Lhx4 cDNA ORF clone, Mus musculus(house mouse)

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP
Development (Cambridge, England)144(18)3289-3302(2017 09)

ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons.
Kim KT, Kim N, Kim HK, Lee H, Gruner HN, Gergics P, Park C, Mastick GS, Park HC, Song MR
Scientific reports636491(2016 Nov)

Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.
Rousso DL, Qiao M, Kagan RD, Yamagata M, Palmiter RD, Sanes JR
Cell reports15(9)1930-44(2016 05)

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.
Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA
The Journal of cell biology212(1)77-89(2016 Jan)

conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 expression in RP epithelium.
Title: Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.

We discovered that expression of Cdkn1a is expanded dorsally in the pituitary primordium of both Lhx3 and Lhx4 mutants. Lhx4 mutants exhibit reduced cyclin D1 expression and have auxiliary pouch-like structures.
Title: Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.

X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
Title: Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

Successful purification and crystallization of an engineered complex comprising the LIM domains of motor neuron protein Lhx4 and the Lim binding domain of Isl2 (islet 2 protein) are reported.
Title: Crystallization and diffraction of an Lhx4-Isl2 complex.

Results show that Lhx3 exhibits specific spatial and temporal expression in the mouse placenta, but that absence of both LHX3 and 4 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr.
Title: Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.