Adgrl4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adgrl4
Entrez Gene ID	170757
Full Name	adhesion G protein-coupled receptor L4
Synonyms	1110033N21Rik,ETL1,Eltd1,Etl
General protein information	Preferred Names adhesion G protein-coupled receptor L4 Names adhesion G protein-coupled receptor L4 EGF, latrophilin seven transmembrane domain containing 1 EGF, latrophilin seven transmembrane domain-containing protein 1 EGF-TM7 receptor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 H3

mRNA and Protein(s)

mRNA	Protein	Name
NM_133222.3	NP_573485.2	adhesion G protein-coupled receptor L4 precursor

Pathways from BioSystems

Homologies

	ELTD1	XP_001100419.1
Gallus gallus (chicken)	ELTD1	XP_004936723.1
Mus musculus (house mouse)	Eltd1	NP_573485.2
Homo sapiens (human)	ELTD1	NP_071442.2
Canis lupus familiaris (dog)	ELTD1	XP_005622081.1
Pan troglodytes (chimpanzee)	ELTD1	XP_001155188.2
Bos taurus (cattle)	ELTD1	NP_001070376.1
Rattus norvegicus (Norway rat)	Eltd1	NP_071630.1
Danio rerio (zebrafish)	eltd1	NP_998532.2
Xenopus tropicalis (tropical clawed frog)	LOC101731473	XP_004913969.1

Gene Ontology
Bibliography

Related articles in PubMed

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).
Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gr?ne HJ, Offermanns S
PloS one12(8)e0183166(2017)

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Hamann J, Aust G, Ara? D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Pr?mel S, Sch?neberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schi?th HB
Pharmacological reviews67(2)338-67(2015)

Gene expression analysis of the embryonic subplate.
Oeschger FM, Wang WZ, Lee S, Garc?a-Moreno F, Goffinet AM, Arbon?s ML, Rakic S, Moln?r Z
Cerebral cortex (New York, N.Y. : 1991)22(6)1343-59(2012 Jun)

Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.
Xiao J, Jiang H, Zhang R, Fan G, Zhang Y, Jiang D, Li H
PloS one7(5)e35779(2012)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
Title: Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by aortic banding-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis.
Title: Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.

The following Adgrl4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adgrl4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09937	NM_133222.3 Latest version!	Mus musculus adhesion G protein-coupled receptor L4 (Adgrl4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adgrl4 ( NM_133222.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573485.2 Mus musculus adhesion G protein-coupled receptor L4 (Adgrl4), mRNA.

Price & Availability↑

CloneID	OMu09937
Clone ID Related Accession (Same CDS sequence)	NM_133222.3
Accession Version	NM_133222.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2220bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Mus musculus(house mouse)
Product	adhesion G protein-coupled receptor L4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127233.2. On Mar 21, 2008 this sequence version replaced NM_133222.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF385682.1, BC017134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849379 [ECO:0000348] ##Evidence-Data-END##

ATGAGACTCC TCCCGCTTCT AGTGGGTTTC TCCACTTTGC TGAATTGTTC CTACACACAA 
AACTGCAGCA AGACAACGTG TCTCCCCAAT GCCAAGTGCG AAGTGCACAA TGGTGTGGAA 
GCCTGCTTCT GCAGCCAGGG GTACTCTGGG AATGGCGTCA CGATTTGTGA AGATATAGAT 
GAGTGCAGCG AGTCTTCTGT CTGCGGTGAT CATGCTGTGT GTGAAAACGT GAACGGGGGC 
TTCAGCTGCT TCTGCAGGGA AGGTTATCAG ACCGCTACGG GGAAGTCACA GTTCACACCT 
AATGATGGCT CTTACTGCCA AGATATAGAT GAGTGCAGCG AGTCTTCTGT CTGCGGTGAT 
CATGCTGTGT GTGAAAACGT GAACGGGGGC TTCAGCTGCT TCTGCAGGGA AGGTTATCAG 
ACCGCCACGG GGAAGTCACA GTTCACACCT AATGATGGCT CTTACTGCCA AGAAAGCATG 
AATTCAAATT GCCACTTAGA GCATGCCTGC ATCGCTGCAA ACATTAATAA AACTTTAAAA 
AGAATTGGAC CCATAACAGA ACAGACAACT TTACTCCAAG AAATCTACAG AAATTCTGAG 
GCTGAGCTCT CTCTGATGGA TATAGTCACA TACATAGAGA TCCTAACTGA ATCATCCTCA 
CTACTAGGCC ACCCGAACAG CACCACTTCA TACAAGGATG CCCACTTCAA CTCAACTCTT 
ACTGAATTTG GGGAAACCAT CAATAATTTT GTTGAAAGGA GTACACATAA AATGTGGGAC 
CAGTTACCGA CAAATCACAG AAGACTTCAT CTCACAAAAC TGATGCACAC TGCTGAGCTA 
GTCACCTTAC AGATCGCTCA GAACACCCAG AAGAATTCTC AGTTTGATAT GAATTCTACT 
GACTTGGCTC TCAAGGTTTT TGCTTTTGAT TCAACTCACA TGAAGCATGC TCACCCCCAC 
ATGAATGTGG ATGGAGGCTA TGTGAAAATA TCCCCAAGGA GAAAGGCTGC ACATGGCACA 
ACTGGCAATG TAGTAGTTGC ATTCCTCTGC TATAAGAGCA TTGGTCCCTT GCTATCCTCA 
TCTGACAACT TCTTACTGGA CACTCAAAAT GATAATTCTG AAGGAAAGGA AAAAGTCATT 
TCTTCAGTGA TTTCTGCCTC AATTAGCTCA AATCCACCCA CATTATATGA ACTTGAAAAA 
ATTACATTTA CACTAAGTCA TGTAAAGCTC TCAGATAAGC ACCGGACCCA GTGTGCCTTT 
TGGAACTACT CAGTTGATGC CATGAACAAT GGCAGCTGGT CAACGGAGGG CTGTGAGCTG 
ACACACTCAA ACGACACCCA CACCTCCTGC CGCTGTAGTC ACCTGACACA CTTTGCGATT 
TTGATGTCCT CTACTTCTTC CATTGGGATT AAGGATTATA ATATCCTGAC GAGGATCACT 
CAACTCGGGA TAATCATCTC CCTGATCTGC CTCGCCATCT GCATCTTCAC CTTCTGGTTC 
TTCAGTGAAA TCCAAAGCAC CAGGACCACG ATTCACAAGA ACCTGTGCTG CAGCCTCTTT 
CTTGCAGAAC TTGTTTTTCT TATTGGGATC AACATAAATA CGAATAAGTT GGTCTGCTCT 
ATCATTGCTG GCCTGCTCCA TTACTTCTTC TTAGCTGCCT TTGCCTGGAT GTGCATCGAA 
GGCATTCACC TATACCTCAT CGTTGTCGGC GTCATCTACA ACAAGGGGTT TTTACACAAG 
AACTTTTATA TCTTTGGCTA TCTCAGCCCA GCTGTAGTTG TTGGATTCTC AGCATCTTTA 
GGATACAGAT ATTATGGAAC CACGAAAGTA TGTTGGCTGA GCACTGAAAA CAACTTCATT 
TGGAGCTTTA TAGGACCAGC GTGTCTAATC ATTCTTGTGA ATCTCTTGGC TTTTGGAGTT 
ATCATATACA AAGTTTTCCG CCACACTGCT GGACTGAAAC CAGAAGTTAG TTGCTATGAG 
AACATAAGGT CTTGTGCCAG AGGTGCCCTA GCCCTCCTCT TCCTTCTGGG TACCACCTGG 
ATCTTTGGGG TTCTCCATGT AGTGCATGCA TCTGTTGTGA CAGCCTACCT CTTCACAGTC 
AGCAATGCTT TCCAAGGGAT GTTCATTTTC TTATTCCTAT GCGTTTTGTC TAGAAAGATT 
CAAGAGGAAT ATTATAGATT GTTCAAAAAT GTCCCCTGCT GCTTTGGATG TTTAAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573485.2
CDS	102..2321
Translation	MRLLPLLVGFSTLLNCSYTQNCSKTTCLPNAKCEVHNGVEACFCSQGYSGNGVTICEDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPNDGSYCQDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPNDGSYCQESMNSNCHLEHACIAANINKTLKRIGPITEQTTLLQEIYRNSEAELSLMDIVTYIEILTESSSLLGHPNSTTSYKDAHFNSTLTEFGETINNFVERSTHKMWDQLPTNHRRLHLTKLMHTAELVTLQIAQNTQKNSQFDMNSTDLALKVFAFDSTHMKHAHPHMNVDGGYVKISPRRKAAHGTTGNVVVAFLCYKSIGPLLSSSDNFLLDTQNDNSEGKEKVISSVISASISSNPPTLYELEKITFTLSHVKLSDKHRTQCAFWNYSVDAMNNGSWSTEGCELTHSNDTHTSCRCSHLTHFAILMSSTSSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLIGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR

Target ORF information:

RefSeq Version	NM_133222.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus adhesion G protein-coupled receptor L4 (Adgrl4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133222.3

ORF Insert Sequence:

ATGAGACTCC TCCCGCTTCT AGTGGGTTTC TCCACTTTGC TGAATTGTTC CTACACACAA 
AACTGCAGCA AGACAACGTG TCTCCCCAAT GCCAAGTGCG AAGTGCACAA TGGTGTGGAA 
GCCTGCTTCT GCAGCCAGGG GTACTCTGGG AATGGCGTCA CGATTTGTGA AGATATAGAT 
GAGTGCAGCG AGTCTTCTGT CTGCGGTGAT CATGCTGTGT GTGAAAACGT GAACGGGGGC 
TTCAGCTGCT TCTGCAGGGA AGGTTATCAG ACCGCTACGG GGAAGTCACA GTTCACACCT 
AATGATGGCT CTTACTGCCA AGATATAGAT GAGTGCAGCG AGTCTTCTGT CTGCGGTGAT 
CATGCTGTGT GTGAAAACGT GAACGGGGGC TTCAGCTGCT TCTGCAGGGA AGGTTATCAG 
ACCGCCACGG GGAAGTCACA GTTCACACCT AATGATGGCT CTTACTGCCA AGAAAGCATG 
AATTCAAATT GCCACTTAGA GCATGCCTGC ATCGCTGCAA ACATTAATAA AACTTTAAAA 
AGAATTGGAC CCATAACAGA ACAGACAACT TTACTCCAAG AAATCTACAG AAATTCTGAG 
GCTGAGCTCT CTCTGATGGA TATAGTCACA TACATAGAGA TCCTAACTGA ATCATCCTCA 
CTACTAGGCC ACCCGAACAG CACCACTTCA TACAAGGATG CCCACTTCAA CTCAACTCTT 
ACTGAATTTG GGGAAACCAT CAATAATTTT GTTGAAAGGA GTACACATAA AATGTGGGAC 
CAGTTACCGA CAAATCACAG AAGACTTCAT CTCACAAAAC TGATGCACAC TGCTGAGCTA 
GTCACCTTAC AGATCGCTCA GAACACCCAG AAGAATTCTC AGTTTGATAT GAATTCTACT 
GACTTGGCTC TCAAGGTTTT TGCTTTTGAT TCAACTCACA TGAAGCATGC TCACCCCCAC 
ATGAATGTGG ATGGAGGCTA TGTGAAAATA TCCCCAAGGA GAAAGGCTGC ACATGGCACA 
ACTGGCAATG TAGTAGTTGC ATTCCTCTGC TATAAGAGCA TTGGTCCCTT GCTATCCTCA 
TCTGACAACT TCTTACTGGA CACTCAAAAT GATAATTCTG AAGGAAAGGA AAAAGTCATT 
TCTTCAGTGA TTTCTGCCTC AATTAGCTCA AATCCACCCA CATTATATGA ACTTGAAAAA 
ATTACATTTA CACTAAGTCA TGTAAAGCTC TCAGATAAGC ACCGGACCCA GTGTGCCTTT 
TGGAACTACT CAGTTGATGC CATGAACAAT GGCAGCTGGT CAACGGAGGG CTGTGAGCTG 
ACACACTCAA ACGACACCCA CACCTCCTGC CGCTGTAGTC ACCTGACACA CTTTGCGATT 
TTGATGTCCT CTACTTCTTC CATTGGGATT AAGGATTATA ATATCCTGAC GAGGATCACT 
CAACTCGGGA TAATCATCTC CCTGATCTGC CTCGCCATCT GCATCTTCAC CTTCTGGTTC 
TTCAGTGAAA TCCAAAGCAC CAGGACCACG ATTCACAAGA ACCTGTGCTG CAGCCTCTTT 
CTTGCAGAAC TTGTTTTTCT TATTGGGATC AACATAAATA CGAATAAGTT GGTCTGCTCT 
ATCATTGCTG GCCTGCTCCA TTACTTCTTC TTAGCTGCCT TTGCCTGGAT GTGCATCGAA 
GGCATTCACC TATACCTCAT CGTTGTCGGC GTCATCTACA ACAAGGGGTT TTTACACAAG 
AACTTTTATA TCTTTGGCTA TCTCAGCCCA GCTGTAGTTG TTGGATTCTC AGCATCTTTA 
GGATACAGAT ATTATGGAAC CACGAAAGTA TGTTGGCTGA GCACTGAAAA CAACTTCATT 
TGGAGCTTTA TAGGACCAGC GTGTCTAATC ATTCTTGTGA ATCTCTTGGC TTTTGGAGTT 
ATCATATACA AAGTTTTCCG CCACACTGCT GGACTGAAAC CAGAAGTTAG TTGCTATGAG 
AACATAAGGT CTTGTGCCAG AGGTGCCCTA GCCCTCCTCT TCCTTCTGGG TACCACCTGG 
ATCTTTGGGG TTCTCCATGT AGTGCATGCA TCTGTTGTGA CAGCCTACCT CTTCACAGTC 
AGCAATGCTT TCCAAGGGAT GTTCATTTTC TTATTCCTAT GCGTTTTGTC TAGAAAGATT 
CAAGAGGAAT ATTATAGATT GTTCAAAAAT GTCCCCTGCT GCTTTGGATG TTTAAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).
PloS one12(8)e0183166(2017)
Lu S,Liu S,Wietelmann A,Kojonazarov B,Atzberger A,Tang C,Schermuly RT,Gr?ne HJ,Offermanns S

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Pharmacological reviews67(2)338-67(2015)
Hamann J,Aust G,Ara? D,Engel FB,Formstone C,Fredriksson R,Hall RA,Harty BL,Kirchhoff C,Knapp B,Krishnan A,Liebscher I,Lin HH,Martinelli DC,Monk KR,Peeters MC,Piao X,Pr?mel S,Sch?neberg T,Schwartz TW,Singer K,Stacey M,Ushkaryov YA,Vallon M,Wolfrum U,Wright MW,Xu L,Langenhan T,Schi?th HB

Gene expression analysis of the embryonic subplate.
Cerebral cortex (New York, N.Y. : 1991)22(6)1343-59(2012 Jun)
Oeschger FM,Wang WZ,Lee S,Garc?a-Moreno F,Goffinet AM,Arbon?s ML,Rakic S,Moln?r Z

Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.
PloS one7(5)e35779(2012)
Xiao J,Jiang H,Zhang R,Fan G,Zhang Y,Jiang D,Li H

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Adgrl4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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