GTAAAAGGCC CAGACATTGG GCTTCTGGGT CTTTCCCTAG GAGCTGATGT CTGTCTGATC 
ATGGCTTCCT TCTTGAATAA TGTCTCAGCC ACAGTTTCCA TCAATGGCTC TGCATTCAGT 
GGAAACAGAC ATATCAAGTA CAAGCAGACC ATGATTCCGC CGTTGGGCCA TGACCTGAGG 
AGAATGAAGG TGGCTTTCTC TGGCATTCTG GACATTGTGG ATATACGGAA TGATGCTGTA 
GGAGGCTGTG AGAACCCCAG CATGATACCA ATAGAGAAGG CCAAGGGGCC CATCCTCTTT 
GTGGCTGGCC AGGATGATCA TTGCTGGAGG AGTGAGTTAT ATACTCAGAT AGCCTCGGAC 
CGGTTACAGG CTCATGGAAA GGAAAGGCCC CAGGTACTCT CTTACCCTGG GACTGGGCAT 
TACATCGAAC CACCTTACTT TCCCATGTGC CCAGCTTCCC TGCACAAAAT AGTGAACGAA 
GCTGTGATTT GGGGAGGGGA GGTCAAGGCT CACTCCAAAG CCCAGATAGA TGCATGGAAG 
CAAATTCTAT TCTTCTTTGG CAAACACCTG GGCAGTACCC ACAGCAGAGC CTCCTGTAGA 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acot4 ( XM_017314967.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017170456.1 Mus musculus acyl-CoA thioesterase 4 (Acot4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu78152
Clone ID Related Accession (Same CDS sequence)	XM_017314967.1 , XM_017314967.2
Accession Version	XM_017314967.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	acyl-coenzyme A thioesterase 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCGA CACTGAGCGT GGAGCCCACG GGCCGCAGCT GCTGGGACGA GCCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCG CGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCGTGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA CGTGCAGACG 
CCCTTCTTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CCGATGGCGG GCGGCGGCTG 
GCGCGGACGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGTCC CGCGTTGGGT CGCCAGATCT 
GTTGCGGCTG GCCAGCGGCT CACATGTCTG GGTTCTAGTC TGAGAAGCAT CTTGGAACCT 
GGAAGAGAAG ATGGGGCTAG GCGATGCGAG AGAGACGGAG CTAAGACAAC CAGGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017170456.1
CDS	1084..1683
Translation	MAATLSVEPTGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGALFRAHARYRADSHGELDLARVPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFLVELEVLDGHEPDGGRRLARTVHERHFMAPGVRRVPVREGRVRATLFLPPVPRWVARSVAAGQRLTCLGSSLRSILEPGREDGARRCERDGAKTTRF

Target ORF information:

RefSeq Version	XM_017314967.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus acyl-CoA thioesterase 4 (Acot4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314967.1

ORF Insert Sequence:

ATGGCAGCGA CACTGAGCGT GGAGCCCACG GGCCGCAGCT GCTGGGACGA GCCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCG CGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCGTGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA CGTGCAGACG 
CCCTTCTTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CCGATGGCGG GCGGCGGCTG 
GCGCGGACGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGTCC CGCGTTGGGT CGCCAGATCT 
GTTGCGGCTG GCCAGCGGCT CACATGTCTG GGTTCTAGTC TGAGAAGCAT CTTGGAACCT 
GGAAGAGAAG ATGGGGCTAG GCGATGCGAG AGAGACGGAG CTAAGACAAC CAGGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acot4 ( XM_017314967.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017170456.1 Mus musculus acyl-CoA thioesterase 4 (Acot4), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu78152
Clone ID Related Accession (Same CDS sequence)	XM_017314967.1 , XM_017314967.2
Accession Version	XM_017314967.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	peroxisomal succinyl-coenzyme A thioesterase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017314967.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCGA CACTGAGCGT GGAGCCCACG GGCCGCAGCT GCTGGGACGA GCCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCG CGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCGTGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA CGTGCAGACG 
CCCTTCTTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CCGATGGCGG GCGGCGGCTG 
GCGCGGACGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGTCC CGCGTTGGGT CGCCAGATCT 
GTTGCGGCTG GCCAGCGGCT CACATGTCTG GGTTCTAGTC TGAGAAGCAT CTTGGAACCT 
GGAAGAGAAG ATGGGGCTAG GCGATGCGAG AGAGACGGAG CTAAGACAAC CAGGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017170456.1
CDS	1258..1857
Translation	MAATLSVEPTGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGALFRAHARYRADSHGELDLARVPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFLVELEVLDGHEPDGGRRLARTVHERHFMAPGVRRVPVREGRVRATLFLPPVPRWVARSVAAGQRLTCLGSSLRSILEPGREDGARRCERDGAKTTRF

Target ORF information:

RefSeq Version	XM_017314967.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus acyl-CoA thioesterase 4 (Acot4), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314967.2

ORF Insert Sequence:

ATGGCAGCGA CACTGAGCGT GGAGCCCACG GGCCGCAGCT GCTGGGACGA GCCGCTGAGC 
ATCGCCGTGC GCGGCCTGGC CCCCGAGCAG CCCGTCACGC TGCGCTCTGT CCTGCGCGAC 
GAGAAGGGCG CGCTCTTCCG AGCCCACGCG CGCTACCGCG CGGACTCCCA CGGCGAGCTG 
GACCTGGCGC GCGTGCCCGC GCTGGGCGGC AGCTTCTCGG GGCTCGAGCC CATGGGGCTG 
CTCTGGGCCA TGGAGCCCGA TCGGCCTTTC TGGCGCCTGA TCAAGCGCGA CGTGCAGACG 
CCCTTCTTGG TGGAGCTGGA GGTGCTGGAC GGACACGAGC CCGATGGCGG GCGGCGGCTG 
GCGCGGACGG TGCACGAGCG TCACTTCATG GCTCCCGGGG TGCGGCGCGT GCCCGTGCGC 
GAGGGCCGGG TGCGCGCCAC GCTCTTCCTG CCCCCAGTCC CGCGTTGGGT CGCCAGATCT 
GTTGCGGCTG GCCAGCGGCT CACATGTCTG GGTTCTAGTC TGAGAAGCAT CTTGGAACCT 
GGAAGAGAAG ATGGGGCTAG GCGATGCGAG AGAGACGGAG CTAAGACAAC CAGGTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Cell151(7)1595-607(2012 Dec)
Boj SF,van Es JH,Huch M,Li VS,Jos? A,Hatzis P,Mokry M,Haegebarth A,van den Born M,Chambon P,Voshol P,Dor Y,Cuppen E,Fillat C,Clevers H

Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(11)1855-64(2006 Sep)
Hunt MC,Rautanen A,Westin MA,Svensson LT,Alexson SE

The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes.
The Journal of biological chemistry280(46)38125-32(2005 Nov)
Westin MA,Hunt MC,Alexson SE

Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases.
The Journal of biological chemistry279(21)21841-8(2004 May)
Westin MA,Alexson SE,Hunt MC

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Acot4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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