Ms4a3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ms4a3
Entrez Gene ID	170813
Full Name	membrane-spanning 4-domains, subfamily A, member 3
Synonyms	HTm4
General protein information	Preferred Names membrane-spanning 4-domains, subfamily A, member 3 Names membrane-spanning 4-domains subfamily A member 3 haematopoietic cell-specific transmembrane-4 hematopoietic-specific transmembrane protein 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 A
Summary	This gene encodes a member of the membrane-spanning-four (MS4) protein group, that contain a four-transmembrane protein structure. This gene is expressed in developing hematopoietic cells and has also been observed in some regions of the adult brain. Expression of the human ortholog of this gene has also been observed in some human cancer cell lines. This protein may play a role in cell cycle regulation, and interactions have been demonstrated between Ms4a3 and KAP phosphatase. [provided by RefSeq, Jul 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133246.5	NP_573509.1	membrane-spanning 4-domains subfamily A member 3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Ms4a3	XP_006231173.1
	MS4A3	XP_001088476.1
Pan troglodytes (chimpanzee)	MS4A3	XP_001136457.2
Bos taurus (cattle)	MS4A3	XP_005216680.1
Mus musculus (house mouse)	Ms4a3	NP_573509.1
Homo sapiens (human)	MS4A3	NP_006129.4

Gene Ontology
Bibliography

Related articles in PubMed

Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis.
Ishibashi T, Yokota T, Satoh Y, Ichii M, Sudo T, Doi Y, Ueda T, Nagate Y, Hamanaka Y, Tanimura A, Ezoe S, Shibayama H, Oritani K, Kanakura Y
Biochemical and biophysical research communications495(3)2338-2343(2018 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.
Kutok JL, Yang X, Folkerth R, Adra CN
Journal of cellular and molecular medicine15(1)86-93(2011 Jan)

The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice.
Kutok JL, Yang X, Folkerth RD, Imitola J, Raddassi K, Yano Y, Salahuddin S, Lawitts J, Imboden H, Chinami M, Shirakawa T, Turner H, Khoury S, Sayegh MH, Scadden D, Adra C
Journal of molecular histology36(1-2)77-87(2005 Feb)

Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4.
Hulett MD, Pagler E, Hornby JR
Immunology and cell biology79(4)345-9(2001 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Murine HTm4 is predominantly a hematopoietic protein and highly expressed in the developing and adult murine nervous system.
Title: The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice.

The following Ms4a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ms4a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09979	NM_133246.5 Latest version!	Mus musculus membrane-spanning 4-domains, subfamily A, member 3 (Ms4a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ms4a3 ( NM_133246.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573509.1 Mus musculus membrane-spanning 4-domains, subfamily A, member 3 (Ms4a3), mRNA.

Price & Availability↑

CloneID	OMu09979
Clone ID Related Accession (Same CDS sequence)	NM_133246.5
Accession Version	NM_133246.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Mus musculus(house mouse)
Product	membrane-spanning 4-domains subfamily A member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK158372.1 and AF321128.1. On or before Jul 11, 2014 this sequence version replaced XM_006526726.1, NM_133246.4. ##Evidence-Data-START## Transcript exon combination :: AF321128.1, AY184359.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGAAGCCAG AGGAGACTGG TGGTTCTGTT TATCAGCCCT TGGATGAGTC ACGCCATGTT 
CAACGAGGTG TACTGCAAGC CCTCGGGGCC ATCCAGATCC TGAATGGAAT ACTGATTCTA 
GCTCTCGGAA TTTTTCTGGT TTGTTTACAA CACGTGTCCC ACCACTTCAG GCATTTCTTC 
TTCTTCACCT TCTACACAGG CTACCCACTG TGGGGTGCTG TGTTTTTTAT CAGCTCAGGA 
TCCTTGACTG TTGCCGCAGG GAGAAACCCC ACACGAATGC TGATGCAAAA CAGTTTTGGG 
ATAAACATTG CCAGTACTAC AATTGCATTT GTTGGGACTG TTTTCCTTTC TGTGCATTTG 
GCATTCAATA CCCAGGCTTT CAAGGGTTGC CAATCTTCAC CGTCACCTGA TGTCTGCATT 
TCCCTGGGTT CCTCATCAGA TGGCCTGGTG TCTTTAATGC TGATTCTCAC CCTGCTGGAG 
CTGTCCGTGA CCATTTCTAT CTCTGCCATG TGGTGCTTGG GAAATGTTTG TGGTTTAAGA 
GAGGCAATTA CTTCACCTCC TAATTCTGTG GAGTCAGGAA TACTTCCTGA AGGAAGTGAT 
TCTGAGAACC TGAACACTCA GCCCCAAGCT TCAGAAGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573509.1
CDS	209..850
Translation	MKPEETGGSVYQPLDESRHVQRGVLQALGAIQILNGILILALGIFLVCLQHVSHHFRHFFFFTFYTGYPLWGAVFFISSGSLTVAAGRNPTRMLMQNSFGINIASTTIAFVGTVFLSVHLAFNTQAFKGCQSSPSPDVCISLGSSSDGLVSLMLILTLLELSVTISISAMWCLGNVCGLREAITSPPNSVESGILPEGSDSENLNTQPQASEE

Target ORF information:

RefSeq Version	NM_133246.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus membrane-spanning 4-domains, subfamily A, member 3 (Ms4a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133246.5

ORF Insert Sequence:

ATGAAGCCAG AGGAGACTGG TGGTTCTGTT TATCAGCCCT TGGATGAGTC ACGCCATGTT 
CAACGAGGTG TACTGCAAGC CCTCGGGGCC ATCCAGATCC TGAATGGAAT ACTGATTCTA 
GCTCTCGGAA TTTTTCTGGT TTGTTTACAA CACGTGTCCC ACCACTTCAG GCATTTCTTC 
TTCTTCACCT TCTACACAGG CTACCCACTG TGGGGTGCTG TGTTTTTTAT CAGCTCAGGA 
TCCTTGACTG TTGCCGCAGG GAGAAACCCC ACACGAATGC TGATGCAAAA CAGTTTTGGG 
ATAAACATTG CCAGTACTAC AATTGCATTT GTTGGGACTG TTTTCCTTTC TGTGCATTTG 
GCATTCAATA CCCAGGCTTT CAAGGGTTGC CAATCTTCAC CGTCACCTGA TGTCTGCATT 
TCCCTGGGTT CCTCATCAGA TGGCCTGGTG TCTTTAATGC TGATTCTCAC CCTGCTGGAG 
CTGTCCGTGA CCATTTCTAT CTCTGCCATG TGGTGCTTGG GAAATGTTTG TGGTTTAAGA 
GAGGCAATTA CTTCACCTCC TAATTCTGTG GAGTCAGGAA TACTTCCTGA AGGAAGTGAT 
TCTGAGAACC TGAACACTCA GCCCCAAGCT TCAGAAGAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis.
Biochemical and biophysical research communications495(3)2338-2343(2018 Jan)
Ishibashi T,Yokota T,Satoh Y,Ichii M,Sudo T,Doi Y,Ueda T,Nagate Y,Hamanaka Y,Tanimura A,Ezoe S,Shibayama H,Oritani K,Kanakura Y

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.
Journal of cellular and molecular medicine15(1)86-93(2011 Jan)
Kutok JL,Yang X,Folkerth R,Adra CN

The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice.
Journal of molecular histology36(1-2)77-87(2005 Feb)
Kutok JL,Yang X,Folkerth RD,Imitola J,Raddassi K,Yano Y,Salahuddin S,Lawitts J,Imboden H,Chinami M,Shirakawa T,Turner H,Khoury S,Sayegh MH,Scadden D,Adra C

Cloning and characterization of a mouse homologue of the human haematopoietic cell-specific four-transmembrane gene HTm4.
Immunology and cell biology79(4)345-9(2001 Aug)
Hulett MD,Pagler E,Hornby JR

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Ms4a3 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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