Ly9 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ly9
Entrez Gene ID	17085
Full Name	lymphocyte antigen 9
Synonyms	AI893573,CD229,Lgp100,Ly-9,SLAMF3,T100
General protein information	Preferred Names lymphocyte antigen 9 Names T-lymphocyte surface antigen Ly-9 SLAM family member 3 cell surface molecule Ly-9 signaling lymphocytic activation molecule 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 79.54 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_008534.3	NP_032560.2	T-lymphocyte surface antigen Ly-9 isoform 1 precursor
NM_001277968.1	NP_001264897.1	T-lymphocyte surface antigen Ly-9 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LY9	XP_001172413.1
Canis lupus familiaris (dog)	LY9	XP_005640937.1
Bos taurus (cattle)	LY9	NP_001069386.1
Rattus norvegicus (Norway rat)	Ly9	NP_001178602.1
Homo sapiens (human)	LY9	NP_002339.2
Mus musculus (house mouse)	Ly9	NP_032560.2

Gene Ontology
Bibliography

Related articles in PubMed

Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice.
Cuenca M, Pu?et-Ortiz J, Ruart M, Terhorst C, Engel P
European journal of immunology48(1)99-105(2018 Jan)

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.
Wu N, Zhong MC, Roncagalli R, P?rez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A
Nature immunology17(4)387-96(2016 Apr)

Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses.
Cuenca M, Romero X, Sintes J, Terhorst C, Engel P
Journal of immunology (Baltimore, Md. : 1950)196(2)726-37(2016 Jan)

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.
Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y
PloS one10(3)e0121550(2015)

Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression.
Marcq I, Nyga R, Cartier F, Amrathlal RS, Ossart C, Ouled-Haddou H, Ghamlouch H, Galmiche A, Chatelain D, Lamotte L, Debuysscher V, Fuentes V, Nguyen-Khac E, Regimbeau JM, Marolleau JP, Latour S, Bouhlal H
PloS one8(12)e82918(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ly9/CD229 cell surface receptor emerges as a uniquely important element for modulating innate T cell function, acting as an inhibitory molecule that regulates invariant natural killer (NK)T cell development and innate-like CD8 T cell expansion.
Title: Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells.

SLAMF3 is an inhibitor of hepatocellular carcinoma cell proliferation and tumor progression.
Title: Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression.

Data show that defective tolerance was observed only in Fcgr2b-deficient mice with autoimmune-type Slam family genes, indicating that epistatic effects of both genes are involved.
Title: Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: implication of epistatic effects of Fcgr2b and Slam family genes.

CD229 is a pan-lymphocyte marker and indicate that mAbs against CD229 are able to down-modulate T-cell activation.
Title: Characterization of mouse CD229 (Ly9), a leukocyte cell surface molecule of the CD150 (SLAM) family.

CD229 is a self-ligand, interacting through its N-terminal V-like domain which contains three amino acid residues critical for the homophilic binding interaction.
Title: CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.

The following Ly9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ly9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02174	NM_008534.3 Latest version!	Mus musculus lymphocyte antigen 9 (Ly9), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$384.30 $549.00
OMu17268	NM_001277968.1 Latest version!	Mus musculus lymphocyte antigen 9 (Ly9), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ly9 ( NM_008534.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032560.2 Mus musculus lymphocyte antigen 9 (Ly9), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu02174
Clone ID Related Accession (Same CDS sequence)	NM_008534.3
Accession Version	NM_008534.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1965bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	T-lymphocyte surface antigen Ly-9 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF244131.1, AK134106.1 and AC083892.19. On May 2, 2013 this sequence version replaced NM_008534.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF244130.1, BC095921.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGATC TAAAGAGATA TTGGTGTGAC TGGGCTCTAG GTCCACTCTC TGAAAATCCA 
AGAATGAGTC AGCAGCAGAT ATTTTCTCCC ATTCTTTGGA TTCCTCTCCT CTTCCTACTC 
ATGGGGCTCG GAGCCTCTGG AAAGGAAACA CCTCCAACAG TGATATCAGG GATGCTAGGG 
GGTTCTGTGA CTTTCTCCCT AAACATCTCA AAGGATGCAG AGATTGAGCA TATCATCTGG 
AATTGTCCCC CAAAGGCTCT TGCTTTAGTA TTCTACAAAA AAGATATAAC TATTCTGGAC 
AAAGGATATA ATGGCAGACT CAAAGTCAGC GAAGATGGCT ACTCCTTGTA CATGAGCAAC 
CTAACCAAAA GTGATTCAGG ATCCTACCAT GCTCAGATAA ACCAAAAGAA TGTTATCCTC 
ACCACAAATA AAGAGTTCAC ACTGCACATC TATGAGAAGC TCCAGAAGCC TCAGATCATC 
GTGGAATCTG TGACCCCATC CGATACTGAT TCCTGCACCT TCACCCTAAT CTGCACTGTA 
AAGGGGACAA AGGACAGTGT CCAGTACAGC TGGACCCGAG AGGACACCCA TTTAAATACA 
TACGATGGAA GCCACACCCT CAGGGTTTCC CAGAGTGTCT GTGACCCCGA CCTACCCTAT 
ACCTGCAAAG CCTGGAATCC AGTCAGCCAA AACAGCTCCC AACCTGTCCG CATCTGGCAA 
TTCTGCACAG GAGCCTCCAG AAGAAAAACA GCAGCGGGGA AGACTGTGGT AGGAATCCTG 
GGAGAGCCAG TGACCCTGCC CTTGGAATTT CGGGCCACTC GGGCCACAAA GAATGTTGTC 
TGGGTGTTTA ACACGTCGGT TATCAGCCAA GAACGGAGAG GAGCAGCAAC AGCGGATTCT 
CGCCGTAAGC CCAAAGGTTC TGAAGAACGG AGGGTGAGGA CCTCTGACCA GGACCAATCC 
CTGAAGATCA GCCAGCTGAA GATGGAGGAC GCGGGCCCCT ACCATGCCTA TGTGTGCTCA 
GAGGCCTCCC GAGACCCCAG TGTGAGACAT TTCACCTTGC TTGTCTACAA GAGACTGGAG 
AAGCCCAGTG TCACCAAGAG TCCTGTGCAC ATGATGAACG GAATCTGCGA GGTTGTCCTG 
ACCTGTTCAG TGGACGGTGG TGGAAACAAT GTGACATACA CATGGATGCC TCTACAAAAC 
AAAGCTGTCA TGTCCCAAGG GAAGTCGCAC CTCAACGTCT CCTGGGAAAG TGGTGAACAC 
CTGCCCAACT TCACATGCAC AGCCCATAAC CCTGTCAGCA ACAGCTCCAG CCAGTTTTCT 
TCTGGGACCA TCTGTTCAGG CCCTGAGAGA AACAAGAGGT TTTGGCTCCT GCTCCTCCTG 
GTTTTGCTCT TGTTGATGCT CATTGGCGGT TACTTCATTT TGAGGAAAAA GAAGCAGTGT 
TCGTCTTTGG CCACCAGGTA CAGACAAGCG GAGGTCCCAG CTGAAATACC AGAAACCCCA 
ACTGGCCATG GACAATTTTC TGTGCTCTCC CAACGGTATG AGAAACTAGA CATGTCTGCT 
AAGACCACCA GGCATCAGCC TACACCCACC TCAGATACCA GCTCTGAGAG CAGCGCAACA 
ACAGAAGAGG ATGACGAAAA GACCAGAATG CACAGCACTG CTAATAGTAG AAATCAGGTG 
TATGACTTGG TCACCCATCA GGACATTGCA CATGCCTTGG CCTATGAGGG GCAAGTAGAA 
TATGAAGCAA TCACTCCATA TGATAAAGTG GATGGGTCTA TGGATGAAGA GGACATGGCA 
TATATACAAG TGTCCCTGAA TGTGCAGGGA GAGACCCCAC TTCCTCAGAA GAAAGAAGAC 
TCAAATACAA TCTACTGCTC TGTGCAGAAG CCTAAAAAGA CGGCACAAAC ACCACAGCAA 
GATGCTGAGT CTCCTGAAAC CCCTACCTAT GAAAATTTCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032560.2
CDS	88..2052
Translation	MADLKRYWCDWALGPLSENPRMSQQQIFSPILWIPLLFLLMGLGASGKETPPTVISGMLGGSVTFSLNISKDAEIEHIIWNCPPKALALVFYKKDITILDKGYNGRLKVSEDGYSLYMSNLTKSDSGSYHAQINQKNVILTTNKEFTLHIYEKLQKPQIIVESVTPSDTDSCTFTLICTVKGTKDSVQYSWTREDTHLNTYDGSHTLRVSQSVCDPDLPYTCKAWNPVSQNSSQPVRIWQFCTGASRRKTAAGKTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERRGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGPYHAYVCSEASRDPSVRHFTLLVYKRLEKPSVTKSPVHMMNGICEVVLTCSVDGGGNNVTYTWMPLQNKAVMSQGKSHLNVSWESGEHLPNFTCTAHNPVSNSSSQFSSGTICSGPERNKRFWLLLLLVLLLLMLIGGYFILRKKKQCSSLATRYRQAEVPAEIPETPTGHGQFSVLSQRYEKLDMSAKTTRHQPTPTSDTSSESSATTEEDDEKTRMHSTANSRNQVYDLVTHQDIAHALAYEGQVEYEAITPYDKVDGSMDEEDMAYIQVSLNVQGETPLPQKKEDSNTIYCSVQKPKKTAQTPQQDAESPETPTYENFT

Target ORF information:

RefSeq Version	NM_008534.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lymphocyte antigen 9 (Ly9), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008534.3

ORF Insert Sequence:

ATGGCGGATC TAAAGAGATA TTGGTGTGAC TGGGCTCTAG GTCCACTCTC TGAAAATCCA 
AGAATGAGTC AGCAGCAGAT ATTTTCTCCC ATTCTTTGGA TTCCTCTCCT CTTCCTACTC 
ATGGGGCTCG GAGCCTCTGG AAAGGAAACA CCTCCAACAG TGATATCAGG GATGCTAGGG 
GGTTCTGTGA CTTTCTCCCT AAACATCTCA AAGGATGCAG AGATTGAGCA TATCATCTGG 
AATTGTCCCC CAAAGGCTCT TGCTTTAGTA TTCTACAAAA AAGATATAAC TATTCTGGAC 
AAAGGATATA ATGGCAGACT CAAAGTCAGC GAAGATGGCT ACTCCTTGTA CATGAGCAAC 
CTAACCAAAA GTGATTCAGG ATCCTACCAT GCTCAGATAA ACCAAAAGAA TGTTATCCTC 
ACCACAAATA AAGAGTTCAC ACTGCACATC TATGAGAAGC TCCAGAAGCC TCAGATCATC 
GTGGAATCTG TGACCCCATC CGATACTGAT TCCTGCACCT TCACCCTAAT CTGCACTGTA 
AAGGGGACAA AGGACAGTGT CCAGTACAGC TGGACCCGAG AGGACACCCA TTTAAATACA 
TACGATGGAA GCCACACCCT CAGGGTTTCC CAGAGTGTCT GTGACCCCGA CCTACCCTAT 
ACCTGCAAAG CCTGGAATCC AGTCAGCCAA AACAGCTCCC AACCTGTCCG CATCTGGCAA 
TTCTGCACAG GAGCCTCCAG AAGAAAAACA GCAGCGGGGA AGACTGTGGT AGGAATCCTG 
GGAGAGCCAG TGACCCTGCC CTTGGAATTT CGGGCCACTC GGGCCACAAA GAATGTTGTC 
TGGGTGTTTA ACACGTCGGT TATCAGCCAA GAACGGAGAG GAGCAGCAAC AGCGGATTCT 
CGCCGTAAGC CCAAAGGTTC TGAAGAACGG AGGGTGAGGA CCTCTGACCA GGACCAATCC 
CTGAAGATCA GCCAGCTGAA GATGGAGGAC GCGGGCCCCT ACCATGCCTA TGTGTGCTCA 
GAGGCCTCCC GAGACCCCAG TGTGAGACAT TTCACCTTGC TTGTCTACAA GAGACTGGAG 
AAGCCCAGTG TCACCAAGAG TCCTGTGCAC ATGATGAACG GAATCTGCGA GGTTGTCCTG 
ACCTGTTCAG TGGACGGTGG TGGAAACAAT GTGACATACA CATGGATGCC TCTACAAAAC 
AAAGCTGTCA TGTCCCAAGG GAAGTCGCAC CTCAACGTCT CCTGGGAAAG TGGTGAACAC 
CTGCCCAACT TCACATGCAC AGCCCATAAC CCTGTCAGCA ACAGCTCCAG CCAGTTTTCT 
TCTGGGACCA TCTGTTCAGG CCCTGAGAGA AACAAGAGGT TTTGGCTCCT GCTCCTCCTG 
GTTTTGCTCT TGTTGATGCT CATTGGCGGT TACTTCATTT TGAGGAAAAA GAAGCAGTGT 
TCGTCTTTGG CCACCAGGTA CAGACAAGCG GAGGTCCCAG CTGAAATACC AGAAACCCCA 
ACTGGCCATG GACAATTTTC TGTGCTCTCC CAACGGTATG AGAAACTAGA CATGTCTGCT 
AAGACCACCA GGCATCAGCC TACACCCACC TCAGATACCA GCTCTGAGAG CAGCGCAACA 
ACAGAAGAGG ATGACGAAAA GACCAGAATG CACAGCACTG CTAATAGTAG AAATCAGGTG 
TATGACTTGG TCACCCATCA GGACATTGCA CATGCCTTGG CCTATGAGGG GCAAGTAGAA 
TATGAAGCAA TCACTCCATA TGATAAAGTG GATGGGTCTA TGGATGAAGA GGACATGGCA 
TATATACAAG TGTCCCTGAA TGTGCAGGGA GAGACCCCAC TTCCTCAGAA GAAAGAAGAC 
TCAAATACAA TCTACTGCTC TGTGCAGAAG CCTAAAAAGA CGGCACAAAC ACCACAGCAA 
GATGCTGAGT CTCCTGAAAC CCCTACCTAT GAAAATTTCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ly9 ( NM_001277968.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001264897.1 Mus musculus lymphocyte antigen 9 (Ly9), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17268
Clone ID Related Accession (Same CDS sequence)	NM_001277968.1
Accession Version	NM_001277968.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1635bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	T-lymphocyte surface antigen Ly-9 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF244131.1, AK134106.1 and AC083892.19. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK088815.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGATC TAAAGAGATA TTGGTGTGAC TGGGCTCTAG GTCCACTCTC TGAAAATCCA 
AGAATGAGTC AGCAGCAGAT ATTTTCTCCC ATTCTTTGGA TTCCTCTCCT CTTCCTACTC 
ATGGAGAAGC TCCAGAAGCC TCAGATCATC GTGGAATCTG TGACCCCATC CGATACTGAT 
TCCTGCACCT TCACCCTAAT CTGCACTGTA AAGGGGACAA AGGACAGTGT CCAGTACAGC 
TGGACCCGAG AGGACACCCA TTTAAATACA TACGATGGAA GCCACACCCT CAGGGTTTCC 
CAGAGTGTCT GTGACCCCGA CCTACCCTAT ACCTGCAAAG CCTGGAATCC AGTCAGCCAA 
AACAGCTCCC AACCTGTCCG CATCTGGCAA TTCTGCACAG GAGCCTCCAG AAGAAAAACA 
GCAGCGGGGA AGACTGTGGT AGGAATCCTG GGAGAGCCAG TGACCCTGCC CTTGGAATTT 
CGGGCCACTC GGGCCACAAA GAATGTTGTC TGGGTGTTTA ACACGTCGGT TATCAGCCAA 
GAACGGAGAG GAGCAGCAAC AGCGGATTCT CGCCGTAAGC CCAAAGGTTC TGAAGAACGG 
AGGGTGAGGA CCTCTGACCA GGACCAATCC CTGAAGATCA GCCAGCTGAA GATGGAGGAC 
GCGGGCCCCT ACCATGCCTA TGTGTGCTCA GAGGCCTCCC GAGACCCCAG TGTGAGACAT 
TTCACCTTGC TTGTCTACAA GAGACTGGAG AAGCCCAGTG TCACCAAGAG TCCTGTGCAC 
ATGATGAACG GAATCTGCGA GGTTGTCCTG ACCTGTTCAG TGGACGGTGG TGGAAACAAT 
GTGACATACA CATGGATGCC TCTACAAAAC AAAGCTGTCA TGTCCCAAGG GAAGTCGCAC 
CTCAACGTCT CCTGGGAAAG TGGTGAACAC CTGCCCAACT TCACATGCAC AGCCCATAAC 
CCTGTCAGCA ACAGCTCCAG CCAGTTTTCT TCTGGGACCA TCTGTTCAGG CCCTGAGAGA 
AACAAGAGGT TTTGGCTCCT GCTCCTCCTG GTTTTGCTCT TGTTGATGCT CATTGGCGGT 
TACTTCATTT TGAGGAAAAA GAAGCAGTGT TCGTCTTTGG CCACCAGGTA CAGACAAGCG 
GAGGTCCCAG CTGAAATACC AGAAACCCCA ACTGGCCATG GACAATTTTC TGTGCTCTCC 
CAACGGTATG AGAAACTAGA CATGTCTGCT AAGACCACCA GGCATCAGCC TACACCCACC 
TCAGATACCA GCTCTGAGAG CAGCGCAACA ACAGAAGAGG ATGACGAAAA GACCAGAATG 
CACAGCACTG CTAATAGTAG AAATCAGGTG TATGACTTGG TCACCCATCA GGACATTGCA 
CATGCCTTGG CCTATGAGGG GCAAGTAGAA TATGAAGCAA TCACTCCATA TGATAAAGTG 
GATGGGTCTA TGGATGAAGA GGACATGGCA TATATACAAG TGTCCCTGAA TGTGCAGGGA 
GAGACCCCAC TTCCTCAGAA GAAAGAAGAC TCAAATACAA TCTACTGCTC TGTGCAGAAG 
CCTAAAAAGA CGGCACAAAC ACCACAGCAA GATGCTGAGT CTCCTGAAAC CCCTACCTAT 
GAAAATTTCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264897.1
CDS	88..1722
Translation	MADLKRYWCDWALGPLSENPRMSQQQIFSPILWIPLLFLLMEKLQKPQIIVESVTPSDTDSCTFTLICTVKGTKDSVQYSWTREDTHLNTYDGSHTLRVSQSVCDPDLPYTCKAWNPVSQNSSQPVRIWQFCTGASRRKTAAGKTVVGILGEPVTLPLEFRATRATKNVVWVFNTSVISQERRGAATADSRRKPKGSEERRVRTSDQDQSLKISQLKMEDAGPYHAYVCSEASRDPSVRHFTLLVYKRLEKPSVTKSPVHMMNGICEVVLTCSVDGGGNNVTYTWMPLQNKAVMSQGKSHLNVSWESGEHLPNFTCTAHNPVSNSSSQFSSGTICSGPERNKRFWLLLLLVLLLLMLIGGYFILRKKKQCSSLATRYRQAEVPAEIPETPTGHGQFSVLSQRYEKLDMSAKTTRHQPTPTSDTSSESSATTEEDDEKTRMHSTANSRNQVYDLVTHQDIAHALAYEGQVEYEAITPYDKVDGSMDEEDMAYIQVSLNVQGETPLPQKKEDSNTIYCSVQKPKKTAQTPQQDAESPETPTYENFT

Target ORF information:

RefSeq Version	NM_001277968.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus lymphocyte antigen 9 (Ly9), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277968.1

ORF Insert Sequence:

ATGGCGGATC TAAAGAGATA TTGGTGTGAC TGGGCTCTAG GTCCACTCTC TGAAAATCCA 
AGAATGAGTC AGCAGCAGAT ATTTTCTCCC ATTCTTTGGA TTCCTCTCCT CTTCCTACTC 
ATGGAGAAGC TCCAGAAGCC TCAGATCATC GTGGAATCTG TGACCCCATC CGATACTGAT 
TCCTGCACCT TCACCCTAAT CTGCACTGTA AAGGGGACAA AGGACAGTGT CCAGTACAGC 
TGGACCCGAG AGGACACCCA TTTAAATACA TACGATGGAA GCCACACCCT CAGGGTTTCC 
CAGAGTGTCT GTGACCCCGA CCTACCCTAT ACCTGCAAAG CCTGGAATCC AGTCAGCCAA 
AACAGCTCCC AACCTGTCCG CATCTGGCAA TTCTGCACAG GAGCCTCCAG AAGAAAAACA 
GCAGCGGGGA AGACTGTGGT AGGAATCCTG GGAGAGCCAG TGACCCTGCC CTTGGAATTT 
CGGGCCACTC GGGCCACAAA GAATGTTGTC TGGGTGTTTA ACACGTCGGT TATCAGCCAA 
GAACGGAGAG GAGCAGCAAC AGCGGATTCT CGCCGTAAGC CCAAAGGTTC TGAAGAACGG 
AGGGTGAGGA CCTCTGACCA GGACCAATCC CTGAAGATCA GCCAGCTGAA GATGGAGGAC 
GCGGGCCCCT ACCATGCCTA TGTGTGCTCA GAGGCCTCCC GAGACCCCAG TGTGAGACAT 
TTCACCTTGC TTGTCTACAA GAGACTGGAG AAGCCCAGTG TCACCAAGAG TCCTGTGCAC 
ATGATGAACG GAATCTGCGA GGTTGTCCTG ACCTGTTCAG TGGACGGTGG TGGAAACAAT 
GTGACATACA CATGGATGCC TCTACAAAAC AAAGCTGTCA TGTCCCAAGG GAAGTCGCAC 
CTCAACGTCT CCTGGGAAAG TGGTGAACAC CTGCCCAACT TCACATGCAC AGCCCATAAC 
CCTGTCAGCA ACAGCTCCAG CCAGTTTTCT TCTGGGACCA TCTGTTCAGG CCCTGAGAGA 
AACAAGAGGT TTTGGCTCCT GCTCCTCCTG GTTTTGCTCT TGTTGATGCT CATTGGCGGT 
TACTTCATTT TGAGGAAAAA GAAGCAGTGT TCGTCTTTGG CCACCAGGTA CAGACAAGCG 
GAGGTCCCAG CTGAAATACC AGAAACCCCA ACTGGCCATG GACAATTTTC TGTGCTCTCC 
CAACGGTATG AGAAACTAGA CATGTCTGCT AAGACCACCA GGCATCAGCC TACACCCACC 
TCAGATACCA GCTCTGAGAG CAGCGCAACA ACAGAAGAGG ATGACGAAAA GACCAGAATG 
CACAGCACTG CTAATAGTAG AAATCAGGTG TATGACTTGG TCACCCATCA GGACATTGCA 
CATGCCTTGG CCTATGAGGG GCAAGTAGAA TATGAAGCAA TCACTCCATA TGATAAAGTG 
GATGGGTCTA TGGATGAAGA GGACATGGCA TATATACAAG TGTCCCTGAA TGTGCAGGGA 
GAGACCCCAC TTCCTCAGAA GAAAGAAGAC TCAAATACAA TCTACTGCTC TGTGCAGAAG 
CCTAAAAAGA CGGCACAAAC ACCACAGCAA GATGCTGAGT CTCCTGAAAC CCCTACCTAT 
GAAAATTTCA CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice.
European journal of immunology48(1)99-105(2018 Jan)
Cuenca M,Pu?et-Ortiz J,Ruart M,Terhorst C,Engel P

A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.
Nature immunology17(4)387-96(2016 Apr)
Wu N,Zhong MC,Roncagalli R,P?rez-Quintero LA,Guo H,Zhang Z,Lenoir C,Dong Z,Latour S,Veillette A

Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses.
Journal of immunology (Baltimore, Md. : 1950)196(2)726-37(2016 Jan)
Cuenca M,Romero X,Sintes J,Terhorst C,Engel P

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.
PloS one10(3)e0121550(2015)
Gu Z,Imai F,Kim IJ,Fujita H,Katayama Ki,Mori K,Yoshihara Y,Yoshida Y

Identification of SLAMF3 (CD229) as an inhibitor of hepatocellular carcinoma cell proliferation and tumour progression.
PloS one8(12)e82918(2013)
Marcq I,Nyga R,Cartier F,Amrathlal RS,Ossart C,Ouled-Haddou H,Ghamlouch H,Galmiche A,Chatelain D,Lamotte L,Debuysscher V,Fuentes V,Nguyen-Khac E,Regimbeau JM,Marolleau JP,Latour S,Bouhlal H

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Ly9 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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