KHDRBS2 cDNA ORF clone, Mus musculus(House mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	KHDRBS2
Entrez Gene ID	170771
Full Name	KH domain containing, RNA binding, signal transduction associated 2
Synonyms	6330586C16Rik,Slim1,Slm-1,Slm1,mSLM-1
General protein information	Preferred Names KH domain containing, RNA binding, signal transduction associated 2 Names KH domain-containing, RNA-binding, signal transduction-associated protein 2 Sam68-like mammalian protein 1
Gene Type	protein-coding
Organism	Mus musculus(House mouse)
Genome	Chromosome: 1 Map Location: 1\|1 B
Summary	The protein encoded by this gene is similar to the src associated in mitosis, 68 kDa protein, which is an RNA-binding protein and a substrate for Src-family tyrosine kinases during mitosis. This protein has a KH RNA-binding motif and proline-rich motifs which may be SH2 and SH3 domain binding sites. A similar rat protein is an RNA-binding protein which is tyrosine phosphorylated by Src during mitosis. These studies also suggest that the rat protein may function as an adaptor protein for Src by binding the SH2 and SH3 domains of various other proteins. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133235.3	NP_573498.1	KH domain-containing, RNA-binding, signal transduction-associated protein 2
NM_133235.2	NP_573498.1	KH domain-containing, RNA-binding, signal transduction-associated protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	KHDRBS2	NP_689901.2
Canis lupus familiaris (dog)	KHDRBS2	XP_005627566.1
Bos taurus (cattle)	KHDRBS2	XP_005223340.1
Danio rerio (zebrafish)	khdrbs2	NP_001070758.1
	LOC713180	XP_001111106.2
Mus musculus (house mouse)	Khdrbs2	NP_573498.1
Xenopus tropicalis (tropical clawed frog)	khdrbs2	NP_001072215.1
Pan troglodytes (chimpanzee)	KHDRBS2	XP_001141327.1
Rattus norvegicus (Norway rat)	Khdrbs2	NP_579852.1
Gallus gallus (chicken)	KHDRBS2	XP_426201.2

Gene Ontology
Bibliography

Related articles in PubMed

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.
Langston RG, Rudenko IN, Cookson MR
The Biochemical journal473(3)221-32(2016 Feb)

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Lavalley NJ, Slone SR, Ding H, West AB, Yacoubian TA
Human molecular genetics25(1)109-22(2016 Jan)

An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.
Tagliaferro P, Kareva T, Oo TF, Yarygina O, Kholodilov N, Burke RE
Neurobiology of disease82359-371(2015 Oct)

Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Mikhail F, Calingasan N, Parolari L, Subramanian A, Yang L, Flint Beal M
Human molecular genetics24(12)3545-56(2015 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Deletion of SLM2 modifies alternative splicing of its paralog Slm1 and stabilizes its mRNA in hippocampus.
Title: Alternative splicing coupled nonsense-mediated decay generates neuronal cell type-specific expression of SLM proteins.

Cell type-specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
Title: Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1.

expression of active BRK/Sik results in increased SLM-1 and SLM-2 phosphorylation which has functional relevance and leads to inhibition of their RNA-binding
Title: The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.

SLIM1 localizes in an integrin-dependent manner to the nucleus and focal adhesions where it functions downstream of integrin activation to promote cell spreading and migration.
Title: Skeletal muscle LIM protein 1 regulates integrin-mediated myoblast adhesion, spreading, and migration.

The following KHDRBS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KHDRBS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17771	NM_133235.3 Latest version!	Mus musculus KH domain containing, RNA binding, signal transduction associated 2 (Khdrbs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu17771	NM_133235.2	Mus musculus KH domain containing, RNA binding, signal transduction associated 2 (Khdrbs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KHDRBS2 ( NM_133235.3 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_573498.1 Mus musculus KH domain containing, RNA binding, signal transduction associated 2 (Khdrbs2), mRNA.

Price & Availability↑

CloneID	OMu17771
Clone ID Related Accession (Same CDS sequence)	NM_133235.3 , NM_133235.2
Accession Version	NM_133235.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	KH domain-containing, RNA-binding, signal transduction-associated protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC140214.3, AC125216.3, AC122027.1 and AC124771.4. On Jan 6, 2017 this sequence version replaced NM_133235.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078160.1, SRR7345562.1931936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGGGAGAAG AGAAATACTT GCCTGAGCTG ATGGCAGAGA AGGATAGCCT GGATCCATCT 
TTTGTGCACG CGTCGCGCCT TCTGGCGGAA GAAATTGAGA AATTTCAAGG TTCAGATGGG 
AAAAAGGAAG ATGAAGAAAA GAAATATCTC GATGTCATCA GCAACAAAAA CATAAAGCTC 
TCTGAAAGAG TATTGATTCC TGTGAAACAG TATCCAAAGT TCAATTTTGT GGGGAAATTG 
CTTGGACCAA GAGGAAACTC CTTGAAGAGG CTACAAGAAG AAACGGGTGC TAAAATGTCT 
ATCCTGGGCA AAGGGTCCAT GCGAGATAAG ACAAAGGAAG AAGAGCTGAG GAAGAGTGGG 
GAGGCCAAGT ATGCCCACCT GAGTGATGAG CTGCATGTAT TAATTGAAGT GTTTGCTCCA 
CCCGGGGAAG CTTATTCACG GATGAGTCAT GCCTTGGAAG AGATTAAAAA ATTCCTGGTT 
CCTGACTACA ATGATGAAAT TCGTCAAGAG CAACTCCGGG AGTTGTCTTA CTTGAATGGC 
TCAGAAGAGT CTGGCCGGGG CCGAGGTATT AGAGGCAGAG GGATCAGAAT AACTCCCACA 
GCTCCATCAA GGGGCCGTGG CGGTGCTGTT CCACCACCAC CACCACCTGG ACGAGGTGTG 
CTTACCCCTC GGGGGACCAC TGTGACCCGT GGAGCTCTTC CAGTGCCCCC AATAGCAAGA 
GGTGTCCCCA CACCTCGAGC CCGGGGGACG GCAGCAGTAC CAGGATACAG AGCACCCCCA 
CCTCCAGCTC ATGATGCTTA TGAAGAATAT GGGTATGATG ATGGCTATGG GGGTGAATAT 
GATGACCAGA CCTATGAGGC TTATGATAAT AGCTACGTGA CCCCAACACA AAGTGTGCCT 
GAATACTATG ACTACGGTCA TGGAGTAAAC GAGGATGCCT ACGACAGCTA CGCACCAGAA 
GAATGGGCCA CAACTCGCTC CAGCCTGAAG GCACCACCAC CAAGGTCAGC CAGAGGGGGA 
TACAGGGAGC ACCCCTATGG TAGATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573498.1
CDS	197..1246
Translation	MGEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKTKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEESGRGRGIRGRGIRITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVTRGALPVPPIARGVPTPRARGTAAVPGYRAPPPPAHDAYEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWATTRSSLKAPPPRSARGGYREHPYGRY

Target ORF information:

RefSeq Version	NM_133235.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus KH domain containing, RNA binding, signal transduction associated 2 (Khdrbs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133235.3

ORF Insert Sequence:

ATGGGAGAAG AGAAATACTT GCCTGAGCTG ATGGCAGAGA AGGATAGCCT GGATCCATCT 
TTTGTGCACG CGTCGCGCCT TCTGGCGGAA GAAATTGAGA AATTTCAAGG TTCAGATGGG 
AAAAAGGAAG ATGAAGAAAA GAAATATCTC GATGTCATCA GCAACAAAAA CATAAAGCTC 
TCTGAAAGAG TATTGATTCC TGTGAAACAG TATCCAAAGT TCAATTTTGT GGGGAAATTG 
CTTGGACCAA GAGGAAACTC CTTGAAGAGG CTACAAGAAG AAACGGGTGC TAAAATGTCT 
ATCCTGGGCA AAGGGTCCAT GCGAGATAAG ACAAAGGAAG AAGAGCTGAG GAAGAGTGGG 
GAGGCCAAGT ATGCCCACCT GAGTGATGAG CTGCATGTAT TAATTGAAGT GTTTGCTCCA 
CCCGGGGAAG CTTATTCACG GATGAGTCAT GCCTTGGAAG AGATTAAAAA ATTCCTGGTT 
CCTGACTACA ATGATGAAAT TCGTCAAGAG CAACTCCGGG AGTTGTCTTA CTTGAATGGC 
TCAGAAGAGT CTGGCCGGGG CCGAGGTATT AGAGGCAGAG GGATCAGAAT AACTCCCACA 
GCTCCATCAA GGGGCCGTGG CGGTGCTGTT CCACCACCAC CACCACCTGG ACGAGGTGTG 
CTTACCCCTC GGGGGACCAC TGTGACCCGT GGAGCTCTTC CAGTGCCCCC AATAGCAAGA 
GGTGTCCCCA CACCTCGAGC CCGGGGGACG GCAGCAGTAC CAGGATACAG AGCACCCCCA 
CCTCCAGCTC ATGATGCTTA TGAAGAATAT GGGTATGATG ATGGCTATGG GGGTGAATAT 
GATGACCAGA CCTATGAGGC TTATGATAAT AGCTACGTGA CCCCAACACA AAGTGTGCCT 
GAATACTATG ACTACGGTCA TGGAGTAAAC GAGGATGCCT ACGACAGCTA CGCACCAGAA 
GAATGGGCCA CAACTCGCTC CAGCCTGAAG GCACCACCAC CAAGGTCAGC CAGAGGGGGA 
TACAGGGAGC ACCCCTATGG TAGATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KHDRBS2 ( NM_133235.2 ) cDNA ORF clone, Mus musculus(House mouse) -> NP_573498.1 Mus musculus KH domain containing, RNA binding, signal transduction associated 2 (Khdrbs2), mRNA.

Price & Availability↑

CloneID	OMu17771
Clone ID Related Accession (Same CDS sequence)	NM_133235.3 , NM_133235.2
Accession Version	NM_133235.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	KH domain-containing, RNA-binding, signal transduction-associated protein 2
Comment

ATGGGAGAAG AGAAATACTT GCCTGAGCTG ATGGCAGAGA AGGATAGCCT GGATCCATCT 
TTTGTGCACG CGTCGCGCCT TCTGGCGGAA GAAATTGAGA AATTTCAAGG TTCAGATGGG 
AAAAAGGAAG ATGAAGAAAA GAAATATCTC GATGTCATCA GCAACAAAAA CATAAAGCTC 
TCTGAAAGAG TATTGATTCC TGTGAAACAG TATCCAAAGT TCAATTTTGT GGGGAAATTG 
CTTGGACCAA GAGGAAACTC CTTGAAGAGG CTACAAGAAG AAACGGGTGC TAAAATGTCT 
ATCCTGGGCA AAGGGTCCAT GCGAGATAAG ACAAAGGAAG AAGAGCTGAG GAAGAGTGGG 
GAGGCCAAGT ATGCCCACCT GAGTGATGAG CTGCATGTAT TAATTGAAGT GTTTGCTCCA 
CCCGGGGAAG CTTATTCACG GATGAGTCAT GCCTTGGAAG AGATTAAAAA ATTCCTGGTT 
CCTGACTACA ATGATGAAAT TCGTCAAGAG CAACTCCGGG AGTTGTCTTA CTTGAATGGC 
TCAGAAGAGT CTGGCCGGGG CCGAGGTATT AGAGGCAGAG GGATCAGAAT AACTCCCACA 
GCTCCATCAA GGGGCCGTGG CGGTGCTGTT CCACCACCAC CACCACCTGG ACGAGGTGTG 
CTTACCCCTC GGGGGACCAC TGTGACCCGT GGAGCTCTTC CAGTGCCCCC AATAGCAAGA 
GGTGTCCCCA CACCTCGAGC CCGGGGGACG GCAGCAGTAC CAGGATACAG AGCACCCCCA 
CCTCCAGCTC ATGATGCTTA TGAAGAATAT GGGTATGATG ATGGCTATGG GGGTGAATAT 
GATGACCAGA CCTATGAGGC TTATGATAAT AGCTACGTGA CCCCAACACA AAGTGTGCCT 
GAATACTATG ACTACGGTCA TGGAGTAAAC GAGGATGCCT ACGACAGCTA CGCACCAGAA 
GAATGGGCCA CAACTCGCTC CAGCCTGAAG GCACCACCAC CAAGGTCAGC CAGAGGGGGA 
TACAGGGAGC ACCCCTATGG TAGATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573498.1
Translation	MGEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKTKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEESGRGRGIRGRGIRITPTAPSRGRGGAVPPPPPPGRGVLTPRGTTVTRGALPVPPIARGVPTPRARGTAAVPGYRAPPPPAHDAYEEYGYDDGYGGEYDDQTYEAYDNSYVTPTQSVPEYYDYGHGVNEDAYDSYAPEEWATTRSSLKAPPPRSARGGYREHPYGRY

Target ORF information:

RefSeq Version	NM_133235.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus KH domain containing, RNA binding, signal transduction associated 2 (Khdrbs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133235.2

ORF Insert Sequence:

ATGGGAGAAG AGAAATACTT GCCTGAGCTG ATGGCAGAGA AGGATAGCCT GGATCCATCT 
TTTGTGCACG CGTCGCGCCT TCTGGCGGAA GAAATTGAGA AATTTCAAGG TTCAGATGGG 
AAAAAGGAAG ATGAAGAAAA GAAATATCTC GATGTCATCA GCAACAAAAA CATAAAGCTC 
TCTGAAAGAG TATTGATTCC TGTGAAACAG TATCCAAAGT TCAATTTTGT GGGGAAATTG 
CTTGGACCAA GAGGAAACTC CTTGAAGAGG CTACAAGAAG AAACGGGTGC TAAAATGTCT 
ATCCTGGGCA AAGGGTCCAT GCGAGATAAG ACAAAGGAAG AAGAGCTGAG GAAGAGTGGG 
GAGGCCAAGT ATGCCCACCT GAGTGATGAG CTGCATGTAT TAATTGAAGT GTTTGCTCCA 
CCCGGGGAAG CTTATTCACG GATGAGTCAT GCCTTGGAAG AGATTAAAAA ATTCCTGGTT 
CCTGACTACA ATGATGAAAT TCGTCAAGAG CAACTCCGGG AGTTGTCTTA CTTGAATGGC 
TCAGAAGAGT CTGGCCGGGG CCGAGGTATT AGAGGCAGAG GGATCAGAAT AACTCCCACA 
GCTCCATCAA GGGGCCGTGG CGGTGCTGTT CCACCACCAC CACCACCTGG ACGAGGTGTG 
CTTACCCCTC GGGGGACCAC TGTGACCCGT GGAGCTCTTC CAGTGCCCCC AATAGCAAGA 
GGTGTCCCCA CACCTCGAGC CCGGGGGACG GCAGCAGTAC CAGGATACAG AGCACCCCCA 
CCTCCAGCTC ATGATGCTTA TGAAGAATAT GGGTATGATG ATGGCTATGG GGGTGAATAT 
GATGACCAGA CCTATGAGGC TTATGATAAT AGCTACGTGA CCCCAACACA AAGTGTGCCT 
GAATACTATG ACTACGGTCA TGGAGTAAAC GAGGATGCCT ACGACAGCTA CGCACCAGAA 
GAATGGGCCA CAACTCGCTC CAGCCTGAAG GCACCACCAC CAAGGTCAGC CAGAGGGGGA 
TACAGGGAGC ACCCCTATGG TAGATATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.
The Biochemical journal473(3)221-32(2016 Feb)
Langston RG,Rudenko IN,Cookson MR

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Human molecular genetics25(1)109-22(2016 Jan)
Lavalley NJ,Slone SR,Ding H,West AB,Yacoubian TA

An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.
Neurobiology of disease82359-371(2015 Oct)
Tagliaferro P,Kareva T,Oo TF,Yarygina O,Kholodilov N,Burke RE

Lack of exacerbation of neurodegeneration in a double transgenic mouse model of mutant LRRK2 and tau.
Human molecular genetics24(12)3545-56(2015 Jun)
Mikhail F,Calingasan N,Parolari L,Subramanian A,Yang L,Flint Beal M

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KHDRBS2 cDNA ORF clone, Mus musculus(House mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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