Psmb8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psmb8
Entrez Gene ID	16913
Full Name	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Synonyms	Lmp-7,Lmp7
General protein information	Preferred Names proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Names proteasome subunit beta type-8 MC13 (LMP7) large multifunctional protease 7 low molecular mass protein 7 macropain subunit C13 multicatalytic endopeptidase complex subunit C13 proteasome component C13 proteasome subunit MC13 proteasome subunit beta-5i proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) proteosome beta 8 subunit
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010724.2	NP_034854.2	proteasome subunit beta type-8

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	PRE2	NP_015428.1
Eremothecium gossypii	AGOS_AEL326C	NP_984534.2
Homo sapiens (human)	PSMB8	NP_683720.2
Kluyveromyces lactis	KLLA0F08228g	XP_455453.1
Schizosaccharomyces pombe (fission yeast)	pts1	NP_593825.1
Magnaporthe oryzae (rice blast fungus)	MGG_00170	XP_003718955.1
Xenopus tropicalis (tropical clawed frog)	psmb8	NP_001103512.1
Mus musculus (house mouse)	Psmb8	NP_034854.2
Neurospora crassa	NCU09309	XP_963951.1
Pan troglodytes (chimpanzee)	PSMB8	XP_001167272.1
	LOC717766	XP_001115562.2
Canis lupus familiaris (dog)	PSMB8	NP_001041550.1
Bos taurus (cattle)	PSMB8	NP_001035570.1
Rattus norvegicus (Norway rat)	Psmb8	NP_542945.2
Danio rerio (zebrafish)	psmb8	XP_005159529.1

Gene Ontology
Bibliography

Related articles in PubMed

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T?cell repertoire.
Basler M, Mundt S, Groettrup M
European journal of immunology(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors found that selective inhibition of LMP7 had neither an influence on allograft survival in an major histocompatibility complex-mismatch model nor in a multiple minor mismatch skin transplantation model.
Title: No prolongation of skin allograft survival by immunoproteasome inhibition in mice.

The regulation of miR-451 via the LMP7/NF-kappaB central inflammatory pathway during progression of DN.
Title: miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy.

LMP7 deficiency decreased inflammatory responses such as macrophage infiltration and chemokine expression while it increased serum adiponection levels.
Title: Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.

these data support that LMP7 inhibition in the context of BMT modulates allogeneic responses by decreasing endogenous miHA presentation and that the consequential reduction in allogeneic stimulation and cytokine production reduces GVHD development.
Title: Inhibition of the Immunoproteasome Subunit LMP7 with ONX?0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched?Minor Histocompatibility Antigen-Disparate Murine Model.

genetic polymorphism is associated with ovarian cancer and metastasis
Title: Association between LMP2/LMP7 genetic variability and the metastasis risk of ovarian cancer in Chinese women in Beijing.

The following Psmb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23755	NM_010724.2 Latest version!	Mus musculus proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psmb8 ( NM_010724.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034854.2 Mus musculus proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8), mRNA.

Price & Availability↑

CloneID	OMu23755
Clone ID Related Accession (Same CDS sequence)	NM_010724.2
Accession Version	NM_010724.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 831bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	proteasome subunit beta type-8
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ235673.1, AK031801.1 and AK150674.1. On Oct 16, 2007 this sequence version replaced NM_010724.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150674.1, AK146182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTTAC TGGATCTGTG CGGTGCCGCT CGGGGGCAGC GGCCCGAGTG GGCTGCCCTG 
GATGCGGGAA GCGGGGGTCG CTCGGACCCG GGACACTACA GTTTCTCCGC GCAAGCTCCG 
GAGCTCGCAC TTCCCCGGGG AATGCAGCCC ACCGCATTCC TGAGGTCCTT TGGTGGTGAC 
CAGGAAAGGA ATGTTCAAAT TGAGATGGCC CACGGCACAA CCACACTCGC CTTCAAGTTC 
CAGCATGGCG TCATCGTGGC TGTGGACTCC AGGGCCACTG CAGGGAGTTA CATTAGCTCC 
TTAAGGATGA ACAAAGTGAT CGAGATTAAC CCTTACCTGC TTGGCACCAT GTCTGGTTGT 
GCAGCCGACT GCCAGTACTG GGAGAGGCTG TTGGCCAAGG AGTGCAGGTT GTATTATCTT 
CGGAATGGGG AACGCATCTC CGTGTCTGCA GCATCCAAGC TGCTTTCCAA CATGATGCTG 
CAGTACCGGG GGATGGGCCT CTCCATGGGC AGCATGATCT GTGGCTGGGA CAAGAAGGGA 
CCAGGACTTT ACTACGTAGA TGACAATGGG ACTCGGCTCT CGGGACAGAT GTTTTCCACT 
GGCAGCGGGA ACACCTATGC CTATGGGGTG ATGGACAGTG GTTACCGGCA GGACCTCAGT 
CCTGAAGAGG CCTACGACCT TGGCCGCAGA GCTATTGCTT ATGCTACCCA CAGAGACAAC 
TATTCTGGAG GAGTCGTCAA CATGTACCAC ATGAAGGAAG ACGGTTGGGT GAAAGTGGAG 
AGTTCCGATG TCAGTGACCT GCTGTACAAG TACGGAGAGG CCGCTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034854.2
CDS	205..1035
Translation	MALLDLCGAARGQRPEWAALDAGSGGRSDPGHYSFSAQAPELALPRGMQPTAFLRSFGGDQERNVQIEMAHGTTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGEAAL

Target ORF information:

RefSeq Version	NM_010724.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) (Psmb8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010724.2

ORF Insert Sequence:

ATGGCGTTAC TGGATCTGTG CGGTGCCGCT CGGGGGCAGC GGCCCGAGTG GGCTGCCCTG 
GATGCGGGAA GCGGGGGTCG CTCGGACCCG GGACACTACA GTTTCTCCGC GCAAGCTCCG 
GAGCTCGCAC TTCCCCGGGG AATGCAGCCC ACCGCATTCC TGAGGTCCTT TGGTGGTGAC 
CAGGAAAGGA ATGTTCAAAT TGAGATGGCC CACGGCACAA CCACACTCGC CTTCAAGTTC 
CAGCATGGCG TCATCGTGGC TGTGGACTCC AGGGCCACTG CAGGGAGTTA CATTAGCTCC 
TTAAGGATGA ACAAAGTGAT CGAGATTAAC CCTTACCTGC TTGGCACCAT GTCTGGTTGT 
GCAGCCGACT GCCAGTACTG GGAGAGGCTG TTGGCCAAGG AGTGCAGGTT GTATTATCTT 
CGGAATGGGG AACGCATCTC CGTGTCTGCA GCATCCAAGC TGCTTTCCAA CATGATGCTG 
CAGTACCGGG GGATGGGCCT CTCCATGGGC AGCATGATCT GTGGCTGGGA CAAGAAGGGA 
CCAGGACTTT ACTACGTAGA TGACAATGGG ACTCGGCTCT CGGGACAGAT GTTTTCCACT 
GGCAGCGGGA ACACCTATGC CTATGGGGTG ATGGACAGTG GTTACCGGCA GGACCTCAGT 
CCTGAAGAGG CCTACGACCT TGGCCGCAGA GCTATTGCTT ATGCTACCCA CAGAGACAAC 
TATTCTGGAG GAGTCGTCAA CATGTACCAC ATGAAGGAAG ACGGTTGGGT GAAAGTGGAG 
AGTTCCGATG TCAGTGACCT GCTGTACAAG TACGGAGAGG CCGCTCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T?cell repertoire.
European journal of immunology(2017 Oct)
Basler M,Mundt S,Groettrup M

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Psmb8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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