Lmna cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lmna
Entrez Gene ID	16905
Full Name	lamin A
Synonyms	Dhe
General protein information	Preferred Names lamin A Names prelamin-A/C lamin C lamin-A/C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 F1\|3 38.84 cM
Summary	This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001111102.2	NP_001104572.1	prelamin-A/C isoform C
XM_006501073.1	XP_006501136.1	prelamin-A/C isoform X1
NM_001002011.3	NP_001002011.2	prelamin-A/C isoform A precursor
NM_019390.3	NP_062263.1	prelamin-A/C isoform C2

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008015	XP_317447.4
	LMNA	XP_001113604.2
Danio rerio (zebrafish)	lmna	NP_694503.1
Pan troglodytes (chimpanzee)	LMNA	NP_001092024.1
Canis lupus familiaris (dog)	LMNA	XP_005622768.1
Mus musculus (house mouse)	Lmna	NP_001002011.2
Rattus norvegicus (Norway rat)	Lmna	NP_001002016.1
Xenopus tropicalis (tropical clawed frog)	lmna	NP_001039148.1
Bos taurus (cattle)	LMNA	NP_001029225.1
Homo sapiens (human)	LMNA	NP_733821.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity.
Jahn D, Schramm S, Benavente R, Alsheimer M
Nucleus (Austin, Tex.)1(3)273-83(2010 May-Jun)

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy.
Sullivan T, Escalante-Alcalde D, Bhatt H, Anver M, Bhat N, Nagashima K, Stewart CL, Burke B
The Journal of cell biology147(5)913-20(1999 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that lamin A plays important roles in maintaining the osteoblast differentiation and function
Title: Lamin A overexpression promotes osteoblast differentiation and calcification in the MC3T3-E1 preosteoblastic cell line.

Lmna-deficient cells show a compromised strain avoidance response, which is completely abolished when topographical cues and uniaxial strain are applied along the same direction.
Title: Cellular strain avoidance is mediated by a functional actin cap - observations in an

changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin, also impact gene regulation and lineage differentiation in early embryos.
Title: Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression.

Activation of WNT/b-catenin activity improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH222P/H222P mice, which was associated with increased expression of myocardial connexin 43. These results indicate that decreased WNT/b-catenin contributes to the pathophysiology of LMNA cardiomyopathy and that drugs activating b-catenin may be beneficial in affected individuals
Title: Decreased WNT/?-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene.

While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
Title: Dynamics of Lamins B and A/C and Nucleoporin Nup160 during Meiotic Maturation in Mouse Oocytes.

The following Lmna gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lmna cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18261	NM_001002011.3 Latest version!	Mus musculus lamin A (Lmna), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu18261	XM_006501073.1 Latest version!	Mus musculus lamin A (Lmna), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu18338	NM_001111102.2 Latest version!	Mus musculus lamin A (Lmna), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$335.30 $479.00
OMu18344	NM_019390.3 Latest version!	Mus musculus lamin A (Lmna), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lmna ( NM_001002011.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001002011.2 Mus musculus lamin A (Lmna), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu18261
Clone ID Related Accession (Same CDS sequence)	XM_006501073.1 , NM_001002011.3
Accession Version	NM_001002011.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1998bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	prelamin-A/C isoform A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC145168.5, AK147150.1, AK004619.2 and AW047412.1. On May 7, 2013 this sequence version replaced NM_001002011.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147150.1, AK004619.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACCC CGTCACAGCG GCGCGCCACC CGCAGTGGGG CGCAGGCCAG CTCTACCCCA 
CTGTCGCCCA CTCGGATCAC CCGGCTGCAG GAGAAGGAGG ACCTGCAGGA GCTCAATGAC 
CGCCTGGCCG TGTACATCGA TCGCGTGCGT TCCCTGGAGA CCGAGAACGC GGGGCTGCGC 
CTTCGCATCA CTGAGTCTGA AGAGGTGGTC AGCCGAGAGG TGTCCGGCAT CAAGGCGGCC 
TACGAGGCCG AGCTGGGGGA TGCCCGCAAG ACCCTTGATT CTGTGGCCAA GGAGCGCGCC 
CGCCTCCAGC TAGAGCTGAG CAAAGTGCGT GAGGAGTTCA AGGAGCTGAA GGCTCGCAAC 
ACCAAGAAGG AGGGGGACTT GTTGGCTGCG CAGGCCCGGC TCAAGGACCT CGAGGCTCTT 
CTCAACTCCA AGGAAGCTGC CCTGAGCACT GCTCTCAGTG AGAAGCGCAC ATTGGAGGGC 
GAGCTCCATG ACCTGCGGGG GCAGGTAGCC AAGCTTGAGG CGGCCCTGGG AGAGGCTAAG 
AAGCAGCTTC AGGATGAGAT GCTGAGGCGA GTGGATGCTG AGAACAGGCT ACAGACGCTG 
AAGGAGGAGC TTGACTTCCA GAAGAACATT TACAGCGAGG AACTGCGTGA GACCAAGCGC 
CGGCATGAGA CGCGGCTTGT GGAGATCGAT AACGGGAAGC AGCGAGAGTT TGAGAGCCGG 
CTGGCAGATG CCCTGCAGGA GCTGCGGGCT CAGCATGAGG ACCAGGTGGA ACAGTATAAG 
AAGGAGCTAG AAAAGACATA CTCCGCCAAG CTGGATAATG CCAGGCAGTC TGCTGAGAGG 
AACAGCAACC TCGTGGGGGC TGCCCATGAG GAACTGCAGC AGTCTCGAAT CCGCATTGAC 
AGCCTCTCGG CCCAGCTCAG CCAGCTCCAA AAGCAGTTGG CAGCCAAGGA GGCAAAGCTG 
CGTGACCTGG AGGACTCGCT GGCCCGTGAG CGCGATACCA GCCGGCGCCT GCTGGCTGAG 
AAAGAGCGAG AGATGGCGGA GATGCGGGCG AGGATGCAGC AGCAGCTGGA CGAGTACCAG 
GAGCTGCTGG ACATCAAGCT GGCCCTGGAC ATGGAGATCC ATGCCTATCG AAAGCTGCTG 
GAGGGCGAGG AGGAGAGGCT GCGCCTGTCC CCCAGCCCTA CCTCGCAGCG CAGCCGTGGC 
CGCGCCTCCT CCCACTCATC CCAGTCTCAG GGTGGAGGCA GCGTCACCAA AAAGCGCAAG 
CTGGAGTCTT CCGAGAGCCG GAGCAGCTTC TCGCAGCATG CTCGCACTAG CGGGCGTGTG 
GCGGTAGAGG AAGTCGATGA AGAGGGAAAG TTCGTGCGGC TGCGCAACAA GTCCAACGAG 
GACCAGTCCA TGGGCAACTG GCAGATCAGG CGTCAGAATG GTGACGATCC TTTGATGACC 
TATCGCTTCC CACCGAAGTT CACCCTAAAG GCTGGGCAGG TGGTGACGAT CTGGGCTTCA 
GGAGCTGGGG CCACCCATAG CCCCCCTACT GACTTGGTGT GGAAGGCGCA GAACACCTGG 
GGCTGTGGGA GCAGCCTTCG CACCGCTCTC ATCAACTCCA CTGGAGAAGA AGTGGCCATG 
CGCAAGCTGG TGCGCTCACT GACCATGGTT GAGGACAATG AGGATGACGA CGAGGATGGA 
GAAGAGCTCC TCCATCACCA CCGTGGTTCC CACTGCAGCG GCTCGGGGGA CCCCGCTGAG 
TACAACCTGC GCTCACGCAC CGTGCTGTGC GGGACGTGTG GGCAGCCTGC TGACAAGGCT 
GCCGGTGGAG CGGGAGCCCA GGTGGGCGGA TCCATCTCCT CTGGCTCTTC TGCCTCCAGT 
GTCACAGTCA CTCGAAGCTT CCGCAGTGTG GGGGGCAGTG GGGGTGGCAG CTTCGGGGAC 
AACCTAGTCA CCCGCTCCTA CCTCCTGGGC AACTCCAGTC CCCGGAGCCA GAGCTCCCAG 
AACTGCAGCA TCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002011.2
CDS	250..2247
Translation	METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGSSLRTALINSTGEEVAMRKLVRSLTMVEDNEDDDEDGEELLHHHRGSHCSGSGDPAEYNLRSRTVLCGTCGQPADKAAGGAGAQVGGSISSGSSASSVTVTRSFRSVGGSGGGSFGDNLVTRSYLLGNSSPRSQSSQNCSIM

Target ORF information:

RefSeq Version	NM_001002011.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lamin A (Lmna), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002011.3

ORF Insert Sequence:

ATGGAGACCC CGTCACAGCG GCGCGCCACC CGCAGTGGGG CGCAGGCCAG CTCTACCCCA 
CTGTCGCCCA CTCGGATCAC CCGGCTGCAG GAGAAGGAGG ACCTGCAGGA GCTCAATGAC 
CGCCTGGCCG TGTACATCGA TCGCGTGCGT TCCCTGGAGA CCGAGAACGC GGGGCTGCGC 
CTTCGCATCA CTGAGTCTGA AGAGGTGGTC AGCCGAGAGG TGTCCGGCAT CAAGGCGGCC 
TACGAGGCCG AGCTGGGGGA TGCCCGCAAG ACCCTTGATT CTGTGGCCAA GGAGCGCGCC 
CGCCTCCAGC TAGAGCTGAG CAAAGTGCGT GAGGAGTTCA AGGAGCTGAA GGCTCGCAAC 
ACCAAGAAGG AGGGGGACTT GTTGGCTGCG CAGGCCCGGC TCAAGGACCT CGAGGCTCTT 
CTCAACTCCA AGGAAGCTGC CCTGAGCACT GCTCTCAGTG AGAAGCGCAC ATTGGAGGGC 
GAGCTCCATG ACCTGCGGGG GCAGGTAGCC AAGCTTGAGG CGGCCCTGGG AGAGGCTAAG 
AAGCAGCTTC AGGATGAGAT GCTGAGGCGA GTGGATGCTG AGAACAGGCT ACAGACGCTG 
AAGGAGGAGC TTGACTTCCA GAAGAACATT TACAGCGAGG AACTGCGTGA GACCAAGCGC 
CGGCATGAGA CGCGGCTTGT GGAGATCGAT AACGGGAAGC AGCGAGAGTT TGAGAGCCGG 
CTGGCAGATG CCCTGCAGGA GCTGCGGGCT CAGCATGAGG ACCAGGTGGA ACAGTATAAG 
AAGGAGCTAG AAAAGACATA CTCCGCCAAG CTGGATAATG CCAGGCAGTC TGCTGAGAGG 
AACAGCAACC TCGTGGGGGC TGCCCATGAG GAACTGCAGC AGTCTCGAAT CCGCATTGAC 
AGCCTCTCGG CCCAGCTCAG CCAGCTCCAA AAGCAGTTGG CAGCCAAGGA GGCAAAGCTG 
CGTGACCTGG AGGACTCGCT GGCCCGTGAG CGCGATACCA GCCGGCGCCT GCTGGCTGAG 
AAAGAGCGAG AGATGGCGGA GATGCGGGCG AGGATGCAGC AGCAGCTGGA CGAGTACCAG 
GAGCTGCTGG ACATCAAGCT GGCCCTGGAC ATGGAGATCC ATGCCTATCG AAAGCTGCTG 
GAGGGCGAGG AGGAGAGGCT GCGCCTGTCC CCCAGCCCTA CCTCGCAGCG CAGCCGTGGC 
CGCGCCTCCT CCCACTCATC CCAGTCTCAG GGTGGAGGCA GCGTCACCAA AAAGCGCAAG 
CTGGAGTCTT CCGAGAGCCG GAGCAGCTTC TCGCAGCATG CTCGCACTAG CGGGCGTGTG 
GCGGTAGAGG AAGTCGATGA AGAGGGAAAG TTCGTGCGGC TGCGCAACAA GTCCAACGAG 
GACCAGTCCA TGGGCAACTG GCAGATCAGG CGTCAGAATG GTGACGATCC TTTGATGACC 
TATCGCTTCC CACCGAAGTT CACCCTAAAG GCTGGGCAGG TGGTGACGAT CTGGGCTTCA 
GGAGCTGGGG CCACCCATAG CCCCCCTACT GACTTGGTGT GGAAGGCGCA GAACACCTGG 
GGCTGTGGGA GCAGCCTTCG CACCGCTCTC ATCAACTCCA CTGGAGAAGA AGTGGCCATG 
CGCAAGCTGG TGCGCTCACT GACCATGGTT GAGGACAATG AGGATGACGA CGAGGATGGA 
GAAGAGCTCC TCCATCACCA CCGTGGTTCC CACTGCAGCG GCTCGGGGGA CCCCGCTGAG 
TACAACCTGC GCTCACGCAC CGTGCTGTGC GGGACGTGTG GGCAGCCTGC TGACAAGGCT 
GCCGGTGGAG CGGGAGCCCA GGTGGGCGGA TCCATCTCCT CTGGCTCTTC TGCCTCCAGT 
GTCACAGTCA CTCGAAGCTT CCGCAGTGTG GGGGGCAGTG GGGGTGGCAG CTTCGGGGAC 
AACCTAGTCA CCCGCTCCTA CCTCCTGGGC AACTCCAGTC CCCGGAGCCA GAGCTCCCAG 
AACTGCAGCA TCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lmna ( XM_006501073.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006501136.1 Mus musculus lamin A (Lmna), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu18261
Clone ID Related Accession (Same CDS sequence)	XM_006501073.1 , NM_001002011.3
Accession Version	XM_006501073.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1998bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	prelamin-A/C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGACCC CGTCACAGCG GCGCGCCACC CGCAGTGGGG CGCAGGCCAG CTCTACCCCA 
CTGTCGCCCA CTCGGATCAC CCGGCTGCAG GAGAAGGAGG ACCTGCAGGA GCTCAATGAC 
CGCCTGGCCG TGTACATCGA TCGCGTGCGT TCCCTGGAGA CCGAGAACGC GGGGCTGCGC 
CTTCGCATCA CTGAGTCTGA AGAGGTGGTC AGCCGAGAGG TGTCCGGCAT CAAGGCGGCC 
TACGAGGCCG AGCTGGGGGA TGCCCGCAAG ACCCTTGATT CTGTGGCCAA GGAGCGCGCC 
CGCCTCCAGC TAGAGCTGAG CAAAGTGCGT GAGGAGTTCA AGGAGCTGAA GGCTCGCAAC 
ACCAAGAAGG AGGGGGACTT GTTGGCTGCG CAGGCCCGGC TCAAGGACCT CGAGGCTCTT 
CTCAACTCCA AGGAAGCTGC CCTGAGCACT GCTCTCAGTG AGAAGCGCAC ATTGGAGGGC 
GAGCTCCATG ACCTGCGGGG GCAGGTAGCC AAGCTTGAGG CGGCCCTGGG AGAGGCTAAG 
AAGCAGCTTC AGGATGAGAT GCTGAGGCGA GTGGATGCTG AGAACAGGCT ACAGACGCTG 
AAGGAGGAGC TTGACTTCCA GAAGAACATT TACAGCGAGG AACTGCGTGA GACCAAGCGC 
CGGCATGAGA CGCGGCTTGT GGAGATCGAT AACGGGAAGC AGCGAGAGTT TGAGAGCCGG 
CTGGCAGATG CCCTGCAGGA GCTGCGGGCT CAGCATGAGG ACCAGGTGGA ACAGTATAAG 
AAGGAGCTAG AAAAGACATA CTCCGCCAAG CTGGATAATG CCAGGCAGTC TGCTGAGAGG 
AACAGCAACC TCGTGGGGGC TGCCCATGAG GAACTGCAGC AGTCTCGAAT CCGCATTGAC 
AGCCTCTCGG CCCAGCTCAG CCAGCTCCAA AAGCAGTTGG CAGCCAAGGA GGCAAAGCTG 
CGTGACCTGG AGGACTCGCT GGCCCGTGAG CGCGATACCA GCCGGCGCCT GCTGGCTGAG 
AAAGAGCGAG AGATGGCGGA GATGCGGGCG AGGATGCAGC AGCAGCTGGA CGAGTACCAG 
GAGCTGCTGG ACATCAAGCT GGCCCTGGAC ATGGAGATCC ATGCCTATCG AAAGCTGCTG 
GAGGGCGAGG AGGAGAGGCT GCGCCTGTCC CCCAGCCCTA CCTCGCAGCG CAGCCGTGGC 
CGCGCCTCCT CCCACTCATC CCAGTCTCAG GGTGGAGGCA GCGTCACCAA AAAGCGCAAG 
CTGGAGTCTT CCGAGAGCCG GAGCAGCTTC TCGCAGCATG CTCGCACTAG CGGGCGTGTG 
GCGGTAGAGG AAGTCGATGA AGAGGGAAAG TTCGTGCGGC TGCGCAACAA GTCCAACGAG 
GACCAGTCCA TGGGCAACTG GCAGATCAGG CGTCAGAATG GTGACGATCC TTTGATGACC 
TATCGCTTCC CACCGAAGTT CACCCTAAAG GCTGGGCAGG TGGTGACGAT CTGGGCTTCA 
GGAGCTGGGG CCACCCATAG CCCCCCTACT GACTTGGTGT GGAAGGCGCA GAACACCTGG 
GGCTGTGGGA GCAGCCTTCG CACCGCTCTC ATCAACTCCA CTGGAGAAGA AGTGGCCATG 
CGCAAGCTGG TGCGCTCACT GACCATGGTT GAGGACAATG AGGATGACGA CGAGGATGGA 
GAAGAGCTCC TCCATCACCA CCGTGGTTCC CACTGCAGCG GCTCGGGGGA CCCCGCTGAG 
TACAACCTGC GCTCACGCAC CGTGCTGTGC GGGACGTGTG GGCAGCCTGC TGACAAGGCT 
GCCGGTGGAG CGGGAGCCCA GGTGGGCGGA TCCATCTCCT CTGGCTCTTC TGCCTCCAGT 
GTCACAGTCA CTCGAAGCTT CCGCAGTGTG GGGGGCAGTG GGGGTGGCAG CTTCGGGGAC 
AACCTAGTCA CCCGCTCCTA CCTCCTGGGC AACTCCAGTC CCCGGAGCCA GAGCTCCCAG 
AACTGCAGCA TCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006501136.1
CDS	411..2408
Translation	METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGSSLRTALINSTGEEVAMRKLVRSLTMVEDNEDDDEDGEELLHHHRGSHCSGSGDPAEYNLRSRTVLCGTCGQPADKAAGGAGAQVGGSISSGSSASSVTVTRSFRSVGGSGGGSFGDNLVTRSYLLGNSSPRSQSSQNCSIM

Target ORF information:

RefSeq Version	XM_006501073.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus lamin A (Lmna), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006501073.1

ORF Insert Sequence:

ATGGAGACCC CGTCACAGCG GCGCGCCACC CGCAGTGGGG CGCAGGCCAG CTCTACCCCA 
CTGTCGCCCA CTCGGATCAC CCGGCTGCAG GAGAAGGAGG ACCTGCAGGA GCTCAATGAC 
CGCCTGGCCG TGTACATCGA TCGCGTGCGT TCCCTGGAGA CCGAGAACGC GGGGCTGCGC 
CTTCGCATCA CTGAGTCTGA AGAGGTGGTC AGCCGAGAGG TGTCCGGCAT CAAGGCGGCC 
TACGAGGCCG AGCTGGGGGA TGCCCGCAAG ACCCTTGATT CTGTGGCCAA GGAGCGCGCC 
CGCCTCCAGC TAGAGCTGAG CAAAGTGCGT GAGGAGTTCA AGGAGCTGAA GGCTCGCAAC 
ACCAAGAAGG AGGGGGACTT GTTGGCTGCG CAGGCCCGGC TCAAGGACCT CGAGGCTCTT 
CTCAACTCCA AGGAAGCTGC CCTGAGCACT GCTCTCAGTG AGAAGCGCAC ATTGGAGGGC 
GAGCTCCATG ACCTGCGGGG GCAGGTAGCC AAGCTTGAGG CGGCCCTGGG AGAGGCTAAG 
AAGCAGCTTC AGGATGAGAT GCTGAGGCGA GTGGATGCTG AGAACAGGCT ACAGACGCTG 
AAGGAGGAGC TTGACTTCCA GAAGAACATT TACAGCGAGG AACTGCGTGA GACCAAGCGC 
CGGCATGAGA CGCGGCTTGT GGAGATCGAT AACGGGAAGC AGCGAGAGTT TGAGAGCCGG 
CTGGCAGATG CCCTGCAGGA GCTGCGGGCT CAGCATGAGG ACCAGGTGGA ACAGTATAAG 
AAGGAGCTAG AAAAGACATA CTCCGCCAAG CTGGATAATG CCAGGCAGTC TGCTGAGAGG 
AACAGCAACC TCGTGGGGGC TGCCCATGAG GAACTGCAGC AGTCTCGAAT CCGCATTGAC 
AGCCTCTCGG CCCAGCTCAG CCAGCTCCAA AAGCAGTTGG CAGCCAAGGA GGCAAAGCTG 
CGTGACCTGG AGGACTCGCT GGCCCGTGAG CGCGATACCA GCCGGCGCCT GCTGGCTGAG 
AAAGAGCGAG AGATGGCGGA GATGCGGGCG AGGATGCAGC AGCAGCTGGA CGAGTACCAG 
GAGCTGCTGG ACATCAAGCT GGCCCTGGAC ATGGAGATCC ATGCCTATCG AAAGCTGCTG 
GAGGGCGAGG AGGAGAGGCT GCGCCTGTCC CCCAGCCCTA CCTCGCAGCG CAGCCGTGGC 
CGCGCCTCCT CCCACTCATC CCAGTCTCAG GGTGGAGGCA GCGTCACCAA AAAGCGCAAG 
CTGGAGTCTT CCGAGAGCCG GAGCAGCTTC TCGCAGCATG CTCGCACTAG CGGGCGTGTG 
GCGGTAGAGG AAGTCGATGA AGAGGGAAAG TTCGTGCGGC TGCGCAACAA GTCCAACGAG 
GACCAGTCCA TGGGCAACTG GCAGATCAGG CGTCAGAATG GTGACGATCC TTTGATGACC 
TATCGCTTCC CACCGAAGTT CACCCTAAAG GCTGGGCAGG TGGTGACGAT CTGGGCTTCA 
GGAGCTGGGG CCACCCATAG CCCCCCTACT GACTTGGTGT GGAAGGCGCA GAACACCTGG 
GGCTGTGGGA GCAGCCTTCG CACCGCTCTC ATCAACTCCA CTGGAGAAGA AGTGGCCATG 
CGCAAGCTGG TGCGCTCACT GACCATGGTT GAGGACAATG AGGATGACGA CGAGGATGGA 
GAAGAGCTCC TCCATCACCA CCGTGGTTCC CACTGCAGCG GCTCGGGGGA CCCCGCTGAG 
TACAACCTGC GCTCACGCAC CGTGCTGTGC GGGACGTGTG GGCAGCCTGC TGACAAGGCT 
GCCGGTGGAG CGGGAGCCCA GGTGGGCGGA TCCATCTCCT CTGGCTCTTC TGCCTCCAGT 
GTCACAGTCA CTCGAAGCTT CCGCAGTGTG GGGGGCAGTG GGGGTGGCAG CTTCGGGGAC 
AACCTAGTCA CCCGCTCCTA CCTCCTGGGC AACTCCAGTC CCCGGAGCCA GAGCTCCCAG 
AACTGCAGCA TCATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lmna ( NM_001111102.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001104572.1 Mus musculus lamin A (Lmna), transcript variant 3, mRNA.

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CloneID	OMu18338
Clone ID Related Accession (Same CDS sequence)	NM_001111102.2
Accession Version	NM_001111102.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1725bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	prelamin-A/C isoform C
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC145168.5, AK149998.1 and AK210245.1. On May 7, 2013 this sequence version replaced NM_001111102.1. Transcript Variant: This variant (3) lacks several 3' exons but contains an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (C) has a distinct and shorter C-terminus, compared to isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149998.1, AK150391.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGACCC CGTCACAGCG GCGCGCCACC CGCAGTGGGG CGCAGGCCAG CTCTACCCCA 
CTGTCGCCCA CTCGGATCAC CCGGCTGCAG GAGAAGGAGG ACCTGCAGGA GCTCAATGAC 
CGCCTGGCCG TGTACATCGA TCGCGTGCGT TCCCTGGAGA CCGAGAACGC GGGGCTGCGC 
CTTCGCATCA CTGAGTCTGA AGAGGTGGTC AGCCGAGAGG TGTCCGGCAT CAAGGCGGCC 
TACGAGGCCG AGCTGGGGGA TGCCCGCAAG ACCCTTGATT CTGTGGCCAA GGAGCGCGCC 
CGCCTCCAGC TAGAGCTGAG CAAAGTGCGT GAGGAGTTCA AGGAGCTGAA GGCTCGCAAC 
ACCAAGAAGG AGGGGGACTT GTTGGCTGCG CAGGCCCGGC TCAAGGACCT CGAGGCTCTT 
CTCAACTCCA AGGAAGCTGC CCTGAGCACT GCTCTCAGTG AGAAGCGCAC ATTGGAGGGC 
GAGCTCCATG ACCTGCGGGG GCAGGTAGCC AAGCTTGAGG CGGCCCTGGG AGAGGCTAAG 
AAGCAGCTTC AGGATGAGAT GCTGAGGCGA GTGGATGCTG AGAACAGGCT ACAGACGCTG 
AAGGAGGAGC TTGACTTCCA GAAGAACATT TACAGCGAGG AACTGCGTGA GACCAAGCGC 
CGGCATGAGA CGCGGCTTGT GGAGATCGAT AACGGGAAGC AGCGAGAGTT TGAGAGCCGG 
CTGGCAGATG CCCTGCAGGA GCTGCGGGCT CAGCATGAGG ACCAGGTGGA ACAGTATAAG 
AAGGAGCTAG AAAAGACATA CTCCGCCAAG CTGGATAATG CCAGGCAGTC TGCTGAGAGG 
AACAGCAACC TCGTGGGGGC TGCCCATGAG GAACTGCAGC AGTCTCGAAT CCGCATTGAC 
AGCCTCTCGG CCCAGCTCAG CCAGCTCCAA AAGCAGTTGG CAGCCAAGGA GGCAAAGCTG 
CGTGACCTGG AGGACTCGCT GGCCCGTGAG CGCGATACCA GCCGGCGCCT GCTGGCTGAG 
AAAGAGCGAG AGATGGCGGA GATGCGGGCG AGGATGCAGC AGCAGCTGGA CGAGTACCAG 
GAGCTGCTGG ACATCAAGCT GGCCCTGGAC ATGGAGATCC ATGCCTATCG AAAGCTGCTG 
GAGGGCGAGG AGGAGAGGCT GCGCCTGTCC CCCAGCCCTA CCTCGCAGCG CAGCCGTGGC 
CGCGCCTCCT CCCACTCATC CCAGTCTCAG GGTGGAGGCA GCGTCACCAA AAAGCGCAAG 
CTGGAGTCTT CCGAGAGCCG GAGCAGCTTC TCGCAGCATG CTCGCACTAG CGGGCGTGTG 
GCGGTAGAGG AAGTCGATGA AGAGGGAAAG TTCGTGCGGC TGCGCAACAA GTCCAACGAG 
GACCAGTCCA TGGGCAACTG GCAGATCAGG CGTCAGAATG GTGACGATCC TTTGATGACC 
TATCGCTTCC CACCGAAGTT CACCCTAAAG GCTGGGCAGG TGGTGACGAT CTGGGCTTCA 
GGAGCTGGGG CCACCCATAG CCCCCCTACT GACTTGGTGT GGAAGGCGCA GAACACCTGG 
GGCTGTGGGA GCAGCCTTCG CACCGCTCTC ATCAACTCCA CTGGAGAAGA AGTGGCCATG 
CGCAAGCTGG TGCGCTCACT GACCATGGTT GAGGACAATG AGGATGACGA CGAGGATGGA 
GAAGAGCTCC TCCATCACCA CCGTGTGAGT GGCAGCCGCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001104572.1
CDS	250..1974
Translation	METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGSSLRTALINSTGEEVAMRKLVRSLTMVEDNEDDDEDGEELLHHHRVSGSRR

Target ORF information:

RefSeq Version	NM_001111102.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus lamin A (Lmna), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001111102.2

ORF Insert Sequence:

ATGGAGACCC CGTCACAGCG GCGCGCCACC CGCAGTGGGG CGCAGGCCAG CTCTACCCCA 
CTGTCGCCCA CTCGGATCAC CCGGCTGCAG GAGAAGGAGG ACCTGCAGGA GCTCAATGAC 
CGCCTGGCCG TGTACATCGA TCGCGTGCGT TCCCTGGAGA CCGAGAACGC GGGGCTGCGC 
CTTCGCATCA CTGAGTCTGA AGAGGTGGTC AGCCGAGAGG TGTCCGGCAT CAAGGCGGCC 
TACGAGGCCG AGCTGGGGGA TGCCCGCAAG ACCCTTGATT CTGTGGCCAA GGAGCGCGCC 
CGCCTCCAGC TAGAGCTGAG CAAAGTGCGT GAGGAGTTCA AGGAGCTGAA GGCTCGCAAC 
ACCAAGAAGG AGGGGGACTT GTTGGCTGCG CAGGCCCGGC TCAAGGACCT CGAGGCTCTT 
CTCAACTCCA AGGAAGCTGC CCTGAGCACT GCTCTCAGTG AGAAGCGCAC ATTGGAGGGC 
GAGCTCCATG ACCTGCGGGG GCAGGTAGCC AAGCTTGAGG CGGCCCTGGG AGAGGCTAAG 
AAGCAGCTTC AGGATGAGAT GCTGAGGCGA GTGGATGCTG AGAACAGGCT ACAGACGCTG 
AAGGAGGAGC TTGACTTCCA GAAGAACATT TACAGCGAGG AACTGCGTGA GACCAAGCGC 
CGGCATGAGA CGCGGCTTGT GGAGATCGAT AACGGGAAGC AGCGAGAGTT TGAGAGCCGG 
CTGGCAGATG CCCTGCAGGA GCTGCGGGCT CAGCATGAGG ACCAGGTGGA ACAGTATAAG 
AAGGAGCTAG AAAAGACATA CTCCGCCAAG CTGGATAATG CCAGGCAGTC TGCTGAGAGG 
AACAGCAACC TCGTGGGGGC TGCCCATGAG GAACTGCAGC AGTCTCGAAT CCGCATTGAC 
AGCCTCTCGG CCCAGCTCAG CCAGCTCCAA AAGCAGTTGG CAGCCAAGGA GGCAAAGCTG 
CGTGACCTGG AGGACTCGCT GGCCCGTGAG CGCGATACCA GCCGGCGCCT GCTGGCTGAG 
AAAGAGCGAG AGATGGCGGA GATGCGGGCG AGGATGCAGC AGCAGCTGGA CGAGTACCAG 
GAGCTGCTGG ACATCAAGCT GGCCCTGGAC ATGGAGATCC ATGCCTATCG AAAGCTGCTG 
GAGGGCGAGG AGGAGAGGCT GCGCCTGTCC CCCAGCCCTA CCTCGCAGCG CAGCCGTGGC 
CGCGCCTCCT CCCACTCATC CCAGTCTCAG GGTGGAGGCA GCGTCACCAA AAAGCGCAAG 
CTGGAGTCTT CCGAGAGCCG GAGCAGCTTC TCGCAGCATG CTCGCACTAG CGGGCGTGTG 
GCGGTAGAGG AAGTCGATGA AGAGGGAAAG TTCGTGCGGC TGCGCAACAA GTCCAACGAG 
GACCAGTCCA TGGGCAACTG GCAGATCAGG CGTCAGAATG GTGACGATCC TTTGATGACC 
TATCGCTTCC CACCGAAGTT CACCCTAAAG GCTGGGCAGG TGGTGACGAT CTGGGCTTCA 
GGAGCTGGGG CCACCCATAG CCCCCCTACT GACTTGGTGT GGAAGGCGCA GAACACCTGG 
GGCTGTGGGA GCAGCCTTCG CACCGCTCTC ATCAACTCCA CTGGAGAAGA AGTGGCCATG 
CGCAAGCTGG TGCGCTCACT GACCATGGTT GAGGACAATG AGGATGACGA CGAGGATGGA 
GAAGAGCTCC TCCATCACCA CCGTGTGAGT GGCAGCCGCC GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lmna ( NM_019390.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062263.1 Mus musculus lamin A (Lmna), transcript variant 2, mRNA.

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CloneID	OMu18344
Clone ID Related Accession (Same CDS sequence)	NM_019390.3
Accession Version	NM_019390.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1389bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Mus musculus(house mouse)
Product	prelamin-A/C isoform C2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC145168.5, BY140664.1 and AC102388.7. On May 7, 2013 this sequence version replaced NM_019390.2. Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and uses an alternate 3' structure, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (C2) has distinct N- and C-termini and is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D14850.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAACG CGGAGGGCCG CAACACCAAG AAGGAGGGGG ACTTGTTGGC TGCGCAGGCC 
CGGCTCAAGG ACCTCGAGGC TCTTCTCAAC TCCAAGGAAG CTGCCCTGAG CACTGCTCTC 
AGTGAGAAGC GCACATTGGA GGGCGAGCTC CATGACCTGC GGGGGCAGGT AGCCAAGCTT 
GAGGCGGCCC TGGGAGAGGC TAAGAAGCAG CTTCAGGATG AGATGCTGAG GCGAGTGGAT 
GCTGAGAACA GGCTACAGAC GCTGAAGGAG GAGCTTGACT TCCAGAAGAA CATTTACAGC 
GAGGAACTGC GTGAGACCAA GCGCCGGCAT GAGACGCGGC TTGTGGAGAT CGATAACGGG 
AAGCAGCGAG AGTTTGAGAG CCGGCTGGCA GATGCCCTGC AGGAGCTGCG GGCTCAGCAT 
GAGGACCAGG TGGAACAGTA TAAGAAGGAG CTAGAAAAGA CATACTCCGC CAAGCTGGAT 
AATGCCAGGC AGTCTGCTGA GAGGAACAGC AACCTCGTGG GGGCTGCCCA TGAGGAACTG 
CAGCAGTCTC GAATCCGCAT TGACAGCCTC TCGGCCCAGC TCAGCCAGCT CCAAAAGCAG 
TTGGCAGCCA AGGAGGCAAA GCTGCGTGAC CTGGAGGACT CGCTGGCCCG TGAGCGCGAT 
ACCAGCCGGC GCCTGCTGGC TGAGAAAGAG CGAGAGATGG CGGAGATGCG GGCGAGGATG 
CAGCAGCAGC TGGACGAGTA CCAGGAGCTG CTGGACATCA AGCTGGCCCT GGACATGGAG 
ATCCATGCCT ATCGAAAGCT GCTGGAGGGC GAGGAGGAGA GGCTGCGCCT GTCCCCCAGC 
CCTACCTCGC AGCGCAGCCG TGGCCGCGCC TCCTCCCACT CATCCCAGTC TCAGGGTGGA 
GGCAGCGTCA CCAAAAAGCG CAAGCTGGAG TCTTCCGAGA GCCGGAGCAG CTTCTCGCAG 
CATGCTCGCA CTAGCGGGCG TGTGGCGGTA GAGGAAGTCG ATGAAGAGGG AAAGTTCGTG 
CGGCTGCGCA ACAAGTCCAA CGAGGACCAG TCCATGGGCA ACTGGCAGAT CAGGCGTCAG 
AATGGTGACG ATCCTTTGAT GACCTATCGC TTCCCACCGA AGTTCACCCT AAAGGCTGGG 
CAGGTGGTGA CGATCTGGGC TTCAGGAGCT GGGGCCACCC ATAGCCCCCC TACTGACTTG 
GTGTGGAAGG CGCAGAACAC CTGGGGCTGT GGGAGCAGCC TTCGCACCGC TCTCATCAAC 
TCCACTGGAG AAGAAGTGGC CATGCGCAAG CTGGTGCGCT CACTGACCAT GGTTGAGGAC 
AATGAGGATG ACGACGAGGA TGGAGAAGAG CTCCTCCATC ACCACCGTGT GAGTGGCAGC 
CGCCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062263.1
CDS	57..1445
Translation	MGNAEGRNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSPPTDLVWKAQNTWGCGSSLRTALINSTGEEVAMRKLVRSLTMVEDNEDDDEDGEELLHHHRVSGSRR

Target ORF information:

RefSeq Version	NM_019390.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus lamin A (Lmna), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019390.3

ORF Insert Sequence:

ATGGGGAACG CGGAGGGCCG CAACACCAAG AAGGAGGGGG ACTTGTTGGC TGCGCAGGCC 
CGGCTCAAGG ACCTCGAGGC TCTTCTCAAC TCCAAGGAAG CTGCCCTGAG CACTGCTCTC 
AGTGAGAAGC GCACATTGGA GGGCGAGCTC CATGACCTGC GGGGGCAGGT AGCCAAGCTT 
GAGGCGGCCC TGGGAGAGGC TAAGAAGCAG CTTCAGGATG AGATGCTGAG GCGAGTGGAT 
GCTGAGAACA GGCTACAGAC GCTGAAGGAG GAGCTTGACT TCCAGAAGAA CATTTACAGC 
GAGGAACTGC GTGAGACCAA GCGCCGGCAT GAGACGCGGC TTGTGGAGAT CGATAACGGG 
AAGCAGCGAG AGTTTGAGAG CCGGCTGGCA GATGCCCTGC AGGAGCTGCG GGCTCAGCAT 
GAGGACCAGG TGGAACAGTA TAAGAAGGAG CTAGAAAAGA CATACTCCGC CAAGCTGGAT 
AATGCCAGGC AGTCTGCTGA GAGGAACAGC AACCTCGTGG GGGCTGCCCA TGAGGAACTG 
CAGCAGTCTC GAATCCGCAT TGACAGCCTC TCGGCCCAGC TCAGCCAGCT CCAAAAGCAG 
TTGGCAGCCA AGGAGGCAAA GCTGCGTGAC CTGGAGGACT CGCTGGCCCG TGAGCGCGAT 
ACCAGCCGGC GCCTGCTGGC TGAGAAAGAG CGAGAGATGG CGGAGATGCG GGCGAGGATG 
CAGCAGCAGC TGGACGAGTA CCAGGAGCTG CTGGACATCA AGCTGGCCCT GGACATGGAG 
ATCCATGCCT ATCGAAAGCT GCTGGAGGGC GAGGAGGAGA GGCTGCGCCT GTCCCCCAGC 
CCTACCTCGC AGCGCAGCCG TGGCCGCGCC TCCTCCCACT CATCCCAGTC TCAGGGTGGA 
GGCAGCGTCA CCAAAAAGCG CAAGCTGGAG TCTTCCGAGA GCCGGAGCAG CTTCTCGCAG 
CATGCTCGCA CTAGCGGGCG TGTGGCGGTA GAGGAAGTCG ATGAAGAGGG AAAGTTCGTG 
CGGCTGCGCA ACAAGTCCAA CGAGGACCAG TCCATGGGCA ACTGGCAGAT CAGGCGTCAG 
AATGGTGACG ATCCTTTGAT GACCTATCGC TTCCCACCGA AGTTCACCCT AAAGGCTGGG 
CAGGTGGTGA CGATCTGGGC TTCAGGAGCT GGGGCCACCC ATAGCCCCCC TACTGACTTG 
GTGTGGAAGG CGCAGAACAC CTGGGGCTGT GGGAGCAGCC TTCGCACCGC TCTCATCAAC 
TCCACTGGAG AAGAAGTGGC CATGCGCAAG CTGGTGCGCT CACTGACCAT GGTTGAGGAC 
AATGAGGATG ACGACGAGGA TGGAGAAGAG CTCCTCCATC ACCACCGTGT GAGTGGCAGC 
CGCCGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity.
Nucleus (Austin, Tex.)1(3)273-83(2010 May-Jun)
Jahn D,Schramm S,Benavente R,Alsheimer M

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy.
The Journal of cell biology147(5)913-20(1999 Nov)
Sullivan T,Escalante-Alcalde D,Bhatt H,Anver M,Bhat N,Nagashima K,Stewart CL,Burke B

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Lmna cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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