Klra17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klra17
Entrez Gene ID	170733
Full Name	killer cell lectin-like receptor, subfamily A, member 17
Synonyms	Ly49q,Ly49q1
General protein information	Preferred Names killer cell lectin-like receptor, subfamily A, member 17 Names killer cell lectin-like receptor, subfamily A, member 17 NK receptor Ly-49Q
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_133203.5	NP_573466.3	killer cell lectin-like receptor, subfamily A, member 17
XM_006505664.1	XP_006505727.1	killer cell lectin-like receptor, subfamily A, member 17 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.
Mahmoud AB, Tu MM, Wight A, Zein HS, Rahim MM, Lee SH, Sekhon HS, Brown EG, Makrigiannis AP
PLoS pathogens12(2)e1005446(2016 Feb)

Ly49 receptors: evolution, genetic diversity, and impact on immunity.
Rahim MM, Makrigiannis AP
Immunological reviews267(1)137-47(2015 Sep)

Ly49 receptors: innate and adaptive immune paradigms.
Rahim MM, Tu MM, Mahmoud AB, Wight A, Abou-Samra E, Lima PD, Makrigiannis AP
Frontiers in immunology5145(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study provides an example in which an ITIM-bearing receptor Ly49Q functions as a positive regulator of osteoclast differentiation.
Title: Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.

crucial for the neutrophil polarization and tissue infiltration during inflammation
Title: The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.

A novel mechanism by which TLR9 signaling is controlled through the spatiotemporal regulation of membrane trafficking by the immunoreceptor tyrosine-based inhibitory motif-bearing receptor Ly49Q.
Title: Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.

Results show that class I MHC recognition by Ly49Q on plasmacytoid dendritic cells is necessary for optimal activation of innate immune responses in vivo.
Title: Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.

These results demonstrate that Ly49Q efficiently binds H-2K(b) ligand.
Title: Recognition of H-2K(b) by Ly49Q suggests a role for class Ia MHC regulation of plasmacytoid dendritic cell function.

The following Klra17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klra17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu36960	XM_006505664.1 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 17 (Klra17), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu09894	NM_133203.5 Latest version!	Mus musculus killer cell lectin-like receptor, subfamily A, member 17 (Klra17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klra17 ( XM_006505664.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006505727.1 Mus musculus killer cell lectin-like receptor, subfamily A, member 17 (Klra17), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu36960
Clone ID Related Accession (Same CDS sequence)	XM_006505664.1
Accession Version	XM_006505664.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor, subfamily A, member 17 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGAGTG AGCAGGAGGT CACTTATTCA ACTGTGAGAT TTCATAAATC TTCAGGATTG 
CAGAACCAAG TGAGGCCTGA GGACAATCAA GGGTCAAGAG AAGCTGGCCA CAAAGAGTGC 
TCTATCCCCT GGCATCTCAT TGTGATAGCT TTTGGAATCC TCTGTGTCCT TCTTCTGGTA 
ATTGTTGCAG TGTTGGTGAC AAACATTTTG CAGTATAAGC AAGAAAAACA TGAACTGCAG 
GAAACTCTAA ACTGCCACCA TAACTGTAGC ACCATGCAAA ATGACATCAA CGCAAAGGAA 
GAAATGCTGA GAAATATGCC TCTAGAGTGT AGTACAGGAG ATGATCTTCT GAAATCCCTC 
AACAGAGAAC AGAAGAGATG GTACAGTGAA ACCAAGAGTG TTTTAAATTC CTCAAAGCAC 
CCAGGTGGAA GCCTGGAAAT ACACTGGTTC TGCTATGGTA TAAAGTGTTA TTATTTCATC 
ATGAATAAAA AAGGATGGCG TAAATGTAAA CAGATATGTG AGCATTACAG CTTATCCCTT 
CTGAAGATAG ATGCTGAGGA TGAACTGAAA TTCCTTCAGT TACAGGTTAC TCCAGACAGT 
TACTGGATTG GCTTCTCATT TGATAAGAAA AGTGAAAAAT GGACATGGAT TGAAAATGGC 
ACATCTAAAT ATGCCTTGAA CATGTCCACA TACAATGTAA AGAGTGGAGA ATGTGTGTTC 
TTATCTAAAA CAAGACTAGA AAATAATAAA TGTGAACATG TCTACCCATG TATTTGTGAG 
AAGAGACTGG ATAAGTTCCC TGATTCGCTC CCCAACAACA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006505727.1
CDS	152..976
Translation	MMSEQEVTYSTVRFHKSSGLQNQVRPEDNQGSREAGHKECSIPWHLIVIAFGILCVLLLVIVAVLVTNILQYKQEKHELQETLNCHHNCSTMQNDINAKEEMLRNMPLECSTGDDLLKSLNREQKRWYSETKSVLNSSKHPGGSLEIHWFCYGIKCYYFIMNKKGWRKCKQICEHYSLSLLKIDAEDELKFLQLQVTPDSYWIGFSFDKKSEKWTWIENGTSKYALNMSTYNVKSGECVFLSKTRLENNKCEHVYPCICEKRLDKFPDSLPNNS

Target ORF information:

RefSeq Version	XM_006505664.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 17 (Klra17), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006505664.1

ORF Insert Sequence:

ATGATGAGTG AGCAGGAGGT CACTTATTCA ACTGTGAGAT TTCATAAATC TTCAGGATTG 
CAGAACCAAG TGAGGCCTGA GGACAATCAA GGGTCAAGAG AAGCTGGCCA CAAAGAGTGC 
TCTATCCCCT GGCATCTCAT TGTGATAGCT TTTGGAATCC TCTGTGTCCT TCTTCTGGTA 
ATTGTTGCAG TGTTGGTGAC AAACATTTTG CAGTATAAGC AAGAAAAACA TGAACTGCAG 
GAAACTCTAA ACTGCCACCA TAACTGTAGC ACCATGCAAA ATGACATCAA CGCAAAGGAA 
GAAATGCTGA GAAATATGCC TCTAGAGTGT AGTACAGGAG ATGATCTTCT GAAATCCCTC 
AACAGAGAAC AGAAGAGATG GTACAGTGAA ACCAAGAGTG TTTTAAATTC CTCAAAGCAC 
CCAGGTGGAA GCCTGGAAAT ACACTGGTTC TGCTATGGTA TAAAGTGTTA TTATTTCATC 
ATGAATAAAA AAGGATGGCG TAAATGTAAA CAGATATGTG AGCATTACAG CTTATCCCTT 
CTGAAGATAG ATGCTGAGGA TGAACTGAAA TTCCTTCAGT TACAGGTTAC TCCAGACAGT 
TACTGGATTG GCTTCTCATT TGATAAGAAA AGTGAAAAAT GGACATGGAT TGAAAATGGC 
ACATCTAAAT ATGCCTTGAA CATGTCCACA TACAATGTAA AGAGTGGAGA ATGTGTGTTC 
TTATCTAAAA CAAGACTAGA AAATAATAAA TGTGAACATG TCTACCCATG TATTTGTGAG 
AAGAGACTGG ATAAGTTCCC TGATTCGCTC CCCAACAACA GTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Klra17 ( NM_133203.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_573466.3 Mus musculus killer cell lectin-like receptor, subfamily A, member 17 (Klra17), mRNA.

Price & Availability↑

CloneID	OMu09894
Clone ID Related Accession (Same CDS sequence)	NM_133203.5
Accession Version	NM_133203.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Mus musculus(house mouse)
Product	killer cell lectin-like receptor, subfamily A, member 17
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK080021.1 and AB033769.1. On Apr 14, 2010 this sequence version replaced NM_133203.4. Sequence Note: This RefSeq contains an upstream AUG immediately upstream of the annotated start codon but, because this uAUG has a weak Kozak signal and is mouse-specific, the dAUG is annotated as the start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK080021.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849377 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGTGAGC AGGAGGTCAC TTATTCAACT GTGAGATTTC ATAAATCTTC AGGATTGCAG 
AACCAAGTGA GGCCTGAGGA CAATCAAGGG TCAAGAGAAG CTGGCCACAA AGAGTGCTCT 
ATCCCCTGGC ATCTCATTGT GATAGCTTTT GGAATCCTCT GTGTCCTTCT TCTGGTAATT 
GTTGCAGTGT TGGTGACAAA CATTTTGCAG TATAAGCAAG AAAAACATGA ACTGCAGGAA 
ACTCTAAACT GCCACCATAA CTGTAGCACC ATGCAAAATG ACATCAACGC AAAGGAAGAA 
ATGCTGAGAA ATATGCCTCT AGAGTGTAGT ACAGGAGATG ATCTTCTGAA ATCCCTCAAC 
AGAGAACAGA AGAGATGGTA CAGTGAAACC AAGAGTGTTT TAAATTCCTC AAAGCACCCA 
GGTGGAAGCC TGGAAATACA CTGGTTCTGC TATGGTATAA AGTGTTATTA TTTCATCATG 
AATAAAAAAG GATGGCGTAA ATGTAAACAG ATATGTGAGC ATTACAGCTT ATCCCTTCTG 
AAGATAGATG CTGAGGATGA ACTGAAATTC CTTCAGTTAC AGGTTACTCC AGACAGTTAC 
TGGATTGGCT TCTCATTTGA TAAGAAAAGT GAAAAATGGA CATGGATTGA AAATGGCACA 
TCTAAATATG CCTTGAACAT GTCCACATAC AATGTAAAGA GTGGAGAATG TGTGTTCTTA 
TCTAAAACAA GACTAGAAAA TAATAAATGT GAACATGTCT ACCCATGTAT TTGTGAGAAG 
AGACTGGATA AGTTCCCTGA TTCGCTCCCC AACAACAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573466.3
CDS	142..963
Translation	MSEQEVTYSTVRFHKSSGLQNQVRPEDNQGSREAGHKECSIPWHLIVIAFGILCVLLLVIVAVLVTNILQYKQEKHELQETLNCHHNCSTMQNDINAKEEMLRNMPLECSTGDDLLKSLNREQKRWYSETKSVLNSSKHPGGSLEIHWFCYGIKCYYFIMNKKGWRKCKQICEHYSLSLLKIDAEDELKFLQLQVTPDSYWIGFSFDKKSEKWTWIENGTSKYALNMSTYNVKSGECVFLSKTRLENNKCEHVYPCICEKRLDKFPDSLPNNS

Target ORF information:

RefSeq Version	NM_133203.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus killer cell lectin-like receptor, subfamily A, member 17 (Klra17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133203.5

ORF Insert Sequence:

ATGAGTGAGC AGGAGGTCAC TTATTCAACT GTGAGATTTC ATAAATCTTC AGGATTGCAG 
AACCAAGTGA GGCCTGAGGA CAATCAAGGG TCAAGAGAAG CTGGCCACAA AGAGTGCTCT 
ATCCCCTGGC ATCTCATTGT GATAGCTTTT GGAATCCTCT GTGTCCTTCT TCTGGTAATT 
GTTGCAGTGT TGGTGACAAA CATTTTGCAG TATAAGCAAG AAAAACATGA ACTGCAGGAA 
ACTCTAAACT GCCACCATAA CTGTAGCACC ATGCAAAATG ACATCAACGC AAAGGAAGAA 
ATGCTGAGAA ATATGCCTCT AGAGTGTAGT ACAGGAGATG ATCTTCTGAA ATCCCTCAAC 
AGAGAACAGA AGAGATGGTA CAGTGAAACC AAGAGTGTTT TAAATTCCTC AAAGCACCCA 
GGTGGAAGCC TGGAAATACA CTGGTTCTGC TATGGTATAA AGTGTTATTA TTTCATCATG 
AATAAAAAAG GATGGCGTAA ATGTAAACAG ATATGTGAGC ATTACAGCTT ATCCCTTCTG 
AAGATAGATG CTGAGGATGA ACTGAAATTC CTTCAGTTAC AGGTTACTCC AGACAGTTAC 
TGGATTGGCT TCTCATTTGA TAAGAAAAGT GAAAAATGGA CATGGATTGA AAATGGCACA 
TCTAAATATG CCTTGAACAT GTCCACATAC AATGTAAAGA GTGGAGAATG TGTGTTCTTA 
TCTAAAACAA GACTAGAAAA TAATAAATGT GAACATGTCT ACCCATGTAT TTGTGAGAAG 
AGACTGGATA AGTTCCCTGA TTCGCTCCCC AACAACAGTT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.
PLoS pathogens12(2)e1005446(2016 Feb)
Mahmoud AB,Tu MM,Wight A,Zein HS,Rahim MM,Lee SH,Sekhon HS,Brown EG,Makrigiannis AP

Ly49 receptors: evolution, genetic diversity, and impact on immunity.
Immunological reviews267(1)137-47(2015 Sep)
Rahim MM,Makrigiannis AP

Ly49 receptors: innate and adaptive immune paradigms.
Frontiers in immunology5145(2014)
Rahim MM,Tu MM,Mahmoud AB,Wight A,Abou-Samra E,Lima PD,Makrigiannis AP

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Klra17 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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